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公开(公告)号：EP2038272A2
公开(公告)日：2009-03-25
申请号：EP07810166.4
申请日：2007-07-02
发明人： LIND, Kenneth, Egnard , CAO, Kathy , LIN, Edward, Yin-shiang , NGUYEN, Thinh, Ba , TANGONAN, Bradley, T. , ERLANSON, Daniel, A. , GUCKIAN, Kevin , SIMMONS, Robert, Lowell , LEE, Wen-cherng , SUN, Lihong , HANSEN, Stig , PATHAN, Nuzhat , ZHANG, Lei
IPC分类号： C07D401/12
CPC分类号： C07D471/04 , A61K31/4412 , A61K31/443 , A61K31/4436 , A61K31/4439 , A61K31/444 , A61K31/4985 , A61K31/506 , A61K31/519 , A61K31/5377 , C07D211/86 , C07D213/64 , C07D401/12 , C07D401/14 , C07D405/12 , C07D405/14 , C07D407/14 , C07D409/12 , C07D409/14 , C07D413/12 , C07D413/14 , C07D417/12 , C07D417/14 , C07D487/04
摘要： The present invention provides pyridinonyl PDKl inhibitors and methods of treating cancer using the same.
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公开(公告)号：EP2038272B1
公开(公告)日：2013-09-04
申请号：EP07810166.4
申请日：2007-07-02
发明人： LIND, Kenneth, Egnard , CAO, Kathy , LIN, Edward, Yin-shiang , NGUYEN, Thinh, Ba , TANGONAN, Bradley, T. , ERLANSON, Daniel, A. , GUCKIAN, Kevin , SIMMONS, Robert, Lowell , LEE, Wen-cherng , SUN, Lihong , HANSEN, Stig , PATHAN, Nuzhat , ZHANG, Lei
IPC分类号： C07D213/64 , C07D401/12 , C07D401/14 , C07D407/14 , C07D409/14 , C07D413/12 , C07D413/14 , C07D417/12 , C07D471/04 , C07D487/04
CPC分类号： C07D471/04 , A61K31/4412 , A61K31/443 , A61K31/4436 , A61K31/4439 , A61K31/444 , A61K31/4985 , A61K31/506 , A61K31/519 , A61K31/5377 , C07D211/86 , C07D213/64 , C07D401/12 , C07D401/14 , C07D405/12 , C07D405/14 , C07D407/14 , C07D409/12 , C07D409/14 , C07D413/12 , C07D413/14 , C07D417/12 , C07D417/14 , C07D487/04
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公开(公告)号：EP2364089A1
公开(公告)日：2011-09-14
申请号：EP09823937.9
申请日：2009-10-30
申请人： Biogen Idec MA Inc.
发明人： GUCKIAN, Kevin, M. , CALDWELL, Richard, D. , KUMARAVEL, Gnanasambandam , LEE, Wen-cherng , LIN, Edward, Yin-shiang , LIU, Xiaogao , MA, Bin , SCOTT, Daniel, M. , SHI, Zhan , ZHENG, Guo, Zhu , TAVERAS, Arthur, G. , THOMAS, Jermaine
IPC分类号： A01N47/10 , A61K31/22 , A61K31/135
CPC分类号： A61K31/135 , A61K31/22 , C07C217/52 , C07C217/74 , C07C2602/10 , C07D215/20 , C07D239/74
摘要： Compounds that have agonist activity at one or more of the SlP receptors are provided. The compounds are sphingosine analogs that, after phosphorylation, can behave as agonists at SlP receptors.
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公开(公告)号：EP2190852A1
公开(公告)日：2010-06-02
申请号：EP08798022.3
申请日：2008-08-15
IPC分类号： C07F9/09 , C07C215/08 , C07C215/10 , C07D271/06 , C07D333/16 , C07D413/04 , A61K31/133 , A61K31/381 , A61K31/4245 , A61K31/661 , A61P19/00
CPC分类号： C07C323/32 , C07C215/38 , C07C217/74 , C07D271/06 , C07D333/16 , C07D413/04 , C07F9/091
摘要： Compounds that have agonist activity at one or more of the SlP receptors are provided. The compounds are sphingosine analogs that, after phosphorylation, can behave as agonists at SlP receptors. Formula (I):
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公开(公告)号：EP1971594A2
公开(公告)日：2008-09-24
申请号：EP06847481.6
申请日：2006-11-21
申请人： Biogen Idec MA Inc.
发明人： LEE, Wen-Cherng , CARTER, Mary, Beth , CHUAQUI, Claudio , GUCKIAN, Kevin , LIN, Edward, Yin-shiang , CHOI, Michael, J. , DENG, Zhan , BORIACK-SJODIN, Paula, Ann , SUN, Lihong
IPC分类号： C07D401/14 , C07D403/04 , C07D413/04 , C07D417/04 , C07D417/14 , C07D419/14 , A61K31/4184 , A61P35/00
CPC分类号： C07D403/04 , C07D401/14 , C07D413/14 , C07D417/04 , C07D417/14 , C07D419/14
摘要： The invention is related to compounds of formula (I) as antagonists of the TGFβ family type I receptors, Alk5 and/or AIk 4, compositions and methods of use. The compounds of formula (I) can be employed in the prevention and/or treatment of diseases such as fibrosis (e.g., renal fibrosis, pulmonary fibrosis, and hepatic fibrosis), progressive cancers, or other diseases for which reduction of TGFβ family signaling activity is desirable.
摘要翻译： 本发明涉及作为TGFβ家族I型受体拮抗剂的式（I）化合物，Alk5和/或Alk4，组合物和使用方法。 式（I）化合物可以用于预防和/或治疗诸如纤维化（例如肾纤维化，肺纤维化和肝纤维化），进行性癌症或其他TGFβ家族信号活性降低的疾病 是可取的。
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公开(公告)号：EP2364088B1
公开(公告)日：2014-04-16
申请号：EP09823936.1
申请日：2009-10-30
申请人： Biogen Idec MA Inc.
发明人： GUCKIAN, Kevin, M. , CALDWELL, Richard, D. , KUMARAVEL, Gnanasambandam , LEE, Wen-cherng , LIN, Edward, Yin-shiang , LIU, Xiaogao , MA, Bin , SCOTT, Daniel, M. , SHI, Zhan , ZHENG, Guo, Zhu , TAVERAS, Arthur, G. , THOMAS, Jermaine
IPC分类号： C07C271/16 , C07F9/653 , C07C205/26 , C07C205/50 , C07C217/52 , C07C217/60 , C07C229/32 , C07D263/38 , C07C215/10 , C07C215/08 , C07F9/09 , A01N47/10 , A61K31/135 , A61K31/27 , A61P11/06 , A61P29/00 , A61P17/06 , A61P19/02
CPC分类号： A61K31/135 , A61K31/27 , C07C205/26 , C07C205/50 , C07C217/52 , C07C217/60 , C07C229/32 , C07C271/16 , C07D263/38 , C07F9/091 , C07F9/093 , C07F9/653 , C07F9/65744
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公开(公告)号：EP2364088A1
公开(公告)日：2011-09-14
申请号：EP09823936.1
申请日：2009-10-30
申请人： Biogen Idec MA Inc.
发明人： GUCKIAN, Kevin, M. , CALDWELL, Richard, D. , KUMARAVEL, Gnanasambandam , LEE, Wen-cherng , LIN, Edward, Yin-shiang , LIU, Xiaogao , MA, Bin , SCOTT, Daniel, M. , SHI, Zhan , ZHENG, Guo, Zhu , TAVERAS, Arthur, G. , THOMAS, Jermaine
IPC分类号： A01N47/10 , A61K31/27 , A61K31/135
CPC分类号： A61K31/135 , A61K31/27 , C07C205/26 , C07C205/50 , C07C217/52 , C07C217/60 , C07C229/32 , C07C271/16 , C07D263/38 , C07F9/091 , C07F9/093 , C07F9/653 , C07F9/65744
摘要： Compounds that have agonist activity at one or more of the SlP receptors are provided. The compounds are sphingosine analogs that, after phosphorylation, can behave as agonists at S lP receptors.
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公开(公告)号：EP2672823A1
公开(公告)日：2013-12-18
申请号：EP12745253.0
申请日：2012-02-03
申请人： Biogen Idec MA Inc.
发明人： THOMAS, Jermaine , MI, Sha , LIN, Edward, Yin-shiang , ZHENG, Guo, Zhu , MA, Bin , CALDWELL, Richard, D. , GUCKIAN, Kevin , KUMARAVEL, Gnanasambandam
IPC分类号： A01N43/40 , A61K31/445
CPC分类号： A61K31/445 , A61K31/225 , A61K31/4545 , A61K31/4709 , A61K31/498 , A61K31/517 , A61K31/55 , A61K31/695 , A61K38/21 , A61K39/3955 , C07D211/34 , C07D211/60 , C07D211/62 , C07D215/20 , C07D401/06 , C07D405/12 , C07K16/2842
摘要： Compounds of formula (I) or (II) can modulate the activity of SIP receptors. Compounds of formula (I) or (II) can modulate the activity of SIP receptors.
摘要翻译： 式（I）或（II）的化合物可以调节SIP受体的活性。
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公开(公告)号：EP3466929A1
公开(公告)日：2019-04-10
申请号：EP18207990.5
申请日：2010-10-05
发明人： ARNDT, Joseph , CHAN, Timothy , GUCKIAN, Kevin , KUMARAVEL, Gnanasambandam , LEE, Wen-Cherng , LIN, Edward, Yin-shiang , SCOTT, Daniel , SUN, Lihong , THOMAS, Jermaine , VAN VLOTEN, Kurt , WANG, Deping , ZHANG, Lei , ERLANSON, Daniel
IPC分类号： C07D213/82 , C07D213/85 , C07D241/28 , A61K31/4427 , A61K31/497 , A61P35/00 , C07D401/12 , C07D401/14 , C07D403/12 , C07D403/14 , C07D409/14 , C07D417/14 , C07D471/04 , C07D473/34 , C07D487/04 , C07D498/04
摘要： The present invention provides compounds I useful as inhibitors of PDK1. The present invention also provides compositions thereof, and methods of treating PDK1-mediated diseases.
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公开(公告)号：EP3070077B1
公开(公告)日：2018-11-28
申请号：EP16167938.6
申请日：2010-10-05
发明人： ARNDT, Joseph , CHAN, Timothy , GUCKIAN, Kevin , KUMARAVEL, Gnanasambandam , LEE, Wen-Cherng , LIN, Edward, Yin-shiang , SCOTT, Daniel , SUN, Lihong , THOMAS, Jermaine , VAN VLOTEN, Kurt , WANG, Deping , ZHANG, Lei , ERLANSON, Daniel
IPC分类号： C07D213/82 , C07D213/85 , C07D241/28 , A61K31/4427 , A61K31/497 , A61P35/00 , C07D401/12 , C07D401/14 , C07D403/12 , C07D403/14 , C07D409/14 , C07D417/14 , C07D471/04 , C07D473/34 , C07D487/04 , C07D498/04
CPC分类号： C07D471/04 , A61K31/437 , A61K31/4439 , A61K31/444 , A61K31/452 , A61K31/4725 , A61K31/496 , A61K31/497 , A61K31/498 , A61K31/4985 , A61K31/517 , A61K31/519 , A61K31/53 , A61K31/5377 , A61K31/5383 , C07D213/82 , C07D213/85 , C07D241/26 , C07D241/28 , C07D401/12 , C07D401/14 , C07D403/12 , C07D403/14 , C07D405/14 , C07D409/04 , C07D409/14 , C07D417/14 , C07D473/34 , C07D487/04 , C07D491/052 , C07D498/04 , C07D519/00
摘要： The present invention provides compounds useful as inhibitors of PDK1. The present invention also provides compositions thereof, and methods of treating PDK1-mediated diseases.
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