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公开(公告)号：EP3552690B1
公开(公告)日：2024-09-25
申请号：EP18248249.7
申请日：2015-10-21
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公开(公告)号：EP3936222A1
公开(公告)日：2022-01-12
申请号：EP21179889.7
申请日：2014-09-02
IPC分类号： B01D57/02 , B01D59/42 , C07H21/02 , C12P21/06 , C12Q1/6869 , G01N33/487
摘要： The present disclosure provides method and systems for improving nanopore-based analyses of polymers. The disclosure provides methods for selectively modifying one or more monomeric subunit(s) of a kind a pre-analyte polymer that results polymer analyte with a modified subunit. The polymer analyte produces a detectable signal in a nanopore-based system. The detectable signal, and/or its deviation from a reference signal, indicates the location of the modified subunit in the polymer analyte and, thus, permits the identification of the subunit at that location in the original pre-analyte polymer.
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3.发明公开
公开(公告)号：EP3209410A1
公开(公告)日：2017-08-30
申请号：EP15851818.3
申请日：2015-10-21
申请人： IntegenX Inc.
发明人： KINDWALL, Alexander , PARK, Chungsoo, Charles , ILKOV, Fedor , JOVANOVICH, Stevan , KING, David , LITTLEHALE, Tristan, Robert , NILSON, David, Grant , PITTARO, Rick , SCHUEREN, Robert, A. , VANGBO, Mattias , WUNDERLE, Philip, Justus
IPC分类号： B01D59/42 , C25B11/02 , G01N27/447 , G01N27/49
CPC分类号： G01N27/44791 , B01L3/502715 , B01L7/52 , B01L2200/04 , B01L2200/10 , B01L2200/16 , B01L2300/0681 , B01L2300/0867 , B01L2300/1822 , B01L2300/1827 , B01L2400/0421 , G01N27/44704 , G01N27/44743 , G01N27/44786 , G01N27/453
摘要： The present disclosure provides systems and methods for sample preparation, processing and analysis. Also provided in the present disclosure is a fully-integrated electrophoresis cartridge which has a small footprint and configured to removably engage with the system.
摘要翻译： 本公开提供了用于样品制备，处理和分析的系统和方法。 在本公开内容中还提供了一种完全集成的电泳盒，其具有小的占用空间并被配置为可移除地与系统接合。
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4.发明授权MESURE ISOTOPIQUE MULTIELEMENTAIRE PAR COUPLAGE DIRECT D'UNE TECHNIQUE D'ISOTACHOPHORESE MULTI-CYCLES ET D'UNE TECHNIQUE DE SPECTROMETRIE DE MASSE 有权MESURE ISOTOPIQUE MULTIELEMENTAIRE PAR COUPLAGE DIRECT D'UNE TECHNIQUE技术等多项技术多周期ET D'UNE技术DE SPECTROMETRIE DE MASSE
公开(公告)号：EP3037153B1
公开(公告)日：2017-08-16
申请号：EP15199766.5
申请日：2015-12-14
IPC分类号： B01D59/42 , G01N27/447 , G01N27/62
CPC分类号： H01J49/105 , B01D59/42 , G01N27/44765 , G01N27/44773 , G01N27/622 , H01J49/0031
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公开(公告)号：EP1578519B1
公开(公告)日：2012-12-19
申请号：EP03784974.2
申请日：2003-08-08
IPC分类号： B01D59/42 , G01N27/447
CPC分类号： G01N27/44747
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6.发明公开Methods and systems for control of microfludic devices 有权Verfahren zur Steuerung digitaler mikrofluidischer Vorrichtungen
公开(公告)号：EP2363207A1
公开(公告)日：2011-09-07
申请号：EP11161032.5
申请日：2002-03-27
申请人： Handylab, Inc.
IPC分类号： B01L3/00 , B01L3/02 , G01N31/00 , G01N1/00 , G01N1/10 , G01N27/26 , G01N27/27 , G01N27/403 , G01N27/453 , B01D57/02 , B01D59/42 , B01J19/00
CPC分类号： B01L7/52 , B01F13/0071 , B01F13/0079 , B01J19/0093 , B01J2219/00783 , B01J2219/00828 , B01J2219/00831 , B01J2219/00833 , B01J2219/00835 , B01J2219/00837 , B01J2219/0086 , B01J2219/00862 , B01J2219/00873 , B01J2219/00889 , B01J2219/00891 , B01J2219/00936 , B01J2219/00943 , B01J2219/00945 , B01J2219/00961 , B01J2219/0097 , B01J2219/00986 , B01L3/502784 , B01L3/502792 , B01L2200/0605 , B01L2200/0673 , B01L2200/14 , B01L2300/0816 , B01L2400/0442 , B01L2400/0493 , B01L2400/0677 , G01N1/4077 , G01N35/1083 , Y10T436/12 , Y10T436/25 , Y10T436/2575
摘要： Method for controlling a digital-type microfluidic including provided at least one micro-droplet processing request for creating, moving, combining or mixing micro-droplets, and at least actuator processing request. The actuator processing request comprises providing a gas pressure in a selected passage by an internal component configured to heat a gas to generate a gas pressure and determining, utilizing at least one internal component, the presence or absence of a micro-droplet at a selected position. Control signals are generated in a pattern and sequence that is responsive to each micro-droplet processing request to perform the requested micro-droplet processing in the MF device.
摘要翻译： 用于控制数字式微流体的方法，包括提供至少一个用于产生，移动，组合或混合微滴的微液滴处理请求，以及至少致动器处理请求。 致动器处理请求包括通过被配置成加热气体以产生气体压力的内部部件提供选定通道中的气体压力，并且利用至少一个内部部件确定在所选择的位置存在或不存在微滴 。 控制信号以对每个微液滴处理请求进行响应以在MF装置中执行所请求的微液滴处理的图案和序列产生。
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公开(公告)号：EP1458462B1
公开(公告)日：2011-02-16
申请号：EP02780721.3
申请日：2002-11-16
申请人： Ionics Incorporated
发明人： CARSON, William, W. , GREBENYUK, Oleg , GREBENYUK, Vladimir , SIMS, Keith, J. , ZANAPALIDOU, Hilda, R. , MACK, Bernard, R. , PARENT, Richard, G.
IPC分类号： B01D59/42 , B01D59/50 , B01D61/44 , B01D61/56 , B01D61/58 , B01D35/06 , B01D61/46 , B01D69/00 , B01D71/00 , C02F1/469 , C25B13/00 , C25B13/02
CPC分类号： B01D69/06 , B01D61/48 , B01D61/50 , B01D2313/08 , B01D2325/06 , B01J47/08 , C02F1/4604 , C02F1/469 , C02F2201/46115
摘要： A spacer element (1) is disclosed having an integral screen for use in filled cell electrodialysis. The spacer (1) has a continuous portion (2) impermeable to flow and a screen (3) which spans a centrally-located flow treatment region that contains active treatment material, such as ion exchange beads. The screen (3) may perform a structural function, allowing operation at elevated pressure, and may also define a minimum gap between adjacent membranes and enhance mixing along the flow path and at cell boundaries. The spacer element (1) may be configured to enhance hydraulic filling of the cells, and cell architecture is readily implemented in a wide range of useful flow path geometries utilizing the screen spacer element (1).
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8.发明授权
公开(公告)号：EP1385603B1
公开(公告)日：2009-10-14
申请号：EP02713876.7
申请日：2002-03-18
发明人： ROONEY, Regina, D. , SCOOT, Bradley, S. , AMSHEY, Joseph, W. , JACKSON, Thomas, R. , ENGELHORN, Sheldon
IPC分类号： B01D57/02 , B01D59/42 , B01D59/50 , B01D61/42 , B01D61/58 , C02F1/469 , C07K1/26 , C08F2/58 , C25B15/00 , C25B7/00 , G01F1/64 , G01N27/447
CPC分类号： G01N27/44795 , C07K1/26 , G01N27/44704 , G01N33/559 , G01N33/561
摘要： Methods and apparatus that are embodied in Figure 2 are presented that facilitate electrophoresis of prior-cast, hydratable separation media, usefully immobilized pH gradient (IPG) strips: The method exploits the swelling of rehydration to help lodge the media in an enclosing member that permits spaced electrical communication with the enclosed separation media. The electrical communication permits a voltage gradient to be established in the enclosed separation medium sufficient to effect separation of analytes therein. Cassettes, buffer cores, electrophoresis systems and kits are presented for effecting the methods of the invention.
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9.发明公开METHOD AND APPARATUS FOR DETECTING CANCEROUS CELLS USING MOLEC ULES THAT CHANGE ELECTROPHORETIC MOBILITY 审中-公开方法和设备以使用癌细胞的检测分子，你的电泳移动变化
公开(公告)号：EP1392417A4
公开(公告)日：2005-02-09
申请号：EP02769700
申请日：2002-05-09
申请人： UNIV CALIFORNIA
发明人： ALLBRITTON NANCY , SIMS CHRISTOPHER
IPC分类号： G01N27/62 , B01D53/62 , B01D57/02 , B03C5/00 , C08F2/58 , C12M1/26 , C12M1/34 , C12M1/42 , C12Q1/00 , C12Q1/02 , C12Q1/48 , G01N27/447 , G01N27/48 , G01N33/483 , G01N33/50 , B01D59/42 , B01D59/50 , B01D61/42 , B01D61/58 , C02F1/26 , C25B7/00 , C25B15/00 , G01F1/64 , G01L1/20 , G01L9/18 , G01N27/26
CPC分类号： C12Q1/00 , B01D53/62 , C12Q1/485 , G01N27/44721 , G01N27/44743 , G01N33/50 , G01N33/5017
摘要： The activity of encogenic intercellular chemical reactions of molecules is measured by the use of fluorescently labeled substrate molecules that underdo a change in electrophoretic mobility upon a chemical reaction such as that catalyzed by an enzyme or kinase. Specificity is achieved by using labeled substrate molecules that can be acted upon only by specific oncogenic enzymes can be determined. Measurements are made with the intercellular presence of such substrate molecules, at some time of interest. To ensure accuracy, measurements must be made in a timely manner so as to minimize chemical reactions occuring subsequent to the time of interest. Fast controllable laser lysis is used to obtain the contents of said cell or cells into which reporter substrate molecules have been introduced. The cell contents are then subjected to capillary electrophoresis and oncogenic enzymatic activity is determined by comparing amounts of unaltered substrate molecules to the amounts of altered substrate molecules which are separated by the electrophoresis and identified by the presence of a fluorescent label.
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公开(公告)号：EP3527280B1
公开(公告)日：2021-07-28
申请号：EP19151505.5
申请日：2014-09-02
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