利索-全球专利检索

  1. 登录
  2. 注册

搜索结果

64 条记录 (耗时 0.015 秒)

    ANTITHROMBOTIC MEDICINE
    2.
    发明专利
    ANTITHROMBOTIC MEDICINE 失效

    公开(公告)号：JPH07149643A

    公开(公告)日：1995-06-13

    申请号：JP22385594

    申请日：1994-09-20

    申请人： TANABE SEIYAKU CO

    发明人： IWASAKI TAMEO ,  NISHITANI TAKASHI ,  OTANI AKIO ,  INAMASU MASANORI

    IPC分类号： C07D401/06 ,  A61K31/40 ,  A61K31/44 ,  A61K31/4427 ,  A61K31/535 ,  A61P7/02 ,  A61P9/00 ,  A61P9/10 ,  C07D207/02 ,  C07D207/46 ,  C07D207/50

    摘要： PURPOSE:To obtain an antithrombotic medicine exhibiting excellent antithrombotic action and capable of using as a medicine for preventing and treating vascular diseases such as cardiac infarction and diabetic complication. CONSTITUTION:This antithrombotic medicine contains a 2,5-pyrrolidine-dione derivative of the formula (ring A is a trialkoxyphenyl; R is a substitutive alkyl, a substitutive alkoxy, a substitutive amino or pyridinylcarbonyl) or its pharmacologically permissible salt, e.g. (3E,4E)-1-methyl-3-benzylidene-4-(3,4,5- trimethoxybenzylidene)-2,5-pyrrolidinedione as an active ingredient. The compound has excellent PA activity promoting action and PAT-1 activity inhibiting action and exhibits excellent antithrombotic action even in either of oral administration and parental administration. The dose of the compound is preferably 0.5-50mg/kg.day in oral administration and preferably 0.05-5mg/kg.day in parental administration. The antithrombotic medicine can be used also as a medicine for preventing reobstruction after percutaneous coronary artery forming operation or after thrombolytic therapy or a medicine for preventing and treating arteriosclerosis.

    OPTICALLY ACTIVE COMPOUND AND ITS PRODUCTION
    3.
    发明专利
    OPTICALLY ACTIVE COMPOUND AND ITS PRODUCTION 失效

    公开(公告)号：JPH0665134A

    公开(公告)日：1994-03-08

    申请号：JP21767192

    申请日：1992-08-17

    申请人： DAICEL CHEM

    发明人： TODA FUMIO

    IPC分类号： C07C49/747 ,  C07D207/02 ,  C07D209/66 ,  C07D307/92 ,  C07D335/08

    摘要： PURPOSE:To obtain an optically active compound, useful as a new optical record ing material or a reagent, etc., for optical resolution and having a new succinimide skeleton etc. CONSTITUTION:The objective optically active compound is expressed by formula I [X is =CH2, O, S or =NR (R is H or alkyl); A is aromatic group; Y is H or substituent group], e.g. a compound expressed by formula II. This optically active compound expressed by formula I is obtained by irradiating a new optically active precursor expressed by formula III with light. This optically active precursor expressed by formula III is obtained by adding acetic acid or an optically active compound to a racemic modification of a compound having the structure expressed by formula III.

    NEW FULGIMIDE DERIVATIVE
    4.
    发明专利
    NEW FULGIMIDE DERIVATIVE 失效

    公开(公告)号：JPH03178961A

    公开(公告)日：1991-08-02

    申请号：JP24666390

    申请日：1990-09-17

    申请人： WAKO PURE CHEM IND LTD

    发明人： IWAMOTO OSAMU ,  HARA TAIZO ,  SUGIYAMA HARUHIKO

    IPC分类号： C07D403/06 ,  C07D207/02 ,  C07D405/06 ,  C07D409/06 ,  C07D413/06 ,  C07D417/06 ,  C07D421/06 ,  C08F20/34 ,  C08F20/52 ,  C08F36/02 ,  C08F36/04 ,  C08F220/36 ,  C08F220/60 ,  C09K9/02

    摘要： NEW MATERIAL:A fulgimide derivative shown by formula I [R , R and R are H, halogen alkyl, alkoxy, cycloalkyl, aryl, aralkyl or aryloxy or R and R are mutually bonded to form cyclic group such as adamanthyl or norbornyl; R is group shown by formula II, formula II, formula VI, etc., (R ' is H, halogen, alkyl, etc.; R ' to R ' are H, alkyl, alkoxy etc.; S is O, S, etc.); X is bifunctional organic residue; R is group shown by formula V, etc., (R' is H or alkyl)]. EXAMPLE:N-(4-Acryloyloxyphenyl)-2-[(E)-1-(2,5-dimehyl-3-furyl)ethylide ne]-3- isopropylidenesuccinimide. USE:Having photochromic action and useful as a recording material, copying material, printing photosensitizer, etc. PREPARATION:For example, a compound shown by formula VI is reacted with a compound shown by formula VII to give a compound shown by formula I.