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公开(公告)号：EP2844754B1
公开(公告)日：2018-10-24
申请号：EP13784528.5
申请日：2013-05-02
发明人： SHUKLA, Vipula , GUPTA, Manju , URNOV, Fyodor , GUSCHIN, Dmitry , JAN DE BOTH, Michiel , BUNDOCK, Paul , SASTRY-DENT, Lakshmi
CPC分类号： C12N9/0006 , A01C14/00 , C12N15/8213 , C12N15/8241 , C12N15/8243 , C12N15/8261 , C12N15/8269 , C12Y101/01037 , C12Y301/00 , Y02A40/146
摘要： Disclosed herein are methods and compositions for targeted modification of one or more endogenous plant malate dehydrogenase genes.
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公开(公告)号：EP2526112B1
公开(公告)日：2018-10-17
申请号：EP11734969.6
申请日：2011-01-24
CPC分类号： C12N15/10 , A01H1/06 , C07K2319/81 , C12N9/22 , C12N15/8213 , C12N15/85 , C12N15/90 , C12N2800/80
摘要： Disclosed herein are methods and compositions for targeted integration and/or targeted excision of one or more sequences into a cell, for example, for expression of one or more polypeptides of interest.
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公开(公告)号：EP2847338B1
公开(公告)日：2018-09-19
申请号：EP13788413.6
申请日：2013-05-07
发明人： COST, Gregory, J. , URNOV, Fyodor , AINLEY, William M. , PETOLINO, Joseph F. , SAMUEL, Jayakumar Pon , WEBB, Steven R. , SASTRY-DENT, Lakshmi
CPC分类号： C12N15/8201 , C12N15/102 , C12N15/8209 , C12N15/8213 , C12N15/8216 , C12N15/8241 , C12N15/8247 , C12N15/8274 , C12N15/8278 , C12N15/8286 , C12N15/85 , C12N15/87 , C12N2800/80 , Y02A40/162
摘要： Disclosed herein are methods and compositions for homology-independent targeted insertion of donor molecules into the genome of a cell.
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公开(公告)号：EP3070169B1
公开(公告)日：2018-05-09
申请号：EP16163183.3
申请日：2007-12-13
发明人： CAI, Qihua C. , MILLER, Jeffrey , URNOV, Fyodor , SHUKLA, Vipula K. , PETOLINO, Joseph F. , BAKER, Lisa W. , GARRISON, Robbi J. , BLUE, Ryan C. , MITCHELL, Jon C. , ARNOLD, Nicole L. , WORDEN, Sarah E.
CPC分类号： C07K14/4702 , C07K2319/81 , C12N15/8213 , C12N15/8243
摘要： Disclosed herein are zinc fingers comprising CCHC zinc coordinating residues. Also described are zinc finger proteins and fusion proteins comprising these CCHC zinc fingers as well as polynucleotides encoding these proteins. Methods of using these proteins for gene editing and gene regulation are also described.
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5.发明授权
公开(公告)号：EP3072973B1
公开(公告)日：2018-11-28
申请号：EP16163658.4
申请日：2008-09-25
发明人： GUPTA, Manju , PALTA, Asha M. , NOVAK, Stephen , URNOV, Fyodor , GOPALAN, Sunita
CPC分类号： C12N15/8213 , C07K2319/00 , C07K2319/81 , C12N9/1092 , C12N15/8243 , C12N15/8274
摘要： The present disclosure relates to engineered zinc finger proteins that target 5-enolpyruvyl shikimate-3-phosphate synthase (EPSPS) genes in plants and methods of using such zinc finger proteins in modulating gene expression, gene inactivation, and targeted gene modification. In particular, the disclosure pertains to zinc finger nucleases for targeted cleavage and alteration of EPSPS genes.
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公开(公告)号：EP2370575B1
公开(公告)日：2017-11-01
申请号：EP09836506.7
申请日：2009-12-17
发明人： BUTLER, Holly J. , CORBIN, David R. , DOYON, Yannick , GAO, Zhifang , SHUKLA, Vipula K. , URNOV, Fyodor , WORDEN, Sarah E.
CPC分类号： C12N15/8213
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公开(公告)号：EP3311822B1
公开(公告)日：2020-05-13
申请号：EP17205646.7
申请日：2011-11-17
发明人： GREGORY, Philip D. , HOLMES, Michael C. , MENDEL, Matthew C. , MENG, Xiangdong , PASCHON, David , REIK, Andreas , URNOV, Fyodor
IPC分类号： A61K31/7088 , C07K14/435 , C07H21/00 , C12N5/0783 , A61P35/00 , A61P31/12 , C12N9/22 , A61K38/17 , A61K35/17
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公开(公告)号：EP1651660B1
公开(公告)日：2018-01-24
申请号：EP04780272.3
申请日：2004-08-06
CPC分类号： C12N15/10 , C07K14/4702 , C07K2319/00 , C07K2319/81 , C12N9/22 , C12N15/902
摘要： Disclosed herein are methods and compositions for targeted cleavage of a genomic sequence, targeted alteration of a genomic sequence, and targeted recombination between a genomic region and an exogenous polynucleotide homologous to M the genomic region. The compositions include fusion proteins comprising a cleavage domain (or cleavage half-domain) and an engineered zinc finger domain and polynucleotides encoding same. Methods for targeted cleavage include introduction of such fusion proteins, or polynucleotides encoding same, into a cell. Methods for targeted recombination additionally include introduction of an exogenous polynucleotide homologous to a genomic region into cells comprising the disclosed fusion proteins.
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公开(公告)号：EP2640399B1
公开(公告)日：2017-12-20
申请号：EP11840913.5
申请日：2011-11-17
发明人： GREGORY, Philip D. , HOLMES, Michael C. , MENDEL, Matthew C. , MENG, Xiangdong , PASCHON, David , REIK, Andreas , URNOV, Fyodor
IPC分类号： A61K31/7088 , C07K14/435 , C07H21/00 , C12N5/0783 , A61P35/00 , A61P31/12 , C12N9/22 , A61K38/17
CPC分类号： A61K38/1709 , A61K35/17 , A61P31/12 , A61P35/00 , C07K2319/71 , C12N9/22
摘要： Disclosed herein are methods and compositions for modulating expression of a PD1 gene.
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公开(公告)号：EP3730615A2
公开(公告)日：2020-10-28
申请号：EP20173697.2
申请日：2014-05-15
发明人： CONWAY, Anthony , COST, Gregory J. , DEKELVER, Russell , REBAR, Edward J. , REIK, Andreas , URNOV, Fyodor , WANG, Jianbin , ZHANG, H. Steve
IPC分类号： C12N15/11 , C12N9/22 , C12N15/90 , C12N15/63 , C07K14/805
摘要： Methods and compositions for genetic alteration of cells are provided
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