公开(公告)号：EP4389895A1

公开(公告)日：2024-06-26

申请号：EP22895642.1

申请日：2022-11-16

申请人： National University Corporation Tottori University

发明人： KAZUKI Yasuhiro ,  TOMIZUKA Kazuma ,  UNO Narumi

IPC分类号： C12N15/13 ,  A01K67/027 ,  C07K16/00 ,  C07K16/06 ,  C12N5/0735 ,  C12N5/10 ,  C12N15/06 ,  C12N15/09 ,  C12N15/10 ,  C12N15/85 ,  C12N15/90 ,  C12P21/08

CPC分类号： C07K16/00 ,  C07K16/06 ,  C12N5/06 ,  C12N5/10 ,  C12N5/16 ,  C12N15/09 ,  C12N15/10 ,  C12N15/85 ,  C12N15/90 ,  A01K67/027

摘要： Provided is an approach for achieving the expansion of a human antibody repertoire in a human antibody-producing non-human animal. Provided is a mammalian artificial chromosome vector comprising a human immunoglobulin heavy chain locus in which a D-region of a human immunoglobulin heavy chain is modified, and a human immunoglobulin light chain locus, a mammalian cell or a non-human animal comprising this mammalian artificial chromosome vector, and a method for substituting a D-region of a human immunoglobulin heavy chain with a modified sequence thereof in the production of this artificial chromosome vector.

公开(公告)号：EP2402754B2

公开(公告)日：2023-07-26

申请号：EP11172812.7

申请日：2007-03-06

发明人： Schellenberger, Volker ,  Stemmer, Willem P. ,  Wang, Chia-wei ,  Scholle, Michael D. ,  Popkov, Mikhail ,  Gordon, Nathaniel C. ,  Crameri, Andreas

IPC分类号： G01N33/53 ,  G01N33/567 ,  C12N15/06

公开(公告)号：EP4092051A1

公开(公告)日：2022-11-23

申请号：EP20940651.1

申请日：2020-06-18

申请人： Shenzhen Mindray Bio-Medical Electronics Co., Ltd

发明人： YU, Lina ,  LI, Ke ,  HE, Jianwen

IPC分类号： C07K16/28 ,  C12N15/06 ,  C12N5/10 ,  A61K39/395

摘要： An anti-soluble CD14 subtype monoclonal antibody or an antigen-binding antibody fragment thereof specifically recognizes an epitope composed of the amino acid sequence of SEQ ID No. 84. A kit for detecting the soluble CD14 subtype, a method for detecting the soluble CD14 subtype and corresponding use.

公开(公告)号：EP3998280A1

公开(公告)日：2022-05-18

申请号：EP20837126.0

申请日：2020-07-03

申请人： TERUMO Kabushiki Kaisha

发明人： URA, Takehiro

IPC分类号： C07K16/00 ,  C12N5/16 ,  C12N15/06 ,  C12P21/08

摘要： [Problem] An object of the present invention is to provide a means that makes it possible to obtain an antibody that specifically binds to the conformational epitope of a protein antigen and to produce a variety of monoclonal antibodies with unique specificity even in the case of conducting a booster.
[Solution] A non-human animal (animal for immunization) is immunized by intradermal administration of a protein antigen, antibody-producing cells are obtained from a regional lymph node corresponding to the administration site for the above antigen in the immunized animal, and a monoclonal antibody is made by hybridoma technology as described above.

公开(公告)号：EP3837361A1

公开(公告)日：2021-06-23

申请号：EP19850555.4

申请日：2019-08-16

申请人： National Health Research Institutes

发明人： CHUANG, Huai-Chia ,  TAN, Tse-Hua

IPC分类号： C12N15/06 ,  C12N15/09 ,  C12N5/00 ,  C12Q1/00

公开(公告)号：EP3114222B1

公开(公告)日：2020-04-22

申请号：EP15757751.1

申请日：2015-03-03

申请人： Sigma-Aldrich Co. LLC

发明人： LIN, Nan ,  MASCARENHAS, Joaquina ,  CHANG, Audrey ,  ONIONS, David ,  GEORGE, Henry ,  KAYSER, Kevin

IPC分类号： C12N15/06 ,  C12N5/00 ,  C12N9/10 ,  C12N5/071

公开(公告)号：EP3114222A1

公开(公告)日：2017-01-11

申请号：EP15757751.1

申请日：2015-03-03

申请人： Sigma-Aldrich Co. LLC

发明人： LIN, Nan ,  MASCARENHAS, Joaquina ,  CHANG, Audrey ,  ONIONS, David ,  GEORGE, Henry ,  KAYSER, Kevin

IPC分类号： C12N15/06

CPC分类号： C12N5/0682 ,  C12N5/00 ,  C12N9/1051 ,  C12N2501/724 ,  C12N2510/02 ,  C12N2720/12011 ,  C12N2750/14311 ,  C12Y204/01101 ,  C12Y204/01144 ,  C12Y204/01155

摘要： The present invention provides mammalian cell lines that have been genetically engineered causing such cell lines to be resistant to viral entry and/or propagation, and provides methods of using said cell lines to reduce or prevent viral contamination of biologic production systems.

摘要翻译： 本发明提供已经进行遗传工程改造的哺乳动物细胞系，使得这种细胞系能够抵抗病毒进入和/或传播，并提供使用所述细胞系减少或防止生物制备系统的病毒污染的方法。

公开(公告)号：EP2402754B9

公开(公告)日：2015-03-11

申请号：EP11172812.7

申请日：2007-03-06

申请人： Amunix Operating Inc.

发明人： Schellenberger, Volker ,  Stemmer, Willem P. ,  Wang, Chia-wei ,  Scholle, Michael D. ,  Popkov, Mikhail ,  Gordon, Nathaniel C. ,  Crameri, Andreas

IPC分类号： G01N33/53 ,  G01N33/567 ,  C12N15/06

CPC分类号： C12N15/1037 ,  A61K38/16 ,  C12N15/1044

公开(公告)号：EP2172486B1

公开(公告)日：2014-11-05

申请号：EP09010591.7

申请日：1998-02-18

申请人： Universität Zürich

发明人： Korth, Carsten ,  Stierli, Beat ,  Moser, Markus ,  Streit, Peter ,  Oesch, Bruno

IPC分类号： C07K16/28 ,  C12N5/20 ,  G01N33/68 ,  G01N33/577 ,  A61K39/395 ,  C07K14/47 ,  C12N15/06

CPC分类号： C07K16/2872 ,  A61K38/00 ,  C07K14/47 ,  C07K2317/34

公开(公告)号：EP2158314B1

公开(公告)日：2013-12-18

申请号：EP09748006.5

申请日：2009-03-31

申请人： Universiti Putra Malaysia

发明人： B. CHE MAN, Yaakob ,  MUSTAFA, Shuhaimi ,  KHALID, Farihah Liyana ,  AZMI , Aida Azrina ,  SAZILI , Awis Qurni ,  ABDUL RAHIM, Raha

IPC分类号： C12N15/06 ,  C12N15/10

CPC分类号： C12Q1/6888 ,  C12Q2600/124

摘要： Pork-specific PCR assay is performed for Halal authentication, by detecting porcine DNA in food products. DNA from raw meat samples is extracted. The extracted DNA is tested using primers that react by amplifying pork DNA but not beef and chicken DNA. The real-time PCR assay is sensitive with a low detection limit when using samples that can be obtained from food products. The methods described herein can have a sensitivity threshold as low as 0.001 ng pork DNA or lower, whereas convention techniques typically do not have a detection limit lower than 0.1 ng pork DNA.