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    METHOD FOR PRODUCING BIPHENYL DERIVATIVE
    2.
    发明公开
    METHOD FOR PRODUCING BIPHENYL DERIVATIVE 有权
    VERFAHREN ZUR HERSTELLUNG EINES BIPHENYL-DERIVATS

    公开(公告)号：EP2075241A1

    公开(公告)日：2009-07-01

    申请号：EP07829693.6

    申请日：2007-10-12

    申请人： Toray Fine Chemicals Co., Ltd. ,  Haqyashi, Tamio

    发明人： HAYASHI, Tamio ,  NAKATANI, Jiro

    IPC分类号： C07C1/26 ,  C07C15/14 ,  C07B49/00 ,  C07B61/00

    CPC分类号： C07C43/2055 ,  C07B37/04 ,  C07B49/00 ,  C07C1/26 ,  C07C1/326 ,  C07C2/84 ,  C07C17/2632 ,  C07C15/14

    摘要： Provided is a method for producing a biphenyl derivative, with an industrially high yield and excellent productivity, by use of a raw material which is low in cost and toxicity. More specifically, the method for producing the biphenyl derivative represented by general formula (1) is characterized in that a chlorine atom in a benzene derivative represented by general formula (2) reacts with magnesium metal to convert the benzene derivative into a Grignard reagent, and then the Grignard reagent is subjected to a coupling reaction in the presence of a catalyst and a dichloropropane:

    and (wherein A represents at least one selected from alkyl groups, alkoxy groups, alkoxymethyl groups, a vinyl group, phenyl groups and chlorine, and n represents an integer of 1 to 4).

    摘要翻译： 本发明提供通过使用低成本，低毒性的原料生产联苯衍生物的方法，工业上的高收率和优异的生产率。 更具体地说，由通式（1）表示的联苯衍生物的制造方法的特征在于，通式（2）表示的苯衍生物中的氯原子与镁金属反应，将苯衍生物转化为格氏试剂， 然后在催化剂和二氯丙烷的存在下对格氏试剂进行偶联反应：（其中A表示选自烷基，烷氧基，烷氧基甲基，乙烯基，苯基和氯中的至少一种，n 表示1〜4的整数）。

    METHOD FOR PRODUCING COMPOUND HAVING N,N-BIS(2-HYDROXY-3-CHLOROPROPYL)AMINO GROUP
    4.
    发明公开
    METHOD FOR PRODUCING COMPOUND HAVING N,N-BIS(2-HYDROXY-3-CHLOROPROPYL)AMINO GROUP 有权
    制备具有N，N-二（2-羟基-3-氯丙基）氨基的化合物的方法

    公开(公告)号：EP3257840A1

    公开(公告)日：2017-12-20

    申请号：EP16749205.7

    申请日：2016-02-08

    申请人： Toray Fine Chemicals Co., Ltd.

    发明人： NAKATANI, Jiro ,  TAKEZAWA, Ryota

    IPC分类号： C07C213/02 ,  C07C217/90 ,  C07D301/27 ,  C07D303/36 ,  C07B61/00

    CPC分类号： C07D301/27 ,  C07B61/00 ,  C07C213/02 ,  C07C213/04 ,  C07C217/90 ,  C07C215/76 ,  C07C215/14

    摘要： A method for efficiently and safely manufacturing, on an industrial scale, a compound having an N,N-bis(2-hydroxy-3-chloropropyl)amino group is provided. (1) an amine compound or a solution thereof, (2) epichlorohydrin or a solution thereof, and (3) an acidic compound or a solution thereof are continuously supplied to a flow reactor and reacted at a reaction temperature of 40 to 130°C and a liquid space velocity of 0.2 to 10 h -1 so that a compound having an N,N-bis(2-hydroxy-3-chloropropyl)amino group is manufactured. The obtained compound having an N,N-bis(2-hydroxy-3-chloropropyl)amino group is dehydrochlorinated by reaction with an alkali so that a polyfunctional glycidylamine type epoxy compound is manufactured.

    摘要翻译： 提供了一种在工业规模上有效和安全地制造具有N，N-双（2-羟基-3-氯丙基）氨基的化合物的方法。 （1）胺化合物或其溶液，（2）表氯醇或其溶液，和（3）酸性化合物或其溶液连续供应到流动反应器中并在40-130℃的反应温度下反应 并且液体空间速度为0.2至10h-1，从而制造具有N，N-双（2-羟基-3-氯丙基）氨基的化合物。 通过与碱反应获得具有N，N-双（2-羟基-3-氯丙基）氨基的所得化合物脱氯化氢，从而制造多官能缩水甘油胺型环氧化合物。

    PROCESS FOR PRODUCTION OF BIPHENYL DERIVATIVES
    6.
    发明公开
    PROCESS FOR PRODUCTION OF BIPHENYL DERIVATIVES 有权
    VERFAHREN ZUR HESTELLUNG VON BIPHENYLDERIVATEN

    公开(公告)号：EP1955990A1

    公开(公告)日：2008-08-13

    申请号：EP06822282.7

    申请日：2006-10-25

    申请人： Toray Fine Chemicals Co., Ltd. ,  Hayashi, Tamio

    发明人： HAYASHI, Tamio ,  NAKATANI, Jiro

    IPC分类号： C07C17/26 ,  C07C22/08 ,  C07B61/00

    CPC分类号： C07C17/263 ,  C07B37/04 ,  C07B49/00 ,  C07C17/2632 ,  C07C22/08 ,  C07C25/18

    摘要： A process for the production of biphenyl derivatives according to the present invention represented by the following general formula (1), wherein the chlorine atom of a benzene derivative represented by the following general formula (2) is reacted with metallic magnesium to form a Grignard reagent, and wherein two molecules of the Grignard reagent are coupled to each other in the presence of a catalyst. This process is excellent in industrial productivity by virtue of using inexpensive and easily available raw materials.


    (wherein A represents at least one member selected from the group consisting of trifluoromethyl and fluoro, and n is an integer of 1 to 4.)

    摘要翻译： 由下述通式（1）表示的本发明的联苯衍生物的制造方法，其中由以下通式（2）表示的苯衍生物的氯原子与金属镁反应形成格氏试剂 ，并且其中两个分子的格氏试剂在催化剂的存在下彼此偶联。 该方法凭借使用便宜且易于获得的原料，在工业生产率方面优异。 （其中A表示选自三氟甲基和氟的至少一个，n为1〜4的整数。）

    PROCESS FOR PRODUCTION OF 2,2'-BIS(TRIFLUOROMETHYL)- 4,4'-DIAMINOBIPHENYL
    7.
    发明公开
    PROCESS FOR PRODUCTION OF 2,2'-BIS(TRIFLUOROMETHYL)- 4,4'-DIAMINOBIPHENYL 审中-公开
    用于生产2,2'-双（三氟甲基）-4,4-二氨基

    公开(公告)号：EP2100874A1

    公开(公告)日：2009-09-16

    申请号：EP07831211.3

    申请日：2007-11-05

    申请人： Toray Fine Chemicals Co., Ltd.

    发明人： NAKATANI, Jiro

    IPC分类号： C07C209/36 ,  C07C209/86 ,  C07C211/52 ,  C07B61/00

    CPC分类号： C07C211/52 ,  C07C209/365

    摘要： The present invention is a method for producing of 2,2'-bis(trifluoromethyl)-4,4'-diaminobiphenyl, wherein 2,2'-bis(trifluoromethyl)biphenyl is produced from o-chlorobenzotrifluoride, further, 2,2'-bis(trifluoromethyl)biphenyl is dinitrated in 1,2-dichloropropane solution, and 2,2'-bis(trifluoromethyl)-4,4'-dinitrobiphenyl is isolated and reduced. The method for producing of 2,2'-bis(trifluoromethyl)-4,4'-diaminobiphenyl of the present invention is an industrially excellent method for producing with high safety and high production efficiency.

    摘要翻译： 本发明是用于2,2'-双（三氟甲基）-4,4-二氨基，worin 2,2'-双制造方法（三氟甲基）联苯从邻氯三氟甲苯，进一步，2,2'产生的 双（三氟甲基）联苯二硝化在1,2-二氯丙烷溶液，和2,2'-双（三氟甲基）-4,4-二硝基分离并减少了。 为2,2'-双（三氟甲基）本发明的-4,4-二氨基的制造方法是用于具有高安全性和高生产效率生产一种工业上优异的方法。

    METHOD FOR PRODUCING 2'-TRIFLUOROMETHYL GROUP-SUBSTITUTED AROMATIC KETONE
    9.
    发明公开
    METHOD FOR PRODUCING 2'-TRIFLUOROMETHYL GROUP-SUBSTITUTED AROMATIC KETONE 审中-公开
    生产2'-三氟甲基取代的芳香酮的方法

    公开(公告)号：EP3196183A1

    公开(公告)日：2017-07-26

    申请号：EP15841268.4

    申请日：2015-09-07

    申请人： Toray Fine Chemicals Co., Ltd.

    发明人： NAKATANI, Jiro ,  NOZOE, Tatsuhiro

    IPC分类号： C07C45/42 ,  C07C49/80

    CPC分类号： C07C45/42 ,  C07C45/455 ,  C07C49/80

    摘要： The present invention is a method of producing a 2'-trifluoromethyl-substituted aromatic ketone comprising reacting a 2-halogen-substituted benzotrifluoride compound with magnesium metal to convert the compound to a Grignard reagent; and reacting the Grignard reagent with an acid anhydride; and then hydrolyzing the resultant to produce a 2'-trifluoromethyl-substituted aromatic ketone. The method of producing a 2'-trifluoromethyl-substituted aromatic ketone of the present invention enables 2'-trifluoromethyl-substituted aromatic ketone to be produced without using expensive raw materials by generating a Grignard reagent as an intermediate and reacting this Grignard reagent with an acid anhydride in an efficient productivity. The 2'-trifluoromethyl-substituted aromatic ketone that is produced by the method of producing a 2'-trifluoromethyl-substituted aromatic ketone of the present invention can be used as fine chemicals, raw materials for pharmaceuticals and agrochemicals, raw materials for resins and plastics, electronics and information related materials, optical materials, and the like.

    摘要翻译： 本发明是一种制备2'-三氟甲基取代的芳族酮的方法，该方法包括使2-卤素取代的三氟甲苯化合物与镁金属反应以将该化合物转化成格利雅试剂; 并使格氏试剂与酸酐反应; 然后水解生成物以产生2'-三氟甲基取代的芳族酮。 生产本发明的2'-三氟甲基取代的芳族酮的方法使得能够在不使用昂贵的原料的情况下通过生成格利雅试剂作为中间体来生产2'-三氟甲基取代的芳族酮并且使该格利雅试剂与酸 酸酐以有效的生产率生产。 通过本发明的2'-三氟甲基取代的芳香族酮的制造方法制造的2'-三氟甲基取代芳香族酮可以作为精细化学品，药品和农药的原料，树脂和塑料的原料 ，电子和信息相关材料，光学材料等。