公开(公告)号：EP3186383A1

公开(公告)日：2017-07-05

申请号：EP15774704.9

申请日：2015-08-25

申请人： Full Spectrum Laboratories Limited

发明人： DONSKY, Marc ,  SUN, Mingyang ,  PEET, Richard ,  WINNICKI, Robert

IPC分类号： C12P7/22 ,  C12P7/42 ,  C12P17/06 ,  C12M1/34 ,  C12M1/36 ,  C12M1/40

CPC分类号： C12P17/06 ,  C07C29/80 ,  C07C37/01 ,  C07C37/74 ,  C12M21/18 ,  C12M29/00 ,  C12M29/04 ,  C12M41/12 ,  C12M41/26 ,  C12M41/30 ,  C12M41/32 ,  C12M41/40 ,  C12M41/48 ,  C12M47/10 ,  C12N9/0004 ,  C12P7/22 ,  C12P7/42 ,  C12Y121/03 ,  C12Y121/03007 ,  C12Y121/03008

摘要： The present invention provides an apparatus for simultaneously producing different cannabinoids in different ratios. Specifically, the apparatus according to the invention produces tetrahydrocannabinolic acid (THCA) and cannabichormenic acid (CBCA) or cannabidiolic acid (CBDA) in different ratios, and it comprises a bioreactor that comprises a first automated supply system configured to deliver a substrate and a cannabinoid acid synthase, and a second automated system to cease the reaction; an extractor configured to recover the cannabionoids so produced; and a controller configured to modify at least on property of the reaction.

摘要翻译： 本发明提供了以不同比例同时生产不同大麻素的装置。 具体而言，根据本发明的设备以不同比例产生四氢大麻酚酸（THCA）和大麻二酚酸（CBCA）或大麻二酚酸（CBDA），并且其包含生物反应器，所述生物反应器包含第一自动化供应系统和第二自动化供应系统，所述第一自动化供应系统配置为递送底物和大麻素 酸合酶和第二自动化系统停止反应; 提取器，其被配置为回收如此产生的大麻素; 以及配置成至少修改反应特性的控制器。

公开(公告)号：EP3067058A1

公开(公告)日：2016-09-14

申请号：EP16159001.3

申请日：2016-03-07

申请人： Farmagens Health Care Srl

发明人： Sannetti, Augusto ,  Cuomo, Rosario ,  Sarnelli, Giovanni ,  Esposito, Giuseppe ,  Lu, Jie

IPC分类号： A61K35/747 ,  C12N15/52

CPC分类号： A23L33/135 ,  A23Y2220/63 ,  A61K35/747 ,  C07K14/435 ,  C12N9/0004 ,  C12N9/1085 ,  C12N9/88 ,  C12N15/52 ,  C12P7/22 ,  C12P17/06 ,  C12Y121/03007 ,  C12Y121/03008 ,  C12Y203/01206 ,  C12Y205/01 ,  C12Y404/01026

摘要： The invention provides a method for producing therapeutic cannabinoids characterized by administering to an host the probiotic Lactobacillus Paracasei subsp. Paracasei F19, genetically modified to produce and secrete cannabinoids from Cannabis sativa, in association with caproic acid, able to establish the enzymatic reactions of the biosynthetic pathway leading to the production of cannabinoids directly in situ in said host.

摘要翻译： 本发明提供了用于制造由给予主办益生菌副干酪乳杆菌为特征的治疗大麻素的方法。 副干酪乳杆菌F19，遗传修饰以产生与从大麻分泌的大麻素，在伴随己酸，能够建立的生物合成途径导致产生大麻素直接在在所述宿主的原位酶促反应。

公开(公告)号：EP2961402B1

公开(公告)日：2024-10-02

申请号：EP14757297.8

申请日：2014-02-27

IPC分类号： A61K31/352 ,  A61K9/127 ,  C12P17/06 ,  C12N9/02 ,  C12N9/10

CPC分类号： A61K31/352 ,  C12Y121/03007 ,  C12Y121/03008 ,  C12Y203/01206 ,  C12N9/0004 ,  C12N9/1029 ,  C12Y205/01102 ,  Y02A50/30

公开(公告)号：EP2961402A1

公开(公告)日：2016-01-06

申请号：EP14757297.8

申请日：2014-02-27

申请人： Full Spectrum Laboratories Limited

发明人： WINNICKI, Robert ,  DONSKY, Marc

IPC分类号： A61K31/352 ,  A61K9/127

CPC分类号： C12P7/26 ,  A01H6/28 ,  A61K31/352 ,  C12M21/18 ,  C12M41/30 ,  C12M41/48 ,  C12N9/0004 ,  C12N9/1029 ,  C12P7/04 ,  C12P7/22 ,  C12P7/42 ,  C12P7/62 ,  C12P17/06 ,  C12Y121/03007 ,  C12Y121/03008 ,  C12Y203/01206 ,  C12Y205/01102

摘要： The present invention provides methods for producing cannabinoids and cannabinoid analogs as well as a system for producing these compounds. The inventive method is directed to contacting a compound according to Formula I or Formula II with a cannabinoid synthase. Also described is a system for producing cannabinoids and cannabinoid analogs by contacting a THCA synthase with a cannabinoid precursor and modifying at least one property of the reaction mixture to influence the quantity formed of a first cannabinoid relative to the quantity formed of a second cannabinoid.

摘要翻译： 还描述了通过使THCA合酶与大麻素前体接触并改变反应混合物的至少一种性质来影响由第二种大麻素形成的量形成的第一种大麻素的量的生产大麻素和大麻素类似物的系统。

公开(公告)号：EP4399304A1

公开(公告)日：2024-07-17

申请号：EP22865949.6

申请日：2022-09-09

申请人： Agriculture Victoria Services Pty Ltd

发明人： MATCHETT-OATES, Lennon James ,  COGAN, Noel ,  SPANGENBERG, German ,  MOHAMADEN, Ehab Ibrahim Ahmed

IPC分类号： C12N15/113 ,  C12N15/82 ,  C12N9/02

CPC分类号： C12N9/0004 ,  C12N15/8243 ,  C12N15/8218 ,  C12Y121/03008 ,  C12Y121/03007 ,  C12Y121/99 ,  C12N15/52

公开(公告)号：EP4370683A2

公开(公告)日：2024-05-22

申请号：EP22843002.1

申请日：2022-07-11

申请人： Amyris, Inc.

发明人： HUNG, John, E. ,  DRAPER, William, E. ,  HOLMES, Victor

IPC分类号： C12N15/52 ,  C12N9/00 ,  C12N1/00 ,  C12N15/82 ,  C12N9/10

CPC分类号： C12Y121/03008 ,  C12N9/0004 ,  C07K2319/0220130101 ,  C07K2319/5020130101 ,  C12P7/42 ,  C12P7/22

公开(公告)号：EP2961402A4

公开(公告)日：2016-11-23

申请号：EP14757297

申请日：2014-02-27

申请人： FULL SPECTRUM LAB LTD

发明人： WINNICKI ROBERT ,  DONSKY MARC

IPC分类号： A61K31/352 ,  A61K9/127 ,  C12P17/06

CPC分类号： C12P7/26 ,  A61K31/352 ,  C12M21/18 ,  C12M41/30 ,  C12M41/48 ,  C12N9/0004 ,  C12N9/1029 ,  C12P7/04 ,  C12P7/22 ,  C12P7/42 ,  C12P7/62 ,  C12P17/06 ,  C12Y121/03007 ,  C12Y121/03008 ,  C12Y203/01206 ,  C12Y205/01102

摘要： The present invention provides methods for producing cannabinoids and cannabinoid analogs as well as a system for producing these compounds. The inventive method is directed to contacting a compound according to Formula I or Formula II with a cannabinoid synthase. Also described is a system for producing cannabinoids and cannabinoid analogs by contacting a THCA synthase with a cannabinoid precursor and modifying at least one property of the reaction mixture to influence the quantity formed of a first cannabinoid relative to the quantity formed of a second cannabinoid.