专利检索 ap:("Moderna Therapeutics, Inc.") AND inv:"GUILD, Justin" 第 1 页

1.

发明公开
MODIFIED POLYNUCLEOTIDES FOR THE PRODUCTION OF BIOLOGICS AND PROTEINS ASSOCIATED WITH HUMAN DISEASE 审中-公开
标题翻译：修饰的多核苷酸将生物材料在人类与疾病的连接产生和蛋白质

公开(公告)号：EP2833920A2

公开(公告)日：2015-02-11

申请号：EP13712973.0

申请日：2013-03-09

申请人： Moderna Therapeutics, Inc.

发明人： BANCEL, Stephane , CHAKRABORTY, Tirtha , DE FOUGEROLLES, Antonin , ELBASHIR, Sayda M. , JOHN, Matthias , ROY, Atanu , WHORISKEY, Susan , WOOD, Kristy M. , HATALA, Paul , SCHRUM, Jason P. , EJEBE, Kenechi , ELLSWORTH, Jeff Lynn , GUILD, Justin

IPC分类号： A61K48/00 , C07K14/47 , C12N15/85

CPC分类号： A61K48/0066 , A61K9/1271 , A61K9/145 , A61K9/5123 , A61K9/5146 , A61K9/5153 , A61K31/7115 , A61K38/00 , A61K38/17 , A61K38/177 , A61K38/1816 , A61K38/1891 , A61K38/191 , A61K38/193 , A61K38/212 , A61K38/45 , A61K38/4846 , A61K47/543 , A61K48/0033 , A61K48/005 , A61K48/0075 , C07H21/02 , C07K14/005 , C07K14/435 , C07K14/43595 , C07K14/47 , C07K14/4705 , C07K14/4713 , C07K14/4723 , C07K14/4746 , C07K14/475 , C07K14/485 , C07K14/495 , C07K14/505 , C07K14/515 , C07K14/525 , C07K14/535 , C07K14/5418 , C07K14/56 , C07K14/61 , C07K14/62 , C07K14/705 , C07K14/745 , C07K16/00 , C07K16/2863 , C07K16/2887 , C07K16/40 , C12N9/0069 , C12N9/0091 , C12N9/1051 , C12N9/1241 , C12N9/16 , C12N9/2402 , C12N9/2445 , C12N9/6435 , C12N9/6437 , C12N9/644 , C12N9/6443 , C12N9/6451 , C12N9/88 , C12N9/93 , C12N15/11 , C12N15/52 , C12N15/85 , C12N15/87 , C12P13/04 , C12P21/00 , C12P21/005 , C12Y113/12007 , C12Y116/03001 , C12Y207/07012 , C12Y304/21007 , C12Y304/21022 , C12Y304/21027 , C12Y403/02001 , C12Y603/02019 , Y02A50/401 , Y02A50/411 , Y02A50/414 , Y02A50/415 , Y02A50/423 , Y02A50/463 , Y02A50/491

摘要： The invention relates to compositions and methods for the preparation, manufacture and therapeutic use of polynucleotides, primary transcripts and mmRNA molecules.

摘要翻译： 本发明涉及组合物和方法用于制备，制造和治疗用途的多核苷酸，初级转录物和mmRNA的分子。

2.

发明公开
MODIFIED POLYNUCLEOTIDES 审中-公开
标题翻译：改性聚丙烯

公开(公告)号：EP2834259A1

公开(公告)日：2015-02-11

申请号：EP13772785.5

申请日：2013-03-09

申请人： Moderna Therapeutics, Inc.

发明人： BANCEL, Stephane , CHAKRABORTY, Tirtha , DE FOUGEROLLES, Antonin , ELBASHIR, Sayda M. , JOHN, Matthias , ROY, Atanu , WHORISKEY, Susan , WOOD, Kristy M. , HATALA, Paul , SCHRUM, Jason P. , EJEBE, Kenechi , ELLSWORTH, Jeff Lynn , GUILD, Justin

IPC分类号： C07H21/00

CPC分类号： A61K48/0066 , A61K9/1271 , A61K9/145 , A61K9/5123 , A61K9/5146 , A61K9/5153 , A61K31/7115 , A61K38/00 , A61K38/17 , A61K38/177 , A61K38/1816 , A61K38/1891 , A61K38/191 , A61K38/193 , A61K38/212 , A61K38/45 , A61K38/4846 , A61K47/543 , A61K48/0033 , A61K48/005 , A61K48/0075 , C07H21/02 , C07K14/005 , C07K14/435 , C07K14/43595 , C07K14/47 , C07K14/4705 , C07K14/4713 , C07K14/4723 , C07K14/4746 , C07K14/475 , C07K14/485 , C07K14/495 , C07K14/505 , C07K14/515 , C07K14/525 , C07K14/535 , C07K14/5418 , C07K14/56 , C07K14/61 , C07K14/62 , C07K14/705 , C07K14/745 , C07K16/00 , C07K16/2863 , C07K16/2887 , C07K16/40 , C12N9/0069 , C12N9/0091 , C12N9/1051 , C12N9/1241 , C12N9/16 , C12N9/2402 , C12N9/2445 , C12N9/6435 , C12N9/6437 , C12N9/644 , C12N9/6443 , C12N9/6451 , C12N9/88 , C12N9/93 , C12N15/11 , C12N15/52 , C12N15/85 , C12N15/87 , C12P13/04 , C12P21/00 , C12P21/005 , C12Y113/12007 , C12Y116/03001 , C12Y207/07012 , C12Y304/21007 , C12Y304/21022 , C12Y304/21027 , C12Y403/02001 , C12Y603/02019 , Y02A50/401 , Y02A50/411 , Y02A50/414 , Y02A50/415 , Y02A50/423 , Y02A50/463 , Y02A50/491

摘要： The invention relates to compositions and methods for the preparation, manufacture and therapeutic use of polynucleotides, primary transcripts and mmRNA molecules.

摘要翻译： 本发明涉及用于制备，制造和治疗性使用多核苷酸，初级转录物和mmRNA分子的组合物和方法。

3.

发明公开
MODIFIED POLYNUCLEOTIDES FOR THE PRODUCTION OF PROTEINS ASSOCIATED WITH HUMAN DISEASE 审中-公开
标题翻译：修饰的多核苷酸为蛋白质相关与疾病在人类生产

公开(公告)号：EP2849799A2

公开(公告)日：2015-03-25

申请号：EP13722158.6

申请日：2013-03-09

申请人： Moderna Therapeutics, Inc.

发明人： BANCEL, Stephane , CHAKRABORTY, Tirtha , DE FOUGEROLLES, Antonin , ELBASHIR, Sayda, M. , JOHN, Matthias , ROY, Atanu , WHORISKEY, Susan , WOOD, Kristy, M. , HATALA, Paul , SCHRUM, Jason, P. , EJEBE, Kenechi , ELLSWORTH, Jeff, Lynn , GUILD, Justin

IPC分类号： A61K48/00 , C07K14/47 , C12N15/85 , A61K31/7115 , C12N9/88

CPC分类号： A61K48/0066 , A61K9/1271 , A61K9/145 , A61K9/5123 , A61K9/5146 , A61K9/5153 , A61K31/7115 , A61K38/00 , A61K38/17 , A61K38/177 , A61K38/1816 , A61K38/1891 , A61K38/191 , A61K38/193 , A61K38/212 , A61K38/45 , A61K38/4846 , A61K47/543 , A61K48/0033 , A61K48/005 , A61K48/0075 , C07H21/02 , C07K14/005 , C07K14/435 , C07K14/43595 , C07K14/47 , C07K14/4705 , C07K14/4713 , C07K14/4723 , C07K14/4746 , C07K14/475 , C07K14/485 , C07K14/495 , C07K14/505 , C07K14/515 , C07K14/525 , C07K14/535 , C07K14/5418 , C07K14/56 , C07K14/61 , C07K14/62 , C07K14/705 , C07K14/745 , C07K16/00 , C07K16/2863 , C07K16/2887 , C07K16/40 , C12N9/0069 , C12N9/0091 , C12N9/1051 , C12N9/1241 , C12N9/16 , C12N9/2402 , C12N9/2445 , C12N9/6435 , C12N9/6437 , C12N9/644 , C12N9/6443 , C12N9/6451 , C12N9/88 , C12N9/93 , C12N15/11 , C12N15/52 , C12N15/85 , C12N15/87 , C12P13/04 , C12P21/00 , C12P21/005 , C12Y113/12007 , C12Y116/03001 , C12Y207/07012 , C12Y304/21007 , C12Y304/21022 , C12Y304/21027 , C12Y403/02001 , C12Y603/02019 , Y02A50/401 , Y02A50/411 , Y02A50/414 , Y02A50/415 , Y02A50/423 , Y02A50/463 , Y02A50/491

摘要： The invention relates to compositions and methods for the preparation, manufacture and therapeutic use of polynucleotides, primary transcripts and mmRNA molecules.

摘要翻译： 本发明涉及组合物和方法用于制备，制造和治疗用途的多核苷酸，初级转录物和mmRNA的分子。

4.

发明公开
MODIFIED POLYNUCLEOTIDES FOR THE PRODUCTION OF CYTOPLASMIC AND CYTOSKELETAL PROTEINS 审中-公开
标题翻译：修饰的多核苷酸准备和细胞质细胞骨架蛋白

公开(公告)号：EP2847329A1

公开(公告)日：2015-03-18

申请号：EP13772653.5

申请日：2013-03-09

申请人： Moderna Therapeutics, Inc.

发明人： BANCEL, Stephane , CHAKRABORTY, Tirtha , DE FOUGEROLLES, Antonin , ELBASHIR, Sayda, M. , JOHN, Matthias , ROY, Atanu , WHORISKEY, Susan , WOOD, Kristy M. , HATALA, Paul , SCHRUM, Jason, P. , EJEBE, Kenechi , ELLSWORTH, Jeff, Lynn , GUILD, Justin

IPC分类号： C12N15/10

CPC分类号： A61K48/0066 , A61K9/1271 , A61K9/145 , A61K9/5123 , A61K9/5146 , A61K9/5153 , A61K31/7115 , A61K38/00 , A61K38/17 , A61K38/177 , A61K38/1816 , A61K38/1891 , A61K38/191 , A61K38/193 , A61K38/212 , A61K38/45 , A61K38/4846 , A61K47/543 , A61K48/0033 , A61K48/005 , A61K48/0075 , C07H21/02 , C07K14/005 , C07K14/435 , C07K14/43595 , C07K14/47 , C07K14/4705 , C07K14/4713 , C07K14/4723 , C07K14/4746 , C07K14/475 , C07K14/485 , C07K14/495 , C07K14/505 , C07K14/515 , C07K14/525 , C07K14/535 , C07K14/5418 , C07K14/56 , C07K14/61 , C07K14/62 , C07K14/705 , C07K14/745 , C07K16/00 , C07K16/2863 , C07K16/2887 , C07K16/40 , C12N9/0069 , C12N9/0091 , C12N9/1051 , C12N9/1241 , C12N9/16 , C12N9/2402 , C12N9/2445 , C12N9/6435 , C12N9/6437 , C12N9/644 , C12N9/6443 , C12N9/6451 , C12N9/88 , C12N9/93 , C12N15/11 , C12N15/52 , C12N15/85 , C12N15/87 , C12P13/04 , C12P21/00 , C12P21/005 , C12Y113/12007 , C12Y116/03001 , C12Y207/07012 , C12Y304/21007 , C12Y304/21022 , C12Y304/21027 , C12Y403/02001 , C12Y603/02019 , Y02A50/401 , Y02A50/411 , Y02A50/414 , Y02A50/415 , Y02A50/423 , Y02A50/463 , Y02A50/491

摘要： The invention relates to compositions and methods for the preparation, manufacture and therapeutic use of polynucleotides, primary transcripts and mmRNA molecules.

5.

发明公开
POLYNUCLEOTIDES ENCODING LOW DENSITY LIPOPROTEIN RECEPTOR 审中-公开
标题翻译：多克隆抗氧化剂低密度脂蛋白

公开(公告)号：EP3052521A1

公开(公告)日：2016-08-10

申请号：EP14789931.4

申请日：2014-10-03

申请人： Moderna Therapeutics, Inc.

发明人： ELLSWORTH, Jeff Lynn , BOLEN, Joseph Beene , GREGOIRE, Francine M. , GUILD, Justin

IPC分类号： C07K14/705

CPC分类号： C07K14/705 , A61K38/00

摘要： The invention relates to compositions and methods for the preparation, manufacture and therapeutic use of polynucleotide molecules encoding low density lipoprotein receptor comprising at least one mutation (e.g., an LDLR signally enhancing mutation).

摘要翻译： 本发明涉及用于制备，制造和治疗使用编码低密度脂蛋白受体的多核苷酸分子的组合物和方法，其包含至少一个突变（例如LDLR信号增强突变）。

6.

发明公开
COMPOSITIONS AND METHODS OF ALTERING CHOLESTEROL LEVELS 审中-公开
标题翻译： ZUSAMMENSETZUNGEN UND VERFAHREN ZURÄNDERUNGDES CHOLESTERINSPIEGELS

公开(公告)号：EP2970987A1

公开(公告)日：2016-01-20

申请号：EP14715521.2

申请日：2014-03-14

申请人： Moderna Therapeutics, Inc.

发明人： HOGE, Stephen, G. , HUANG, Eric, Yi-Chun , BOLEN, Joseph, Beene , GUILD, Justin , DE FOUGEROLLES, Antonin , ELLSWORTH, Jeff, Lynn

IPC分类号： C12N15/63 , C07K14/705 , A61K48/00 , C12N15/67 , C12N15/12 , A61K31/70

CPC分类号： A61K38/177 , A61K31/70 , A61K31/7088 , A61K31/713 , A61K38/44 , A61K45/06 , A61K48/00 , A61K48/0066 , C07K14/705 , C12N9/0073 , C12N15/63 , C12N2310/00 , C12Y114/13017

摘要： The present invention relates to compositions, methods and kits using polynucleotides, primary transcripts and mmRNA molecules.

摘要翻译： 本发明涉及使用多核苷酸，初级转录物和mmRNA分子的组合物，方法和试剂盒。