公开(公告)号：EP2936222A4

公开(公告)日：2016-09-07

申请号：EP13863794

申请日：2013-12-16

Applicant: PACIFIC BIOSCIENCES CALIFORNIA

Inventor： GROT ANNETTE ,  WANG SHANG ,  CALLEBAUT HANS ,  LUNDQUIST PAUL ,  TURNER STEPHEN

IPC: G01N21/64 ,  B82Y5/00 ,  B82Y15/00 ,  B82Y20/00 ,  G01N21/77 ,  G01N33/543 ,  G01N33/553 ,  G02B6/10

CPC classification number: G02B6/0016 ,  B82Y15/00 ,  B82Y20/00 ,  G01N21/6452 ,  G01N21/648 ,  G01N21/6486 ,  G01N21/7703 ,  G02B6/024 ,  G02B6/10 ,  G02B6/12004 ,  G02B6/122 ,  G02B23/2461

Abstract: Optical analytical devices and their methods of use are provided. The devices are useful in the analysis of highly multiplexed optical reactions in large numbers at high densities, including biochemical reactions, such as nucleic acid sequencing reactions. The devices include optical waveguides for illumination of the optical reactions. The devices further provide for the efficient coupling of optical excitation energy from the waveguides to the optical reactions. Optical signals emitted from the reactions can thus be measured with high sensitivity and discrimination using features such as spectra, amplitude, and time resolution, or combinations thereof. The devices of the invention are well suited for miniaturization and high throughput.

公开(公告)号：EP3186617A4

公开(公告)日：2018-04-25

申请号：EP15835461

申请日：2015-08-26

Applicant: PACIFIC BIOSCIENCES CALIFORNIA INC

Inventor： GROT ANNETTE ,  SAXENA RAVI ,  LUNDQUIST PAUL

IPC: G01N21/64 ,  G01N21/77 ,  G02B5/18 ,  G02B5/20 ,  G02B5/28 ,  G02B6/12 ,  G02B6/132 ,  G02B6/136 ,  G02B27/42 ,  H01L27/146

CPC classification number: G01N21/6454 ,  G01N21/6428 ,  G01N21/648 ,  G01N21/7703 ,  G01N21/78 ,  G01N2021/6439 ,  G01N2021/6478 ,  G01N2021/7756 ,  G01N2021/7786 ,  G01N2201/068 ,  G01N2201/0873 ,  G02B5/1895 ,  G02B5/201 ,  G02B5/285 ,  G02B6/132 ,  G02B6/136 ,  G02B27/4238 ,  G02B27/4244 ,  G02B2006/12102 ,  G02B2006/12109 ,  H01L27/14621 ,  H01L27/14627 ,  H01L27/14685

Abstract: Arrays of integrated analytical devices and their methods for production are provided. The arrays are useful in the analysis of highly multiplexed optical reactions in large numbers at high densities, including biochemical reactions, such as nucleic acid sequencing reactions. The devices allow the highly sensitive discrimination of optical signals using features such as spectra, amplitude, and time resolution, or combinations thereof. The devices include an integrated diffractive beam shaping element that provides for the spatial separation of light emitted from the optical reactions.

公开(公告)号：EP2362947A4

公开(公告)日：2012-10-24

申请号：EP09818087

申请日：2009-09-25

Applicant: PACIFIC BIOSCIENCES CALIFORNIA

Inventor： ZACCARIN DENIS ,  LUNDQUIST PAUL ,  ZHAO PEIQIAN ,  ZHONG FRANK ,  TURNER STEPHEN ,  HUANG YANQIAO ,  MONADGEMI PEZHMAN ,  SAXENA RAVI ,  GROT ANNETTE ,  RULISON AARON

IPC: G02B6/12 ,  G01N21/00

CPC classification number: G01N21/6452 ,  B05D1/005 ,  C23C16/50 ,  G01N21/253 ,  G02B6/12002 ,  G02B6/131 ,  G02B6/132 ,  G02B6/136 ,  G02B2006/12035 ,  G02B2006/12061 ,  G02B2006/12104 ,  G02B2006/12164 ,  G02B2006/12197