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    PROCESS FOR PRODUCING HINOKITIOL
    2.
    发明公开
    PROCESS FOR PRODUCING HINOKITIOL 有权
    用于生产桧醇

    公开(公告)号：EP1069104A4

    公开(公告)日：2003-04-16

    申请号：EP99910743

    申请日：1999-03-29

    申请人： ASAHI CHEMICAL IND

    发明人： NAGATO YASUHIRO ,  SHIMIZU KATSUYA ,  YAMAMOTO SHINICHI

    IPC分类号： C07C45/42 ,  C07C45/69 ,  C07C49/717 ,  C07C45/64

    CPC分类号： C07C49/717 ,  C07C45/42 ,  C07C45/69 ,  C07C2601/18 ,  Y02P20/582 ,  C07C49/693

    摘要： A process for producing hinokitiol which comprises obtaining 1-isopropylcyclopentadiene from cyclopentadiene and an isopropylating agent represented by the general formula R-X (wherein R represents isopropyl; and X represents halogeno, etc.) (the step 1); reacting the obtained product with a dihaloketene to give a ketene-adduct (the step 2); and then decomposing this ketene-adduct (the step 3); wherein the above step 1 involves the following three steps: (a) the step of preparing a cyclopentadienyl metal; (b) the step of isopropylating the cyclopentadienyl metal in an aprotic polar solvent to give isopropylcyclopentadiene; and (c) the step of isomerizing 5-isopropylcyclopentadiene contained in the product selectively into 1-isopropylcyclopentadiene under heating.

    Oximino ether compounds
    5.
    发明公开
    Oximino ether compounds 失效
    肟基粥-Verbindungen。

    公开(公告)号：EP0291114A2

    公开(公告)日：1988-11-17

    申请号：EP88200850.1

    申请日：1988-04-29

    申请人： SHELL INTERNATIONALE RESEARCH MAATSCHAPPIJ B.V.

    发明人： Gilkerson, Terence ,  Jennens, David Clifford ,  Shaw, Robert William

    IPC分类号： C07C251/44 ,  C07C251/50

    CPC分类号： C07D317/54 ,  A01N35/10 ,  A01N37/02 ,  A01N37/10 ,  A01N41/04 ,  C07C45/455 ,  C07C45/54 ,  C07C49/657 ,  C07C49/693 ,  C07C49/747 ,  C07C49/753 ,  C07C205/45 ,  C07C255/56 ,  C07C311/17 ,  C07C2601/14 ,  C07C2601/16

    摘要： The invention provides compounds of the general formula
    wherein R represents a hydrogen atom, or an optionally substituted alkyl or acyl group, or an alkenyl or alkynyl group or an inorganic or organic cation;

    R 1 represents an alkyl, haloalkyl, alkenyl, alkynyl or phenyl group;
    R 2 represents an optionally substituted alkyl or phenalkyl group or a cycloalkyl, alkenyl, haloalkenyl, alkynyl or haloalkynyl group;
    R 3 represents a hydrogen atom or an alkyl group; and
    one of R 4 and R 5 represents a hydrogen atom or an alkyl group, while the other of R 4 and R 5 represents an optionally substituted phenyl group; together with their use as herbicides and their preparation using novel intermediates.

    摘要翻译： 本发明提供通式为CHEM的化合物，其中R代表氢原子，或任意取代的烷基或酰基，或烯基或炔基或无机或有机阳离子; R 1表示烷基，卤代烷基，烯基，炔基或苯基; R 2表示任选取代的烷基或苯烷基或环烷基，烯基，卤代烯基，炔基或卤代炔基; R 3表示氢原子或烷基; R 4和R 5中的一个表示氢原子或烷基，R 4和R 5中的另一个表示任选取代的苯基; 以及它们作为除草剂的用途及其使用新型中间体的制备。

    Novel substituted (4.2.0)Bicyclooctane derivatives with valuable therapeutic properties
    10.
    发明公开
    Novel substituted (4.2.0)Bicyclooctane derivatives with valuable therapeutic properties 失效
    新的取代（4.2.0）具有有价值的治疗性质二环的衍生物。

    公开(公告)号：EP0257609A2

    公开(公告)日：1988-03-02

    申请号：EP87112250.3

    申请日：1987-08-24

    申请人： SYNTEX (U.S.A.) INC.

    发明人： Wu, Helen Y. ,  Kurz, Walter

    IPC分类号： C07C43/18 ,  C07C35/31 ,  C07C43/192 ,  C07C47/277 ,  C07C47/267 ,  C07C69/732 ,  C07C69/734 ,  C07C59/46 ,  C07C59/62 ,  C07C43/253 ,  C07C49/84

    CPC分类号： C07C59/62 ,  C07C35/31 ,  C07C43/196 ,  C07C45/292 ,  C07C45/305 ,  C07C45/455 ,  C07C45/59 ,  C07C45/71 ,  C07C45/78 ,  C07C47/267 ,  C07C47/27 ,  C07C47/273 ,  C07C47/277 ,  Y10S514/824 ,  C07C49/693 ,  C07C49/753

    摘要： Compounds useful in treating cardiovascular disorders such as thrombosis, hypertension and atherosclerosis , in inhibiting gastric acid secretion and in preventing and treating peptic and intestinal ulcers, are depicted in formulas (1), (2) and (3) :
    wherein:

    A is -C≡C-, trans -HC = CH-, -CH 2 CH 2 -or -CH=CHCH 2 -;
    X is lower alkoxy, hydroxy, or (2,2,2)-trifluoroethoxy;
    Y is hydrogen, exo-(lower alkyl) or endo-(lower alkyl);
    n is an integer of 2-4;
    R 1 is -CH 2 OH, -CHO, -CO 2 R or -COzH, and the olefin formed by the R 1 (CHz) n CH = moiety is either (E) or (Z);
    R 2 is hydrogen or methyl, or optionally -CH = CH 2 when A is -CH = CHCHr; and
    R 3 is linear or branched alkyl, alkenyl or alkynyl having 5-10 carbon atoms,
    , -(CH 2 ) m -phenyl or CH 2 O-phenyl;
    in which each phenyl may be optionally substituted with lower alkyl, lower alkoxy, trifluoromethyl, or halogen;
    in which: a is an integer of 0, 1 or 2;
    b is an integer of 3-7;
    m is an integer of 0, 1 or 2; and
    R is
    wherein X is
    or

    in which each R 4 is independently hydrogen or lower alkyl having 1-6 carbon atoms, and the pharmaceutically acceptable, non-toxic salts and esters thereof.

    摘要翻译： 治疗心血管疾病的化合物：如血栓形成，高血压和动脉粥样硬化，在抑制胃酸分泌和用于预防和治疗消化性溃疡和肠溃疡，在式被描述（1），（2）和（3）： worin： A是-C IDENTICAL C-，反式-HC = CH-，-CH 2 CH 2或-CH = CHCH 2; X是低级烷氧基，羟基，或（2,2,2） - 三氟乙氧基; Y是氢，外 - （低级烷基）或内 - （低级烷基）; n是2-4的整数; R 1是-CH 2 OH，-CHO，-CO 2或-CO 2 H，和由R1（CH 2）形成的烯烃N =部分是（E）或（Z）; R2是氢或甲基，或-CH = CH 2可选地，当A是-CH = CHCH 2; 且R 3为直链或支链烷基，链烯基或具有5-10个碳原子的炔基，， - （CH 2）M - 苯基或CH 2 O - 苯基; 这在每个苯基可被低级烷基，低级烷氧基，三氟甲基，或卤素任选地被substituiertem; 其中：a为0，1或2的整数; b是3-7的整数; m是0,1或2的整数; 且R为 worin X是 - @ -CH 3，-NH @ CH 3， - @ -C6H5，NH @ -C6H5，或-NH @N（R 4）2; 其中每个R 4是氢或unabhängig具有1-6个碳原子的低级烷基，和其药学上可接受的，无毒的盐和酯。