-
公开(公告)号：EP3241837A1
公开(公告)日：2017-11-08
申请号：EP15874972.1
申请日：2015-11-11
发明人： GUO, Yanghui , ZHAO, Shiguo , ZHANG, Yue , ZHANG, Liang , YANG, Zhiqing , CHAI, Jian
IPC分类号： C07H19/10 , C07H1/06 , A61K31/7072 , A61P31/14
摘要： The present invention relates to a method for preparing Sofosbuvir crystal form-6. The method is simple in operation, stable in process condition, good in reproducibility, high in yield rate and high in purity, viscous gel-type products are not formed during the process, the problem of blocking of a discharge port is solved, and the method is suitable for mass industrial production and has high economic value.
摘要翻译： Sofosbuvir晶形-6的制备方法技术领域本发明涉及Sofosbuvir晶形-6的制备方法。 该方法操作简单，工艺条件稳定，重复性好，收率高，纯度高，在工艺过程中不形成粘性凝胶型产品，解决了出料口堵塞问题， 方法适用于大量工业生产，具有较高的经济价值。
-
2.发明公开METHOD FOR PREPARING 3-O-BENZYL-1,2-O-ISOPROPYLIDENE- -L-FURAN IDOSE 审中-公开用于生产3-O-苄基1,2-O-异亚丙基-L- FURANIDOSE
公开(公告)号：EP2818476A1
公开(公告)日：2014-12-31
申请号：EP13751650.6
申请日：2013-02-22
发明人： GUO, Yanghui , WEI, Hegeng , ZHOU, Junhui , WU, Yingqiu , ZHANG, Yue , BAI, Hua , HE, Liang , DING, Yili
IPC分类号： C07H15/18 , C07H15/26 , C07H15/00 , C07H9/00 , C07H9/02 , C07H9/04 , C07D493/00 , C07D493/02 , C07D493/04
摘要： Provided is a method for preparing 3-O-benzyl-1,2-O-isopropylidene-α-L-idofuranose, which comprises: (1) protecting hydroxyl of 3-O-benzyl-1,2-O-isopropylidene-α-D-glucofuranose (III) by benzoyl and methylsulfonyl to obtain 6-O-benzoyl-3-O-benzyl-1,2-O-isopropylidene-5-O-methylsulfonyl-α-D-glucofuranose (V); (2) subjecting compound (V) to a cyclization reaction under an alkaline condition to obtain 5,6-epoxy-3-O-benzyl-1,2-O-isopropylidene-α-L-idofuranose (VI); and (3) subjecting compound (VI) to a ring-opening reaction to obtain 3-O-benzyl-1,2-O-isopropylidene-α-L-idofuranose.
-
3.发明公开
公开(公告)号：EP2837635A1
公开(公告)日：2015-02-18
申请号：EP13772346.6
申请日：2013-04-02
发明人： GUO, Yanghui , WEI, Hegeng , BAI, Hua , WU, Yingqiu , ZHANG, Yue , ZHOU, Junhui , DING, Yili , BAI, Lingwei , YANG, Shibao
CPC分类号： C08B37/0075 , C07H1/00 , C07H5/06 , C07H11/00 , C07H15/04 , C07H15/18 , C08B37/006
摘要： The present invention relates to a process of a chemically synthetic drug, and in particular, to a new intermediate of a heparin pentasaccharide and a preparation method thereof. The process has high reaction efficiency, and an easy reaction operation. The reaction intermediate is easy to be purified, and is appropriate for an industrialization production.
摘要翻译： 化学合成药物的方法及其制备方法技术领域本发明涉及化学合成药物的方法，特别涉及肝素五糖的新中间体及其制备方法。 该方法反应效率高，反应操作简单。 反应中间体易于提纯，适合工业化生产。
-
4.发明授权
公开(公告)号：EP2837635B1
公开(公告)日：2017-10-18
申请号：EP13772346.6
申请日：2013-04-02
发明人： GUO, Yanghui , WEI, Hegeng , BAI, Hua , WU, Yingqiu , ZHANG, Yue , ZHOU, Junhui , DING, Yili , BAI, Lingwei , YANG, Shibao
CPC分类号： C08B37/0075 , C07H1/00 , C07H5/06 , C07H11/00 , C07H15/04 , C07H15/18 , C08B37/006
-
公开(公告)号：EP3070094A1
公开(公告)日：2016-09-21
申请号：EP14861246.8
申请日：2014-04-28
发明人： GUO, Yanghui , ZHOU, Junhui , CAI, Qingfeng , WEI, Hegeng , BAI, Hua , LONG, Fei , ZHANG, Yue , WU, Yingqiu
摘要： The present invention relates to a disaccharide intermediate and a synthesis method thereof, relates to the chemical pharmaceutical field, and more specifically relates to a method for preparing a disaccharide segment of a key intermediate for chemically synthesizing heparin and heparinoid compounds. Disclosed are a new disaccharide intermediate and three methods for synthesizing the disaccharide intermediate, that is, compounds of a formula (4) and glucopyranose protected by different anomeric carbon are made to react in the presence of an active agent, to obtain the disaccharide intermediate. According to the technical solutions of the present invention, synthetic raw materials are easy to obtain, have a mild reaction condition, and are suitable for industrialized production.
摘要翻译： 本发明涉及二糖中间体及其合成方法，涉及化学药物领域，更具体地涉及一种用于化学合成肝素和类肝素化合物的关键中间体的二糖片段的制备方法。 公开了一种新的二糖中间体和三种合成二糖中间体的方法，即式（4）化合物和被不同异头碳保护的吡喃葡萄糖在活性剂存在下反应，得到二糖中间体。 根据本发明的技术方案，合成原料容易获得，反应条件温和，适合工业化生产。
-
-
-
-
搜索结果
5 条记录 (耗时 0.011 秒)
