公开(公告)号：EP4460303A1

公开(公告)日：2024-11-13

申请号：EP23737274.3

申请日：2023-01-06

申请人： MSN Laboratories Private Limited, R&D Center ,  Srinivasan, Thirumalai Rajan

发明人： SAJJA, Eswaraiah ,  MATHAD, Vijayavitthal T ,  THIPPIREDDY, Purna Chandrasekhar Reddy ,  RACHALA, Sridhar Goud ,  PATLOLLA, Srimanth Reddy ,  SRINIVASAN, Thirumalai Rajan

IPC分类号： A61K31/4184 ,  C07D235/10 ,  C07D417/14

公开(公告)号：EP4134080B1

公开(公告)日：2024-11-13

申请号：EP22177635.4

申请日：2017-11-22

发明人： MIAO, Zhenhua ,  SCHALL, Thomas ,  SINGH, Rajinder

IPC分类号： A61K31/444 ,  A61K31/519 ,  A61K31/4184 ,  A61P13/12 ,  A61K31/44 ,  A61K31/18 ,  A61K31/437 ,  A61K45/06

公开(公告)号：EP4438594A1

公开(公告)日：2024-10-02

申请号：EP22887172.9

申请日：2022-10-28

申请人： Mitsubishi Tanabe Pharma Corporation

发明人： HAYASHI Norimitsu ,  IKUBO Masaya ,  NAKAO Akira ,  OGATA Shingo ,  NAGAOKA Minami ,  FUKUNAGA Kenji ,  KANNO Rentarou ,  YAMADA Takahiro

IPC分类号： C07D205/12 ,  A61K31/397 ,  A61K31/4025 ,  A61K31/4035 ,  A61K31/416 ,  A61K31/4178 ,  A61K31/4184 ,  A61K31/429 ,  A61K31/437 ,  A61K31/4375 ,  A61K31/4427 ,  A61K31/4436 ,  A61K31/4725 ,  A61K31/4985 ,  A61K31/502 ,  A61K31/506 ,  A61K31/5355 ,  A61K31/5377 ,  A61K31/541 ,  A61K31/55 ,  A61K31/551

CPC分类号： A61K31/397 ,  A61K31/4025 ,  A61K31/4035 ,  A61K31/416 ,  A61K31/4178 ,  A61K31/4184 ,  A61K31/429 ,  A61K31/437 ,  A61K31/4375 ,  A61K31/4427 ,  A61K31/4436 ,  A61K31/4725 ,  A61K31/4985 ,  A61K31/502 ,  A61K31/506 ,  A61K31/5355 ,  A61K31/5377 ,  A61K31/541 ,  A61K31/55 ,  A61K31/551 ,  A61K31/553 ,  A61K31/554 ,  A61P25/04 ,  A61P25/16 ,  A61P25/20 ,  A61P25/24 ,  A61P25/28 ,  A61P43/00 ,  C07D205/12 ,  C07D401/04 ,  C07D401/12 ,  C07D401/14 ,  C07D403/04 ,  C07D403/12 ,  C07D403/14 ,  C07D405/14 ,  C07D409/14 ,  C07D413/04 ,  C07D413/14 ,  C07D417/04 ,  C07D471/04 ,  C07D487/04 ,  C07D498/04 ,  C07D513/04 ,  C07D519/00

摘要： The present invention provides a novel spiro compound or a pharmacologically acceptable salt thereof that has a TRH-DE inhibitory activity and is useful for preventing or treating various diseases associated with TRH and/or symptoms associated therewith, a method for producing the same, a use thereof, and a pharmaceutical composition containing the compound or the pharmacologically acceptable salt thereof as an active ingredient.
There is provided a compound represented by the following Formula [I]:

wherein,
a ring A represents an aryl group which may be substituted, a heteroaryl group which may be substituted, or an aliphatic heterocyclyl group which may be substituted, and
R1 and R2 represent, indipendently, an alkyl group which may be substituted, a cycloalkyl group which may be substituted, an alkenyl group which may be substituted, a cycloalkenyl group which may be substituted, an alkynyl group which may be substituted, an aryl group which may be substituted, a heteroaryl group which may be substituted, an aliphatic heterocyclyl group which may be substituted and may have a double bond in a part of a ring, an amino group which may be substituted, an alkoxy group which may be substituted, or an alkylthio group which may be substituted, or a group in which R1 and R2 together form a ring,
or a pharmacologically acceptable salt thereof.

公开(公告)号：EP3962915B1

公开(公告)日：2024-09-04

申请号：EP20721394.3

申请日：2020-04-25

IPC分类号： C07D471/04 ,  C07D513/04 ,  A61K31/429 ,  A61K31/4184 ,  A61K31/437 ,  A61P3/00

CPC分类号： A61K31/437 ,  A61P3/00 ,  C07D471/04 ,  C07D513/04 ,  C07D487/04 ,  A61K45/06

公开(公告)号：EP4408530A1

公开(公告)日：2024-08-07

申请号：EP22790423.2

申请日：2022-09-26

申请人： Janssen Pharmaceutica NV

发明人： DECKHUT, Charlotte, Pooley ,  BEHENNA, Douglas, C. ,  BEMBENEK, Scott ,  GOLDBERG, Steven, D. ,  JACKSON, Paul, F. ,  KEITH, John ,  LOSKOT, Steven, A. ,  MARTIN, Connor ,  MCCARVER, Stefan ,  MEDUNA, Steven, P. ,  RHORER, Timothy, B. ,  SHIH, Amy, Y. ,  TANIS, Virginia, M. ,  WOODS, Craig, R. ,  XUE, Xiaohua

IPC分类号： A61P17/06 ,  A61P19/02 ,  A61P29/00 ,  C07D235/14 ,  C07D403/12 ,  C07D405/14 ,  C07D409/12 ,  C07D413/12 ,  C07D413/14 ,  C07D417/12 ,  C07D487/04 ,  A61K31/4184 ,  A61K31/4192 ,  A61K31/4196 ,  A61K31/4245

CPC分类号： C07D413/12 ,  C07D403/12 ,  C07D405/14 ,  C07D413/14 ,  C07D417/12 ,  C07D409/12 ,  C07D487/04 ,  C07D235/14 ,  A61P29/00 ,  A61P19/02 ,  A61P17/06

公开(公告)号：EP4364796A3

公开(公告)日：2024-07-24

申请号：EP24158250.1

申请日：2014-03-14

申请人： Boehringer Ingelheim International GmbH

发明人： JOHANSEN, Odd-Erik ,  VON EYNATTEN, Maximilian ,  KLEIN, Thomas ,  WOERLE, Hans-Juergen

IPC分类号： A61K31/522 ,  A61K38/28 ,  A61K45/06 ,  A61K31/155 ,  A61K31/4184 ,  A61P9/00 ,  A61P9/10 ,  A61P13/12 ,  A61P3/10

CPC分类号： A61K38/28 ,  A61K31/155 ,  A61K31/4184 ,  A61P9/10 ,  A61P9/00 ,  A61P13/12 ,  A61P3/10 ,  A61K31/522 ,  A61K45/06

摘要： The present invention relates to a certain DPP-4 inhibitor for use in cardio- and/or renoprotective therapy, including in patients at high vascular risk.

公开(公告)号：EP4095133B1

公开(公告)日：2024-07-24

申请号：EP21792336.6

申请日：2021-03-10

IPC分类号： C07D401/14 ,  A61K31/444 ,  A61K31/4439 ,  A61K31/5377 ,  A61K31/4184 ,  A61K31/4178 ,  A61K31/427 ,  A61P29/00 ,  C07D413/14 ,  C07D401/12 ,  C07D235/26 ,  C07D403/12 ,  C07D405/14 ,  C07D409/14 ,  C07D417/12

CPC分类号： A61K31/4184 ,  A61K31/427 ,  A61K31/4439 ,  A61K31/5377 ,  A61P29/00 ,  C07D401/12 ,  C07D401/14 ,  C07D413/14 ,  C07D409/14 ,  C07D403/12 ,  C07D417/12 ,  C07D235/26 ,  C07D405/14 ,  A61K31/07 ,  A61K31/355 ,  A61K31/525 ,  A61K31/4415 ,  A61K31/714 ,  A61K31/375 ,  A61K31/519 ,  A61K31/4188 ,  A61K45/06 ,  A23L33/10

公开(公告)号：EP4395774A1

公开(公告)日：2024-07-10

申请号：EP22768985.8

申请日：2022-08-30

申请人： Yeda Research and Development Co. Ltd ,  The Medical Research, Infrastructure and Health Services Fund of the Tel Aviv Medical Center

发明人： STRAUSSMAN, Ravid ,  GAVERT, Nancy ,  ZWANG, Yaara

IPC分类号： A61K31/4184 ,  A61K31/496 ,  A61K31/5025 ,  A61K31/506 ,  A61K31/517 ,  A61K31/519 ,  A61K45/06 ,  A61P35/00

CPC分类号： A61K45/06 ,  A61K31/519 ,  A61K31/4184 ,  A61K31/496 ,  A61K31/506 ,  A61K31/517 ,  A61K31/5025 ,  A61P35/00

公开(公告)号：EP4387735A2

公开(公告)日：2024-06-26

申请号：EP22868219.1

申请日：2022-08-11

申请人： SOUTHWEST RESEARCH INSTITUTE ,  The Government of The United States, as Represented by The Secretary of The Army ,  The Henry M. Jackson Foundation for the Advancement of Military Medicine, Inc.

发明人： BOHMANN, Jonathan A. ,  GUTIERREZ, Nadean M. ,  MCDONOUGH, Joseph A. ,  CAMPBELL, Robert Francis ,  JOYCE, Michael Gordon ,  PANCHAL, Rekha ,  SANKHALA, Rajeshwer ,  DUPLANTIER, Allen

IPC分类号： A61P31/14 ,  A61K31/4184 ,  C07D235/04

CPC分类号： A61K31/445 ,  A61K31/4184

公开(公告)号：EP4344743A3

公开(公告)日：2024-06-19

申请号：EP24158115.6

申请日：2019-08-07

申请人： Emory University

发明人： YE, Keqiang

IPC分类号： C07D491/052 ,  A61P25/24 ,  A61P25/28 ,  A61K31/4184

CPC分类号： C07D491/052 ,  A61P25/24 ,  A61P25/28 ,  A61K31/4184

摘要： In certain embodiments, the disclosure relates to heterocyclic flavone derivatives, such as those described by formula provided herein, pharmaceutical compositions, and methods related thereto. In certain embodiments, the disclosure relates to methods of treating or preventing diseases or conditions related to BDNF and TrkB activity, such as depression, stroke, Rett syndrome, Parkinson's disease, and Alzheimer's disease by administering effective amounts of pharmaceutical compositions comprising compounds disclosed herein to a subject in need thereof.