公开(公告)号：JP2005272474A

公开(公告)日：2005-10-06

申请号：JP2005124034

申请日：2005-04-21

申请人： Eisai Co Ltd ,  エーザイ株式会社

发明人： FUNABASHI YASUHIRO ,  TSURUOKA AKIHIKO ,  MATSUKURA MASAYUKI ,  HANEDA TORU ,  FUKUDA YOSHIO ,  KAMATA JUNICHI ,  TAKAHASHI KEIKO ,  MATSUSHIMA TOMOHIRO ,  MIYAZAKI KAZUSHIRO ,  NOMOTO KENICHI ,  WATANABE TATSUO ,  OHAISHI HIROSHI ,  YAMAGUCHI ATSUYOSHI ,  SUZUKI SACHI ,  NAKAMURA KATSUJI ,  MIMURA FUSAYO ,  YAMAMOTO HIROYUKI ,  MATSUI JUNJI ,  MATSUI KENJI ,  YOSHIBA TAKAKO ,  SUZUKI YASUYUKI ,  ARIMOTO TATSU

IPC分类号： C07D239/34 ,  A61K20060101 ,  A61K31/4355 ,  A61K31/437 ,  A61K31/4375 ,  A61K31/4409 ,  A61K31/4418 ,  A61K31/4545 ,  A61K31/455 ,  A61K31/47 ,  A61K31/4709 ,  A61K31/496 ,  A61K31/505 ,  A61K31/519 ,  A61K31/5377 ,  A61P20060101 ,  A61P3/10 ,  A61P9/00 ,  A61P9/10 ,  A61P17/06 ,  A61P19/02 ,  A61P27/02 ,  A61P29/00 ,  A61P35/00 ,  A61P35/04 ,  A61P43/00 ,  C07D20060101 ,  C07D207/34 ,  C07D213/26 ,  C07D213/68 ,  C07D213/73 ,  C07D213/74 ,  C07D213/75 ,  C07D213/81 ,  C07D213/82 ,  C07D215/18 ,  C07D215/22 ,  C07D215/233 ,  C07D215/36 ,  C07D215/38 ,  C07D215/48 ,  C07D239/42 ,  C07D239/46 ,  C07D239/88 ,  C07D249/04 ,  C07D261/14 ,  C07D277/48 ,  C07D307/68 ,  C07D319/06 ,  C07D401/04 ,  C07D401/12 ,  C07D401/14 ,  C07D405/12 ,  C07D405/14 ,  C07D409/12 ,  C07D413/12 ,  C07D417/12 ,  C07D417/14 ,  C07D471/04 ,  C07D487/04 ,  C07D491/04 ,  C07D491/048 ,  C07D495/04

CPC分类号： C07D213/73 ,  A61K31/4706 ,  A61K31/4745 ,  A61K31/517 ,  A61K31/519 ,  C07D207/34 ,  C07D213/26 ,  C07D213/68 ,  C07D213/74 ,  C07D213/75 ,  C07D213/81 ,  C07D213/82 ,  C07D215/18 ,  C07D215/233 ,  C07D215/36 ,  C07D215/38 ,  C07D215/48 ,  C07D239/34 ,  C07D239/42 ,  C07D239/47 ,  C07D239/88 ,  C07D249/04 ,  C07D261/14 ,  C07D277/48 ,  C07D307/68 ,  C07D319/06 ,  C07D401/04 ,  C07D401/12 ,  C07D401/14 ,  C07D405/12 ,  C07D405/14 ,  C07D409/12 ,  C07D413/12 ,  C07D417/12 ,  C07D417/14 ,  C07D471/04 ,  C07D487/04 ,  C07D491/04 ,  C07D495/04

摘要： PROBLEM TO BE SOLVED: To provide a new compound effective for prevention and therapy of various diseases caused by aberrant growth of vascularization. SOLUTION: The compound represented by general formula (I), or its salt or hydrate äwherein, A g is a (substituted) 5- to 14-membered heterocyclic group or the like; X g is O, S or the like; Y g is a (substituted) 6-14C aryl, a 5- to 14-membered heterocyclic group or the like; and T g1 is a group represented by formula 1, or the like, [wherein, E g is a single bond or N(R g2 ) or the like; R g1 and R g2 are each independently H or a (substituted) 1-6C alkyl or the like; and Z g is a 1-8C alkyl, a 3-8C alicyclic hydrocarbon, a 6-14C aryl or the like]} is provided. COPYRIGHT: (C)2006,JPO&NCIPI

摘要翻译： 要解决的问题：提供一种有效预防和治疗由血管形成异常生长引起的各种疾病的新化合物。 解决方案：由通式（I）表示的化合物或其盐或水合物，其中A为取代的5至14元杂环基等; X g 是O，S等; （取代的）6-14C芳基，5至14元杂环基等; 并且T g1 是由式1等表示的基团，[其中，E g 是单键或N（R g2 ）等; R g1 和R g2 各自独立地为H或（取代的）1-6C烷基等; 并且Z g 是1-8C烷基，3-8C脂环族烃，6-14C芳基等〕。 版权所有（C）2006，JPO＆NCIPI

公开(公告)号：JP2001161376A

公开(公告)日：2001-06-19

申请号：JP2000263266

申请日：2000-08-28

申请人： EISAI CO LTD ,  NAT INST OF ADVANCED IND SCIEN

发明人： TSUKAHARA KATSUHEI ,  WATANABE TATSUO ,  YOKOO TAKEHIKO ,  CHIKAMI YOSHIFUMI

IPC分类号： C12N15/09 ,  C07K14/00 ,  C07K14/39 ,  C12N1/00 ,  C12N1/15 ,  C12N1/19 ,  C12N1/21 ,  C12N5/10 ,  C12N9/10 ,  C12P21/02 ,  C12R1/645

摘要： PROBLEM TO BE SOLVED: To provide a method for specifying a gene encoding a glycosyltransferase derived from a fission yeast, and a method for producing an extraneous protein having less added sugar chains using a fission yeast in which the function of the gene was lost. SOLUTION: The finding that och1+ having a specific base sequence derived from a fission yeast Schizosaccharomyces pombe is homologous to a glycosyltransferase of a budding yeast permits producing a protein in which a high mannose-type sugar chain was not added using a fission yeast in which the function of the gene was lost, i.e., och+-destroyed strain.

公开(公告)号：JPH0539256A

公开(公告)日：1993-02-19

申请号：JP19968791

申请日：1991-08-09

申请人： EISAI CO LTD

发明人： YOSHINO HIROSHI ,  UEDA NORIHIRO ,  SUGUMI HIROYUKI ,  NIIJIMA ATSUSHI ,  KOTAKE YOSHIHIKO ,  OKADA TOSHIMI ,  KOYANAGI NOZOMI ,  WATANABE TATSUO ,  ASADA MAKOTO ,  YOSHIMATSU KENTARO ,  IIJIMA ATSUYOSHI ,  NAGASU TAKESHI ,  TSUKAHARA KATSUHIRA ,  KITO KYOSUKE

IPC分类号： A61K31/44 ,  A61K31/4402 ,  A61K31/4406 ,  A61K31/4409 ,  A61K31/4418 ,  A61P35/00 ,  C07C311/44 ,  C07D213/74 ,  C07D213/76 ,  C07D213/82 ,  C07D239/48 ,  C07D307/68 ,  C07D333/38

摘要： PURPOSE:To obtain a new sulfonamide derivative having excellent antitumor activity and low toxicity. CONSTITUTION:A compound shown by formula I [R is H, halogen, alkyl, alkoxy, OH, NO2, phenoxy, CN, acetyl or (protected)amino; R and R are H, halogen, alkyl or alkoxy; R and R are H or alkyl; R and R are H, halogen, alkoxy or (substituted)amino; A is N or CH; B is N or CR (R is H or alkyl); E is C(=Q)-R (Q is O or S; R is H, alkyl, NH2, alkoxy, 2-thienyl, 2-furyl, etc.) or aromatic 6-membered ring group which may contain 1-3 substituent groups] or a pharmaceutically permissible salt thereof such as N-(2-anilino-3- pyridyl)-p-toluenesulfonamide. The compound is obtained by reacting a sulfonic acid shown by formula II or a reactive derivative thereof with a compound shown by formula III and optionally eliminating a protecting group.

公开(公告)号：JP2002355078A

公开(公告)日：2002-12-10

申请号：JP2002057753

申请日：2002-03-04

申请人： EISAI CO LTD

发明人： YAMAMOTO HIROYUKI ,  FUNABASHI YASUHIRO ,  NOMOTO KENICHI ,  WATANABE TATSUO

IPC分类号： G01N33/50 ,  A61K45/00 ,  A61P35/00 ,  C12N5/10 ,  C12N15/09 ,  C12Q1/02 ,  C12R1/91 ,  G01N33/15

摘要： PROBLEM TO BE SOLVED: To provide a cell useful for inspecting the effect of a neovascular factor. SOLUTION: The cell which has obtained hematogenous metastasis, lymphogenous metastasis, dissemination, cancerous ascites or pleuritis, cancerous cachexia and a shortened host life time caused thereby is produced by introducing a gene of a neovascular factor into a human or animal cell having low neovascular induction potency and selecting a cell highly expressing the neovascular factor. By using the cell strain, neovascular inhibitors and carcinostatic agents can be screened.

公开(公告)号：JPH0344313A

公开(公告)日：1991-02-26

申请号：JP17899089

申请日：1989-07-13

申请人： EISAI CO LTD

发明人： TACHIBANA SHINRO ,  MORITA YUTAKA ,  WATANABE TATSUO ,  UCHIYAMA YASUO

IPC分类号： A61K8/00 ,  A61K8/64 ,  A61Q5/00 ,  A61Q7/00

摘要： PURPOSE:To obtain a hair growing agent containing a caloitonin generelated peptide. CONSTITUTION:Raw materials (e.g. animal or vegetable oil, mineral oil, ester oil, wax, alcohol and water) for hair growing agent are blended with 0.0005-2.0w/w% calcitonin gene-related peptide, a kind of peptide hormone in a vertebrate. Further the blend is optionally mixed with a medicinal component, a keratin solubilizer, a humectant, a germicide, a cell activator, vitamins, an antiseptic, a stabilizer, perfume, etc., to give the objective substance. The substance is prepared into a dosage form such as hair tonic, hair lotion, hair cream, aerosol or foam type. When the calcitonin gene-related peptide is administered to blood capillary, hair root is sufficiently provided with nutrition by vasodilatory action and blood stream promoting action to show hair growing effect.

公开(公告)号：JPH0881441A

公开(公告)日：1996-03-26

申请号：JP17464394

申请日：1994-07-26

申请人： EISAI CO LTD

发明人： YOSHINO HIROSHI ,  UEDA NORIHIRO ,  NIIJIMA ATSUSHI ,  HANEDA TORU ,  KOTAKE YOSHIHIKO ,  YOSHIMATSU KENTARO ,  WATANABE TATSUO ,  NAGASU TAKESHI ,  TSUKAHARA NAOKO ,  KOYANAGI NOZOMI ,  KITO KYOSUKE

IPC分类号： C07D243/38 ,  A61K31/395 ,  A61K31/40 ,  A61K31/403 ,  A61K31/435 ,  A61K31/47 ,  A61K31/473 ,  A61K31/495 ,  A61K31/498 ,  A61K31/535 ,  A61K31/536 ,  A61K31/538 ,  A61K31/54 ,  A61K31/5415 ,  A61K31/542 ,  A61K31/55 ,  A61K31/553 ,  A61K31/554 ,  A61P35/00 ,  C07D209/88 ,  C07D219/08 ,  C07D221/12 ,  C07D223/26 ,  C07D223/28 ,  C07D241/46 ,  C07D265/38 ,  C07D267/18 ,  C07D267/20 ,  C07D279/18 ,  C07D279/20 ,  C07D279/22 ,  C07D281/14 ,  C07D285/20 ,  C07D285/36 ,  C07D285/38 ,  C07D498/04 ,  C07D513/04

摘要： PURPOSE: To obtain a heterocyclic ring-containing tricyclic sulfonamide which is represented by a specific formula and has an excellent antitumor activity with low toxicity. CONSTITUTION: The compound of formula I G is an aromatic 5- or 6-membered ring which may be mono- or disubstituted; L is-N(R )-(R is H, a lower alkyl), O; M is a tricyclic structure of formula II-formula V [ring A and ring B are (substituted) unsaturated 5- or 6-membered ring; X is-N(R )- (R is H, a lower alkyl), -NHCO-; Y is O,-S(O)n - (n is 0, 1, 2)] }, for example, 4-methoxy-N-(10H- phenothiazin-1-yl)benzenesulfonamide. It is preferred that this compound is obtained by reaction of a sulfonic acid (or its reactive derivative) of Gb-SO3 H (Gb is G which may be protected) with H-L-Ma (M a is M which may be protected), when desired, followed by deprotection of the product.