公开(公告)号：EP2342339A2

公开(公告)日：2011-07-13

申请号：EP09816848.7

申请日：2009-09-24

申请人： Trana Discovery, Inc.

发明人： GUENTHER, Richard, H. ,  YENNE, Samuel, P.

IPC分类号： C12N15/11 ,  C07H21/00 ,  C12Q1/68 ,  G01N33/15 ,  C12R1/445

CPC分类号： C12N15/11 ,  C12Q1/18 ,  C12Q1/6806 ,  C12Q1/6895 ,  C12Q2600/136 ,  C12Q2600/158 ,  G01N2333/31 ,  Y10T436/143333 ,  C12Q2525/117 ,  C12Q2563/107

摘要： Methods of inhibiting S. aureus propagation, and screening for compounds that inhibit S. aureus propagation, are described. A method of inhibiting S. aureus propagation comprises inhibiting ribosomal binding of a specific S. aureus tRNA in the S. aureus by an amount sufficient to inhibit S. aureus protein expression. A method of screening for compounds useful for inhibiting S. aureus propagation comprises contacting a specific S. aureus tRNA to a ribosome that binds that tRNA in the presence of the test compound, and then determining whether the compound inhibits the binding of that tRNA.

公开(公告)号：EP2691542A1

公开(公告)日：2014-02-05

申请号：EP12764343.5

申请日：2012-03-29

申请人： Trana Discovery, Inc.

发明人： GUENTHER, Richard, H. ,  YENNE, Samuel, P. ,  SZEWCZYK, Jerzy, R.

IPC分类号： C12Q1/68 ,  C12N15/11 ,  C12R1/445 ,  C07H21/02

CPC分类号： C12Q1/6897 ,  A61K31/137 ,  A61K31/192 ,  A61K31/352 ,  A61K31/424 ,  A61K31/433 ,  A61K31/4439 ,  A61K31/4545 ,  A61K31/4738 ,  A61K31/496 ,  A61K31/506 ,  A61K31/517 ,  A61K31/519 ,  A61K31/5377 ,  A61K31/55 ,  C07H21/02 ,  C12N1/36 ,  C12Q1/689 ,  C12Q2600/136 ,  Y02A50/473

摘要： Methods of inhibiting S. aureus propagation, and screening for compounds that inhibit S. aureus propagation, are described. A method of inhibiting S. aureus propagation comprises either inhibiting or stabilizing ribosomal binding of a specific S. aureus tRNA in the S. aureus by an amount sufficient to inhibit S. aureus protein expression. A method of screening for compounds useful for inhibiting S. aureus propagation comprises contacting a specific S. aureus tRNA to a ribosome that binds that tRNA in the presence of the test compound and an mRNA that codes for methionine and arginine (i.e., includes the sequence AUGAGA), and then determining whether the compound inhibits the binding of that tRNA.