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公开(公告)号：EP2834358A4
公开(公告)日：2016-03-09
申请号：EP13772943
申请日：2013-03-09
发明人： BANCEL STEPHANE , CHAKRABORTY TIRTHA , DE FOUGEROLLES ANTONIN , ELBASHIR SAYDA M , JOHN MATTHIAS , ROY ATANU , WHORISKEY SUSAN , WOOD KRISTY M , HATALA PAUL , SCHRUM JASON P , EJEBE KENECHI , ELLSWORTH JEFF LYNN , GUILD JUSTIN
IPC分类号： A61K48/00 , A61K9/127 , A61K31/7115 , A61K38/17 , A61K38/45 , C07K14/435 , C07K14/47 , C07K14/485 , C07K14/705 , C12N9/10 , C12N9/16 , C12N9/24 , C12N9/42 , C12N9/64 , C12N9/88 , C12N15/52 , C12N15/85 , C12N15/87 , C12P13/04 , C12P21/00
CPC分类号： A61K48/0066 , A61K9/1271 , A61K9/145 , A61K9/5123 , A61K9/5146 , A61K9/5153 , A61K31/7115 , A61K38/00 , A61K38/17 , A61K38/177 , A61K38/1816 , A61K38/1891 , A61K38/191 , A61K38/193 , A61K38/212 , A61K38/45 , A61K38/4846 , A61K47/543 , A61K48/0033 , A61K48/005 , A61K48/0075 , C07H21/02 , C07K14/005 , C07K14/435 , C07K14/43595 , C07K14/47 , C07K14/4705 , C07K14/4713 , C07K14/4723 , C07K14/4746 , C07K14/475 , C07K14/485 , C07K14/495 , C07K14/505 , C07K14/515 , C07K14/525 , C07K14/535 , C07K14/5418 , C07K14/56 , C07K14/61 , C07K14/62 , C07K14/705 , C07K14/745 , C07K16/00 , C07K16/2863 , C07K16/2887 , C07K16/40 , C12N9/0069 , C12N9/0091 , C12N9/1051 , C12N9/1241 , C12N9/16 , C12N9/2402 , C12N9/2445 , C12N9/6435 , C12N9/6437 , C12N9/644 , C12N9/6443 , C12N9/6451 , C12N9/88 , C12N9/93 , C12N15/11 , C12N15/52 , C12N15/85 , C12N15/87 , C12P13/04 , C12P21/00 , C12P21/005 , C12Y113/12007 , C12Y116/03001 , C12Y207/07012 , C12Y304/21007 , C12Y304/21022 , C12Y304/21027 , C12Y403/02001 , C12Y603/02019
摘要： The invention relates to compositions and methods for the preparation, manufacture and therapeutic use of polynucleotides, primary transcripts and mmRNA molecules.
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公开(公告)号：EP2834260A4
公开(公告)日：2016-08-10
申请号：EP13773019
申请日：2013-03-09
发明人： BANCEL STEPHANE , CHAKRABORTY TIRTHA , DE FOUGEROLLES ANTONIN , ELBASHIR SAYDA M , JOHN MATTHIAS , ROY ATANU , WHORISKEY SUSAN , WOOD KRISTY M , HATALA PAUL , SCHRUM JASON P , EJEBE KENECHI , ELLSWORTH JEFF LYNN , GUILD JUSTIN
CPC分类号： A61K48/0066 , A61K9/1271 , A61K9/145 , A61K9/5123 , A61K9/5146 , A61K9/5153 , A61K31/7115 , A61K38/00 , A61K38/17 , A61K38/177 , A61K38/1816 , A61K38/1891 , A61K38/191 , A61K38/193 , A61K38/212 , A61K38/45 , A61K38/4846 , A61K47/543 , A61K48/0033 , A61K48/005 , A61K48/0075 , C07H21/02 , C07K14/005 , C07K14/435 , C07K14/43595 , C07K14/47 , C07K14/4705 , C07K14/4713 , C07K14/4723 , C07K14/4746 , C07K14/475 , C07K14/485 , C07K14/495 , C07K14/505 , C07K14/515 , C07K14/525 , C07K14/535 , C07K14/5418 , C07K14/56 , C07K14/61 , C07K14/62 , C07K14/705 , C07K14/745 , C07K16/00 , C07K16/2863 , C07K16/2887 , C07K16/40 , C12N9/0069 , C12N9/0091 , C12N9/1051 , C12N9/1241 , C12N9/16 , C12N9/2402 , C12N9/2445 , C12N9/6435 , C12N9/6437 , C12N9/644 , C12N9/6443 , C12N9/6451 , C12N9/88 , C12N9/93 , C12N15/11 , C12N15/52 , C12N15/85 , C12N15/87 , C12P13/04 , C12P21/00 , C12P21/005 , C12Y113/12007 , C12Y116/03001 , C12Y207/07012 , C12Y304/21007 , C12Y304/21022 , C12Y304/21027 , C12Y403/02001 , C12Y603/02019
摘要： The invention relates to compositions and methods for the preparation, manufacture and therapeutic use of polynucleotides, primary transcripts and mmRNA molecules.
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3.发明公开MODIFIED POLYNUCLEOTIDES FOR THE PRODUCTION OF ONCOLOGY-RELATED PROTEINS AND PEPTIDES 审中-公开修饰的多核苷酸用于制造在肿瘤学有用的蛋白质和肽
公开(公告)号：EP2833892A4
公开(公告)日：2016-07-20
申请号：EP13772721
申请日：2013-03-09
发明人： BANCEL STEPHANE , CHAKRABORTY TIRTHA , DE FOUGEROLLES ANTONIN , ELBASHIR SAYDA M , JOHN MATTHIAS , ROY ATANU , WHORISKEY SUSAN , WOOD KRISTY M , HATALA PAUL , SCHRUM JASON P , EJEBE KENECHI , ELLSWORTH JEFF LYNN , GUILD JUSTIN
IPC分类号： A61K31/7105
CPC分类号： A61K48/0066 , A61K9/1271 , A61K9/145 , A61K9/5123 , A61K9/5146 , A61K9/5153 , A61K31/7115 , A61K38/00 , A61K38/17 , A61K38/177 , A61K38/1816 , A61K38/1891 , A61K38/191 , A61K38/193 , A61K38/212 , A61K38/45 , A61K38/4846 , A61K47/543 , A61K48/0033 , A61K48/005 , A61K48/0075 , C07H21/02 , C07K14/005 , C07K14/435 , C07K14/43595 , C07K14/47 , C07K14/4705 , C07K14/4713 , C07K14/4723 , C07K14/4746 , C07K14/475 , C07K14/485 , C07K14/495 , C07K14/505 , C07K14/515 , C07K14/525 , C07K14/535 , C07K14/5418 , C07K14/56 , C07K14/61 , C07K14/62 , C07K14/705 , C07K14/745 , C07K16/00 , C07K16/2863 , C07K16/2887 , C07K16/40 , C12N9/0069 , C12N9/0091 , C12N9/1051 , C12N9/1241 , C12N9/16 , C12N9/2402 , C12N9/2445 , C12N9/6435 , C12N9/6437 , C12N9/644 , C12N9/6443 , C12N9/6451 , C12N9/88 , C12N9/93 , C12N15/11 , C12N15/52 , C12N15/85 , C12N15/87 , C12P13/04 , C12P21/00 , C12P21/005 , C12Y113/12007 , C12Y116/03001 , C12Y207/07012 , C12Y304/21007 , C12Y304/21022 , C12Y304/21027 , C12Y403/02001 , C12Y603/02019
摘要： The invention relates to compositions and methods for the preparation, manufacture and therapeutic use of polynucleotides, primary transcripts and mmRNA molecules.
摘要翻译： 本发明涉及组合物和方法用于制备，制造和治疗用途的多核苷酸，初级转录物和mmRNA的分子。
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公开(公告)号：EP2834259A4
公开(公告)日：2016-08-24
申请号：EP13772785
申请日：2013-03-09
发明人： BANCEL STEPHANE , CHAKRABORTY TIRTHA , DE FOUGEROLLES ANTONIN , ELBASHIR SAYDA M , JOHN MATTHIAS , ROY ATANU , WHORISKEY SUSAN , WOOD KRISTY M , HATALA PAUL , SCHRUM JASON P , EJEBE KENECHI , ELLSWORTH JEFF LYNN , GUILD JUSTIN
IPC分类号： C07K14/47 , A61K38/00 , A61K38/17 , A61K38/45 , C07K14/505 , C07K14/535 , C07K14/62 , C12N9/88 , C12N15/85
CPC分类号： A61K48/0066 , A61K9/1271 , A61K9/145 , A61K9/5123 , A61K9/5146 , A61K9/5153 , A61K31/7115 , A61K38/00 , A61K38/17 , A61K38/177 , A61K38/1816 , A61K38/1891 , A61K38/191 , A61K38/193 , A61K38/212 , A61K38/45 , A61K38/4846 , A61K47/543 , A61K48/0033 , A61K48/005 , A61K48/0075 , C07H21/02 , C07K14/005 , C07K14/435 , C07K14/43595 , C07K14/47 , C07K14/4705 , C07K14/4713 , C07K14/4723 , C07K14/4746 , C07K14/475 , C07K14/485 , C07K14/495 , C07K14/505 , C07K14/515 , C07K14/525 , C07K14/535 , C07K14/5418 , C07K14/56 , C07K14/61 , C07K14/62 , C07K14/705 , C07K14/745 , C07K16/00 , C07K16/2863 , C07K16/2887 , C07K16/40 , C12N9/0069 , C12N9/0091 , C12N9/1051 , C12N9/1241 , C12N9/16 , C12N9/2402 , C12N9/2445 , C12N9/6435 , C12N9/6437 , C12N9/644 , C12N9/6443 , C12N9/6451 , C12N9/88 , C12N9/93 , C12N15/11 , C12N15/52 , C12N15/85 , C12N15/87 , C12P13/04 , C12P21/00 , C12P21/005 , C12Y113/12007 , C12Y116/03001 , C12Y207/07012 , C12Y304/21007 , C12Y304/21022 , C12Y304/21027 , C12Y403/02001 , C12Y603/02019
摘要： The invention relates to compositions and methods for the preparation, manufacture and therapeutic use of polynucleotides, primary transcripts and mmRNA molecules.
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公开(公告)号：EP2755986A4
公开(公告)日：2015-05-20
申请号：EP12831509
申请日：2012-09-11
CPC分类号： A61K48/0066 , A61K48/0091 , C07H21/02 , C07K14/4723
摘要： Provided are compositions and methods for delivering biological moieties such as modified nucleic acids into cells to kill or reduce the growth of microorganisms. Such compositions and methods include the use of modified messenger RNAs, and are useful to treat or prevent microbial infection, or to improve a subject's heath or wellbeing.
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6.发明公开MODIFIED POLYNUCLEOTIDES FOR THE PRODUCTION OF CYTOPLASMIC AND CYTOSKELETAL PROTEINS 审中-公开改性多羟基化合物ZER HOSTELLUNG VON ZYTOPLASMA- UND ZYTOSKELETT-PROTEINEN
公开(公告)号：EP2847329A4
公开(公告)日：2016-08-10
申请号：EP13772653
申请日：2013-03-09
发明人： BANCEL STEPHANE , CHAKRABORTY TIRTHA , DE FOUGEROLLES ANTONIN , ELBASHIR SAYDA M , JOHN MATTHIAS , ROY ATANU , WHORISKEY SUSAN , WOOD KRISTY M , HATALA PAUL , SCHRUM JASON P , EJEBE KENECHI , ELLSWORTH JEFF LYNN , GUILD JUSTIN
IPC分类号： C12N15/10
CPC分类号： A61K48/0066 , A61K9/1271 , A61K9/145 , A61K9/5123 , A61K9/5146 , A61K9/5153 , A61K31/7115 , A61K38/00 , A61K38/17 , A61K38/177 , A61K38/1816 , A61K38/1891 , A61K38/191 , A61K38/193 , A61K38/212 , A61K38/45 , A61K38/4846 , A61K47/543 , A61K48/0033 , A61K48/005 , A61K48/0075 , C07H21/02 , C07K14/005 , C07K14/435 , C07K14/43595 , C07K14/47 , C07K14/4705 , C07K14/4713 , C07K14/4723 , C07K14/4746 , C07K14/475 , C07K14/485 , C07K14/495 , C07K14/505 , C07K14/515 , C07K14/525 , C07K14/535 , C07K14/5418 , C07K14/56 , C07K14/61 , C07K14/62 , C07K14/705 , C07K14/745 , C07K16/00 , C07K16/2863 , C07K16/2887 , C07K16/40 , C12N9/0069 , C12N9/0091 , C12N9/1051 , C12N9/1241 , C12N9/16 , C12N9/2402 , C12N9/2445 , C12N9/6435 , C12N9/6437 , C12N9/644 , C12N9/6443 , C12N9/6451 , C12N9/88 , C12N9/93 , C12N15/11 , C12N15/52 , C12N15/85 , C12N15/87 , C12P13/04 , C12P21/00 , C12P21/005 , C12Y113/12007 , C12Y116/03001 , C12Y207/07012 , C12Y304/21007 , C12Y304/21022 , C12Y304/21027 , C12Y403/02001 , C12Y603/02019
摘要： The invention relates to compositions and methods for the preparation, manufacture and therapeutic use of polynucleotides, primary transcripts and mmRNA molecules.
摘要翻译： 本发明涉及用于制备，制造和治疗性使用多核苷酸，初级转录物和mmRNA分子的组合物和方法。
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公开(公告)号：EP2833923A4
公开(公告)日：2016-02-24
申请号：EP13772137
申请日：2013-03-09
发明人： BANCEL STEPHANE , CHAKRABORTY TIRTHA , DE FOUGEROLLES ANTONIN , ELBASHIR SAYDA M , JOHN MATTHIAS , ROY ATANU , WHORISKEY SUSAN , WOOD KRISTY M , HATALA PAUL , SCHRUM JASON P , EJEBE KENECHI , ELLSWORTH JEFF LYNN , GUILD JUSTIN
CPC分类号： A61K48/0066 , A61K9/1271 , A61K9/145 , A61K9/5123 , A61K9/5146 , A61K9/5153 , A61K31/7115 , A61K38/00 , A61K38/17 , A61K38/177 , A61K38/1816 , A61K38/1891 , A61K38/191 , A61K38/193 , A61K38/212 , A61K38/45 , A61K38/4846 , A61K47/543 , A61K48/0033 , A61K48/005 , A61K48/0075 , C07H21/02 , C07K14/005 , C07K14/435 , C07K14/43595 , C07K14/47 , C07K14/4705 , C07K14/4713 , C07K14/4723 , C07K14/4746 , C07K14/475 , C07K14/485 , C07K14/495 , C07K14/505 , C07K14/515 , C07K14/525 , C07K14/535 , C07K14/5418 , C07K14/56 , C07K14/61 , C07K14/62 , C07K14/705 , C07K14/745 , C07K16/00 , C07K16/2863 , C07K16/2887 , C07K16/40 , C12N9/0069 , C12N9/0091 , C12N9/1051 , C12N9/1241 , C12N9/16 , C12N9/2402 , C12N9/2445 , C12N9/6435 , C12N9/6437 , C12N9/644 , C12N9/6443 , C12N9/6451 , C12N9/88 , C12N9/93 , C12N15/11 , C12N15/52 , C12N15/85 , C12N15/87 , C12P13/04 , C12P21/00 , C12P21/005 , C12Y113/12007 , C12Y116/03001 , C12Y207/07012 , C12Y304/21007 , C12Y304/21022 , C12Y304/21027 , C12Y403/02001 , C12Y603/02019
摘要： The invention relates to compositions and methods for the preparation, manufacture and therapeutic use of polynucleotides, primary transcripts and mmRNA molecules.
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公开(公告)号：EP2791160A4
公开(公告)日：2016-01-06
申请号：EP12858350
申请日：2012-12-14
发明人： DE FOUGEROLLES ANTONIN , WOOD KRISTY M , ELBASHIR SAYDA M , AFEYAN NOUBAR B , VALENCIA PEDRO , SCHRUM JASON P
IPC分类号： A61K48/00 , A61K9/00 , A61K9/127 , A61K9/14 , A61K9/16 , A61K31/7088 , A61K31/7105 , A61K31/7115 , C07K2/00 , C07K14/47 , C12N9/88 , C12N15/00 , C12N15/117 , C12N15/85 , C12N15/88 , C12P21/00
CPC分类号： A61K38/193 , A61K9/0019 , A61K9/0024 , A61K9/0048 , A61K9/1271 , A61K9/1272 , A61K9/14 , A61K9/16 , A61K9/1647 , A61K31/7088 , A61K31/7105 , A61K38/4833 , A61K48/00 , A61K48/0033 , A61K48/0041 , A61K48/005 , A61K48/0066 , C07K2/00 , C07K14/535 , C12N15/00 , C12N15/117 , C12N15/88 , C12P21/00
摘要： The present disclosure provides, inter alia, formulation compositions comprising modified nucleic acid molecules which may encode a protein, a protein precursor, or a partially or fully processed form of the protein or a protein precursor. The formulation composition may further include a modified nucleic acid molecule and a delivery agent. The present invention further provides nucleic acids useful for encoding polypeptides capable of modulating a cell's function and/or activity.
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9.发明公开
公开(公告)号：EP2763701A4
公开(公告)日：2015-12-16
申请号：EP12838676
申请日：2012-10-03
发明人： DE FOUGEROLLES ANTONIN , ROY ATANU , SCHRUM JASON P , SIDDIQI SUHAIB , HATALA PAUL , BANCEL STEPHANE
CPC分类号： A61K48/0066 , A61K38/193 , C07H21/02 , C07K14/535 , C12N15/11 , C12N15/67
摘要： The present disclosure provides methods of increasing the level of a polypeptide of interest in a mammalian subject by administering a polynucleotide having one or more chemical modifications and a Protein:Cytokine ratio of greater than 100.
摘要翻译： 本发明提供了修饰的核苷，核苷酸和核酸，以及使用它们的方法。
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10.发明公开ENGINEERED NUCLEIC ACIDS AND METHODS OF USE THEREOF 审中-公开MANIPULIERTENUKLEINSÄURENUND ANWENDUNGSVERFAHRENDAFÜR
公开(公告)号：EP2755693A4
公开(公告)日：2015-05-20
申请号：EP12831612
申请日：2012-09-11
CPC分类号： A61K48/005 , A61K45/06 , A61K48/0066 , C07K14/4723 , C12N2320/32
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