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    COMPOSITIONS FOR LINKING ZINC FINGER MODULES
    4.
    发明公开
    COMPOSITIONS FOR LINKING ZINC FINGER MODULES 审中-公开
    ZUSAMMENSETZUNGEN ZURVERKNÜPFUNGVON ZINKFINGERMODULEN

    公开(公告)号：EP2566972A4

    公开(公告)日：2014-01-01

    申请号：EP11777690

    申请日：2011-05-02

    申请人： SANGAMO BIOSCIENCES INC

    发明人： PASCHON DAVID ,  REBAR EDWARD J

    IPC分类号： C12P21/06 ,  A61K38/04 ,  C07H21/04 ,  C12N5/00

    CPC分类号： C12N15/62

    摘要： Disclosed herein are compositions for linking DNA binding modules to allow for specific and selective binding to module subsites separated by 1 or more base pairs. Also described are methods of making and using compositions comprising these linkers.

    摘要翻译： 本文公开了用于连接DNA结合模块以允许特定和选择性结合由1个或更多个碱基对分开的模块亚型的组合物。 还描述了制备和使用包含这些接头的组合物的方法。

    SELECTION OF SITES FOR TARGETING BY ZINC FINGER PROTEINS AND METHODS OF DESIGNING ZINC FINGER PROTEINS TO BIND TO PRESELECTED SITES
    6.
    发明公开
    SELECTION OF SITES FOR TARGETING BY ZINC FINGER PROTEINS AND METHODS OF DESIGNING ZINC FINGER PROTEINS TO BIND TO PRESELECTED SITES 有权
    SELEKTION VON ZIELREGIONENFÜRZINK指条PROTEINE UND METHODEN ZUM设计VON ZINK指条PROTEINEN WELCHE AN VORSELEKTIERTE REGIONEN BINDEN

    公开(公告)号：EP1075540A4

    公开(公告)日：2001-07-25

    申请号：EP00905563

    申请日：2000-01-06

    申请人： SANGAMO BIOSCIENCES INC

    发明人： EISENBERG STEPHEN P ,  CASE CASEY C ,  COX GEORGE N III ,  JAMIESON ANDREW ,  REBAR EDWARD J

    IPC分类号： C12N15/09 ,  C07K14/00 ,  C07K14/47 ,  C12N15/10 ,  C12Q1/68 ,  G06F17/30 ,  G06F19/18 ,  G06F19/00

    CPC分类号： C12N15/1089 ,  C07K14/47 ,  C07K14/4702 ,  C12Q1/6811 ,  G01N33/5308 ,  G01N33/6875 ,  G06F19/18

    摘要： The invention provides criteria and methods for selecting optimum subsequence(s) from a target for targeting by a zinc finger protein. Some of the methods of targetgene site selection seek to identify one or more target segments having a DNA motif containing one or more so-called D-able subsites having the sequence 5'NNGK3'. Other methods of the invention are directed to selection of target segments within target genes using a correspondence regime between different triplets of three bases and the three possible positions of a triplet within a nine-base site. In another aspect, the invention provides methods of designing zinc finger proteins that bind to a preselected target site. These methods can be used following the preselection of target sites according to the procedures and criteria described above. The methods of design use a database containing information about previously characterized zinc finger proteins.

    摘要翻译： 本发明提供了用于从靶标选择最佳子序列以通过锌指蛋白进行靶向的标准和方法。 目标基因位点选择的一些方法试图鉴定具有包含一个或多个具有序列5'NNGK3'的所谓的D-能位点的DNA基序的一个或多个靶区段。 本发明的其他方法涉及使用三碱基的不同三联体与九碱基位点内三联体的三个可能位置之间的对应体系来选择靶基因内的目标片段。 另一方面，本发明提供了设计结合预选靶位点的锌指蛋白的方法。 根据上述程序和标准预选目标地点后可以使用这些方法。 设计方法使用含有先前表征的锌指蛋白质信息的数据库。