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    A METHOD FOR PREDICTING THE RISK OF GETTING CANCER IN A FEMALE SUBJECT
    2.
    发明授权
    A METHOD FOR PREDICTING THE RISK OF GETTING CANCER IN A FEMALE SUBJECT 有权
    一种预测女性癌症风险的方法

    公开(公告)号：EP2904398B1

    公开(公告)日：2018-04-11

    申请号：EP13779755.1

    申请日：2013-10-01

    申请人： SphingoTec GmbH

    发明人： BERGMANN, Andreas ,  MELANDER, Olle

    IPC分类号： G01N33/574

    CPC分类号： G01N33/57415 ,  G01N33/57423 ,  G01N2333/665 ,  G01N2800/50

    摘要： Subject matter of the present invention is a method for predicting the risk of getting cancer in a female subject that does not suffer from cancer or alternatively diagnosing cancer in a female subject comprising: determining the level of Pro-Enkephalin or fragments thereof including Leu-Enkephalin and Met-Enkephalin of at least 5 amino acids in a bodily fluid obtained from said female subject; and correlating said level of Pro-Enkephalin or fragments thereof with a risk for getting cancer, wherein a reduced level is predictive for an enhanced risk of getting cancer or alternatively diagnosing cancer wherein an reduced level is correlated with the diagnosis of cancer.

    A METHOD FOR PREDICTING THE RISK OF GETTING CANCER OR DIAGNOSING CANCER IN A FEMALE SUBJECT
    4.
    发明公开
    A METHOD FOR PREDICTING THE RISK OF GETTING CANCER OR DIAGNOSING CANCER IN A FEMALE SUBJECT 有权
    VERFAHREN ZUR VORHERSAGE DES RISIKOS VON KREBS BEI EINER WEIBLICHEN PATIENTIN

    公开(公告)号：EP2904398A1

    公开(公告)日：2015-08-12

    申请号：EP13779755.1

    申请日：2013-10-01

    申请人： sphingotec GmbH

    发明人： BERGMANN, Andreas ,  MELANDER, Olle

    IPC分类号： G01N33/574

    CPC分类号： G01N33/57415 ,  G01N33/57423 ,  G01N2333/665 ,  G01N2800/50

    摘要： Subject matter of the present invention is a method for predicting the risk of getting cancer in a female subject that does not suffer from cancer or alternatively diagnosing cancer in a female subject comprising: determining the level of Pro-Enkephalin or fragments thereof including Leu-Enkephalin and Met-Enkephalin of at least 5 amino acids in a bodily fluid obtained from said female subject; and correlating said level of Pro-Enkephalin or fragments thereof with a risk for getting cancer, wherein a reduced level is predictive for an enhanced risk of getting cancer or alternatively diagnosing cancer wherein an reduced level is correlated with the diagnosis of cancer.

    摘要翻译： 本发明的主题是用于预测在女性受试者中不患有癌症或替代性诊断癌症的女性受试者患癌症的风险的方法，包括：测定前脑啡肽或其片段的水平，包括Leu-脑啡肽 和在所述女性受试者获得的体液中至少5个氨基酸的Met-脑啡肽; 并且将所述水平的前脑啡肽或其片段与获得癌症的风险相关联，其中降低的水平预示出增加的癌症风险或替代性诊断癌症的风险，其中降低的水平与癌症的诊断相关。

    BIOMARKER FOR EFFICACY OF APPETITE SUPPRESSANT DRUGS
    9.
    发明公开
    BIOMARKER FOR EFFICACY OF APPETITE SUPPRESSANT DRUGS 审中-公开
    生物标志物抑制食欲的功效

    公开(公告)号：EP1483580A2

    公开(公告)日：2004-12-08

    申请号：EP03711370.1

    申请日：2003-03-03

    申请人： Merck & Co., Inc.

    发明人： FONG, Tung, M. ,  SHEN, Chun-Pyn ,  VAN DER PLOEG, Leonardus, H., T.

    IPC分类号： G01N33/53

    CPC分类号： G01N33/5088 ,  G01N33/5091 ,  G01N33/74 ,  G01N2333/665 ,  G01N2333/72 ,  G01N2800/52

    摘要： The present invention relates to a biomarker for the efficacy of appetite suppressant drugs given to humans or other mammals for the treatment of obesity. It further relates to a novel method of determining the efficacy of a test compound given to a subject for the treatment of obesity, wherein the test compound is an appetite suppressant which does not stimulate the release of serotonin. It also relates to a method for following the progress of a therapeutic regime designed to alleviate obesity and to a method for determining the appropriate dosage of an appetite suppressant given to a subject for the treatment of obesity.