公开(公告)号：EP4323515A1

公开(公告)日：2024-02-21

申请号：EP22789036.5

申请日：2022-04-15

申请人： Altius Institute For Biomedical Sciences ,  Cherone, Jennifer M. ,  Funnell, Alister PW ,  Stamatoyannopoulos, John A. ,  Haugen, Eric David

发明人： CHERONE, Jennifer M. ,  FUNNELL, Alister PW ,  STAMATOYANNOPOULOS, John A. ,  HAUGEN, Eric David

IPC分类号： C12N9/22 ,  A61K38/46 ,  C07K14/805 ,  C12N15/09 ,  C12Q1/68

公开(公告)号：EP3848045A1

公开(公告)日：2021-07-14

申请号：EP21150097.0

申请日：2014-05-21

申请人： President and Fellows of Harvard College

发明人： SUPER, Michael ,  WATTERS, Alexander L. ,  SNELL, Philip T. ,  INGBER, Donald E.

IPC分类号： A61K38/00 ,  C07K14/805 ,  A61P21/00 ,  A61P31/00

摘要： Described herein are heme-binding compositions and methods relating to their use, e.g. methods of treatment of, for example, sepsis and rhabdomyolysis.

公开(公告)号：EP3788070A1

公开(公告)日：2021-03-10

申请号：EP19796746.6

申请日：2019-04-30

申请人： The Children's Hospital Of Philadelphia

发明人： RIVELLA, Stefano ,  BREDA, Laura ,  DONG, Alisa ,  LOURENCO, Silvia, Pires ,  GONZALEZ, Amaliris

IPC分类号： C07K14/805 ,  C12N15/867

公开(公告)号：EP3595702A1

公开(公告)日：2020-01-22

申请号：EP18711670.2

申请日：2018-03-13

申请人： University of Essex Enterprises Limited

发明人： COOPER, Chris E. ,  REEDER, Brandon ,  SILKSTONE, Gary

IPC分类号： A61K38/42 ,  C07K14/805 ,  A61P9/10

公开(公告)号：EP3502240A1

公开(公告)日：2019-06-26

申请号：EP18203436.3

申请日：2013-11-27

申请人： The Children's Medical Center Corporation

发明人： ORKIN, Stuart H. ,  BAUER, Daniel E. ,  XU, Jian

IPC分类号： C12N5/10 ,  C12N5/0789 ,  C12N15/09 ,  A61K35/12 ,  A61K38/46 ,  C07K14/805 ,  C12N15/10 ,  C12N15/63 ,  C07K14/47 ,  C12N15/01 ,  C12N9/22

摘要： Provided herein are methods and compositions for increasing fetal hemoglobin levels in a cell by disrupting BCL11A expression at the genomic level. Also provided herein are methods and compositions relating to the treatment of hemoglobinopathies by reinduction of fetal hemoglobin levels.

公开(公告)号：EP2834329B1

公开(公告)日：2018-10-17

申请号：EP13771756.7

申请日：2013-03-15

申请人： Schindler, William

发明人： VANDEGRIFF, Kim D. ,  MALAVALLI, Ashok ,  MKRTCHYAN, Gnel

IPC分类号： C07D207/416 ,  C07D401/12 ,  C07D401/14 ,  C07D403/12 ,  C07K14/765 ,  C07K14/805 ,  A61K38/42

CPC分类号： C07K14/805 ,  A61K38/42 ,  C07D207/416 ,  C07D401/12 ,  C07D401/14 ,  C07D403/12 ,  C07K14/765

摘要： The present invention relates to succinimide-activated nitroxyl compounds and methods for the synthesis of such compounds. The present invention also relates to the use of succinimide-activated nitroxyl compounds to prepare nitroxylated proteins, for example nitroxylated heme proteins (e.g., nitroxylated hemoglobin and nitroxylated myoglobin). The nitroxylated proteins are optionally also conjugated to a polyalkylene oxide (PAO), for example to a polyethylene glycol (PEG). Polynitroxylated heme proteins are useful as oxygen therapeutic agents (OTAs). The invention further relates to pharmaceutical compositions of the nitroxylated proteins and methods for the use of nitroxylated proteins in the treatment of various conditions.

公开(公告)号：EP3212793A4

公开(公告)日：2018-05-16

申请号：EP15855964

申请日：2015-11-01

申请人： ARCTURUS THERAPEUTICS INC

发明人： CHIVUKULA PADMANABH ,  WARREN LUIGI ,  TACHIKAWA KIYOSHI ,  PAYNE JOSEPH E

IPC分类号： C12N15/11 ,  A61K39/00 ,  A61K48/00 ,  C07K14/445 ,  C07K14/46 ,  C07K14/47 ,  C07K14/505 ,  C07K14/52 ,  C07K14/575 ,  C07K14/705 ,  C07K14/745 ,  C07K14/805 ,  C07K14/81 ,  C12N9/02 ,  C12N9/10 ,  C12N9/12 ,  C12N9/44 ,  C12N9/64 ,  C12N9/88 ,  C12N15/85

CPC分类号： C12N9/1018 ,  A61K39/00 ,  A61K48/00 ,  C07K14/445 ,  C07K14/463 ,  C07K14/47 ,  C07K14/4712 ,  C07K14/4717 ,  C07K14/505 ,  C07K14/524 ,  C07K14/575 ,  C07K14/705 ,  C07K14/745 ,  C07K14/805 ,  C07K14/8125 ,  C12N9/0071 ,  C12N9/1051 ,  C12N9/1205 ,  C12N9/2451 ,  C12N9/644 ,  C12N9/88 ,  C12N2740/16222 ,  C12N2840/105 ,  C12N2840/60 ,  C12Y114/16001 ,  C12Y201/03003 ,  C12Y204/01025 ,  C12Y207/0104 ,  C12Y302/01033 ,  C12Y304/21022 ,  C12Y403/02001

摘要： This invention provides a range of translatable messenger UNA (mUNA) molecules. The mUNA molecules can be translated in vitro and in vivo to provide an active polypeptide or protein, or to provide an immunization agent or vaccine component. The mUNA molecules can be used as an active agent to express an active polypeptide or protein in cells or subjects. Among other things, the mUNA molecules are useful in methods for treating rare diseases.

公开(公告)号：EP3279660A1

公开(公告)日：2018-02-07

申请号：EP16773083.7

申请日：2016-03-31

申请人： Eiken Kagaku Kabushiki Kaisha

发明人： SAKATA Kozue ,  SUGO Shin ,  YASUI Ryota

IPC分类号： G01N33/531 ,  C07K14/805 ,  G01N1/28

CPC分类号： G01N1/28 ,  C07K14/805 ,  G01N33/531

摘要： An object of the present invention is to provide a novel preservative solution for a heme protein and a method for stabilizing a heme protein, which are effective against denaturation or degradation of a heme protein, and the present invention specifically relates to a preservative solution for a heme protein comprising a disulfonic acid or a salt thereof, and a method for stabilizing a heme protein, which involves bringing a disulfonic acid or a salt thereof into coexistence in a sample comprising a heme protein.

摘要翻译： 本发明的一个目的是提供一种新的血红素蛋白质保存液和稳定血红素蛋白质的方法，它们能有效地抵抗血红素蛋白质的变性或降解，本发明特别涉及一种用于 包含二磺酸或其盐的血红素蛋白质以及稳定血红素蛋白质的方法，其包括使二磺酸或其盐共存于包含血红素蛋白质的样品中。

公开(公告)号：EP3164412A1

公开(公告)日：2017-05-10

申请号：EP15815035.9

申请日：2015-07-01

申请人： Cheer Global Ltd.

发明人： WONG, Bing Lou ,  WAI, Norman Fung Man ,  KWOK, Sui Yi

IPC分类号： C07K14/805 ,  A61K38/42 ,  A61K31/505 ,  A61K31/4188 ,  A61K33/24 ,  A61K51/08 ,  A61K101/00 ,  A61P7/08 ,  A61P35/00 ,  G01N33/574

CPC分类号： A61K38/1709 ,  A61K31/7068 ,  A61K38/42 ,  A61K45/06 ,  A61K47/6445 ,  C07K14/805 ,  A61K2300/00

摘要： The present invention provides a pharmaceutical composition containing recombinant hemoglobin protein or tetramer or dimer or subunit for tissue oxygenation and treating cancer. The recombinant hemoglobin protein or tetramer or dimer or subunit-based therapeutic agent is also effective for treating cancer. The recombinant hemoglobin or tetramer or dimer or its subunit moiety can target cancer cells and the therapeutic moiety (i.e. active agent/therapeutic drug) can kill the cancer cells efficiently. The recombinant hemoglobin or tetramer or dimer or its subunit-based therapeutic agent used in the present invention can be used in the treatment of various cancers such as pancreatic cancer, leukemia, head and neck cancer, colorectal cancer, lung cancer, breast cancer, liver cancer, nasopharyngeal cancer, esophageal cancer, prostate cancer, stomach cancer and brain cancer. The composition can be used alone or in combination with other therapeutic agent(s) such as chemotherapeutic agent, radiotherapeutic agent, anti-cancer protein drug to give a synergistic effect on cancer treatment, inhibiting metastasis and/or reducing recurrence.

摘要翻译： 本发明提供了含有重组蛋白的血红蛋白四聚体或二聚体或亚基或用于组织氧合和治疗癌症的药物组合物。 所述重组蛋白质的血红蛋白四聚体或二聚体或或基于亚基 - 治疗剂是用于治疗癌症非常有效。 重组血红蛋白四聚体或二聚体或或它的亚单位部分可以靶向癌细胞和治疗性部分（即活性剂/治疗药物）能有效地杀死癌细胞。 如胰腺癌，白血病，头颈癌，结肠直肠癌，肺癌，乳腺癌，肝癌：在本发明使用的重组血红蛋白或四聚体或二聚体或它的基于亚基治疗剂可以以各种癌症的治疗中使用 癌，鼻咽癌，食道癌，前列腺癌，胃癌和脑癌。 如化疗剂，放疗剂，抗癌蛋白药物给予癌症治疗，转移抑制和/或减少复发的协同效应：所述组合物可单独使用或与其它治疗剂组合使用。

公开(公告)号：EP2170948B1

公开(公告)日：2016-11-02

申请号：EP08775775.3

申请日：2008-06-26

申请人： University of Essex Enterprises Limited

发明人： COOPER, Christopher Eric ,  WILSON, Michael Thomas ,  REEDER, Brandon Jon

IPC分类号： C07K14/805 ,  A61K38/42 ,  A61K9/00

CPC分类号： C07K14/805 ,  A61K38/00 ,  A61K47/60 ,  A61K47/62 ,  A61K47/6445