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公开(公告)号：JPH09281109A
公开(公告)日：1997-10-31
申请号：JP23216596
申请日：1996-09-02
申请人： NPS PHARMA INC
IPC分类号： G01N33/15 , A61K20060101 , A61K31/13 , A61K31/135 , A61K31/14 , A61K31/16 , A61K31/165 , A61K31/235 , A61K31/275 , A61K31/395 , A61K31/40 , A61K31/403 , A61K31/404 , A61K31/44 , A61K31/55 , A61K31/554 , A61K31/715 , A61K31/785 , A61K33/06 , A61K38/00 , A61K38/16 , A61K45/00 , A61P3/00 , A61P3/14 , A61P5/18 , A61P5/22 , A61P9/00 , A61P9/12 , A61P19/08 , A61P19/10 , A61P43/00 , C07C211/02 , C07C211/03 , C07C211/15 , C07C211/16 , C07C211/17 , C07C211/19 , C07C211/26 , C07C211/27 , C07C211/29 , C07C211/30 , C07C211/42 , C07C215/46 , C07C215/48 , C07C215/50 , C07C215/52 , C07C217/54 , C07C217/56 , C07C217/58 , C07C217/60 , C07C219/14 , C07C225/16 , C07C229/38 , C07C233/05 , C07C235/34 , C07C235/44 , C07C237/22 , C07C237/30 , C07C255/24 , C07C255/45 , C07C255/58 , C07C279/14 , C07C323/18 , C07C323/32 , C07D209/14 , C07D209/16 , C07D209/18 , C07D209/30 , C07D209/40 , C07D211/90 , C07D213/28 , C07D213/36 , C07D213/38 , C07D215/12 , C07D215/14 , C07D233/54 , C07D257/02 , C07D281/10 , C07D295/00 , C07D413/04 , C07H21/00 , C07K5/00 , C07K7/00 , C07K14/435 , C07K14/705 , C08G69/10 , C12N5/10 , C12N15/09 , C12N15/12 , C12Q1/02 , C12R1/91 , G01N20060101 , G01N33/50 , G01N33/566 , G01N33/567 , G01N33/574 , G01N33/68 , G01N33/84
摘要： PROBLEM TO BE SOLVED: To provide a screening method of a calcium receptor activation compound. SOLUTION: The method for screening a compound which can produce an effect on the activity of a calcium receptor, by using a recombinant cell making a functional calcium receptor expressed. This method comprises processes of providing the cell with the compound and measuring the capacity of the compound producing the effect on one or more activities of the calcium receptor, and the recombinant cell contains a heterogenous nucleic acid making the functional calcium receptor expressed.
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公开(公告)号：JPH06503229A
公开(公告)日：1994-04-14
申请号：JP50820592
申请日：1992-02-27
申请人： FMC CORP , NPS PHARMA INC
IPC分类号： A01H5/00 , A01N37/18 , A01N63/00 , A01N63/02 , C07K1/22 , C07K14/00 , C07K14/435 , C07K16/00 , C12N1/21 , C12N5/10 , C12N15/09 , C12N15/82 , C12N15/866 , C12P21/02 , C12P21/08 , C12Q1/68 , C12R1/92 , G01N33/53 , C07K7/10 , C12N15/12
摘要： The invention provides insecticidally effective peptides isolatable from Diguetia spider venom, methods for preparing and using insecticides, and DNA encoding such insecticidally effective peptides.
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公开(公告)号：JPH09173084A
公开(公告)日：1997-07-08
申请号：JP30880696
申请日：1996-11-20
申请人： FMC CORP , NPS PHARMA INC
IPC分类号： A01H5/00 , A01N37/18 , A01N63/00 , A01N63/02 , C07K1/22 , C07K14/00 , C07K14/435 , C07K16/00 , C12N1/21 , C12N5/10 , C12N15/09 , C12N15/82 , C12N15/866 , C12P21/02 , C12P21/08 , C12Q1/68 , C12R1/92 , G01N33/53
摘要： The invention provides insecticidally effective peptides isolatable from Diguetia spider venom, methods for preparing and using insecticides, and DNA encoding such insecticidally effective peptides.
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公开(公告)号：JP2591705B2
公开(公告)日：1997-03-19
申请号：JP50820592
申请日：1992-02-27
申请人： FMC CORP , NPS PHARMA INC
IPC分类号： A01H5/00 , A01N37/18 , A01N63/00 , A01N63/02 , C07K1/22 , C07K14/00 , C07K14/435 , C07K16/00 , C12N1/21 , C12N5/10 , C12N15/09 , C12N15/82 , C12N15/866 , C12P21/02 , C12P21/08 , C12Q1/68 , C12R1/92 , G01N33/53 , C12N7/01
摘要： The invention provides insecticidally effective peptides isolatable from Diguetia spider venom, methods for preparing and using insecticides, and DNA encoding such insecticidally effective peptides.
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公开(公告)号：JPH09173066A
公开(公告)日：1997-07-08
申请号：JP27312096
申请日：1996-10-16
申请人： FMC CORP , NPS PHARMA INC
发明人： KAREN JIYOON KURAPUCHIYO , JIYON RANDORUFU HANTAA JIYAKUS , JIYANISU HEREN JIYONSON , ERITSUKU JIYOOJI DERUMAA
IPC分类号： A01H5/00 , A01N37/20 , A01N37/44 , A01N37/46 , A01N63/00 , A01N63/02 , C07K1/20 , C07K14/00 , C07K14/435 , C07K16/00 , C07K16/18 , C12N1/21 , C12N5/10 , C12N15/09 , C12N15/82 , C12P21/02 , C12R1/19
摘要： This invention provides a family of insecticidally effective peptides which may be isolated from Tegenaria spider venom, DNA encoding such insecticidally effective peptides and methods for controlling invertebrate pests.
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公开(公告)号：JPH07267989A
公开(公告)日：1995-10-17
申请号：JP34067094
申请日：1994-12-21
申请人： FMC CORP , NPS PHARMA INC
IPC分类号： A01H5/00 , A01N37/18 , A01N63/00 , A01N63/02 , C07K1/22 , C07K14/00 , C07K14/435 , C07K16/00 , C12N1/21 , C12N5/10 , C12N15/09 , C12N15/82 , C12N15/866 , C12P21/02 , C12P21/08 , C12Q1/68 , C12R1/92 , G01N33/53
摘要： The invention provides insecticidally effective peptides isolatable from Diguetia spider venom, methods for preparing and using insecticides, and DNA encoding such insecticidally effective peptides.
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公开(公告)号：JP2805448B2
公开(公告)日：1998-09-30
申请号：JP34067094
申请日：1994-12-21
申请人： FMC CORP , NPS PHARMA INC
IPC分类号： A01H5/00 , A01N37/18 , A01N63/00 , A01N63/02 , C07K1/22 , C07K14/00 , C07K14/435 , C07K16/00 , C12N1/21 , C12N5/10 , C12N15/09 , C12N15/82 , C12N15/866 , C12P21/02 , C12P21/08 , C12Q1/68 , C12R1/92 , G01N33/53
摘要： The invention provides insecticidally effective peptides isolatable from Diguetia spider venom, methods for preparing and using insecticides, and DNA encoding such insecticidally effective peptides.
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公开(公告)号：JPH09328420A
公开(公告)日：1997-12-22
申请号：JP23213096
申请日：1996-09-02
申请人： NPS PHARMA INC
IPC分类号： G01N33/15 , A61K20060101 , A61K31/13 , A61K31/135 , A61K31/14 , A61K31/16 , A61K31/165 , A61K31/235 , A61K31/275 , A61K31/395 , A61K31/40 , A61K31/403 , A61K31/404 , A61K31/44 , A61K31/55 , A61K31/554 , A61K31/715 , A61K31/785 , A61K33/06 , A61K38/00 , A61K38/16 , A61K45/00 , A61P3/00 , A61P3/14 , A61P5/18 , A61P5/22 , A61P9/00 , A61P9/12 , A61P19/08 , A61P19/10 , A61P43/00 , C07C211/02 , C07C211/03 , C07C211/15 , C07C211/16 , C07C211/17 , C07C211/19 , C07C211/26 , C07C211/27 , C07C211/29 , C07C211/30 , C07C211/42 , C07C215/46 , C07C215/48 , C07C215/50 , C07C215/52 , C07C217/54 , C07C217/56 , C07C217/58 , C07C217/60 , C07C219/14 , C07C225/16 , C07C229/38 , C07C233/05 , C07C235/34 , C07C235/44 , C07C237/22 , C07C237/30 , C07C255/24 , C07C255/45 , C07C255/58 , C07C279/14 , C07C323/18 , C07C323/32 , C07D209/14 , C07D209/16 , C07D209/18 , C07D209/30 , C07D209/40 , C07D211/90 , C07D213/28 , C07D213/36 , C07D213/38 , C07D215/12 , C07D215/14 , C07D233/54 , C07D257/02 , C07D281/10 , C07D295/00 , C07D413/04 , C07H21/00 , C07K5/00 , C07K7/00 , C07K14/435 , C07K14/705 , C08G69/10 , C12N5/10 , C12N15/09 , C12N15/12 , C12Q1/02 , C12R1/91 , G01N20060101 , G01N33/50 , G01N33/566 , G01N33/567 , G01N33/574 , G01N33/68 , G01N33/84
摘要： PROBLEM TO BE SOLVED: To obtain a calcium receptor-active composition effective against primary and secondary hyperparathyroidism, Behcet disease, maligant hypercalcemia, osteoporosis, etc., by using a specific amine derivative as an active ingredient. SOLUTION: This calcium receptor active composition comprises a compound of formula I [X is H, an alkyl, an alkoxy, etc.; Ar is phenyl, 2-pyridyl, benzyl, etc.; R is H, methyl, ethyl, etc.; Y is CH, etc.; Z is O, S, etc,; (m) is 0-5] or its pharmaceutically permissible acid addition salt or complex and a pharmaceutically permissible carrier. The compound of formula I is preferably a compound of formula II (Alk is an alkylene; R1 is an alkyl; R2 and R3 are each an alkyl, an alkoxy, etc.). NPS R-467, i.e., (R)-N-(3-phenylpropyl)-1-(3-methoxyphenyl) ethylamine, etc., are especially cited as the compound of formula I.
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