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    HEALTH-LEVEL MEASURING METHOD, HEALTH-LEVEL DETERMINING APPARATUS, AND HAIR-HEALTH DIAGNOSIS SYSTEM
    2.
    发明公开
    HEALTH-LEVEL MEASURING METHOD, HEALTH-LEVEL DETERMINING APPARATUS, AND HAIR-HEALTH DIAGNOSIS SYSTEM 审中-公开

    公开(公告)号：EP3499231A1

    公开(公告)日：2019-06-19

    申请号：EP17839479.7

    申请日：2017-08-08

    申请人： Organ Technologies Inc. ,  Riken

    发明人： TSUJI, Takashi ,  TOYOSHIMA, Koh-ei

    IPC分类号： G01N33/50 ,  G01N33/48

    摘要： The purpose of the present invention is to propose a method for measuring the level of health of a subject, with which it is possible: to perform health examination that is non-invasive to the human body and that employs a simple method; to provide highly reliable analysis results having a scientific basis; and to, additionally, provide appropriate solutions to the subject. Another purpose of the present invention is to propose a health-level determining apparatus employing said method and a new business model employing said method. The present invention is a method for measuring the level of health of a subject, including a hair analyzing step (A) for analyzing hair of the subject. It is preferable that the aforementioned hair analyzing step (A) include a step (A-1) for analyzing hair in the occipital region. In addition, it is preferable that the aforementioned hair analyzing step (A) include a step (A-2) for analyzing hair in a site other than the occipital region.

    METHOD FOR PRODUCING ARTIFICIAL SKIN HAVING HAIR FOLLICLES, SEBACEOUS GLANDS, AND PORES
    3.
    发明公开
    METHOD FOR PRODUCING ARTIFICIAL SKIN HAVING HAIR FOLLICLES, SEBACEOUS GLANDS, AND PORES 审中-公开

    公开(公告)号：EP3473705A1

    公开(公告)日：2019-04-24

    申请号：EP17815338.3

    申请日：2017-06-19

    申请人： Organ Technologies, Inc. ,  Riken

    发明人： TSUJI, Takashi ,  TOYOSHIMA, Koh-ei ,  OGAWA, Miho

    IPC分类号： C12N5/071 ,  A61L27/36 ,  A61L27/60 ,  C12N5/0775

    摘要： The object of the present invention is to provide an artificial skin having hair follicles, sebaceous glands, and hair pores. The present invention provides a method for manufacturing artificial skin having hair follicles, sebaceous glands, and hair pores, characterized in that it comprises each of the following steps:
    (A) : a step of preparing an artificial skin having dermal and epidermal layers or an artificial skin having only a dermal layer; and
    (B): a step of transplanting isolated hair follicles to the artificial skin prepared in step (A);
    wherein said isolated hair follicle comprises a sebaceous gland, and said isolated hair follicle is transplanted to said artificial skin so that the surface of said dermal layer of said artificial skin is in alignment with the position of the hair pore portion of said isolated hair follicle.

    METHOD OF PREPARING REGENERATED HAIR FOLLICLE GERM FOR TRANSPLANTATION IN WHICH HAIR COLOR IS CONTROLLED, COMPOSITION INCLUDING REGENERATED HAIR FOLLICLE GERM FOR TRANSPLANTATION, AND METHOD OF TRANSPLANTING REGENERATED HAIR FOLLICLE GERM
    5.
    发明公开
    METHOD OF PREPARING REGENERATED HAIR FOLLICLE GERM FOR TRANSPLANTATION IN WHICH HAIR COLOR IS CONTROLLED, COMPOSITION INCLUDING REGENERATED HAIR FOLLICLE GERM FOR TRANSPLANTATION, AND METHOD OF TRANSPLANTING REGENERATED HAIR FOLLICLE GERM 审中-公开
    用于生产再生沥青HAARFOLLIKELKEIME对于与再生HAARFOLLIKELPFLANZENKEIMEN控制染发成分进行移植，和方法移植再生沥青HAARFOLLIKELKEIME TRANSPLANT

    公开(公告)号：EP2679674A1

    公开(公告)日：2014-01-01

    申请号：EP12749896.2

    申请日：2012-02-21

    申请人： Organ Technologies Inc.

    发明人： TOYOSHIMA, Koh-ei ,  TSUJI, Takashi

    IPC分类号： C12N5/10 ,  A61L27/00

    CPC分类号： C12N5/0697 ,  A61L27/3813 ,  A61L27/3834 ,  A61L27/3886 ,  A61L27/3891 ,  A61L2430/18 ,  C12N2506/092 ,  C12N2506/1376

    摘要： [Problem] To provide a technique for regenerating hair through the transplantation of hair follicle germ in which the color of the regenerated hair is controlled.
    [Solution] Provided is a method for producing a regenerative hair follicle germ for transplantation in which a color of hair that grows after transplantation is controlled, said method including: preparing a first cell mass including mesenchymal cells; preparing a second cell mass including epithelial cells; preparing a cell mass including pigment stem cells; binding the cell mass including the pigment stem cells to at least one among the first cell mass and the second cell mass, and closely contacting the first cell mass and the second cell mass, at least one of which has been bound to the cell mass including the pigment stem cells, and culturing them within a support.

    摘要翻译： [问题]为了提供一种通过在其中再生头发的颜色被控制毛囊胚芽移植再生毛发的技术。 [解决方法]本发明提供一种制造用于移植的再生毛囊胚芽中哪一个发色没被控制移植后，所述的方法包括生长的方法：制备第1细胞集合体包含间充质细胞; 制备第二细胞集合体包括上皮细胞; 制备细胞块包含色素干细胞; 结合细胞块包括第1细胞集合体和第2细胞集合体之间的色素干细胞的至少一种，并且紧密接触第1细胞集合体和第2细胞集合体，其中至少一个的已结合到细胞块包括 颜料的干细胞，和一个支撑件内培养之。

    METHOD OF PRODUCING FULL THICKNESS SKIN HAVING SKIN ACCESSORY ORGANS
    8.
    发明公开
    METHOD OF PRODUCING FULL THICKNESS SKIN HAVING SKIN ACCESSORY ORGANS 审中-公开
    生产具有皮肤附属器官的完整厚度皮肤的方法

    公开(公告)号：EP3192533A1

    公开(公告)日：2017-07-19

    申请号：EP15839965.9

    申请日：2015-09-07

    申请人： ORGAN TECHNOLOGIES, INC.

    发明人： TSUJI, Takashi ,  TOYOSHIMA, Koh-ei

    IPC分类号： A61L27/00 ,  C12N5/071

    CPC分类号： A61L27/00 ,  A01K67/0271 ,  A01K2207/10 ,  A01K2207/12 ,  A01K2227/105 ,  A01K2267/025 ,  A01K2267/0331 ,  A61L27/36 ,  A61L27/3604 ,  A61L27/38 ,  A61L27/40 ,  A61L27/60 ,  C12N5/0696 ,  C12N2501/415 ,  C12N2502/1323

    摘要： The present invention provides a method for efficiently manufacturing full-thickness skin with skin appendage. The present invention provides a method for manufacturing full-thickness skin with skin appendage, characterized in that said method comprises the following steps (a) - (d): (a) a step of stimulating an embryoid body with a bioactive substance that may activate the Wnt pathway, (b) a step of preparing a conjugate comprising all or a part of said embryoid body stimulated in step (a) and a scaffolding material, (c) a step of transplanting said conjugate prepared in said step (b) to an animal, and (d) a step of manufacturing full-thickness skin derived from said conjugate in said animal.

    摘要翻译： 本发明提供一种有效制造具有皮肤附属物的全层皮肤的方法。 本发明提供了一种制造具有皮肤附属物的全层皮肤的方法，其特征在于，所述方法包括以下步骤（a） - （d）：（a）用可能活化的生物活性物质刺激胚状体的步骤 （b）制备包含在步骤（a）中刺激的全部或部分所述胚状体和支架材料的缀合物的步骤，（c）将所述步骤（b）中制备的所述缀合物移植到 （d）在所述动物中制造源自所述缀合物的全层皮肤的步骤。