公开(公告)号：EP3578547B1

公开(公告)日：2021-05-26

申请号：EP19187141.7

申请日：2016-02-16

发明人： O'NEILL, Luke ,  COOPER, Matthew ,  ROBERTSON, Avril ,  SCHRODER, Kate , 

IPC分类号： C07D231/18 ,  C07D307/64 ,  C07D311/60 ,  C07D407/12 ,  C07D405/12 ,  C07D403/12 ,  C07D213/71 ,  C07D217/22 ,  C07D249/12 ,  C07D271/12 ,  C07D333/34 ,  C07D277/36 ,  C07D333/62 ,  C07D249/04 ,  C07D417/12 ,  C07D307/82 ,  C07C311/54 ,  C07C311/56 ,  C07D307/18 ,  C07D309/08

公开(公告)号：EP3259253A1

公开(公告)日：2017-12-27

申请号：EP16751821.6

申请日：2016-02-16

申请人： The University Of Queensland ,  The Provost, Fellows, Foundation Scholars, and The Other Members of Board, of The College of The Holy and Undivided Trinity of Queen Elizabeth

发明人： O'NEILL, Luke ,  COLL, Rebecca ,  COOPER, Matthew ,  ROBERTSON, Avril ,  SCHRODER, Kate

IPC分类号： C07D231/18 ,  C07D307/64 ,  C07D311/60 ,  C07D407/12 ,  C07D405/12 ,  C07D403/12 ,  C07D213/71 ,  C07D217/22 ,  C07D249/12 ,  C07D271/12 ,  C07D333/34 ,  C07D277/36 ,  C07D333/62 ,  C07D249/04 ,  C07D417/12 ,  C07D307/82 ,  C07C311/54 ,  C07C311/56 ,  C07D307/18 ,  C07D309/08

摘要： The present invention provides for certain sulfonyl ureas and related compounds which have advantageous properties and show useful activity in the inhibition of activation of the NLRP3 inflammasome. Such compounds are useful in the treatment of a wide range of disorders in which the inflammation process, or more specifically the NLRP3 inflammasome, have been implicated as being a key factor.

公开(公告)号：EP2970167A2

公开(公告)日：2016-01-20

申请号：EP14773258.0

申请日：2014-03-12

申请人： Micromidas, Inc.

发明人： BROWNING, Shawn, M. ,  MASUNO, Makoto, N. ,  BISSELL, John ,  NICHOLSON, Benjamin, F. ,  HIRSCH-WEIL, Dimitri, A. ,  SMITH, Ryan, L.

IPC分类号： C07D307/18

CPC分类号： C07D307/46 ,  C07D307/18 ,  C07D307/48

摘要： Provided are solid forms of 5-(halomethyl)furfural, including a crystalline form of 5- (chloromethyl)furfural. Provided are also methods for preparing solid forms of 5- (halomethyl)furfural by crystallization using certain solvents.

摘要翻译： 提供5-（卤代甲基）糠醛的固体形式，包括5-（氯甲基）糠醛的结晶形式。 还提供了通过使用某些溶剂进行结晶来制备5-（卤代甲基）糠醛的固体形式的方法。

公开(公告)号：EP1501844A1

公开(公告)日：2005-02-02

申请号：EP03714557.0

申请日：2003-04-24

申请人： Alchemia Limited

发明人： MEUTERMANS, Wim ,  WEST, Michael, Leo ,  ADAMSON, George ,  THANH LE, Giang ,  DRINNAN, Nicholas, Barry ,  ABBENANTE, Giovani ,  BECKER, Bernd ,  GRATHWOHL, Matthias ,  RAJARATNAM, Premraj ,  TOMETZKI, Gerald

IPC分类号： C07H3/04 ,  C07H3/02 ,  C07D307/18 ,  C07D309/10 ,  C07D309/14

CPC分类号： C07H3/04 ,  C07H3/02 ,  C40B40/12 ,  C40B50/14

摘要： Methods are described for the preparation of combinatorial libraries of potentially biologically active disaccharide compounds. These compounds are variously functionalized, with a view to varying lipid solubility size, function and other properties, with the particular aim of discovering novel drug or drug-like compounds, or compounds with useful properties. The invention provides intermediates, processes and synthetic strategies for the solution or solid phase synthesis of disaccharides, variously functionalised about the sugar ring, including the addition of aromaticity and charge, and the placement of pharmaceutically useful groups and isosteres.

公开(公告)号：EP0577962A1

公开(公告)日：1994-01-12

申请号：EP93108499.0

申请日：1993-05-26

申请人： BRACCO INTERNATIONAL B.V.

发明人： Arunachalam, Thangavel ,  Ranganathan, Ramachandran

IPC分类号： C07D307/18 ,  A61K49/04

CPC分类号： C07D307/24 ,  A61K49/0433

摘要： Novel nonionic contrast agents of the formula

or dimers of the formula

are disclosed where X, Z and R₁-R₅ are as defined herein.

摘要翻译： 公开了式（CHEM）的新型非离子造影剂或式（CHEM）的二聚体，其中X，Z和R 1 -R 5如本文所定义。

公开(公告)号：EP0380588A4

公开(公告)日：1991-04-03

申请号：EP88910246

申请日：1988-09-28

申请人： THE UNIVERSITY OF TENNESSEE RESEARCH CORPORATION

发明人： KENNEDY, THOMAS, P. ,  KABALKA, GEORGE, W.

IPC分类号： C07D307/81 ,  A61K31/34 ,  A61K31/343 ,  A61P9/00 ,  A61P9/08 ,  C07D307/80 ,  C07D307/18 ,  C07D405/10 ,  C07D407/10

CPC分类号： C07D307/80

摘要： The disclosure relates to compounds of formula (I) and pharmaceutically acceptable addition salts thereof wherein X represents a single, direct bond or a substituted or unsubstituted alkylene chain containing 1 to 4 carbon atoms, wherein R5 is a lower alkyl group, wherein R6 is either hydrogen or methyl, wherein Am is selected from the class consisting of amino, lower mono and dialkylamino, piperidino, piperazino, N-lower alkyl piperazino, pyrrrolidino, and morpholino groups wherein Y1 and Y2 are identical and are hydrogen, a halogen, methyl or ethyl and n is an integer in the range of 1-5. They are useful in treating arrhythmic conditions and conditions for which treatment with a vasodilator is indicated.

公开(公告)号：EP0199324A3

公开(公告)日：1988-02-10

申请号：EP86105471

申请日：1986-04-21

申请人： MERCK & CO. INC.

发明人： Biftu, Tesfaye ,  Hwang, San-Bao ,  Doebber, Thomas W. ,  Beattie, Thomas R. ,  Shen, Tsung-Ying

IPC分类号： C07D307/10 ,  C07D307/18 ,  C07D405/04 ,  C07D405/14 ,  C07D417/04 ,  A61K31/34

CPC分类号： C07D307/18 ,  C07D307/12 ,  C07D307/14 ,  C07D307/16 ,  C07D307/20 ,  C07D307/24 ,  C07D307/34 ,  C07D405/04 ,  C07D405/14 ,  C07D407/12 ,  C07D409/14 ,  C07D417/04

摘要： Compounds of formula:
are disclosed wherein R and R' are
(a) hydrogen; (b) haloloweralkyl; (c) halo; (d) CONR 2 R 3 wherein R 2 and R 3 independently represent hydrogen, C 1-8 alkyl, or C 3-8 cycloalkyl; (e) loweralkenyl; (f) -COR 2 ; (g) -CH 2 OR 2 ; (h) loweralkynyl; (i) -CH 2 NR 2 R 2 ; (j) -CH 2 SR 2 ; (k) = O; or (l) -OR 2 ; (m) -R 2 ; Ar and Ar 1 are (a) phenyl or substituted phenyl of formula where R 4 -R 8 independently where R 4 -R 8 independently represent H; R 2 ; YO-wherein Y is loweralkenyl, loweralkynyl, - CH 2 -, -CH 2 C(O)OR 2 , -CH 2 OR 2 , -CH 2 C 3- 8 cycloalkyl, -CH 2 Ar 2 wherein Ar 2 is phenyl or substituted phenyl, -CH 2 -CH(OH)CH 2 OH; R 2 S-(O) n wherein R 2 can only be C 3-8 cycloalkyl and n is 0 to 2; CF 3 SO, CF 3 SO 2 ; - CONR 2 R 3 ; -NR 2 COR 3 ; -OCONH 2 -CR 2 R 3 R 9 wherein R 9 is the same as or different from R Z ; -CH 2 OR 2 ; -CH 2 CO 2 R 2 ; -CH 2 OCOR 3 ; -GH 2 O-CO-OR 2 ; -NHCH 2 COOR 2 ; halo; or N + R 2 R 3 R 9 X- wherein X- is an anion;
(b) monoheteroaryl, di-or polyheteroaryl or fused heteroaryl containing 1 to 3 of any one or more of the heteroatoms N, S or O; (c) heteroarylalkyl; (d) heterocycloalkyl; or (e) heterocycloalkenyl. These compounds are found to have potent and specific PAF - (Platelet Activating Factor) antagonistic activities.

公开(公告)号：EP3259253A4

公开(公告)日：2018-07-25

申请号：EP16751821

申请日：2016-02-16

申请人： UNIV QUEENSLAND ,  THE PROVOST FELLOWS FOUND SCHOLARS AND THE OTHER MEMBERS OF BOARD OF THE COLLEGE OF THE HOLY AND UND

发明人： O'NEILL LUKE ,  COLL REBECCA ,  COOPER MATTHEW ,  ROBERTSON AVRIL ,  SCHRODER KATE

IPC分类号： C07D231/18 ,  C07C311/54 ,  C07C311/56 ,  C07D213/71 ,  C07D217/22 ,  C07D249/04 ,  C07D249/12 ,  C07D271/12 ,  C07D277/36 ,  C07D307/18 ,  C07D307/64 ,  C07D307/82 ,  C07D309/08 ,  C07D311/60 ,  C07D333/34 ,  C07D333/62 ,  C07D403/12 ,  C07D405/12 ,  C07D407/12 ,  C07D417/12

CPC分类号： C07C311/56 ,  C07C311/60 ,  C07C2601/02 ,  C07C2601/08 ,  C07C2601/14 ,  C07C2601/16 ,  C07C2602/08 ,  C07C2602/10 ,  C07C2603/10 ,  C07D207/38 ,  C07D213/71 ,  C07D215/36 ,  C07D217/02 ,  C07D217/22 ,  C07D217/24 ,  C07D221/18 ,  C07D231/18 ,  C07D235/02 ,  C07D241/24 ,  C07D241/42 ,  C07D241/44 ,  C07D249/04 ,  C07D249/06 ,  C07D249/12 ,  C07D261/18 ,  C07D271/12 ,  C07D277/36 ,  C07D307/18 ,  C07D307/64 ,  C07D307/68 ,  C07D307/82 ,  C07D309/08 ,  C07D311/16 ,  C07D311/18 ,  C07D311/60 ,  C07D317/62 ,  C07D333/34 ,  C07D333/52 ,  C07D333/62 ,  C07D401/06 ,  C07D401/12 ,  C07D403/12 ,  C07D405/12 ,  C07D407/12 ,  C07D413/12 ,  C07D417/12 ,  C07D487/04 ,  C07D493/04 ,  C07D495/04 ,  C07D495/06 ,  C07D498/04

摘要： The present invention provides for certain sulfonyl ureas and related compounds which have advantageous properties and show useful activity in the inhibition of activation of the NLRP3 inflammasome. Such compounds are useful in the treatment of a wide range of disorders in which the inflammation process, or more specifically the NLRP3 inflammasome, have been implicated as being a key factor.

公开(公告)号：EP3050873A1

公开(公告)日：2016-08-03

申请号：EP16152544.9

申请日：2011-12-09

申请人： ALLERGAN, INC.

发明人： Yuan, Haiqing ,  Beard, Richard, L. ,  Liu, Xiaoxia ,  Donello, John E. ,  Viswanath, Veena ,  Garst, Michael E.

IPC分类号： C07D213/34 ,  C07D213/62 ,  C07D233/64 ,  C07D307/18 ,  C07D307/82 ,  C07D333/34 ,  C07D407/12 ,  C07D417/12 ,  A61K31/343 ,  A61P31/00 ,  C07C311/00

CPC分类号： C07C311/21 ,  C07C317/34 ,  C07C317/36 ,  C07C317/42 ,  C07C317/44 ,  C07C317/50 ,  C07C321/30 ,  C07C323/49 ,  C07C323/52 ,  C07C323/56 ,  C07C323/60 ,  C07C323/67 ,  C07C2601/08 ,  C07D207/09 ,  C07D207/46 ,  C07D213/32 ,  C07D213/52 ,  C07D233/64 ,  C07D277/40 ,  C07D295/13 ,  C07D295/185 ,  C07D295/24 ,  C07D307/64 ,  C07D307/82 ,  C07D333/34 ,  C07D405/12 ,  C07D413/12 ,  C07D417/12 ,  C07F9/304 ,  C07F9/3229 ,  C07F9/4021 ,  C07F9/5325 ,  C07F9/591 ,  C07F9/6533

摘要： The present invention relates to novel sulfur derivatives, processes for preparing them, pharmaceutical compositions containing them and their use as pharmaceuticals as modulators of chemokine receptors.

摘要翻译： 本发明涉及新的硫衍生物，它们的制备方法，含有它们的药物组合物以及它们作为药物作为趋化因子受体调节剂的用途。

公开(公告)号：EP1548014A4

公开(公告)日：2008-04-02

申请号：EP03792778

申请日：2003-08-21

申请人： ASAHI GLASS CO LTD

发明人： MATSUKURA IKUO ,  OKAMOTO HIDEKAZU ,  MUROTANI EISUKE ,  OHARU KAZUYA

IPC分类号： A47G1/12 ,  B44F1/00 ,  C07D307/16 ,  C07D307/18 ,  C07D307/30 ,  C08F34/02 ,  G03F1/62 ,  G03F1/64 ,  G03F9/00 ,  G03F1/14

CPC分类号： C07D307/16 ,  C07D307/18 ,  C07D307/30 ,  C08F34/02 ,  G03F1/62 ,  G03F1/64

摘要： Pellicles are provided, which are excellent in permeability to light of short wavelengths and endurance and usable even in photolithography with KrF excimer laser. A pellicle for exposure to light having a wavelength of 200 nm or below which is constituted of a frame and a pellicle membrane bonded to the frame via an adhesive, wherein the pellicle membrane and/or the adhesive is made from a polymer containing repeating units represented by the general formula (1): (1) wherein Q is linear C1-3 polyfluoroalkylene, a group derived from polyfluoroalkylene by replacing one or more hydrogen and/or fluorine atoms by polyfluoroalkyl optionally containing an etheric oxygen atom, or the like; and X is hydrogen, fluoro, or C1-3 polyfluoroalkyl optionally containing an etheric oxygen atom.