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公开(公告)号：EP0696198A1
公开(公告)日：1996-02-14
申请号：EP94914087.0
申请日：1994-04-08
摘要： A novel polypeptide derived from the leech Hirudo medicinalis was found to be able to inhibit Factor Xa thereby reducing the extent of blood coagulation. The polypeptide is useful in treating conditions of excessive blood coagulation. A recombinant organism containing cDNA encoding the polypeptide has been deposited in the ATCC under Accession No. 69134. Recombinant microorganisms able to produce the polypeptide have been deposited in the ATCC under Accession Nos. 69135, 69137 and 69269.
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公开(公告)号：EP0693925A1
公开(公告)日：1996-01-31
申请号：EP94914102.0
申请日：1994-04-08
申请人： BIO-TECHNOLOGY GENERAL CORP. , YISSUM RESEARCH DEVELOPMENT COMPANY OF THE HEBREW UNIVERSITY OF JERUSALEM
发明人： WERBER, Moshe M. , ZEELON, Elisha P. , LEVANON, Avigdor , GUY, Rachel , GOLDLUST, Arie , RIGBI, Meir , PANET, Amos , FISCHER, Meir
IPC分类号： C12N15 , A61K38 , A61P7 , A61P31 , A61P43 , C07K1 , C07K14 , C07K16 , C12N1 , C12N9 , C12P21 , C12R1
CPC分类号： C07K14/815 , A61K38/00 , C07K16/38
摘要： The present invention provides a recombinant polypeptide having the amino acid sequence X-tyr?26 - gly110¿ where tyr?26 - gly110¿ is identical to the sequence shown in Figure 10, and wherein X is methionine or absent and wherein asn72 may be substituted by pro. The invention further provides a method of producing the polypeptide which comprises transforming a host cell with an expression plasmid encoding the polypeptide, culturing the transformed host cell so that the cell produces the polypeptide encoded by the plasmid, and a method of recovering the polypeptide so produced.
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公开(公告)号：EP0659085A1
公开(公告)日：1995-06-28
申请号：EP93919995.0
申请日：1993-08-12
发明人： VOGEL, Tikva , PANET, Amos
CPC分类号： C07K14/775 , A61K38/1709 , A61K2300/00
摘要： The present invention provides a use of ApoE for inhibition of proliferation of actively proliferating cells including tumor cells. This method comprises contacting the cells with an amount of Apolipoprotein E (ApoE) effective to inhibit cell proliferation.
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公开(公告)号：EP0871474A4
公开(公告)日：2004-08-18
申请号：EP95907193
申请日：1994-12-29
IPC分类号： C12N15/09 , A61K38/00 , A61K38/28 , A61P3/10 , C07K1/107 , C07K1/113 , C07K14/62 , C12N15/17 , C12P21/00 , C12P21/02 , C12P21/06 , C12R1/19
CPC分类号： C07K1/1136 , A61K38/00 , C07K14/62
摘要： An improved and efficient process for the production of recombinant human insulin by folding of a proinsulin hybrid polypeptide is provided.
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公开(公告)号：EP0701606A4
公开(公告)日：1999-06-30
申请号：EP94915405
申请日：1994-04-22
发明人： GARFINKEL LEONARD , GORECKI MARIAN , PANET AMOS
IPC分类号： C12N15/09 , A61K31/60 , A61K31/715 , A61K38/00 , A61K38/37 , A61K38/46 , A61K38/49 , A61P7/02 , A61P9/00 , C07K14/755 , C12N9/64 , C12P21/02 , C12R1/19 , A61K38/43 , A61K38/48 , C12N9/70 , C12N9/72
CPC分类号： C07K14/755 , A61K38/37 , A61K38/49 , A61K31/60 , A61K2300/00
摘要： A method is provided for the use of a fragment of von Willebrand Factor (vWF) comprising the platelet glycoprotein Ib (GPIb) binding domain in conjunction with known therapies to obtain enhanced protection against thrombosis, improved thrombolysis, and a decreased likelihood of reocclusion following thrombolytic treatment. Additionally, a method is provided for the use of the vWF fragment and aspirin to prevent complications following traumatic vascular damage.
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公开(公告)号：EP0715521A4
公开(公告)日：1998-01-14
申请号：EP94925276
申请日：1994-08-12
发明人： VOGEL TIKVA , GALLO ROBERT C , BROWNING PHILIP J , ROBERTS DAVID D , PANET AMOS
IPC分类号： A61K38/00 , C07K14/775
CPC分类号： C07K14/775 , A61K38/00
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公开(公告)号：EP0764202A4
公开(公告)日：1998-01-07
申请号：EP95914162
申请日：1995-03-22
发明人： FISCHER MEIR
IPC分类号： C12N15/09 , C07K14/02 , C07K14/61 , C12N1/21 , C12N9/02 , C12N9/08 , C12N9/16 , C12N15/55 , C12N15/70 , C12P21/00 , C12R1/19 , C12N15/18 , C12N15/53
CPC分类号： C07K14/005 , C07K14/61 , C12N9/0089 , C12N9/16 , C12N15/70 , C12N2730/10122
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公开(公告)号：EP0408742A4
公开(公告)日：1992-12-09
申请号：EP90907882
申请日：1990-02-07
发明人： EVEN-CHEN ZEEV
IPC分类号： C12P21/00 , A61K39/29 , A61P31/12 , C07K1/16 , C07K14/005 , C07K14/02 , C07K14/195 , C12N15/09 , C12N15/85 , C12R1/91
CPC分类号： C07K14/005 , C12N15/85 , C12N2730/10122
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9.发明公开METHOD OF REMOVING N-TERMINAL AMINO ACID RESIDUES FROM EUCARYOTIC POLYPETIDE ANALOGS AND POLYPEPTIDES PRODUCED THEREBY. 失效程序对除去正ENDAMINOSÄURERESTENOFF EUKARYOTPOLYPEPTIDANLAGEN和这样产生的多肽。
公开(公告)号：EP0191827A4
公开(公告)日：1988-09-28
申请号：EP85904198
申请日：1985-08-09
IPC分类号： C12N9/48 , A61K35/74 , A61K38/27 , C07K1/22 , C07K14/00 , C07K14/195 , C07K14/41 , C07K14/52 , C07K14/555 , C07K14/575 , C07K14/61 , C07K14/65 , C12N15/18 , C12N15/20 , C12N15/23 , C12P21/00 , C12P21/06 , C12R1/01 , C12R1/07 , C12R1/545
CPC分类号： C12P21/06 , C07K14/555 , C07K14/61 , C12N9/48
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10.发明公开METHOD OF PRODUCING HIGH MOLECULAR WEIGHT SODIUM HYALURONATE BY FERMENTATION OF -i(STREPTOCOCCUS). 失效用于生产高分子量透明质酸钠BY链球菌的的外观。
公开(公告)号：EP0211037A4
公开(公告)日：1988-09-07
申请号：EP86900929
申请日：1986-01-16
发明人： NIMROD ABRAHAM , GREENMAN BENJAMIN , KANNER DOV , LANDSBERG MOSHE
IPC分类号： C12N15/00 , A61K8/72 , A61K8/73 , A61K8/99 , A61K31/715 , A61P27/02 , A61P29/00 , A61Q19/00 , C08B37/00 , C08B37/08 , C12N1/20 , C12N15/01 , C12P19/04 , C12P19/26 , C12Q1/14 , C12R1/46
CPC分类号： A61K31/715 , A61K8/735 , A61K2800/75 , A61Q19/00 , C08B37/0072 , C12P19/26 , C12R1/46 , Y10S435/803 , Y10S435/818 , Y10S435/885
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