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1.发明公开USE OF INHIBITORS OF SOLUBLE EPOXIDE HYDROLASE TO SYNERGIZE ACTIVITY OF COX AND 5-LOX INHIBITORS 审中-公开对于即时环氧化物水解酶抑制剂的用途SYNERGIERUNG COX和5-LOX抑制剂的活性
公开(公告)号：EP1845976A4
公开(公告)日：2010-10-27
申请号：EP06733676
申请日：2006-01-10
申请人： UNIV CALIFORNIA
IPC分类号： A61K31/415 , A61K31/12 , A61K31/132 , A61K31/167 , A61K31/17 , A61K31/192 , A61K31/196 , A61K31/20 , A61K31/201 , A61K31/202 , A61K31/22 , A61K31/336 , A61K31/341 , A61K31/40 , A61K31/403 , A61K31/405 , A61K31/407 , A61K31/42 , A61K31/444 , A61K31/5415 , A61K31/557 , A61K31/603 , A61K31/606 , A61K31/612 , A61K31/616 , A61K31/635 , A61K45/06 , A61P29/00
CPC分类号： A61K31/17 , A61K31/12 , A61K31/132 , A61K31/167 , A61K31/192 , A61K31/196 , A61K31/20 , A61K31/201 , A61K31/202 , A61K31/22 , A61K31/336 , A61K31/341 , A61K31/365 , A61K31/40 , A61K31/403 , A61K31/405 , A61K31/407 , A61K31/415 , A61K31/42 , A61K31/444 , A61K31/5415 , A61K31/557 , A61K31/60 , A61K31/603 , A61K31/606 , A61K31/612 , A61K31/616 , A61K31/635 , A61K45/06 , A61K2300/00
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2.发明公开USE OF CIS-EPOXYEICOSANTRIENOIC ACIDS AND INHIBITORS OF SOLUBLE EPOXIDE HYDROLASE TO REDUCE PULMONARY INFILTRATION BY NEUTROPHILS 审中-公开CIS EPOXYEICOSATRIEN酸和可溶EOXIDHYDROLASE抑制剂用于减少肺浸润中性粒细胞USE
公开(公告)号：EP1737443A4
公开(公告)日：2010-04-07
申请号：EP05761459
申请日：2005-03-31
申请人： UNIV CALIFORNIA
IPC分类号： A61K31/145 , A61K31/155 , A61K31/17 , A61K31/20 , A61K31/335 , A61K31/558 , A61K45/06
CPC分类号： A61K31/558 , A61K9/146 , A61K31/17 , A61K31/20 , A61K45/06
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3.发明公开REDUCING NEPHROPATHY WITH INHIBITORS OF SOLUBLE EPOXIDE HYDROLASE AND EPOXYEICOSANOIDS 审中-公开异径肾病可溶性环氧化物水解酶和EPOXYEICOSANOIDEN抑制剂的
公开(公告)号：EP1765311A4
公开(公告)日：2009-04-29
申请号：EP05732924
申请日：2005-03-16
申请人： UNIV CALIFORNIA
发明人： HAMMOCK BRUCE D , WATANABE TAKAHO , MA SEUNG JIN , BENNETT SUSAN E , STERN JUDITH S , MORISSEAU CHRISTOPHE , KIM IN-HAE
CPC分类号： A61K31/70 , A61K31/17 , A61K31/355
摘要： The invention provides uses and methods for reducing nephropathy in persons with diabetes mellitus (particularly Type 2 diabetes), in persons with metabolic syndrome, in persons with triglyceride levels over 215 mg/dL, and in persons with a cholesterol level over 200 mg/dL, by administering an inhibitor of soluble epoxide hydrolase ("sEH"). Optionally, a cis-epoxyeicosantrienoic acid ("EET") can be administered with the sEH inhibitor. The invention further provides for using EETs in conjunction with one or more sEH inhibitors to reduce hypertension, and for compositions of EETs coated with a material insoluble in an acid of pH 3 but soluble in a solution with a pH of 7.4 or higher.
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公开(公告)号：EP2675274B1
公开(公告)日：2017-05-03
申请号：EP12746691
申请日：2012-02-14
申请人： UNIV CALIFORNIA
IPC分类号： C07D213/81 , C07C275/26 , C07C275/30 , C07C275/34 , C07C275/38 , C07D213/64 , C07D213/643 , C07D213/79 , C07D401/06
CPC分类号： C07C275/38 , C07C275/26 , C07C275/30 , C07C275/34 , C07C2601/14 , C07D213/64 , C07D213/643 , C07D213/79 , C07D213/81 , C07D401/06
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5.发明公开USE OF CIS-EPOXYEICOSATRIENOIC ACIDS AND INHIBITORS OF SOLUBLE EPOXIDE HYDROLASE TO ALLEVIATE EYE DISORDERS 审中-公开环氧二十碳三和立竿见影的效果眼疾抑制剂的使用环氧化物水解酶
公开(公告)号：EP1909796A4
公开(公告)日：2009-11-11
申请号：EP06787043
申请日：2006-07-12
申请人： UNIV CALIFORNIA
发明人： HAMMOCK BRUCE D , WATANABE TAKAHO , GEE SHIRLEY J
IPC分类号： A61K31/20 , A61K31/336 , A61P27/02
CPC分类号： A61K31/336 , A61K31/20 , A61K31/537
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公开(公告)号：EP0654076A4
公开(公告)日：1997-06-11
申请号：EP94906743
申请日：1993-08-10
申请人： UNIV CALIFORNIA
CPC分类号： C12N15/86 , A01N63/00 , C12N9/18 , C12N2710/14143
摘要： A diagnostic or control composition is useful to characterize or control insects and comprises a nucleotide sequence coding for juvenile hormone esterase (JHE). The coding sequence may be combined with a promoter sequence regulating the transcription thereof in a recombinant expression vector for use in controlling insects having a juvenile hormone esterase dependency. Preferred embodiments of the invention are recombinant baculoviruses in which a mutated JHE coding sequence provides relatively rapid speed of kill in insects.
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公开(公告)号：EP2675274A4
公开(公告)日：2014-08-06
申请号：EP12746691
申请日：2012-02-14
申请人： UNIV CALIFORNIA
IPC分类号： A61K31/44 , C07C275/30 , C07C275/34 , C07D213/64 , C07D213/79 , C07D213/81
CPC分类号： C07C275/38 , C07C275/26 , C07C275/30 , C07C275/34 , C07C2601/14 , C07D213/64 , C07D213/643 , C07D213/79 , C07D213/81 , C07D401/06
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公开(公告)号：EP2219450A4
公开(公告)日：2012-01-25
申请号：EP08847164
申请日：2008-11-07
申请人： UNIV CALIFORNIA
发明人： HAMMOCK BRUCE D , INCEOGLU A BORA , JINKS STEVEN
IPC分类号： A01N43/20 , A61K31/17 , A61K31/202 , A61K31/215 , A61K45/06 , A61P25/00
CPC分类号： A61K31/215 , A61K31/17 , A61K31/202
摘要： The invention discloses methods of using cis-epoxyeicosantrienoic acids (EETs), inhibitors of soluble epoxide hydrolase (sEH), or a combination of an EET and an inhibitor of sEH, to alleviate neuropathic pain in subjects suffering from such pain.
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公开(公告)号：EP1608319A4
公开(公告)日：2007-02-28
申请号：EP04758831
申请日：2004-04-02
申请人： UNIV CALIFORNIA
IPC分类号： A61K20060101 , A61K6/00 , A61K31/365 , A61K31/381 , A61K31/4015 , A61K31/4178 , A61K31/422 , A61K31/427 , A61K31/513 , A61K38/04 , A61K38/05 , A61K38/06 , A61K38/08 , C07C275/26 , C07C275/30 , C07C275/42 , C07C311/05 , C07C311/51 , C07C275/00
CPC分类号： C07C275/26 , C07C275/30 , C07C275/42 , C07C311/04 , C07C311/05 , C07C311/51 , C07C323/59 , C07C2601/02 , C07C2601/14 , C07C2603/74 , C07D207/16 , C07D233/24 , C07D233/64
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10.发明公开METHODS OF TREATING PULMONARY DISEASES MEDIATED BY POLYUNSATURATED LIPID METABOLITES AND ASSAYS FOR EPOXIDE HYDROLASE INHIBITORS 失效为多不饱和脂质代谢物治疗方法而切换肺病和测试为环氧化物水解酶抑制剂
公开(公告)号：EP0926951A4
公开(公告)日：2001-08-08
申请号：EP97938335
申请日：1997-08-13
申请人： UNIV CALIFORNIA
发明人： HAMMOCK BRUCE D , MOGHADDAM MEHRAN F , CHEEK JEFFREY M , BORHAN BABAK , FERGUSSON JAMES , GRANT DAVID F , GREENE JESSICA F , MATOBA KAZU , ZHENG JIANG , SISEMORE MARLENE F
IPC分类号： A61K31/155 , A61K31/20 , A61K31/336 , A01N33/02 , A01N37/02 , A01N43/20 , A01N43/24 , A61K31/13 , A61K31/23 , A61K31/335
CPC分类号： A61K31/7088 , A61K31/155 , A61K31/20 , A61K31/336 , G01N2500/10
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