摘要:
PROBLEM TO BE SOLVED: To provide a pharmaceutical agent for oral administration comprising active ingredient belonging to the family of substituted benzhydrylpiperazines and at least one kind of cyclodextrin. SOLUTION: The pharmaceutical composition contains a mixture comprising an active substance belonging to the family of substituted benzhydrylpiperazines, an optically active isomer thereof or a pharmaceutically permissible salt thereof, and at least one kind of cyclodextrin, wherein the mixture contains no inclusion complex. COPYRIGHT: (C)2007,JPO&INPIT
摘要:
PROBLEM TO BE SOLVED: To provide a 1,4-disubstituted piperazine derivative of high optical purity having valuable pharmacological activity, particularly antihistaminic activity, and to provide an intermediate for producing the above derivative. SOLUTION: This 1,4-disubstituted piperazine derivative is obtained by reaction under heating of an enantiomer of 1-[(4-chlorophenyl)]piperazine with a halide of the formula: RX [R is methyl, (3-methylphenyl)methyl or the like; and X is a halogen atom]. The other objective method for producing the above derivative is provided as described above.
摘要:
PURPOSE: To provide a resist having submicron resolution equal or superior to a multilayer resist system by selecting a phenolic polymer composition of the resist from mixtures of phenolic polymers or mixtures of a phenolic polymer(s) and another aromatic polymer(s). CONSTITUTION: In the production of this resist, a wide variety of polymers can be used, however, a phenolic polymer selected from among the following polymers and polymer mixtures is preferably used: (1) a condensation product of phenol, naphthol or any one of their derivatives, whose ring(s) is substituted by an alkyl or aryl group(s) or a halogen atom(s) and an aliphatic or aromatic aldehyde optionally substituted by a halogen atom(s); (2) poly(vinylphenol) having phenol groups each optionally substituted by an alkyl or aryl group(s) or a halogen atom(s); (3) a copolymer of vinylphenol and an ethylenically unsaturated compound; and (4) mixtures of plural polymers selected from the above polymers or mixtures of a polymer(s) selected from the above polymers and another aromatic polymer(s) such as polystyrene or poly(N-vinylcarbazole). Thus, high resolution and a high aspect ratio of the resist can be realized.
摘要:
PURPOSE: To ensure high resolution and high selectivity ratio only by etching with oxygen plasma by incorporating a radiation sensitive resin and an acid generating material. CONSTITUTION: A quinonediazido radiation sensitive resin such as a condensation product of a quinonediazido compd. and an alkali-soluble resin or a mixture of a quinonediazido compd. with an alkali-soluble resin and a material (acid generating material) which generates an acid when irradiated are incorporated. The acid generating material generates an org. acid such as sulfonic acid, phosphoric acid or iodic acid when irradiated with UV, far UV, X-rays or other radiation. The absorption reaction of a silicon compd. in the irradiated part of the resultant compsn. is selectively accelerated and a high precision image can be formed by etching with high resolution, high selectivity ratio and satisfactory reproducibility.