公开(公告)号：EP3581565A1

公开(公告)日：2019-12-18

申请号：EP18177725.1

申请日：2018-06-14

申请人： Beijing Zhibo Bio-Medical Technology Co., Ltd. ,  Zhang, Zhiyong

发明人： CUI, Mengchao ,  LIN, Chunping ,  LIU, Boli ,  GUO, Yuzhi ,  ZHANG, Zhiyong

IPC分类号： C07D213/64 ,  A61K31/085 ,  A61K31/09 ,  A61K31/10 ,  A61K31/136 ,  A61K31/137 ,  A61K31/44 ,  C07C201/12 ,  C07C43/225 ,  C07C205/37 ,  C07C43/23 ,  C07C209/78 ,  C07C211/53 ,  C07C213/06 ,  C07C319/14 ,  C07C217/86 ,  C07C323/20 ,  C07D213/65 ,  A61P25/28 ,  A61K49/00 ,  A61K51/04

摘要： The present invention relates to a phenyl benzyl ether derivative, a preparation method thereof and application of the phenyl benzyl ether derivative to the preparation of medicine for diagnosing and treating the Alzheimer's disease (AD), wherein part of compounds, after being labeled by radionuclide, of the phenyl benzyl ether derivative, are used as Aβ plaque imaging agent. The structural formula of the phenyl benzyl ether derivative is shown by formula (I). The present invention develops a kind of brand new phenyl benzyl ether derivative which has high affinity with Aβ plaques in brains of AD patients. The chemical structure of the phenyl benzyl ether derivative is different from that of compounds disclosed in the prior art and the phenyl benzyl ether derivative belongs to a brand new compound for diagnosing and treating AD. The obtained Aβ plaque imaging agent has the advantages that the in-vivo stability is good, the fat solubility is low, the removal speed for the brain is fast, the problem of removing the radionuclide in vivo does not exist, and the application prospect and the market value are great.

公开(公告)号：EP3147321A4

公开(公告)日：2018-01-03

申请号：EP15795903

申请日：2015-05-22

申请人： OTSUKA CHEMICAL CO LTD

发明人： SAIKI AYA ,  MINASHIMA HIDEHIRO ,  YANO YUZABURO ,  SHIINA NORIAKI ,  KODAMA KAZUHIRO ,  UENO MIFUYU ,  SATO TAKASHI ,  NAKASHIMA SHINYA ,  ABE MASAKI

IPC分类号： C08L9/00 ,  B60C1/00 ,  C07C211/53 ,  C07C211/55 ,  C08K5/18 ,  C08L7/00

CPC分类号： C08K5/18 ,  B60C1/00 ,  C07C211/53 ,  C07C211/55 ,  C08L7/00 ,  C08L9/00 ,  C08L2201/08

摘要： Provided is a rubber composition that has better weather resistance than conventional rubber compositions and can inhibit surface discoloration of a rubber article. The rubber composition contains at least one rubber component selected from natural rubber and diene-based synthetic rubbers and, blended therewith, at least one amine compound represented by formula (I) shown below. In formula (I), R 1 and R 2 each represent, independently of one another, an alkyl group having a carbon number of 1-10, an aralkyl group, or a phenyl group, and A represents an alkylene group having a carbon number of 6-30 that may include an interposed phenylene group.

公开(公告)号：EP2776387A1

公开(公告)日：2014-09-17

申请号：EP12846967.3

申请日：2012-11-07

申请人： Emory University

发明人： NATCHUS, Michael G. ,  ARRENDALE, Richard F.

IPC分类号： C07C229/60 ,  C07C211/53 ,  C07D213/74 ,  C07C211/52 ,  C07D401/12 ,  C07D403/12 ,  C07D239/42 ,  C07C217/84 ,  C07C229/54 ,  A61K31/517 ,  A61K31/505 ,  A61K31/506 ,  A61K31/44 ,  A61K31/444 ,  A61K31/138 ,  A61K31/277 ,  A61K31/4166 ,  A61K31/167 ,  A61K31/57 ,  A61K31/585 ,  A61K31/569

CPC分类号： A61K31/506 ,  A61K31/137 ,  A61K31/138 ,  A61K31/167 ,  A61K31/4166 ,  A61K31/444 ,  A61K31/505 ,  A61K31/57 ,  A61K31/575 ,  A61K31/58 ,  A61K38/2073 ,  A61K45/06 ,  C07C211/27 ,  C07C211/52 ,  C07C211/53 ,  C07C229/60 ,  C07C233/11 ,  C07C233/58 ,  C07C233/64 ,  C07C233/65 ,  C07C233/75 ,  C07C237/40 ,  C07C255/58 ,  C07C279/04 ,  C07C279/18 ,  C07D213/72 ,  C07D213/74 ,  C07D239/42 ,  C07D401/12 ,  C07D403/12 ,  A61K2300/00

摘要： The disclosure provides methods of use of certain compounds that are useful for treating certain symptoms of endocrine disturbances, and in particular those associated with hot flashes.

公开(公告)号：EP2301950A1

公开(公告)日：2011-03-30

申请号：EP09770125.4

申请日：2009-06-22

申请人： Tosoh Corporation

发明人： MASUMOTO, Seiji ,  KOMIYA, Katsuo ,  NAKAMURA, Koji

IPC分类号： C07K1/22 ,  B01J20/22 ,  B01J20/34 ,  C07C211/53 ,  G01N30/88

CPC分类号： C07K1/16 ,  B01D15/327 ,  B01D15/361 ,  B01J20/3208 ,  B01J20/321 ,  B01J20/3219 ,  B01J20/3253 ,  B01J20/3255 ,  B01J20/3285 ,  C07B2200/11 ,  C07C211/53 ,  C07C237/20 ,  C07D213/56 ,  C07K1/22 ,  C08F120/06

摘要： A novel separating agent for protein purification which not only can adsorb proteins in a sufficient amount for protein purification from a low concentration buffer but also can desorb the adsorbed protein easily just by altering the pH of the buffer and a simple and economical method for its production and a method for protein purification using it.
One or two ligands selected from the group consisting of a ligand represented by the following formula (1):

(wherein m is an integer of from 2 to 6) and a ligand represented by the following formula (2):

(wherein each of R 1 and R 2 is independently a hydrogen atom or a C 1-4 alkyl group, and n is an integer of from 1 to 6) are immobilized on a support via a urethane bond without intervention of a spacer arm.

摘要翻译： 一种用于蛋白质纯化的新型分离剂，其不仅可以从低浓度缓冲液中吸收足够量的蛋白质进行蛋白质纯化，而且可以通过改变缓冲液的pH容易地解吸所吸附的蛋白质，并且其简单且经济的方法用于其生产 以及使用其进行蛋白质纯化的方法。 选自由下式（1）表示的配体的一种或两种配体：（其中m为2-6的整数）和由下式（2）表示的配体：（其中R 1和R 2独立地是氢原子或C 1-4烷基，并且n是1至6的整数）通过氨基甲酸酯键固定在载体上而不介入间隔臂。

公开(公告)号：EP1748755A1

公开(公告)日：2007-02-07

申请号：EP05774856.8

申请日：2005-04-30

申请人： Henkel Kommanditgesellschaft auf Aktien

发明人： KNÜBEL, Georg ,  HÖFFKES, Horst ,  NEMITZ, Ralf

IPC分类号： A61K8/18 ,  C07D413/10 ,  C07C211/53

CPC分类号： A61K8/411 ,  A61Q5/10 ,  C07C215/16 ,  C07D263/24

摘要： The invention relates to an agent for dying keratin fibers, particularly human hair, containing, in a cosmetically acceptable carrier and in the form of coupler components, at least one m-phenylene diamine derivative of general formula (I) or salts thereof, in which: R1, R2, R3, R4, independent of one another, represent H, C1-6-alkyl, C2-6-hydroxyalkyl, C2-6-alkoxyalkyl, C2-6-aminoalkyl, C3-10-alkylaminoalkyl, C4-12-dialkylaminoalkyl, with the provision that at least one of the radicals R1, R2, R3, R4 is not H, and; R5 and R6, independent of one another, represent H, C1-6-hydroxyalkyl and C2-6-alkoxyalkyl, whereby also one of the radicals R5, R6 can represent -OH, C1-6-alkoxy, -NH2, -NHR, -NR2 with R being, independent of one another, optionally OH-substituted C1-4-alkyl.

公开(公告)号：EP1568686A1

公开(公告)日：2005-08-31

申请号：EP05290424.0

申请日：2005-02-24

申请人： L'OREAL

发明人： Sabelle, Stéphane

IPC分类号： C07C233/36 ,  C07C237/06 ,  C07C211/53 ,  C07D295/00 ,  C07D207/00 ,  C07D211/00

CPC分类号： C07D207/27 ,  C07C211/53 ,  C07C233/36 ,  C07C237/06 ,  C07D295/13

摘要： La présente demande concerne de nouvelles para-phénylènediamines secondaires N-alkylaminées ortho et/ou méta-substituées, une composition pour la teinture des fibres kératiniques, et en particulier les fibres kératiniques humaines telles que les cheveux, contenant, dans un milieu approprié pour la teinture, au moins une para-phénylènediamine secondaire N-alkylaminée ortho et/ou méta-substituée, un procédé de teinture des fibres kératiniques qui consiste à appliquer cette composition ainsi que les utilisations de cette composition en particulier sous la forme d'un "kit" de teinture.

摘要翻译： 次级对苯二胺的N-烷基胺的邻位和/或metasubstituted衍生物（I）是新的。 次级对苯二胺的N-烷基胺的邻位和/或式（I）的衍生物metasubstituted是新的。 或者R1，R2H或烷基; 或R1，R2 + N：5-6饱和环链（任选地具有至少一个氮原子和/或具有至少一个羰基与至少一种烷基，其任选substituiertem中断）; R：2-10C亚烷基（与N或O OPTIONALLY substituiertem与（单烷基）氨基，二烷基氨基，烷基羰基，酰氨基，烷氧基羰基，单或二烷基氨基羰OPTIONALLY中断; R“：烷基，烷氧基烷基，烷氧基，烷氧基烷基，单/多羟基或Cl ;和n：1（I）不是N-1-（2-二乙氨基乙基） - 2-甲氧基 - 苯-1,4-二胺; N-1-（3-二乙基氨基丙基）-3-甲基 - 苯 -1,4-二胺和-N 1 - （3-吡咯烷子基 - 丙基）-3-甲基 - 苯-1,4-二胺和（II）不为N-1（3-二乙基氨基）-3-甲基-4-硝基 1。氨基苯等N-1-（3-吡咯烷基 - 丙基）-3-甲基-4-硝基-1-氨基苯因此独立权利要求中包括了：（1）式（II）的硝基化合物;（2）化妆品 组合物（A），其包含（I）;.（3）的即用型组合物（B）[图像] [图像] [图像] [图像]。

公开(公告)号：EP1183227A1

公开(公告)日：2002-03-06

申请号：EP01919309.3

申请日：2001-02-20

申请人： Wella Aktiengesellschaft

发明人： CHASSOT, Laurent

IPC分类号： C07C211/53 ,  C07C215/68 ,  C07C215/16 ,  A61K7/13

CPC分类号： C07C211/53 ,  A61K8/411 ,  A61Q5/10 ,  C07C215/16 ,  C07C215/68

摘要： The invention relates to p-diaminobenzene derivatives of general formula (I) or the physiologically acceptable, water-soluble salts thereof and the use thereof as developer substance in oxidation colorants for keratin fibres.

公开(公告)号：EP0779765B1

公开(公告)日：2001-08-01

申请号：EP96309019.6

申请日：1996-12-11

申请人： TOYO INK MANUFACTURING CO., LTD.

发明人： Tamano, Michiko, c/o Toyo Ink Manufacturing Co Ltd ,  Okutsu, Satoshi, c/o Toyo Ink Manufacturing Co Ltd ,  Enokida, Toshio, c/o Toyo Ink Manufacturing Co Ltd

IPC分类号： H05B33/12 ,  G03G5/06 ,  H05B33/14 ,  C07C211/58 ,  C07C211/53 ,  C08G73/02

CPC分类号： C07C211/58 ,  C07C211/60 ,  C07C211/61 ,  C07C2601/02 ,  C07C2602/10 ,  C07C2602/12 ,  C08G73/026 ,  C09K11/06 ,  G03G5/0614 ,  H05B33/12

公开(公告)号：EP0775689A4

公开(公告)日：1999-08-11

申请号：EP95921126

申请日：1995-06-07

申请人： C & C RESEARCH LABS

发明人： CHUNG YOU ,  KIM HAK YEOP ,  JUNG KYUNG YUN ,  MIN JAE KI ,  TANABE SHIGERU

IPC分类号： C07C211/29 ,  C07C211/53 ,  C07C217/20 ,  C07C217/60 ,  C07C217/84 ,  C07C233/25 ,  C07C233/43 ,  C07C255/54 ,  C07C311/08 ,  C07D207/32 ,  C07D207/325 ,  C07D217/04 ,  C07D233/61 ,  C07D233/64 ,  C07D277/42 ,  C07D277/46 ,  C07D295/096 ,  C07D295/135 ,  C07D521/00 ,  C07C211/27 ,  C07C211/45 ,  C07C211/50 ,  C07C211/52 ,  C07C211/54 ,  C07C211/56 ,  C07C217/08 ,  C07C217/56

CPC分类号： C07D207/325 ,  C07C211/53 ,  C07C217/20 ,  C07C217/60 ,  C07C217/84 ,  C07C233/25 ,  C07C233/43 ,  C07C255/54 ,  C07C311/08 ,  C07D217/04 ,  C07D231/12 ,  C07D233/56 ,  C07D249/08 ,  C07D277/42 ,  C07D277/46 ,  C07D295/096 ,  C07D295/135

摘要： A novel amine derivative represented by general formula (I) and a salt thereof, each being useful as an antiarrhythmic, wherein, for example, A represents -(CH2)-O-, -(CH2)2-O- or -(CH2)2-NH-; B represents -(CH2)2-; R1 represents hydrogen, halogen, nitro, 1-pyrrolyl, acetamido, amino or dimethylamino; R2 represents hydrogen or nitro; R3 and R4 represent each hydrogen; R8a and R8b both represent chloro or methoxy at the same time; R9 represents hydrogen or amino; R represents methyl; and X represents methanesulfonamido, 1-imidazolyl or nitro.

公开(公告)号：EP0596130B1

公开(公告)日：1997-09-24

申请号：EP93904376.6

申请日：1993-03-02

申请人： SDS Biotech K.K.

发明人： MATSUSHITA, Utaro, Yokohama Works ,  WATANABE, Masao, Yokohama Works ,  TACHIBANA, Yoshiyuki, Yokohama Works

IPC分类号： C07C209/68 ,  C07C211/53 ,  C07C231/06 ,  C07C233/62

CPC分类号： C07C209/68 ,  C07C237/30

摘要： A process for producing 2-halo-3,5-difluoroaniline by heating 4-amino-5-halo-2,6-difluoroisophthalonitrile in the presence of sulfuric acid with a concentration of 50 wt.% or above at a temperature ranging from 80 °C to the boiling point of the reaction mixture; 4-amino-5-halo-2,6-difluoroisophthalamide as an intermediate for the production of the aniline; and a process for producing the amide. The above aniline and amide are useful as the starting material or intermediate for producing pharmaceutical, agricultural and industrial chemicals.