公开(公告)号：EP1189609A1

公开(公告)日：2002-03-27

申请号：EP00928735.0

申请日：2000-05-03

申请人： SMITHKLINE BEECHAM CORPORATION

发明人： LUENGO, Juan I. ,  PRICE, Alan, Thomas ,  SHAW, Antony ,  WIGGALL, Kenneth

IPC分类号： A61K31/33 ,  A61K31/415 ,  A61K31/425 ,  A61K31/44 ,  A61K31/445 ,  A61K31/47 ,  A61K31/495 ,  A61K31/50 ,  A61K31/535 ,  A61K31/54 ,  A61K31/55 ,  A61K31/555 ,  C07D225/00 ,  C07D235/04 ,  C07D257/02 ,  C07D401/14

CPC分类号： C07D231/12 ,  C07D233/56 ,  C07D249/08 ,  C07D257/02 ,  C07D401/10 ,  C07D401/12 ,  C07D401/14 ,  C07D403/10 ,  C07D403/12 ,  C07D405/12 ,  C07D405/14 ,  C07D413/10 ,  C07D417/10 ,  C07D417/12

摘要： Invented are substituted cyclam derivatives, pharmaceutical compositions containing these compounds, the use of these compounds as CXCR-4 receptor antagonists and to use of these compounds as thrombopoietin (TPO) mimetics.

公开(公告)号：EP1885362A2

公开(公告)日：2008-02-13

申请号：EP06770657.2

申请日：2006-05-18

申请人： SMITHKLINE BEECHAM CORPORATION

发明人： DUFFY, Kevin, J. ,  CHAI, Deping ,  COLON, Mariela ,  FITCH, Duke, M. ,  JOHNSON, Neil, W. ,  KING, Sarah, Rae ,  SHAW, Anthony, N. ,  TEDESCO, Rosanna ,  WIGGALL, Kenneth ,  ZIMMERMAN, Michael, N.

IPC分类号： A61K31/47 ,  A61K31/50 ,  C07D215/12 ,  C07D241/36

CPC分类号： C07D417/12 ,  C07D417/14

摘要： This invention relates to newly identified compounds for inhibiting hYAK3 proteins and methods for treating diseases associated with hYAK3 activity.

摘要翻译： 本发明涉及新鉴定的用于抑制hYAK3蛋白的化合物和治疗与hYAK3活性有关的疾病的方法。

公开(公告)号：EP2037922A2

公开(公告)日：2009-03-25

申请号：EP07798915.0

申请日：2007-06-22

申请人： SmithKline Beecham Corporation

发明人： DUFFY, Kevin, J. ,  FITCH, Duke, M. ,  JIN, Jian ,  LIU, Ronggang ,  SHAW, Antony, N. ,  WIGGALL, Kenneth

IPC分类号： A61K31/47 ,  A61K31/495 ,  C07D487/08

CPC分类号： C07D239/60 ,  A61K31/515 ,  C07D239/22 ,  C07D239/54 ,  C07D239/62 ,  C07D401/04 ,  C07D405/04 ,  C07D405/10 ,  C07D409/04 ,  C07D409/10 ,  C07D413/06 ,  C07D413/10 ,  C07D417/10

摘要： The invention described herein relates to certain pyrimidinetrione N-substituted glycine derivatives of formula (I) which are antagonists of HIF prolyl hydroxylases and are useful for treating diseases benefiting from the inhibition of this enzyme, anemia being one example.

公开(公告)号：EP1879563A2

公开(公告)日：2008-01-23

申请号：EP06784387.0

申请日：2006-05-03

申请人： SMITHKLINE BEECHAM CORPORATION

发明人： DUFFY, Kevin, J. ,  CHAI, Deping ,  COLON, Mariela ,  FITCH, Duke, M. ,  KING, Sarah, Rae ,  SHAW, Antony, N. ,  TEDESCO, Rosanna ,  WIGGALL, Kenneth ,  JOHNSON, Neil, W. ,  KASPAREC, Jiri ,  ZIMMERMAN, Michael, N.

IPC分类号： A61K31/13 ,  C07C209/00

CPC分类号： C07D417/06

摘要： This invention relates to newly identified compounds for inhibiting hYAK3 proteins and methods for treating diseases associated with hYAK3 activity.

公开(公告)号：EP1294378B1

公开(公告)日：2007-10-03

申请号：EP01941599.1

申请日：2001-05-24

申请人： SMITHKLINE BEECHAM CORPORATION

发明人： DUFFY, Kevin, J. ,  ERICKSON-MILLER, Connie, L. ,  EPPLEY, Daniel, F. ,  JENKINS, Julian ,  LUENGO, Juan, I. ,  LIU, Nannan ,  PRICE, Alan, T. ,  SHAW, Antony, N. ,  VISONNEAU, Sophie ,  WIGGALL, Kenneth

IPC分类号： C07D417/12 ,  C07D231/48 ,  C07D401/04 ,  C07D401/12 ,  C07D401/14 ,  C07D403/04 ,  C07D403/12 ,  C07D403/14 ,  C07D405/04 ,  C07D405/14 ,  C07D409/04 ,  C07D417/04 ,  A61K31/4439 ,  A61K31/415 ,  A61K31/506

CPC分类号： C07D403/12 ,  C07D231/48 ,  C07D401/04 ,  C07D401/12 ,  C07D401/14 ,  C07D403/04 ,  C07D403/14 ,  C07D405/04 ,  C07D405/14 ,  C07D409/04 ,  C07D417/04 ,  C07D417/12

摘要： Invented are non-peptide TPO mimetics. Also invented are novel processes and intermediates used in the preparation of the presently invented compounds. Also invented is a method of treating thrombocytopenia, in a mammal, including a human, in need thereof which comprises administering to such mammal an effective amount of a selected hydroxy-1-azobenzene derivative.

公开(公告)号：EP1294378A2

公开(公告)日：2003-03-26

申请号：EP01941599.1

申请日：2001-05-24

申请人： SMITHKLINE BEECHAM CORPORATION ,  GLAXO GROUP LIMITED

发明人： DUFFY, Kevin, J. ,  ERICKSON-MILLER, Connie, L. ,  EPPLEY, Daniel, F. ,  JENKINS, Julian ,  LUENGO, Juan, I. ,  LIU, Nannan ,  PRICE, Alan, T. ,  SHAW, Antony, N. ,  VISONNEAU, Sophie ,  WIGGALL, Kenneth

IPC分类号： A61K31/41 ,  A61K31/4152 ,  A61K31/44 ,  A61K31/4709 ,  A61K31/655 ,  C07D213/79 ,  C07D231/20 ,  C07D257/04 ,  C07D401/02 ,  C07D403/02 ,  C07D405/04 ,  C07D409/04

CPC分类号： C07D403/12 ,  C07D231/48 ,  C07D401/04 ,  C07D401/12 ,  C07D401/14 ,  C07D403/04 ,  C07D403/14 ,  C07D405/04 ,  C07D405/14 ,  C07D409/04 ,  C07D417/04 ,  C07D417/12

摘要： Invented are non-peptide TPO mimetics. Also invented are novel processes and intermediates used in the preparation of the presently invented compounds. Also invented is a method of treating thrombocytopenia, in a mammal, including a human, in need thereof which comprises administering to such mammal an effective amount of a selected hydroxy-1-azobenzene derivative.

摘要翻译： 发明的是非肽TPO模拟物。 还发明了用于制备目前发明的化合物的新型方法和中间体。 还发明了一种治疗需要治疗的哺乳动物包括人的血小板减少症的方法，该方法包括给予这种哺乳动物有效量的选择的羟基-1-偶氮苯衍生物。