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公开(公告)号:JPWO2012036215A1
公开(公告)日:2014-02-03
申请号:JP2012534041
申请日:2011-09-14
Applicant: 独立行政法人科学技術振興機構
IPC: A61K31/7125 , A61K48/00 , A61P1/04 , A61P29/00 , A61P31/04 , A61P35/00 , A61P37/06 , A61P37/08 , C12N15/09 , C12Q1/68 , G01N33/15 , G01N33/50
CPC classification number: A61K31/7088 , A61K31/7125 , C12N15/113 , C12N15/117 , C12N2310/14 , C12N2310/17 , C12N2310/315 , G01N33/6875 , G01N2333/4703 , G01N2500/02
Abstract: ホスホロチオエートオリゴヌクレオチド及びその誘導体からなる群から選択される1種以上の化合物からなる、HMGBタンパクによって仲介される免疫応答の活性化の抑制剤、及び、被検物質の存在下及び非存在下で、HMGBタンパクと標識核酸とを混合する混合ステップと、標識核酸に結合したHMGBタンパクを定量する定量ステップと、被検物質の存在下で標識核酸に結合したHMGBタンパクの量が、被検物質の非存在下で標識核酸に結合したHMGBタンパクの量よりも少ない場合に、当該被検物質が、HMGBタンパクによって仲介される免疫応答の活性化の抑制剤であると判定し、被検物質の存在下で標識核酸に結合したHMGBタンパクの量が、被検物質の非存在下で標識核酸に結合したHMGBタンパクの量よりも多い場合に、当該被検物質が、HMGBタンパクによって仲介される免疫応答の活性化の促進剤であると判定する、判定ステップと、を含む、HMGBタンパクによって仲介される免疫応答の活性化の抑制剤又は促進剤のスクリーニング方法を提供する。
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公开(公告)号:JP2014016663A
公开(公告)日:2014-01-30
申请号:JP2012151695
申请日:2012-07-05
Applicant: Japan Science & Technology Agency , 独立行政法人科学技術振興機構
Inventor: SHOEMAKER JASON , KITANO HIROAKI , KAWAOKA YOSHIHIRO
IPC: G06F19/20
Abstract: PROBLEM TO BE SOLVED: To provide a cell type analyzing apparatus and method, and a program which enable data analysis using genes whose expression levels increase depending on cell types as cell type signatures.SOLUTION: A cell type analysis apparatus acquires a gene list including gene information, detects stored gene information that matches the gene information included in the acquired gene list, identifies a type of cell or tissue that corresponds to the gene list based on the detected gene information and stored cell information or tissue information, and outputs output information comprising cell information including the identified cell type and/or tissue information including the identified tissue type.
Abstract translation: 要解决的问题:提供一种细胞类型分析装置和方法,以及使用基于细胞类型的表达水平随着细胞类型特征而增加的基因进行数据分析的程序。解决方案:细胞型分析装置获取包含基因的基因列表 信息,检测与获取的基因列表中包含的基因信息相匹配的存储基因信息,基于检测到的基因信息和存储的细胞信息或组织信息来识别与基因列表相对应的细胞或组织的类型,并输出包含 包括所识别的细胞类型和/或组织信息的细胞信息,包括所鉴定的组织类型。
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公开(公告)号:JP5403537B2
公开(公告)日:2014-01-29
申请号:JP2009058729
申请日:2009-03-11
Applicant: 国立大学法人 東京大学 , 独立行政法人科学技術振興機構 , 新日鐵住金株式会社 , 新日鉄住金エンジニアリング株式会社 , 新日鉄住金化学株式会社
IPC: C08G64/34
CPC classification number: C08G64/34
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公开(公告)号:JP2014005158A
公开(公告)日:2014-01-16
申请号:JP2012139897
申请日:2012-06-21
Applicant: Japan Science & Technology Agency , 独立行政法人科学技術振興機構
Inventor: SUZAKI TOMOFUMI , HOSONO HIDEO , FUJIHASHI TADAHIRO , TODA YOSHITAKE
Abstract: PROBLEM TO BE SOLVED: To provide a producing method capable of producing a flat MgO(111) surface by a simple method, and a treatment plate having a flat MgO(111) surface.SOLUTION: In this method, a magnesium oxide thin film 3 is deposited on a substrate 2 by using a sintered body or single crystal of magnesium oxide as a target by a laser ablation method. This method produces the flat treatment film 3 which comprises magnesium oxide in which a (111) surface is a surface 3a, by using the substrate 2 which comprises strontium titanate in which the (111) surface is a principal surface 2a or yttria-stabilized zirconia in which the (111) surface is the principal surface 2a, and by directly depositing a film on the principal surface 2a of the substrate 2 and epitaxially growing it.
Abstract translation: 要解决的问题:提供一种能够通过简单的方法制备平坦的MgO(111)表面的制造方法和具有平坦的MgO(111)表面的处理板。方法:在该方法中,将氧化镁薄膜3 通过使用烧结体或氧化镁单晶作为靶,通过激光烧蚀法沉积在基板2上。 该方法通过使用包括其中(111)表面是主表面2a或氧化钇稳定的氧化锆的钛酸锶的基板2产生包括其中(111)表面为表面3a的氧化镁的平坦处理膜3 其中(111)表面是主表面2a,并且通过在基板2的主表面2a上直接沉积膜并外延生长它。
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公开(公告)号:JP5379973B2
公开(公告)日:2013-12-25
申请号:JP2007513224
申请日:2005-05-06
Applicant: ザ リージェンツ オブ ザ ユニバーシティ オブ カリフォルニア , 独立行政法人科学技術振興機構
Inventor: アーパン・チャクラボーティ , ベンジャミン・エー・ハスケル , ステーシア・ケラー , ジェームス・エス・スペック , スティーブン・ピー・デンバース , 修二 中村 , ウメシュ・ケー・ミシュラ
IPC: H01L33/32 , H01L21/205 , H01L29/15 , H01L29/20 , H01L31/0312 , H01L33/00 , H01S5/02 , H01S5/343
CPC classification number: H01S5/34333 , B82Y20/00 , H01L21/02389 , H01L21/0243 , H01L21/02433 , H01L21/02458 , H01L21/02502 , H01L21/0254 , H01L21/0262 , H01L29/2003 , H01L33/0075 , H01S5/0213 , H01S2304/04 , H01S2304/12
Abstract: A method for the fabrication of nonpolar indium gallium nitride (InGaN) films as well as nonpolar InGaN-containing device structures using metalorganic chemical vapor deposition (MOVCD). The method is used to fabricate nonpolar InGaN/GaN violet and near-ultraviolet light emitting diodes and laser diodes.
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公开(公告)号:JP5371021B2
公开(公告)日:2013-12-18
申请号:JP2006024415
申请日:2006-02-01
Applicant: 独立行政法人科学技術振興機構 , 日本電気株式会社
IPC: C01B31/02
Abstract: PROBLEM TO BE SOLVED: To provide a carbon nanohorn composite which can prevent corrosion or elution of an included metal, an included its oxide or the like even under an acidic condition or in an organic solvent and maintains electrical conductivity, and whose surface is not oxidized; and to provide a method for producing the same. SOLUTION: A small size opening is formed in each carbon nanohorn, and a metal, an oxide, a functional molecule, or the like is included in the carbon nanohorn. Thereafter, the opening is closed by a heat treatment in vacuum or an inert gas. Thereby, the included substance is shielded from external environment by the carbon nanohorn and stably exists in the carbon nanohorn. COPYRIGHT: (C)2007,JPO&INPIT
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公开(公告)号:JP5368284B2
公开(公告)日:2013-12-18
申请号:JP2009280652
申请日:2009-12-10
Applicant: 独立行政法人科学技術振興機構
IPC: G01N33/53 , G01N21/27 , G01N21/78 , G01N33/543 , G01N33/553
Abstract: PROBLEM TO BE SOLVED: To provide a reagent for detecting amyloid aggregate capable of rapidly detecting the amyloid aggregate having cytotoxity containing a soluble oligomer, and a method for detecting the amyloid aggregate. SOLUTION: The reagent for detecting the amyloid aggregate comprises metal colloid carrying an antibody which recognizes an amyloid monomer. COPYRIGHT: (C)2011,JPO&INPIT
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公开(公告)号:JP5357883B2
公开(公告)日:2013-12-04
申请号:JP2010525700
申请日:2009-08-19
Applicant: 独立行政法人科学技術振興機構
CPC classification number: C12P19/34 , C07H19/067 , C07H19/10 , C07H19/20 , C07H23/00
Abstract: Disclosed is a method for preparing a nuclease-resistant nucleic acid, which comprises the steps of mixing a nucleic acid composed of at least three nucleotides, a terminal deoxynucleotide transferase and a 2',4'-crosslinked nucleoside triphosphate with one another and incubating the resulting mixture. Examples of the 2',4'-crosslinked nucleoside triphosphate to be used in the method include 5-methyl-2'-O,4'-C-(methyleneoxy- methylene)uridine-5'-triphosphate, 5-methyl-2'-O,4'-C- (aminomethylene)uridine-5'-triphosphate and 5-methyl-2'-O,4'-C-(benzyloxymethylene)uridine-5'- triphosphate. According to the method, it becomes possible to impart excellent nuclease resistance to an existing functional nucleic acid afterward in a simple manner.
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公开(公告)号:JP5352892B2
公开(公告)日:2013-11-27
申请号:JP2008041827
申请日:2008-02-22
Applicant: 独立行政法人国立高等専門学校機構 , 独立行政法人科学技術振興機構
Abstract: PROBLEM TO BE SOLVED: To suppress chattering vibration of a grinding tool and to process the surface of a workpiece into a high quality mirror surface. SOLUTION: Using a grinding tool 5 having a body 51 with a plurality of abrasive particles 52 fixed thereon, the respective abrasive particles 52 are truncated so that the height of the cutting edges is aligned to form flat parts 52b. Next, the truncated grinding tool 5 is relatively moved along the workpiece surface 8a at a predetermined cut depth by rotating and ultrasonically vibrating the grinding tool 5 to grind the workpiece surface 8a by the edge parts 52c of the flat parts 52b of the abrasive particles 52. Simultaneously, a finish processing is performed on the workpiece surface 8a by squeezing the workpiece surface 8a by the flat parts 52b. COPYRIGHT: (C)2009,JPO&INPIT
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公开(公告)号:JP5352236B2
公开(公告)日:2013-11-27
申请号:JP2008543156
申请日:2007-11-12
Applicant: 独立行政法人科学技術振興機構 , 株式会社 東北テクノアーチ , 株式会社ナノキャスト
CPC classification number: B01F13/0809 , C21C1/06 , C21C5/5247 , C22B9/003 , F27D27/00 , Y02P10/253
Abstract: An object is to provide an electromagnetic stirrer that can provide an excellent stirring force more than before. An electromagnetic stirrer has a vertical electromagnetic field generating coil (1) vertically and circumferentially provided on the outer side of a container (5), and a rotational electromagnetic field generating coil (2) provided on the outer side of the vertical electromagnetic field generating coil (1), in which an iron core (3) is inserted between the vertical electromagnetic field generating coils (1) and between the rotational electromagnetic field generating coils (2), the iron core (3) being formed of a magnetic material with magnetic isotropy and having comb teeth 3a extended to the inner surface of the vertical electromagnetic field generating coil (1).
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