公开(公告)号：EP2984910B1

公开(公告)日：2020-01-01

申请号：EP14782878.4

申请日：2014-04-11

申请人： The Board of Trustees of the University of Illinois

发明人： ROGERS, John A. ,  KANG, Seung-Kyun ,  HWANG, SukWon ,  CHENG, Jianjun ,  ZHANG, Yanfeng ,  YING, Hanze

IPC分类号： H01L21/02 ,  A61B5/00 ,  A61M5/44 ,  G06K19/077 ,  H05K1/02 ,  H05K3/22 ,  H05K3/28 ,  H01L23/29 ,  H01L23/31 ,  H01L23/498 ,  H01L21/56 ,  H01L21/311 ,  H01L25/065 ,  H05K1/03 ,  H05K13/00

公开(公告)号：EP2646048B1

公开(公告)日：2017-11-01

申请号：EP11845856.1

申请日：2011-11-30

申请人： The Board of Trustees of the University of Illinois

发明人： CHENG, Jianjun ,  LU, Hua

IPC分类号： A61K39/00

CPC分类号： C08G69/48 ,  A01N43/36 ,  A61K31/785 ,  A61K47/34 ,  A61K47/595 ,  C07K14/001 ,  C08G63/08 ,  C08G63/68 ,  C08G69/08 ,  C08G69/10 ,  C08G69/22 ,  C08L77/02 ,  C08L77/04

摘要： The invention provides polymers comprising Formula I: wherein monomer is a repeating unit comprising 2, 3, 4, 5, 6 or 7 carbon atoms and the monomers are linked together through amide or ester bonds; n is about 6 to about 1000; and Linker is an optionally substituted carbon chain that is optionally interrupted by moieties such as oxygen, nitrogen, sulfur, phosphorus, or silicon. Charge is a moiety having a positive or negative charge on a heteroatom, such as nitrogen, oxygen, phosphorus, or sulfur; where the Linker separates the monomer and the Charge by at least six linear atoms. The invention also provides methods of preparing the polymers and the copolymers and methods of using the polymers and copolymers, for example, as drug delivery systems, as membrane penetrating peptides, and as therapeutic agents.

公开(公告)号：EP2831142A2

公开(公告)日：2015-02-04

申请号：EP13727723.2

申请日：2013-05-20

申请人： The Board Of Trustees Of The University Of Illinois

发明人： CHENG, Jianjun ,  ZHANG, Yanfeng

IPC分类号： C08G65/00 ,  A61K47/34

CPC分类号： C08G18/384 ,  A61K9/19 ,  A61K9/5146 ,  A61K31/4375 ,  A61K47/34 ,  C08G18/73 ,  C08G65/34 ,  C08G71/04 ,  C08G2650/12

摘要： Disclosed are polymers containing a backbone comprising alternating N-protected hydroxymethylaniline units (“spacer”) and linker units.

公开(公告)号：EP2646048A2

公开(公告)日：2013-10-09

申请号：EP11845856.1

申请日：2011-11-30

申请人： The Board of Trustees of the University of Illinois

发明人： CHENG, Jianjun ,  LU, Hua

IPC分类号： A61K39/00

CPC分类号： C08G69/48 ,  A01N43/36 ,  A61K31/785 ,  A61K47/34 ,  A61K47/595 ,  C07K14/001 ,  C08G63/08 ,  C08G63/68 ,  C08G69/08 ,  C08G69/10 ,  C08G69/22 ,  C08L77/02 ,  C08L77/04

摘要： The invention provides polymers comprising Formula I: wherein monomer is a repeating unit comprising 2, 3, 4, 5, 6 or 7 carbon atoms and the monomers are linked together through amide or ester bonds; n is about 6 to about 1000; and Linker is an optionally substituted carbon chain that is optionally interrupted by moieties such as oxygen, nitrogen, sulfur, phosphorus, or silicon. Charge is a moiety having a positive or negative charge on a heteroatom, such as nitrogen, oxygen, phosphorus, or sulfur; where the Linker separates the monomer and the Charge by at least six linear atoms. The invention also provides methods of preparing the polymers and the copolymers and methods of using the polymers and copolymers, for example, as drug delivery systems, as membrane penetrating peptides, and as therapeutic agents.

公开(公告)号：EP3595729A1

公开(公告)日：2020-01-22

申请号：EP18751686.9

申请日：2018-02-12

申请人： The Board of Trustees of the University of Illinois

发明人： CHENG, Jianjun ,  CAI, Kaimin ,  YU, Jin

IPC分类号： A61K47/56 ,  A61K47/68 ,  C07H15/26

公开(公告)号：EP3250549A1

公开(公告)日：2017-12-06

申请号：EP16703034.5

申请日：2016-01-27

申请人： The Board of Trustees of the University of Illinois

发明人： KOZIKOWSKI, Alan ,  CHENG, Jianjun

IPC分类号： C07C217/74 ,  A61K31/135 ,  A61P3/00 ,  A61P25/00

CPC分类号： C07C217/74 ,  C07C2601/02

摘要： Disclosed are 2-phenyl-cyclopropylmethanamines which are selective 5-HT(2C) receptor agonists and are used in the treatments of diseases and conditions wherein modulation of 5-HT(2C) receptors provides a benefit, such as obesity and psychiatric disorders.

公开(公告)号：EP3781661A1

公开(公告)日：2021-02-24

申请号：EP19721460.4

申请日：2019-04-15

申请人： Dow Global Technologies, LLC ,  The Board Of Trustees Of The University Of Illinois

发明人： CHEN, Xue ,  KING, Steven ,  SONG, Ziyuan ,  CHENG, Jianjun

IPC分类号： C11D3/39 ,  C11D3/48 ,  A01N37/20 ,  A01N59/00

公开(公告)号：EP3371200A1

公开(公告)日：2018-09-12

申请号：EP16854444.3

申请日：2016-10-07

申请人： The Board of Trustees of the University of Illinois

发明人： CHENG, Jianjun ,  WANG, Hua

IPC分类号： C07H15/00 ,  A61K31/7034 ,  A61K31/7042

CPC分类号： C07H15/26 ,  A61K31/7034 ,  A61K31/7042 ,  A61K47/552 ,  A61P35/00 ,  C07H15/18 ,  G01N33/57492

摘要： Disclosed are compounds for the selective labeling of cell-surface sugars in cancer cells. The compounds are activatable by triggers specific to cancer cells, and, when metabolized, label a cancer cell surface sugar with an azide chemical group. Facilitated by a click chemistry reaction, combination of the cell surface-expressed azide with a alkynyl-drug conjugate enables efficient targeted drug delivery to cancer cells with reduced toxicity. Also disclosed are compounds for delivering a drug to an azide-bearing cancer cell, and methods of treating cancer using the compounds of the invention.

公开(公告)号：EP2984910A1

公开(公告)日：2016-02-17

申请号：EP14782878.4

申请日：2014-04-11

申请人： The Board of Trustees of the University of Illinois

发明人： ROGERS, John A. ,  KANG, Seung-Kyun ,  HWANG, SukWon ,  CHENG, Jianjun ,  ZHANG, Yanfeng ,  YING, Hanze

IPC分类号： H05K1/09 ,  H05K1/03 ,  H05K3/02

摘要： The invention provides transient devices, including active and passive devices that physically, chemically and/or electrically transform upon application of at least one internal and/or external stimulus. Incorporation of degradable device components, degradable substrates and/or degradable encapsulating materials each having a programmable, controllable and/or selectable degradation rate provides a means of transforming the device. In some embodiments, for example, transient devices of the invention combine degradable high performance single crystalline inorganic materials with selectively removable substrates and/or encapsulants.

公开(公告)号：EP2132133A1

公开(公告)日：2009-12-16

申请号：EP08743635.8

申请日：2008-03-02

申请人： The Board Of Trustees Of The University Of Illinois

发明人： CHENG, Jianjun ,  TONG, Rong

IPC分类号： B82B1/00 ,  B82B3/00

CPC分类号： A61K47/59 ,  A61K9/5146 ,  A61K9/5192 ,  A61K31/337 ,  A61K31/4355 ,  A61K31/704 ,  A61K38/09 ,  A61K38/13 ,  A61K47/593 ,  A61K47/60 ,  A61K47/605 ,  A61K47/6803 ,  A61K47/6809 ,  A61K47/6811 ,  A61K47/6851 ,  A61K47/6855 ,  A61K47/6857 ,  A61K47/6877 ,  A61K47/6927 ,  A61K47/6935 ,  A61K47/6937 ,  C08G63/823 ,  C08G81/00

摘要： Methods for efficient preparation of drug-polymer (or oligomer) conjugates which are useful in the preparation of particles, including microparticles and nanoparticles, for delivery of the drug in vivo for therapeutic applications. The invention additionally provides certain drug-polymer and drug-oligomer conjugates which are useful in the preparation of particles for delivery of the drug in vivo. The invention also provides nanoparticles of this invention prepared by nanoprecipitation using drug-polymer/oligomer conjugates of the invention. The drug conjugates are formed during polymerization of the polymer or oligomer in which the drug is employed as an initiator of the polymerization of the monomers which form the polymer and/or oligomer. More specifically, the drug conjugates are formed by ring-opening polymerization of cyclic monomers in the presence of an appropriate ring-opening polymerization catalyst and the initiator (the drug). The method is particularly useful for formation of polymer/oligomer conjugates with drugs and other chemical species containing one or more hydroxyl groups or thiol groups.