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公开(公告)号：EP2771457A4
公开(公告)日：2015-04-08
申请号：EP12844270
申请日：2012-10-25
发明人： COST GREGORY J , HOLMES MICHAEL C , KASAHARA NORIYUKI , LAGANIERE JOSEE , MILLER JEFFREY C , PASCHON DAVID , REBAR EDWARD J , URNOV FYODOR , ZHANG LEI
CPC分类号： C12N15/85 , C07K2319/81 , C12N9/1077 , C12N9/22 , C12N9/96 , C12N15/907 , C12Y204/02008 , C12Y301/21004
摘要： Nucleases and methods of using these nucleases for modification of an HPRT locus and for increasing the frequency of gene modification at a targeted locus and clones and for generating animals.
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2.发明公开
公开(公告)号：EP2534163A4
公开(公告)日：2013-10-16
申请号：EP11742576
申请日：2011-02-09
发明人： COST GREGORY J , GUSCHIN DMITRY Y , URNOV FYODOR
CPC分类号： C12N15/902 , C07K2319/80 , C07K2319/81 , C12N9/22 , C12N15/907
摘要： Disclosed herein are donor molecules comprising single-stranded complementary regions flanking one or more sequences of interest. The donor molecules and/or compositions comprising these molecules can be used in methods for targeted integration of an exogenous sequence into a specified region of interest in the genome of a cell.
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公开(公告)号：EP1435779A4
公开(公告)日：2005-06-01
申请号：EP02766356
申请日：2002-09-24
IPC分类号： C12N5/0735 , G01N33/50 , A01N37/18 , A01N43/04 , A01N63/00 , C07H21/04 , C07K1/00 , C12N5/00 , C12N15/63
CPC分类号： C12N15/85 , A61K35/12 , C07H21/04 , C12N5/0606 , C12N15/62 , C12N15/63 , C12N2501/40 , C12N2503/02 , G01N33/5008 , G01N33/5023 , G01N33/5073
摘要： Methods and compositions for modifying stem cells using one or more ZFPs are disclosed. Such methods and compositions are useful for facilitating processes such as, for example, dedifferentiating cells, differentiating stem cells into the desired phenotype, propagating stem cells and/or facilitating cloning.
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4.发明公开NUCLEASE-MEDIATED REGULATION OF GENE EXPRESSION 审中-公开NUKLEASEVERMITTELTE REGULIERUNG DER GENEXPRESSION
公开(公告)号：EP3068881A4
公开(公告)日：2017-04-19
申请号：EP14861930
申请日：2014-11-13
发明人： ORKIN STUART H , REIK ANDREAS , URNOV FYODOR
IPC分类号： C12N15/09 , A61K35/12 , A61K35/28 , A61K38/46 , A61P7/00 , C07K14/47 , C12N9/22 , C12N15/113
CPC分类号： C12N9/22 , A61K35/12 , A61K35/28 , A61K38/465 , A61K48/00 , C07K14/4702 , C07K2319/80 , C07K2319/81 , C12N15/113 , C12N15/85 , C12N2310/10 , C12N2310/20
摘要： The present disclosure is in the field of genome engineering, particularly targeted modification of the genome of a hematopoietic cell.
摘要翻译： 本公开内容在基因组工程领域，特别是造血细胞基因组的靶向修饰。
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5.发明公开GENOME EDITING IN RATS USING ZINC-FINGER NUCLEASES 有权GEMONÄNDERUNGBEI RATTEN MITHILFE VON ZINK-FINGER-NUKLEASEN
公开(公告)号：EP2352369A4
公开(公告)日：2012-05-02
申请号：EP09830727
申请日：2009-12-03
发明人： CUI XIAOXIA , GEURTS ARON M , URNOV FYODOR
IPC分类号： A01K67/027 , C12N9/22 , C12N15/11 , C12N15/85
CPC分类号： C12N15/907 , A01K67/0275 , A01K67/0276 , A01K67/0278 , A01K2217/054 , A01K2217/15 , A01K2227/10 , A01K2227/105 , A01K2267/03 , A01K2267/0393 , C07K2319/00 , C07K2319/81 , C12N9/22 , C12N15/1024 , C12N15/8509 , C12N2015/8527 , C12N2800/80
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公开(公告)号：EP1913149A4
公开(公告)日：2009-08-05
申请号：EP06788559
申请日：2006-07-26
CPC分类号： C12N15/907 , A61K48/0008 , A61K48/005 , A61K48/0058 , C07K2319/00 , C07K2319/81 , C12N9/22 , C12N15/62 , C12N15/90
摘要： Disclosed herein are methods and compositions for targeted integration of a exogenous sequence into a predetermined target site in a genome for use, for example, in protein expression and gene inactivation.
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7.发明公开METHODS AND COMPOSITIONS FOR NUCLEASE-MEDIATED TARGETED INTEGRATION OF TRANSGENES 审中-公开FOR NUKLEASEVERMITTELTEN方法和的组合物靶向转基因整合
公开(公告)号：EP2847338A4
公开(公告)日：2015-12-09
申请号：EP13788413
申请日：2013-05-07
发明人： COST GREGORY J , URNOV FYODOR , AINLEY WILLIAM M , PETOLINO JOSEPH F , SAMUEL JAYAKUMAR PON , WEBB STEVEN R , SASTRY-DENT LAKSHMI
CPC分类号： C12N15/8201 , C12N15/102 , C12N15/8209 , C12N15/8213 , C12N15/8216 , C12N15/8241 , C12N15/8247 , C12N15/8274 , C12N15/8278 , C12N15/8286 , C12N15/85 , C12N15/87 , C12N2800/80 , Y02A40/162
摘要： Disclosed herein are methods and compositions for homology-independent targeted insertion of donor molecules into the genome of a cell.
摘要翻译： 公开在用于同源性无关的目标供体分子的插入细胞的基因组中的方法和组合物。
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8.发明公开METHODS AND COMPOSITIONS FOR TARGETED CLEAVAGE AND RECOMBINATION 有权VERFAHREN UND ZUSAMMENSETZUNGEN ZUR GEZIELTEN SPALTUNG UND REKOMBINATION
公开(公告)号：EP1651660A4
公开(公告)日：2012-05-23
申请号：EP04780272
申请日：2004-08-06
CPC分类号： C12N15/10 , C07K14/4702 , C07K2319/00 , C07K2319/81 , C12N9/22 , C12N15/902
摘要： Disclosed herein are methods and compositions for targeted cleavage of a genomic sequence, targeted alteration of a genomic sequence, and targeted recombination between a genomic region and an exogenous polynucleotide homologous to M the genomic region. The compositions include fusion proteins comprising a cleavage domain (or cleavage half-domain) and an engineered zinc finger domain and polynucleotides encoding same. Methods for targeted cleavage include introduction of such fusion proteins, or polynucleotides encoding same, into a cell. Methods for targeted recombination additionally include introduction of an exogenous polynucleotide homologous to a genomic region into cells comprising the disclosed fusion proteins.
摘要翻译： 本文公开了用于基因组序列的靶向切割，基因组序列的靶向改变以及基因组区域和与该基因组区域同源的外源多核苷酸之间的靶向重组的方法和组合物。 组合物包括包含切割结构域（或切割半结构域）和工程化锌指结构域的融合蛋白和编码它们的多核苷酸。 用于靶向切割的方法包括将这种融合蛋白或编码其的多核苷酸引入细胞。 靶向重组的方法还包括将与基因组区域同源的外源多核苷酸引入包含所公开的融合蛋白的细胞中。
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公开(公告)号：EP1579005A4
公开(公告)日：2007-07-25
申请号：EP03786893
申请日：2003-11-17
发明人： URNOV FYODOR , RHODES ERIC
CPC分类号： C12Q1/6837 , C12N15/1034
摘要： Methods for constructing arrays of regulatory sequences, and the arrays so obtained, are provided. Regulatory sequences for use on the arrays are isolated based on their accessibility in cellular chromatin. A number of methods for using the arrays are disclosed, including regulatory DNA profiling, epigenome profiling, toxicological profiling and identification of in vivo binding sites of DNA binding proteins in complex genomes.
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公开(公告)号：EP2844754A4
公开(公告)日：2015-12-30
申请号：EP13784528
申请日：2013-05-02
发明人： SHUKLA VIPULA , GUPTA MANJU , URNOV FYODOR , GUSCHIN DMITRY , JAN DE BOTH MICHIEL , BUNDOCK PAUL , SASTRY-DENT LAKSHMI
CPC分类号： C12N9/0006 , A01C14/00 , C12N15/8213 , C12N15/8241 , C12N15/8243 , C12N15/8261 , C12N15/8269 , C12Y101/01037 , C12Y301/00 , Y02A40/146
摘要： Disclosed herein are methods and compositions for targeted modification of one or more endogenous plant malate dehydrogenase genes.
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