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1.发明公开METHODS AND SYSTEMS FOR ANALYSIS OF FLUORESCENT REACTIONS WITH MODULATED EXCITATION 审中-公开方法和系统的分析荧光反应的方法调制的激发
公开(公告)号：EP2245444A4
公开(公告)日：2014-04-16
申请号：EP09700236
申请日：2009-01-09
Applicant: PACIFIC BIOSCIENCES CALIFORNIA
Inventor： LUONG KHAI , LUNDQUIST PAUL , DALAL RAVI , LYLE JOHN , TURNER STEPHEN
CPC classification number: C12M1/34 , G01N21/6428 , G01N21/645 , G01N2021/6417 , G01N2021/6419 , G01N2021/6421 , G01N2021/6441 , G01N2021/7786 , Y10T436/2525
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2.发明公开METHODS AND SYSTEMS FOR SIMULTANEOUS REAL-TIME MONITORING OF OPTICAL SIGNALS FROM MULTIPLE SOURCES 有权用于同时实时监测来自多个源的光信号的方法和系统
公开(公告)号：EP1984712A4
公开(公告)日：2013-02-20
申请号：EP07750629
申请日：2007-02-09
Applicant: PACIFIC BIOSCIENCES CALIFORNIA
Inventor： LUNDQUIST PAUL , ZACCARIN DENIS , LACROIX YVES , TURNER STEPHEN , DIXON JOHN
CPC classification number: G01N21/6452 , G01J3/02 , G01J3/0224 , G01J3/10 , G01J3/14 , G01J3/2803 , G01N21/6445 , G01N21/6456 , G01N21/648 , G01N2021/6417 , G01N2021/6441
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公开(公告)号：EP2331934A4
公开(公告)日：2015-04-01
申请号：EP09814888
申请日：2009-09-15
Applicant: PACIFIC BIOSCIENCES CALIFORNIA
Inventor： ZHONG CHENG FRANK , LUNDQUIST PAUL , FOQUET MATHIEU , KORLACH JONAS , BAYANDORIAN HOVIG
CPC classification number: C12Q1/6874 , C12Q1/68 , C12Q1/6825 , G01N21/6428 , G01N21/648 , G01N21/7703 , G01N33/54373 , G01N2021/6463 , G01N2201/06113 , G01N2201/0638 , G01N2201/08
Abstract: This invention provides substrates for use in various applications, including single-molecule analytical reactions. Methods for propagating optical energy within a substrate are provided. Devices comprising waveguide substrates and dielectric omnidirectional reflectors are provided. Waveguide substrates with improved uniformity of optical energy intensity across one or more waveguides and enhanced waveguide illumination efficiency within an analytic detection region of the arrays are provided.
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4.发明公开METHODS AND SYSTEMS FOR MONITORING MULTIPLE OPTICAL SIGNALS FROM A SINGLE SOURCE 审中-公开方法和系统几种光信号从一个源监测
公开(公告)号：EP1920277A4
公开(公告)日：2013-01-16
申请号：EP06813384
申请日：2006-08-10
Applicant: PACIFIC BIOSCIENCES CALIFORNIA
Inventor： LUNDQUIST PAUL , TURNER STEPHEN , ZACCARIN DENIS
CPC classification number: G01N21/6452 , G01J3/2803 , G01J3/36 , G01N21/6428
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公开(公告)号：EP3186617A4
公开(公告)日：2018-04-25
申请号：EP15835461
申请日：2015-08-26
Applicant: PACIFIC BIOSCIENCES CALIFORNIA INC
Inventor： GROT ANNETTE , SAXENA RAVI , LUNDQUIST PAUL
IPC: G01N21/64 , G01N21/77 , G02B5/18 , G02B5/20 , G02B5/28 , G02B6/12 , G02B6/132 , G02B6/136 , G02B27/42 , H01L27/146
CPC classification number: G01N21/6454 , G01N21/6428 , G01N21/648 , G01N21/7703 , G01N21/78 , G01N2021/6439 , G01N2021/6478 , G01N2021/7756 , G01N2021/7786 , G01N2201/068 , G01N2201/0873 , G02B5/1895 , G02B5/201 , G02B5/285 , G02B6/132 , G02B6/136 , G02B27/4238 , G02B27/4244 , G02B2006/12102 , G02B2006/12109 , H01L27/14621 , H01L27/14627 , H01L27/14685
Abstract: Arrays of integrated analytical devices and their methods for production are provided. The arrays are useful in the analysis of highly multiplexed optical reactions in large numbers at high densities, including biochemical reactions, such as nucleic acid sequencing reactions. The devices allow the highly sensitive discrimination of optical signals using features such as spectra, amplitude, and time resolution, or combinations thereof. The devices include an integrated diffractive beam shaping element that provides for the spatial separation of light emitted from the optical reactions.
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Patent Agency Ranking6.发明公开METHODS AND SYSTEMS FOR ANALYZING FLUORESCENT MATERIALS WITH REDUCED AUTOFLUORESCENCE 审中-公开方法和系统的分析荧光材料与荧光减少OWN
公开(公告)号：EP2150806A4
公开(公告)日：2013-01-02
申请号：EP08767652
申请日：2008-05-09
Applicant: PACIFIC BIOSCIENCES CALIFORNIA
Inventor： LUNDQUIST PAUL , ZHONG CHENG-FRANK , ZACCARIN DENIS , ZHAO PEGIAN , TURNER STEPHEN
CPC classification number: G01N27/447 , G01N21/6452 , G01N21/6458 , G02B21/0032
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公开(公告)号：EP2362947A4
公开(公告)日：2012-10-24
申请号：EP09818087
申请日：2009-09-25
Applicant: PACIFIC BIOSCIENCES CALIFORNIA
Inventor： ZACCARIN DENIS , LUNDQUIST PAUL , ZHAO PEIQIAN , ZHONG FRANK , TURNER STEPHEN , HUANG YANQIAO , MONADGEMI PEZHMAN , SAXENA RAVI , GROT ANNETTE , RULISON AARON
CPC classification number: G01N21/6452 , B05D1/005 , C23C16/50 , G01N21/253 , G02B6/12002 , G02B6/131 , G02B6/132 , G02B6/136 , G02B2006/12035 , G02B2006/12061 , G02B2006/12104 , G02B2006/12164 , G02B2006/12197
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公开(公告)号：EP2936222A4
公开(公告)日：2016-09-07
申请号：EP13863794
申请日：2013-12-16
Applicant: PACIFIC BIOSCIENCES CALIFORNIA
Inventor： GROT ANNETTE , WANG SHANG , CALLEBAUT HANS , LUNDQUIST PAUL , TURNER STEPHEN
IPC: G01N21/64 , B82Y5/00 , B82Y15/00 , B82Y20/00 , G01N21/77 , G01N33/543 , G01N33/553 , G02B6/10
CPC classification number: G02B6/0016 , B82Y15/00 , B82Y20/00 , G01N21/6452 , G01N21/648 , G01N21/6486 , G01N21/7703 , G02B6/024 , G02B6/10 , G02B6/12004 , G02B6/122 , G02B23/2461
Abstract: Optical analytical devices and their methods of use are provided. The devices are useful in the analysis of highly multiplexed optical reactions in large numbers at high densities, including biochemical reactions, such as nucleic acid sequencing reactions. The devices include optical waveguides for illumination of the optical reactions. The devices further provide for the efficient coupling of optical excitation energy from the waveguides to the optical reactions. Optical signals emitted from the reactions can thus be measured with high sensitivity and discrimination using features such as spectra, amplitude, and time resolution, or combinations thereof. The devices of the invention are well suited for miniaturization and high throughput.
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公开(公告)号：EP2959283A4
公开(公告)日：2016-08-03
申请号：EP14754479
申请日：2014-02-21
Applicant: PACIFIC BIOSCIENCES CALIFORNIA
Inventor： LUNDQUIST PAUL , TURNER STEPHEN
CPC classification number: C12Q1/6874 , G01N21/6428 , G01N21/6454 , G01N21/648 , G01N21/7746 , G01N2021/7789 , G01N2201/08 , G02B6/0229 , G02B2006/12147
Abstract: Optical analytical devices and their methods of use are provided. The devices are useful in the analysis of highly multiplexed optical reactions in large numbers at high densities, including biochemical reactions, such as nucleic acid sequencing reactions. The devices include integrated illumination elements and optical waveguides for illumination of the optical reactions. The devices further provide for the efficient coupling of optical excitation energy from the waveguides to the optical reactions. Optical signals emitted from the reactions can thus be measured with high sensitivity and discrimination using features such as spectra, amplitude, and time resolution, or combinations thereof. The devices of the invention are well suited for miniaturization and high throughput.
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公开(公告)号：EP2064488A4
公开(公告)日：2016-01-06
申请号：EP07814642
申请日：2007-08-31
Applicant: PACIFIC BIOSCIENCES CALIFORNIA
Inventor： LUNDQUIST PAUL , TURNER STEPHEN
CPC classification number: G01N21/648 , G01N21/6428 , G01N21/6452 , G01N21/7703 , G01N2021/7786 , G02B6/43
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