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公开(公告)号：EP1592773A2
公开(公告)日：2005-11-09
申请号：EP04704892.1
申请日：2004-01-23
IPC分类号： C12N1/00
CPC分类号： C12N15/86 , A01K2217/05 , A01K2227/30 , A01K2267/01 , C12N15/8509 , C12N15/902 , C12N2740/13043 , C12N2799/027 , C12N2830/008 , C12N2830/15 , C12N2830/40 , C12N2830/90 , C12N2840/20 , C12N2840/203
摘要： This invention provides vectors and methods for the stable introduction of exogenous nucleic acid sequences into the genome of avians in order to express the exogenous sequences to alter the phenotype of the avians or to produce desired proteins. In particular, transgenic avians are produced which express exogenous sequences in their oviducts and which deposit exogenous proteins into their eggs. Avian eggs that contain exogenous proteins are encompassed by this invention. The instant invention further provides novel forms of interferon and erythropoietin which are efficiently expressed in the oviduct of transgenic avians and deposited into avian eggs.
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公开(公告)号：EP2007803A1
公开(公告)日：2008-12-31
申请号：EP07751151.7
申请日：2007-02-20
IPC分类号： C07K14/535
CPC分类号： C07K14/535
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公开(公告)号：EP1023442A1
公开(公告)日：2000-08-02
申请号：EP98954994.4
申请日：1998-10-15
IPC分类号： C12N15/00 , A01K67/027 , C12N15/90
CPC分类号： C12N9/00 , A01K67/0275 , A01K2217/05 , A01K2217/072 , A01K2227/30 , A01K2267/01 , A01K2267/025 , C07K14/77 , C07K16/00 , C12N15/8509 , C12N15/86 , C12N15/902 , C12N2740/11043 , C12N2799/027 , C12N2800/30 , C12N2800/90 , C12N2830/00 , C12N2830/008 , C12N2830/40 , C12N2830/42 , C12N2830/90 , C12N2840/20 , C12N2840/203 , C12N2840/44
摘要： This invention provides vectors and methods for the stable introduction of exogenous nucleic acid sequences into the genome of a bird and for expressing said exogenous sequences to alter the phenotype of the bird or to produce desired proteins. In particular, transgenic chickens are produced which express exogenous sequences in their oviducts. Eggs which contain exogenous proteins are also produced.
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公开(公告)号：EP1023442B1
公开(公告)日：2010-11-24
申请号：EP98954994.4
申请日：1998-10-15
IPC分类号： C12N15/00 , A01K67/027 , C12N15/90
CPC分类号： C12N9/00 , A01K67/0275 , A01K2217/05 , A01K2217/072 , A01K2227/30 , A01K2267/01 , A01K2267/025 , C07K14/77 , C07K16/00 , C12N15/8509 , C12N15/86 , C12N15/902 , C12N2740/11043 , C12N2799/027 , C12N2800/30 , C12N2800/90 , C12N2830/00 , C12N2830/008 , C12N2830/40 , C12N2830/42 , C12N2830/90 , C12N2840/20 , C12N2840/203 , C12N2840/44
摘要： This invention provides vectors and methods for the stable introduction of exogenous nucleic acid sequences into the genome of a bird and for expressing said exogenous sequences to alter the phenotype of the bird or to produce desired proteins. In particular, transgenic chickens are produced which express exogenous sequences in their oviducts. Eggs which contain exogenous proteins are also produced.
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公开(公告)号：EP1725091A1
公开(公告)日：2006-11-29
申请号：EP05723783.6
申请日：2005-02-28
申请人： Avigenics, Inc.
IPC分类号： A01K67/027
CPC分类号： A01K67/0275 , A01K2217/07 , A01K2227/30 , A01K2267/00 , A01K2267/01 , C12N15/8509 , C12N15/907 , C12N2800/90 , C12N2840/203
摘要： The invention includes transchromosomal avians and transchromosomal avian cells and methods for the introduction of artificial chromosomes into the genome of avians and avian cells.
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公开(公告)号：EP1461430A2
公开(公告)日：2004-09-29
申请号：EP02786838.9
申请日：2002-12-02
申请人： Avigenics, Inc.
发明人： HARVEY, Alex, J. , WANG, Youliang
CPC分类号： C07K14/8135 , A01K2227/30 , C07K14/56 , C12N2799/021
摘要： The present invention provides novel isolated nucleic acids that comprise an avian nucleic acid sequence comprising a ovomucoid gene expression control region. The ovomucoid promoter region of the present invention will allow expression of an operably linked heterologous nucleic acid insert in a transfected avian cell such as, for example, an oviduct cell. The isolated avian ovomucoid of the present invention may be operably linked with a selected nucleic acid insert, wherein the nucleic acid insert encodes a polypeptide desired to be expressed in a transfected cell. The recombinant DNA of the present invention may further comprise a polyadenylation signal sequence. The present invention further includes expression vectors comprising an isolated avian ovomucoid gene expression control region of the present invention, and transfected cells and transgenic avians comprising the expression vectors.
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公开(公告)号：EP1503627A2
公开(公告)日：2005-02-09
申请号：EP03724449.8
申请日：2003-05-02
申请人： Avigenics, Inc.
发明人： HARVEY, Alex, J.
IPC分类号： A21C11/16
CPC分类号： C12N15/1003 , C12Q1/6806 , C12Q2537/149 , C12Q2527/125
摘要： Genetic modification or selection of avians requires that large numbers of birds be genetically analyzed for sequences of interest. Typically, DNA is extracted on an individual basis from samples taken from the birds. Current methods of DNA extraction extract the DNA from blood or other tissue using tedious and time-consuming procedures. The present invention provides a high throughput screening assay for detecting a genetic sequence in multiple samples. The assay further provides a DNA extraction method that allows DNA to be extracted rapidly from multiple avian samples, such as red blood cells. The extraction method is extremely reliable and does not require that each sample be quantitated post-extraction. The extracted DNA can be used for a variety of genetic assays, including a high throughput screening assay to identify insertions of a transgene. The present invention is particularly useful for extracting DNA from nucleated RBCs. Therefore, the method can be applied towards genetic analysis of avians, fish, reptiles and amphibians.
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