公开(公告)号：EP1093579B1

公开(公告)日：2010-09-01

申请号：EP99928693.3

申请日：1999-06-16

申请人： UT-Battelle, LLC

发明人： JACOBSON, Stephen, C. ,  RAMSEY, J., Michael

IPC分类号： G01N27/26 ,  G01N27/447

CPC分类号： B01F13/0076 ,  B01F13/0059 ,  B01F13/0062 ,  B01L3/502738 ,  B01L3/502776 ,  B01L2200/0647 ,  B01L2300/0816 ,  B01L2300/0861 ,  B01L2400/0415 ,  B01L2400/0418 ,  B01L2400/0421 ,  B01L2400/0487 ,  G01N15/1404 ,  G01N15/1459 ,  G01N15/1463 ,  G01N15/1484 ,  G01N27/44721 ,  G01N27/44773 ,  G01N27/44791 ,  G01N30/6095 ,  G01N2015/149 ,  Y10S366/01 ,  Y10T137/2082

摘要： One embodiment of the present invention provides a microchip (10) adapted for the simultaneous spatial confinement of electrokinetically driven fluidic material streams on the microchip. The microchip includes a focusing chamber (22) formed in the surface of the microchip and in fluid communication with two sample channels (28, 36) and three focusing channels (32, 40, 42). The embodiment further includes electromotive means operatively connected to the sources of the sample fluids (14, 18) and the sources of focusing fluid (12, 16, 20) for electrokinetically driving the respective streams of the sample and focusing fluids such that the focusing fluid streams spatially confine the first and second sample streams within the focusing chamber. Another embodiment of the present invention provides a cytometry method for analyzing microscopic particles in a fluid medium on a microchip by utilizing the focusing function of the microchip. In this process the width of the fluid stream is narrowed in the focusing chamber.

公开(公告)号：EP0910474B1

公开(公告)日：2004-03-24

申请号：EP97932185.8

申请日：1997-06-13

申请人： University of Washington

发明人： YAGER, Paul ,  BRODY, James, P.

IPC分类号： B03B5/28 ,  G01N30/00

CPC分类号： G01N30/0005 ,  A61M1/3679 ,  B01J19/0093 ,  B01J2219/00828 ,  B01J2219/00952 ,  B01J2219/00995 ,  B03B5/00 ,  G01N30/02 ,  G01N30/6095 ,  G01N2030/582 ,  Y10S366/01 ,  B01D15/3804

公开(公告)号：EP1352010A2

公开(公告)日：2003-10-15

申请号：EP01991985.1

申请日：2001-10-25

申请人： Crompton Corporation

发明人： AUSTIN, Paul, E. ,  HEISLER, Ladislau ,  DAVIS, David, B.

IPC分类号： C08G77/38 ,  C08G77/46 ,  B01J19/18

CPC分类号： C08G77/06 ,  C08G77/38 ,  C08G77/46 ,  Y10S366/01 ,  Y10S366/02 ,  Y10S366/03

摘要： A continuous process for the manufacture of silicone copolymer utilizing at least one static mixing plug flow reactor, and optionally two static mixing plug flow reactors in a series or parallel. Silicone copolymers produced in accordance thereof are substantially free of unreacted hydrogen siloxane starting material and may be used without further purification. The static mixing plug flow reactor contains static mixing elements capable of creating eddies and vortices of sufficient intensity that a biphasic liquid mixture such as a hydrogen siloxane fluid and an polyether olefinic reactant, undergoes shearing of the droplets of each material so that one phase disperses into another to provide intimate contact between the two phases to allow the reaction to proceed.

公开(公告)号：EP1187671A1

公开(公告)日：2002-03-20

申请号：EP00943820.1

申请日：2000-06-16

申请人： Forschungszentrum Karlsruhe GmbH ,  BAYER AG

发明人： SCHUBERT, Klaus ,  FICHTNER, Maximilian ,  WIESSMEIER, Georg ,  EHLERS, Stefan ,  ELGETI, Klaus

IPC分类号： B01F5/02 ,  B01F13/00 ,  B01F15/00

CPC分类号： B01F5/06 ,  B01F5/0644 ,  B01F13/0066 ,  B01J2219/00822 ,  B01J2219/00824 ,  B01J2219/00833 ,  B01J2219/00889 ,  B22F5/00 ,  B22F2999/00 ,  B29C64/00 ,  Y02P10/295 ,  Y10S366/01 ,  Y10S366/03 ,  B22F3/004 ,  B22F3/1055

摘要： The invention relates to a static micromixer comprising at least one mixing chamber and one guide component (1) which is connected upstream therefrom and which is provided for separately supplying fluids to be mixed or dispersed. Slotted channels (2a, 2b) running diagonal to the longitudinal axis of the micromixer pass through said guide component. The channels (2a, 2b) alternately cross without touching, open into a mixing chamber (4) and form a common outlet cross-section (3a) there. The aim of the invention is to configure the guide component (1), which improves upon the prior art, such that fluid pressure losses occurring in the guide component (1) are further reduced between the inlet side (2a, 2b) and the common outlet side (3a). To this end, the cross-sections of the channels (2a, 2b) enlarge, toward the inlet side, for at least a portion of the media flows to be mixed.

摘要翻译： 在静态微混合器中，其包括至少一个混合室和一个引导部件，该引导部件设置在混合室的上游，并且包括以与微混合器的纵向轴线成一定角度延伸穿过的通道，使得交替层的通道不与每个 另一方面，通道的横截面从引导部件的入口端到出口端稳定地减小，以便减少流过混合腔中混合通道的流体的压力损失。

公开(公告)号：EP1162455B1

公开(公告)日：2007-10-03

申请号：EP01203481.5

申请日：1995-08-01

申请人： UT-Battelle, LLC

发明人： Ramsey, Michael J.

IPC分类号： G01N27/447 ,  B01L3/00

CPC分类号： B01L3/5027 ,  B01F13/0059 ,  B01F13/0062 ,  B01F13/0076 ,  B01J19/0093 ,  B01J2219/00783 ,  B01J2219/00826 ,  B01J2219/00828 ,  B01J2219/00831 ,  B01J2219/00853 ,  B01J2219/00889 ,  B01J2219/00891 ,  B01J2219/00912 ,  B01J2219/00916 ,  B01J2219/00952 ,  B01J2219/0097 ,  B01J2219/00995 ,  B01L3/502715 ,  B01L3/50273 ,  B01L3/502738 ,  B01L3/502753 ,  B01L3/502776 ,  B01L3/502784 ,  B01L2200/0605 ,  B01L2300/0816 ,  B01L2300/0867 ,  B01L2300/0883 ,  B01L2400/0415 ,  B01L2400/0418 ,  B01L2400/0421 ,  B29C65/4895 ,  B29C66/026 ,  B29C66/034 ,  B29C66/54 ,  G01N27/44743 ,  G01N27/44791 ,  G01N30/02 ,  G01N30/16 ,  G01N30/6095 ,  G01N2030/027 ,  G01N2030/162 ,  G01N2030/285 ,  G01N2030/383 ,  G01N2030/8435 ,  Y10S366/01 ,  B01D15/3842

公开(公告)号：EP1382962A1

公开(公告)日：2004-01-21

申请号：EP03078261.9

申请日：1995-08-01

申请人： UT-Battelle, LLC

发明人： Ramsey, Michael J.

IPC分类号： G01N27/447 ,  B01L3/00

CPC分类号： B01L3/5027 ,  B01F13/0059 ,  B01F13/0062 ,  B01F13/0076 ,  B01J19/0093 ,  B01J2219/00783 ,  B01J2219/00826 ,  B01J2219/00828 ,  B01J2219/00831 ,  B01J2219/00853 ,  B01J2219/00889 ,  B01J2219/00891 ,  B01J2219/00912 ,  B01J2219/00916 ,  B01J2219/00952 ,  B01J2219/0097 ,  B01J2219/00995 ,  B01L3/502715 ,  B01L3/50273 ,  B01L3/502738 ,  B01L3/502753 ,  B01L3/502776 ,  B01L3/502784 ,  B01L2200/0605 ,  B01L2300/0816 ,  B01L2300/0867 ,  B01L2300/0883 ,  B01L2400/0415 ,  B01L2400/0418 ,  B01L2400/0421 ,  B29C65/4895 ,  B29C66/026 ,  B29C66/034 ,  B29C66/54 ,  G01N27/44743 ,  G01N27/44791 ,  G01N30/02 ,  G01N30/16 ,  G01N30/6095 ,  G01N2030/027 ,  G01N2030/162 ,  G01N2030/285 ,  G01N2030/383 ,  G01N2030/8435 ,  Y10S366/01 ,  B01D15/3842

摘要： A microchip laboratory system (10) and method provide fluidic manipulations for a variety of applications, including sample injection for microchip chemical separations. The microchip is fabricated using standard photolithographic procedures and chemical wet etching, with the substrate and cover plate joined using direct bonding. Capillary electrophoresis and electrochomatography are performed in channels (26, 28, 30, 32, 34, 36, 38) formed in the substrate. Analytes are loaded into a four-way intersection of channels by electrokinetically pumping the analyte through the intersection (40), followed by a switching of the potentials to force an analyte plug into the separation channel (34).

摘要翻译： 一种微芯片实验室系统（10）和方法提供了多种应用的流体操作，包括样品注射微芯片化学分离。 微芯片使用标准光刻过程和化学湿蚀刻制成，与基片和覆盖板使用直接接合连接起来。 毛细管电泳和electrochomatography执行在所形成的基板的通道（26，28，30，32，34，36，38）。 分析物是通过随后的电势的切换的交叉点（40）的电动泵送所述分析物以迫使堵塞分析物到分离通道（34）加载到通道的四通交叉点。

公开(公告)号：EP0890094A4

公开(公告)日：1999-10-06

申请号：EP97936008

申请日：1997-03-31

申请人： UNIV WASHINGTON

发明人： WEIGL BERNHARD H ,  YAGER PAUL ,  BRODY JAMES P ,  HOLL MARK R ,  KENNY MARGARET ,  SCHUTTE DAVID ,  HIXSON GREGORY ,  ZEBERT M DIANE ,  KAMHOLZ ANDREW ,  WU CAICAI ,  ALTENDORF ERIC

IPC分类号： G01N37/00 ,  B01F5/04 ,  B01F13/00 ,  B01J19/00 ,  B01L3/00 ,  G01N15/06 ,  G01N15/14 ,  G01N30/00 ,  G01N30/38 ,  G01N30/60 ,  G01N30/74 ,  G01N31/20 ,  G01N35/08 ,  G01N21/64

CPC分类号： B01F5/0403 ,  B01F13/0059 ,  B01F13/0093 ,  B01J19/0093 ,  B01J2219/00828 ,  B01J2219/00831 ,  B01J2219/00952 ,  B01L3/502776 ,  B01L2200/0636 ,  B01L2300/0654 ,  B01L2300/0816 ,  B01L2300/0861 ,  B01L2300/0867 ,  B01L2300/087 ,  B01L2400/0487 ,  G01N15/14 ,  G01N30/0005 ,  G01N30/38 ,  G01N30/6095 ,  G01N30/74 ,  G01N35/085 ,  Y10S366/01 ,  Y10T436/25375 ,  Y10T436/2575

摘要： A channel-cell system is provided for detecting the presence and/or measuring the presence of analyte particles in a sample stream comprising a laminar flow channel (100), two inlet means (30, 20) in fluid connection with said laminar flow channel (100) for respectively conducting into the laminar flow channel (100) an indicator stream (70) which may comprise an indicator substance which indicates the presence of said analyte particles by a detectable change in property when contacted with said analyte particles, and the sample stream (80), wherein the laminar flow channel (100) has a depth sufficiently small to allow laminar flow of the streams and a length sufficient to allow particles of the analyte to diffuse into said indicator stream (70) to the substantial exclusion of said larger particles in the sample stream (80) to form a detection area; and outlet means (60) for conducting the streams out of the laminar flow channel (100) to form a single mixed stream.

摘要翻译： 提供通道 - 细胞系统用于检测样品流中存在和/或测量分析物颗粒的存在，所述样品流包括层流通道（100），与所述层流通道（100）流体连接的两个入口装置（30,20） 100），用于分别将指示剂流（70）导入层流通道（100）中，所述指示剂流可包含指示剂物质，所述指示剂物质在与所述分析物颗粒接触时通过可检测的性质变化来指示所述分析物颗粒的存在，并且样品流 （80），其中所述层流通道（100）具有足够小的深度以允许所述流的层流，并且所述层流通道的长度足以允许所述分析物的颗粒扩散到所述指示剂流（70）中以基本排除所述较大 样品流（80）中的颗粒形成检测区域; 和用于将物流引导出层流通道（100）以形成单一混合物流的出口装置（60）。

公开(公告)号：EP0890094A1

公开(公告)日：1999-01-13

申请号：EP97936008.0

申请日：1997-03-31

申请人： UNIVERSITY OF WASHINGTON

发明人： WEIGL, Bernhard, H. ,  YAGER, Paul ,  BRODY, James, P. ,  HOLL, Mark, R. ,  KENNY, Margaret ,  SCHUTTE, David ,  HIXSON, Gregory ,  ZEBERT, M., Diane ,  KAMHOLZ, Andrew ,  WU, Caicai ,  ALTENDORF, Eric

IPC分类号： G01N37 ,  B01F5 ,  B01F13 ,  B01J19 ,  B01L3 ,  G01N15 ,  G01N30 ,  G01N31 ,  G01N35

CPC分类号： B01F5/0403 ,  B01F13/0059 ,  B01F13/0093 ,  B01J19/0093 ,  B01J2219/00828 ,  B01J2219/00831 ,  B01J2219/00952 ,  B01L3/502776 ,  B01L2200/0636 ,  B01L2300/0654 ,  B01L2300/0816 ,  B01L2300/0861 ,  B01L2300/0867 ,  B01L2300/087 ,  B01L2400/0487 ,  G01N15/14 ,  G01N30/0005 ,  G01N30/38 ,  G01N30/6095 ,  G01N30/74 ,  G01N35/085 ,  Y10S366/01 ,  Y10T436/25375 ,  Y10T436/2575

摘要： A channel-cell system is provided for detecting the presence and/or measuring the presence of analyte particles in a sample stream comprising a laminar flow channel (100), two inlet means (30, 20) in fluid connection with said laminar flow channel (100) for respectively conducting into the laminar flow channel (100) an indicator stream (70) which may comprise an indicator substance which indicates the presence of said analyte particles by a detectable change in property when contacted with said analyte particles, and the sample stream (80), wherein the laminar flow channel (100) has a depth sufficiently small to allow laminar flow of the streams and a length sufficient to allow particles of the analyte to diffuse into said indicator stream (70) to the substantial exclusion of said larger particles in the sample stream (80) to form a detection area; and outlet means (60) for conducting the streams out of the laminar flow channel (100) to form a single mixed stream.

公开(公告)号：EP0839318A1

公开(公告)日：1998-05-06

申请号：EP96925261.0

申请日：1996-06-14

申请人： University of Washington

发明人： YAGER, Paul ,  BRODY, James, P. ,  HOLL, Mark, R. ,  FORSTER, Fred, K. ,  GALAMBOS, Paul, C.

IPC分类号： B01D11 ,  B01D43 ,  B01F13 ,  B01J19 ,  G01N1 ,  G01N15 ,  G01N30 ,  G01N37 ,  G01N35

CPC分类号： B01D11/0492 ,  B01D11/0496 ,  B01F13/0059 ,  B01F13/0093 ,  B01F2005/0031 ,  B01J19/0093 ,  B01J2219/00783 ,  B01J2219/00828 ,  B01J2219/00889 ,  B01J2219/00905 ,  B01J2219/00952 ,  B01J2219/0097 ,  B01J2219/00995 ,  G01N15/06 ,  G01N30/0005 ,  G01N2001/4072 ,  G01N2035/00237 ,  Y10S366/01 ,  Y10T436/255

摘要： This invention provides a microfabricated extraction system and methods for extracting desired particles from a sample stream containing desired and undesired particles. The sample stream is placed in laminar flow contact with an extraction stream under conditions in which inertial effects are negligible. The contact between the two streams is maintained for a sufficient period of time to allow differential transport of the desired particles from the sample stream into the extraction stream. In a preferred embodiment the differential transport mechanism is diffusion. The extraction system of this invention coupled to a microfabricated diffusion-based mixing device and/or sensing means allows picoliter quantities of fluid to be processed or analyzed on devices no larger than silicon wafers.

公开(公告)号：EP0775306A1

公开(公告)日：1997-05-28

申请号：EP95927492.0

申请日：1995-08-01

申请人： LOCKHEED MARTIN ENERGY SYSTEMS, INC.

发明人： RAMSEY, J., Michael

IPC分类号： G01N33 ,  B01F13 ,  B01J19 ,  B01L3 ,  C07B61 ,  C12Q1 ,  G01N27 ,  G01N30 ,  G01N37 ,  G05D11 ,  B29C65

CPC分类号： B01L3/5027 ,  B01F13/0059 ,  B01F13/0062 ,  B01F13/0076 ,  B01J19/0093 ,  B01J2219/00783 ,  B01J2219/00826 ,  B01J2219/00828 ,  B01J2219/00831 ,  B01J2219/00853 ,  B01J2219/00889 ,  B01J2219/00891 ,  B01J2219/00912 ,  B01J2219/00916 ,  B01J2219/00952 ,  B01J2219/0097 ,  B01J2219/00995 ,  B01L3/502715 ,  B01L3/50273 ,  B01L3/502738 ,  B01L3/502753 ,  B01L3/502776 ,  B01L3/502784 ,  B01L2200/0605 ,  B01L2300/0816 ,  B01L2300/0867 ,  B01L2300/0883 ,  B01L2400/0415 ,  B01L2400/0418 ,  B01L2400/0421 ,  B29C65/4895 ,  B29C66/026 ,  B29C66/034 ,  B29C66/54 ,  G01N27/44743 ,  G01N27/44791 ,  G01N30/02 ,  G01N30/16 ,  G01N30/6095 ,  G01N2030/027 ,  G01N2030/162 ,  G01N2030/285 ,  G01N2030/383 ,  G01N2030/8435 ,  Y10S366/01 ,  B01D15/3842

摘要： A microchip loboratory system (10) and method provide fluidic manipulations for a variety of applications, including sample injection for microchip chemical separations. The microchip is fabricated using standard photolithographic procedures and chemical wet etching, with the substrate and cover plate joined using direct bonding. Capillary electrophoresis and electrochromatography are performed in channels (26, 28, 30, 32, 34, 36, 38) formed in the substrate. Analytes are loaded into a four-way intersection of channels by electrokinetically pumping the analyte through the intersection (40), followed by a switching of the potentials to force an analyte plug into the separation channel (34).