公开(公告)号：EP2918307B1

公开(公告)日：2018-05-23

申请号：EP13853875.6

申请日：2013-11-05

申请人： Toppan Printing Co., Ltd.

发明人： UEMURA, Daizo

IPC分类号： A61M37/00 ,  B29C33/42 ,  B24B19/16

CPC分类号： A61M37/0015 ,  A61M2037/0023 ,  A61M2037/0046 ,  A61M2037/0053 ,  B29C33/3857 ,  B29C33/3892 ,  B29C33/42 ,  B29C41/085 ,  B29C41/12 ,  B29C43/04 ,  B29L2031/753 ,  B29L2031/7544 ,  B29L2031/756 ,  Y10T428/24479

摘要： [Problem] To fabricate needle portions each having a tip with appropriate dimension and shape and improve puncture properties. [Solution] A method for manufacturing a needle-like structure includes: a step of forming, for a surface of a substrate 11, a plurality of first linear grooves 12 parallel to each other, the first linear grooves being formed along a first direction by means of grinding, to thereby form a plurality of projections 15 each having a triangular cross section perpendicular to the first direction; and a step of forming, for each of the projections 15, a plurality of second linear grooves 14 parallel to each other, the second linear grooves being formed along a second direction intersecting the first direction by means of grinding so as to have a depth smaller than that of the first linear grooves 12, to thereby form a plurality of needle portions 15 each having a triangular cross section perpendicular to the second direction.

公开(公告)号：EP3133145A4

公开(公告)日：2018-03-14

申请号：EP15779517

申请日：2015-04-10

申请人： TOKYO OHKA KOGYO CO LTD

发明人： SENZAKI TAKAHIRO

IPC分类号： C12M1/00 ,  B29C41/12 ,  C08F2/46 ,  C08J7/00

CPC分类号： C12M23/20 ,  B29C35/002 ,  B29C35/0805 ,  B29C41/003 ,  B29C41/12 ,  B29C41/42 ,  B29C71/0009 ,  B29C71/04 ,  B29C2035/0827 ,  B29C2071/0045 ,  B29D7/00 ,  B29K2033/04 ,  B29K2067/06 ,  B29K2071/00 ,  B29L2007/00 ,  C08F2/46 ,  C08J7/00

摘要： Provided are: a photosensitive resin composition for cell culture substrates that enables the low-cost manufacture of a cell culture substrate, that can easily form patterns of various shapes when providing a pattern on the surface of a cell culture substrate, that has low cytotoxicity, and that can form a cell culture substrate with which cells can be cultured well; a cell culture substrate that is formed using the photosensitive resin composition; and a cell culture substrate manufacturing method that uses the photosensitive resin composition. In the photosensitive resin composition, which includes a photopolymerizable monomer (A) and a photopolymerization initiator (B), the photopolymerizable monomer (A) used contains a defined amount of a polyfunctional monomer (A1) that is at least trifunctional, and the content of the photopolymerization initiator (B) is within a prescribed range.

公开(公告)号：EP3271127A1

公开(公告)日：2018-01-24

申请号：EP16765674.3

申请日：2016-03-16

申请人： President and Fellows of Harvard College

发明人： COON, James ,  HAMKINS-INDIK, Tiama ,  INGBER, Donald E. ,  INGRAM, Miles ,  LEVNER, Daniel ,  NOVAK, Richard ,  PUERTA, Jefferson ,  SHEA, Daniel E. ,  SLIZ, Josiah ,  WEN, Norman

IPC分类号： B29C41/18 ,  B29C41/38 ,  B29C33/20

CPC分类号： B01D67/0034 ,  B01D71/70 ,  B01L3/502707 ,  B01L2300/123 ,  B01L2400/086 ,  B29C33/424 ,  B29C33/68 ,  B29C39/006 ,  B29C39/26 ,  B29C41/12 ,  B29C41/36 ,  B29C41/38 ,  B29C2043/025 ,  B29L2031/755 ,  B29L2031/756 ,  C12M25/02

摘要： A method for micro-molding a polymeric membrane and including pouring a predetermined volume of curable polymer unto a micro-fabricated mold having a post array with pillars, and overlaying the polymer with a support substrate. A spacer, such as a rubber spacer, is placed in contact with the support substrate and a force is applied to an exposed side of the spacer to compress the support substrate and the polymer together. While applying the force, the polymer is cured on the mold for a predetermined time period and at a predetermined temperature to form a polymeric membrane having a pore array with a plurality of pores corresponding to the plurality of pillars of the post array. The polymeric membrane is removed from the support substrate.

公开(公告)号：EP3223964A1

公开(公告)日：2017-10-04

申请号：EP15864047.4

申请日：2015-11-25

申请人： The University of Akron

发明人： CAKMAK, Mukerrem ,  GUO, Yuanhao ,  BATRA, Saurabh

IPC分类号： B05D3/14 ,  C08J5/18 ,  B32B27/18

CPC分类号： B29C71/0072 ,  B29C41/12 ,  B29C41/32 ,  B29C71/0081 ,  B29K2105/0073 ,  B29L2007/008 ,  C08L27/12 ,  H01B1/22 ,  C08L101/12

摘要： A method of preparing a polymer film having an oriented dispersed material includes casting a multi-layer polymer solution having a first polymer solution layer and a second polymer solution layer where the second polymer solution layer is at least partially immiscible with the first polymer solution layer. The method further includes passing the multi-layer polymer solution through an electric field application zone, to thereby induce orientation of the dispersed material. A multi-layer polymer film can then be formed by drying the solvent from the multi-layer polymer solution. An apparatus for preparing polymer films includes a top electrode made from a flexible metal mesh coated with a non-stick, non-conductive coating.

摘要翻译： 制备具有取向分散材料的聚合物膜的方法包括流延具有第一聚合物溶液层和第二聚合物溶液层的多层聚合物溶液，其中第二聚合物溶液层与第一聚合物溶液层至少部分不混溶。 该方法还包括使多层聚合物溶液通过电场施加区域，从而诱导分散材料的取向。 然后可以通过干燥来自多层聚合物溶液的溶剂来形成多层聚合物膜。 用于制备聚合物膜的装置包括由柔性金属网制成的顶部电极，该柔性金属网涂覆有不粘的非导电涂层。

公开(公告)号：EP3215213A1

公开(公告)日：2017-09-13

申请号：EP15857785.8

申请日：2015-11-06

申请人： University of Pittsburgh - Of the Commonwealth System of Higher Education ,  Carnegie Mellon University

发明人： FALO, Louis D., Jr. ,  ERDOS, Geza ,  OZDOGANLAR, Burak O.

IPC分类号： A61M37/00

CPC分类号： A61M37/0015 ,  A61K9/0021 ,  A61K31/704 ,  A61K31/713 ,  A61K45/06 ,  A61K47/38 ,  A61M2037/0023 ,  A61M2037/0046 ,  A61M2037/0053 ,  A61M2037/0061 ,  B29C41/003 ,  B29C41/12 ,  B29C41/22 ,  B29C41/34 ,  B29K2995/0056 ,  B29K2995/006 ,  B29L2009/00 ,  B29L2031/7544 ,  B29L2031/756 ,  A61K2300/00

摘要： A method of forming a microneedle array can include forming a microneedle array having one or more chemotherapeutic agents. The microneedle array can include a base portion and plurality of microneedles extending from the base portion, and the one or more chemotherapeutic agents can be present in a higher concentration in the plurality of microneedles than in the base portion.

摘要翻译： 形成微针阵列的方法可以包括形成具有一种或多种化学治疗剂的微针阵列。 微针阵列可以包括基部和从基部延伸的多个微针，并且一种或多种化学治疗剂可以在多个微针中以比在基部中更高的浓度存在。

公开(公告)号：EP3133145A1

公开(公告)日：2017-02-22

申请号：EP15779517.0

申请日：2015-04-10

申请人： Tokyo Ohka Kogyo Co., Ltd.

发明人： SENZAKI, Takahiro

IPC分类号： C12M1/00 ,  B29C41/12 ,  C08F2/46 ,  C08J7/00

CPC分类号： C12M23/20 ,  B29C35/002 ,  B29C35/0805 ,  B29C41/003 ,  B29C41/12 ,  B29C41/42 ,  B29C71/0009 ,  B29C71/04 ,  B29C2035/0827 ,  B29C2071/0045 ,  B29D7/00 ,  B29K2033/04 ,  B29K2067/06 ,  B29K2071/00 ,  B29L2007/00 ,  C08F2/46 ,  C08J7/00

摘要： Provided are: a photosensitive resin composition for cell culture substrates that enables the low-cost manufacture of a cell culture substrate, that can easily form patterns of various shapes when providing a pattern on the surface of a cell culture substrate, that has low cytotoxicity, and that can form a cell culture substrate with which cells can be cultured well; a cell culture substrate that is formed using the photosensitive resin composition; and a cell culture substrate manufacturing method that uses the photosensitive resin composition. In the photosensitive resin composition, which includes a photopolymerizable monomer (A) and a photopolymerization initiator (B), the photopolymerizable monomer (A) used contains a defined amount of a polyfunctional monomer (A1) that is at least trifunctional, and the content of the photopolymerization initiator (B) is within a prescribed range.

摘要翻译： 提供：一种细胞培养基材的感光性树脂组合物，其能够低成本地制造细胞培养基材，当在细胞培养基材的表面上提供具有低细胞毒性的表面时可以容易地形成各种形状的图案， 可以形成能够良好培养细胞的细胞培养基质; 使用该感光性树脂组合物形成的细胞培养基材; 以及使用该感光性树脂组合物的细胞培养基板的制造方法。 在包含光聚合性单体（A）和光聚合引发剂（B）的感光性树脂组合物中，使用的光聚合性单体（A）含有规定量的至少三官能的多官能单体（A1），其含量 光聚合引发剂（B）在规定范围内。

公开(公告)号：EP2821096A4

公开(公告)日：2015-11-04

申请号：EP13755630

申请日：2013-02-01

申请人： TOPPAN PRINTING CO LTD

发明人： KATO HIROYUKI ,  YAMAMOTO TAKAKO ,  TAROURA YOSHIKAZU

IPC分类号： A61M37/00 ,  A61K9/00 ,  A61K47/12 ,  A61K47/36

CPC分类号： A61M37/0015 ,  A61K9/0021 ,  A61K47/12 ,  A61K47/36 ,  A61M2037/0046 ,  A61M2037/0053 ,  B29C39/003 ,  B29C41/12 ,  B29K2005/00 ,  F04C2270/041

摘要： A needle-shaped structure includes a needle-shaped projection and a support substrate supporting the projection wherein the projection contains at least a chitosan and an organic acid, places a low burden on a living body and is able to keep the microscopic form after puncture into the skin.

公开(公告)号：EP2533963A4

公开(公告)日：2015-01-21

申请号：EP11742884

申请日：2011-02-11

申请人： TAN YUNG-CHIEH

发明人： TAN YUNG-CHIEH

IPC分类号： B29C45/16 ,  B65D1/22

CPC分类号： B29C44/385 ,  B01D39/00 ,  B26F1/26 ,  B26F1/28 ,  B26F3/004 ,  B29C31/042 ,  B29C33/0033 ,  B29C39/24 ,  B29C39/26 ,  B29C39/42 ,  B29C41/12 ,  B29C41/36 ,  B29C41/38 ,  B29C2793/0045 ,  B29L2031/14 ,  B29L2031/737 ,  B29L2031/7544 ,  B29L2031/756 ,  B81B2201/055 ,  B81C1/00373 ,  B82Y30/00

摘要： Methods of and devices for making pores, nozzles, and slits are described. In some embodiments, the methods create pattern in the molded substrate by controlling the location and direction of a controlled flow stream through molding plates. The molding plate contains a predefined pattern that is able to be used to create the desired pattern in the molding plate.

公开(公告)号：EP1385704B1

公开(公告)日：2011-11-16

申请号：EP02789141.5

申请日：2002-05-08

申请人： Z Corporation

发明人： RUSSELL, David, B. ,  ZENGERLE, Walter, Henry, III ,  CONWAY, Peter, Charles ,  BREDT, James, F. ,  SWEET-BLOCK, Benjamin Daniel ,  PHILLIPS, Robert, Anthony

IPC分类号： B29C67/00

CPC分类号： B41J2/16552 ,  B29C41/12 ,  B29C64/165 ,  B29C64/35 ,  B29C64/386 ,  B29K2995/0021 ,  B33Y10/00 ,  B33Y30/00 ,  B33Y40/00 ,  B41J2/01 ,  B41J2/16541 ,  H04N1/58

摘要： An apparatus (3) and a method for fabricating a three-dimensional object, the apparatus comprising a feed reservoir (24) having stored therein a supply of build material for forming the object, a build chamber (27) for receiving layers of the build material from the feed reservoir (24) and a vacuum pump (258) coupled to the feed reservoir to create an airflow through the feed reservoir.

摘要翻译： 一种装置（3）和一种用于制造三维物体的方法，所述装置包括：储存器（24），其中存储有用于形成物体的构建材料供应源，构建室（27），用于接收构建物的层 来自进料储存器（24）的材料和联接到进料储存器的真空泵（258）以产生通过进料储存器的气流。

公开(公告)号：EP1616584A1

公开(公告)日：2006-01-18

申请号：EP04726621.8

申请日：2004-04-08

申请人： TEIJIN LIMITED

发明人： FUKUHIRA, Yukako, Teijin Limited ,  KITAZONO, Eiichi, Teijin Limited ,  KANEKO, Hiroaki, Teijin Limited ,  SUMI, Yoshihiko, Teijin Limited ,  SHIMOMURA, Masatsugu, Hokkaido University ,  TANAKA, Masaru, Hokkaido University

IPC分类号： A61L31/00 ,  B29C41/12

CPC分类号： B29C41/12 ,  A61L31/06 ,  A61L31/14 ,  C08L67/04

摘要： The invention relates to a honeycomb film made of a biodegradable polymer which has biodegradation properties as an anti-adhesion membrane for preventing adhesion after an operation, is excellent in handling properties, and exhibits a satisfactory adhesion preventive effect stably over a desired period of time, and to a production process of the same. Above all, the invention provides an anti-adhesion membrane of a honeycomb film made of polylactic acid as a biodegradable polymer and a phospholipid and a production process of the same.

摘要翻译： 本发明涉及一种由生物降解性聚合物制成的蜂窝膜，其具有生物降解性，作为用于防止操作后粘附的防粘附膜，处理性能优异，并且在期望的时间段内稳定地显示出令人满意的粘合防止效果， 并对其进行生产过程。 最重要的是，本发明提供了由聚乳酸作为生物可降解聚合物和磷脂制成的蜂窝膜的抗粘附膜及其制造方法。