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公开(公告)号：EP1804803A4
公开(公告)日：2008-07-30
申请号：EP05815083
申请日：2005-10-28
申请人： IRM LLC , SCRIPPS RESEARCH INST
发明人： WU XU , DING SHENG , SCHULTZ PETER G
IPC分类号： A61K31/427 , A61K31/435 , A61K31/437 , A61P35/00
CPC分类号： A61K31/427 , A61K31/435 , A61K31/437
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公开(公告)号：EP1529048A4
公开(公告)日：2005-09-14
申请号：EP02801053
申请日：2002-10-12
申请人： IRM LLC , SCRIPPS RESEARCH INST
发明人： DING SHENG , DING QIANG , GRAY NATHANAEL S , SCHULTZ PETER G
IPC分类号： C07D473/06 , A61K31/52 , A61K31/522 , A61K31/5355 , A61P9/00 , A61P25/00 , A61P29/00 , A61P35/00 , A61P43/00 , C07D473/16 , C07D473/18 , C07D473/40 , C07D519/00
CPC分类号： C07D473/16 , C07D473/18 , C07D473/40
摘要： The invention provides general methods for preparing 2,9-, 2,6,9-, O6-aryl- and O6-alkyl-substituted purines in a combinatorial and traceless fashion. The methods involve, in some embodiments, Mitsunobu alkylation of 2-fluoro-6-phenylsulfenylpurine at N9 with alcohols in solution, followed by C2-capture of the purine core with a resin-bound amine and subsequent oxidation and displacement of the C6 sulfonyl group with amines and anilines.
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公开(公告)号：EP1794312A4
公开(公告)日：2009-08-12
申请号：EP05815524
申请日：2005-09-21
申请人： SCRIPPS RESEARCH INST , IRM LLC
CPC分类号： C12P21/02 , C12N9/93 , G01N33/532 , G01N33/60 , G01N2458/15 , G01R33/1269 , Y10T436/24
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4.发明公开CHIMERIC ANTIGEN RECEPTOR T CELL SWITCHES AND USES THEREOF 有权CHIMÄREANTIGENREZEPTOR-T-ZELL-SCHALTER UND VERWENDUNGEN DAVON
公开(公告)号：EP3057991A4
公开(公告)日：2017-07-26
申请号：EP14853242
申请日：2014-10-15
发明人： KIM CHANHYUK , YOUNG TRAVIS , CAO YU , MA JENNIFER , KIM MINSOO , PINKERTON STEPHANIE , SCHULTZ PETER G
IPC分类号： C07K16/28 , A61K31/352 , A61K31/4188 , A61K39/385 , A61K39/395 , A61K49/00 , C07K16/32 , C07K16/40 , C07K16/44 , C07K19/00
CPC分类号： A61K47/48507 , A61K31/352 , A61K31/4188 , A61K39/385 , A61K39/3955 , A61K47/6835 , A61K49/0041 , A61K49/0058 , C07K16/2803 , C07K16/2863 , C07K16/2878 , C07K16/2887 , C07K16/2896 , C07K16/32 , C07K16/40 , C07K16/44 , C07K2317/522 , C07K2317/567 , C07K2317/622
摘要： Disclosed herein are switches for regulating the activity of a chimeric antigen receptor effector cells (CAR-ECs). The switches generally comprise a chimeric antigen receptor-interacting domain (CAR-ID) and a target interacting domain (TID). The switch may further comprise a linker. Further disclosed herein are methods of using the switches for the treatment of one or more conditions or diseases in a subject in need thereof.
摘要翻译： 本文公开了用于调节嵌合抗原受体效应细胞（CAR-EC）活性的开关。 开关通常包含嵌合抗原受体相互作用结构域（CAR-ID）和靶相互作用结构域（TID）。 交换机可以进一步包括连接器。 本文进一步公开了使用开关治疗有需要的受试者中的一种或多种病症或疾病的方法。
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5.发明公开
公开(公告)号：EP3004083A4
公开(公告)日：2016-11-16
申请号：EP14800797
申请日：2014-05-22
发明人： CHATTERJEE ARNAB K , WANG FENG , SCHULTZ PETER G , XU CHUNPING , AJAYI KEHINDE , WANG JIANING , HALDER RAJKUMAR , KUMAR PUNEET , YANG BAIYUAN , LIU RENHE , CHENG BO , KANEKO TAKUSHI
IPC分类号： C07D409/12 , A61K31/38 , A61K31/428 , C07D409/10 , C07D409/14
CPC分类号： C07D333/38 , C07D409/12 , C07D409/14 , C07D413/12 , C07D417/12 , C07D417/14 , C07D471/04 , C07D487/04 , C07D491/048 , C07D495/04 , C07D513/04
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公开(公告)号：EP2217707A4
公开(公告)日：2010-11-10
申请号：EP08840980
申请日：2008-10-23
发明人： SEYEDSAYAMDOST MOHAMMAD R , XIE JIANMING , CHAN CLEMENT TSZ , ALFONTA LITAL , SCHULTZ PETER G , STUBBE JOANNE
IPC分类号： C12N15/53 , C12N5/10 , C12Q1/26 , G01N33/573
CPC分类号： C12N9/0093 , C12Q1/26 , G01N2333/9029
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7.发明公开UNNATURAL REACTIVE AMINO ACID GENETIC CODE ADDITIONS 审中-公开ERGÄNZUNGENZUM GENETICHEN CODE VONUNNATÜRLICHENREAKTIVENAMINOSÄUREN
公开(公告)号：EP1636340A4
公开(公告)日：2009-02-11
申请号：EP04785787
申请日：2004-04-16
IPC分类号： G01N33/53 , A61K38/17 , C12N20060101 , C12N5/00 , C12N9/00 , C12N9/16 , C12N15/85 , C12P21/06
CPC分类号： G01N33/583 , C07C227/22 , C07C229/36 , C07C269/06 , C07C311/41 , C07K1/1072 , C07K1/13 , C07K14/001 , C07K16/18 , C09B11/08 , C09B57/00 , C12N9/93 , C12N15/67 , C12N2510/02 , C12P17/04 , C12P21/02 , G01N33/532 , G01N33/582 , C07C271/22
摘要： This invention provides compositions and methods for producing translational components that expand the number of genetically encoded amino acids in eukaryotic cells. The components include orthogonal tRNAs, orthogonal aminoacyl-tRNAsynthetases, pairs of tRNAs/synthetases and unnatural amino acids. Proteins and methods of producing proteins with unnatural amino acids in eukaryotic cells are also provided.
摘要翻译： 本发明提供了用于产生扩增真核细胞中遗传编码氨基酸数量的翻译组分的组合物和方法。 组分包括正交tRNA，正交氨酰-tRNA合成酶，tRNA /合成酶和非天然氨基酸对。 还提供了在真核细胞中产生具有非天然氨基酸的蛋白质的蛋白质和方法。
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8.发明公开COMPOSITIONS OF ORTHOGONAL GLUTAMYL-TRNA AND AMINOACYL TRNA SYNTHETASE PAIRS AND USES THEREOF 审中-公开正交谷氨酰tRNA和组合物氨酰-tRNA SYNTHETASEPAAREN及其用途
公开(公告)号：EP1658366A4
公开(公告)日：2006-08-09
申请号：EP04777719
申请日：2004-07-07
CPC分类号： C12N9/93
摘要： Compositions and methods of producing components of protein biosynthetic machinery that include glutamyl orthogonal tRNAs, glutamyl orthogonal aminoacyl-tRNA synthetases, and orthogonal pairs of glutamyl tRNAs/synthetases are provided. Methods for identifying these orthogonal pairs are also provided along with methods of producing proteins using these orthogonal pairs.
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公开(公告)号：EP3250036A4
公开(公告)日：2018-06-27
申请号：EP15867774
申请日：2015-12-09
IPC分类号： C07D405/14 , A61K31/4196 , A61P11/00
CPC分类号： C07D405/14 , A01N57/00 , C07D403/10 , C07D405/12 , C07D495/04
摘要： Described herein are compounds and compositions for the treatment of a fibrotic disease.
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公开(公告)号：EP3003038A4
公开(公告)日：2016-11-16
申请号：EP14807059
申请日：2014-06-05
发明人： LAIRSON LUKE , BOLLONG MICHAEL , SCHULTZ PETER G , CHATTERJEE ARNAB K , YANG BAIYUAN , KUMAR PUNEET , URKALAN KAVERI
IPC分类号： A01N43/40 , C07D405/14
CPC分类号： C07D405/14 , A61K31/496 , A61K31/497 , A61K31/498 , A61K31/501 , A61K31/506 , A61K31/5377 , C07D413/14 , C07D417/14
摘要： Described herein are compounds and compositions for the treatment of a fibrotic disease.
摘要翻译： 本文描述了用于治疗纤维化疾病的化合物和组合物。
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