POROUS CELLULOSE MEDIUM AND METHOD FOR PRODUCING SAME

    公开(公告)号:EP3988204A1

    公开(公告)日:2022-04-27

    申请号:EP20825674.3

    申请日:2020-06-19

    摘要: Provided is a novel porous cellulose medium that can efficiently separate a large target molecule in a calibration standard having a large pore diameter and a large pore volume and a weight average molecular weight from approximately 10 5.0 to 10 5.5 . A porous cellulose medium including a porous cellulose particle having a particle size from 1 to 600 µm, wherein, in sieving the porous cellulose medium for classification and using a fraction corresponding to aperture openings between 53 µm and 106 µm as a support for size exclusion chromatography, a polyethylene oxide standard is run through size exclusion chromatography with pure water as a mobile phase, and a weight average molecular weight Mw and a gel partition coefficient K av of the polyethylene oxide standard satisfy Relationships (A) and (B) above:
    in a case where 4 . 80 ≤ logMw ≤ 5 . 50 , K av > − 0.445 × logMw + 2.55
    in a case where 5 . 75 ≤ logMw , 0 ≤ K av 0.19

    METHOD FOR PRODUCING MICROPARTICLES COVERED WITH MAGNETIC OR MAGNETISABLE NANOPARTICLES

    公开(公告)号:EP3702324A1

    公开(公告)日:2020-09-02

    申请号:EP19159391.2

    申请日:2019-02-26

    申请人: LGC Genomics GmbH

    发明人: SCHUBERT, Frank

    IPC分类号: B82Y25/00 H01F1/00 B01J2/00

    摘要: The present invention is directed to a method for the production of microparticles covered with magnetic or magnetisable nanoparticles, the method comprising the steps of providing microparticles with a mean particle size S m selected from 1 µm to 1000 µm; providing magnetic or magnetisable nanoparticles with a mean particle size S n selected from 1 nm to 1000 nm; contacting said microparticles and said magnetic or magnetisable nanoparticles to form a mixture; and of physically agitating said mixture of said microparticles and said magnetic or magnetisable nanoparticles under non-liquid conditions until the surface of said microparticles is at least partly covered with said magnetic or magnetisable nanoparticles.