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    CYANOPYRROLIDINE DERIVATIVES
    1.
    发明公开
    CYANOPYRROLIDINE DERIVATIVES 审中-公开
    CYANOPYRROLIDINDERIVATE

    公开(公告)号：EP1333025A4

    公开(公告)日：2004-03-24

    申请号：EP01981047

    申请日：2001-11-09

    申请人： TAISHO PHARMA CO LTD

    发明人： FUKUSHIMA HIROSHI ,  HIRATATE AKIRA ,  TAKAHASHI MASATO ,  KAMEO KAZUYA

    IPC分类号： A61P3/10 ,  A61P29/00 ,  A61P31/18 ,  A61P35/04 ,  A61P37/02 ,  A61P43/00 ,  C07D207/16 ,  C07D401/06 ,  A61K31/40 ,  C07D401/12

    CPC分类号： C07D401/06 ,  C07D207/16 ,  Y02P20/55

    摘要： Cyanopyrrolidine derivatives represented by the general formula (1) or pharmaceutically acceptable salts thereof: (1) wherein R1 is halogeno, hydroxyl, or the like, and R2 is hydrogen, halogeno, or the like, or alternatively R?1 and R2¿ are united to form oxo, hydroxyimino, or the like; R?3 and R4¿ are each hydrogen, halogeno, or the like, or alternatively R?3 and R4¿ are united to form oxo, hydroxyimino, or the like; X is oxygen or sulfur; Y is CR5R6- (wherein R?5 and R6¿ are each independently hydrogen, halogeno, or the like) or CR?7R8-CR9R10¿- (wherein R?7, R8, R9, and R10¿ are each independently hydrogen, halogeno, or the like, or alternatively R?7 and R9¿ together with the carbon atoms adjacent thereto form C¿3-8? cycloalkyl or the like); and Z is hydrogen, C1-10 alkyl, or the like, or alternatively Y and Z together with the nitrogen atom adjacent thereto form cyclic C2-10 amino or the like.

    摘要翻译： （1）代表的氰基吡咯烷衍生物或其药学上可接受的盐：（1）其中R1是卤代，羟基等，R2是氢，卤素等，或者R1和R2是 结合形成氧代，羟基亚氨基等; R 3和R 4各自为氢，卤素等，或者R 3和R 4结合形成氧代，羟基亚氨基等; X是氧或硫; Y是CR 5 R 6 - （其中R 5和R 6各自独立地是氢，卤素等）或CR 7 R 8 -CR 9 R 10 - （其中R 7，R 8，R 9和R 10各自独立地是氢，卤素 或者类似的，或者R7和R9与其相邻的碳原子一起形成C8-8环烷基等）。 并且Z是氢，C1-10烷基等，或者Y和Z与其相邻的氮原子一起形成环状的C2-10氨基或类似基团。