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    Selective sequential polyacylation and device therefor
    2.
    发明专利
    Selective sequential polyacylation and device therefor 审中-公开
    选择性的顺式聚乙烯和其设备

    公开(公告)号：JP2007291096A

    公开(公告)日：2007-11-08

    申请号：JP2007096927

    申请日：2007-04-02

    申请人： National Institute Of Advanced Industrial & Technology ,  独立行政法人産業技術総合研究所

    发明人： IKUSHIMA YUTAKA ,  SATO MASAHIRO ,  KAWANAMI HAJIME

    IPC分类号： C07C231/02 ,  B01J3/00 ,  C07C233/18 ,  C07C233/24 ,  C07C233/36 ,  C07C233/45 ,  C07D263/12 ,  C07D265/08

    摘要： PROBLEM TO BE SOLVED: To provide a method for synthesizing a polyacyl compound in the absence of catalyst, from a carboxylic anhydride and a polyheterohydride, in a short time, continuously, at high yield and high selectivity, and to provide reaction products thereby.
    SOLUTION: The polyacyl compound production method comprises using, as the reaction solvent, a normal temperature fluid in the case of exothermic reaction, or a 100-400°C 0.1-40 MPa subcritical fluid or critical fluid in the case of endothermic reaction, introducing a substrate and the reaction solvent to a normal-temperature high-pressure flow reactor in the case of exothermic reaction, or a high temperature high pressure flow reactor in the case of endothermic reaction and, by changing several conditions of temperature and carboxylic anhydride amount, performing N-acylation and then O-acylation of the carboxylic anhydride and the polyheterohydride compound to selectively synthesizing the sequential polyacyl compound in the absence of catalyst, at a high rate, continuously and at high yield and high selectivity. And reaction products thereby and devices therefor are provided.
    COPYRIGHT: (C)2008,JPO&INPIT

    摘要翻译： 待解决的问题：为了提供一种在不存在催化剂的情况下从羧酸酐和多元醇合成多酰基化合物的方法，在短时间内以高产率和高选择性连续地提供反应产物 从而。 多酰基化合物的制备方法包括在放热反应的情况下使用常温液体，或在吸热的情况下使用100-400℃的0.1-40MPa亚临界流体或临界流体 反应，在放热反应的情况下将反应溶剂引入常温高压流动反应器，或在高温高压流动反应器中，在吸热反应的情况下，通过改变温度和羧酸的几个条件 酸酐量，进行羧酸酐和多元醇酐化合物的N-酰化，然后O-酰化反应，在不存在催化剂的情况下以高速率，高收率和高选择性选择性合成顺序的多酰基化合物。 由此提供反应产物及其装置。 版权所有（C）2008，JPO＆INPIT

    METHOD FOR PRODUCING AMINO DERIVATIVE OF C-H ACIDIC COMPOUND
    5.
    发明专利
    METHOD FOR PRODUCING AMINO DERIVATIVE OF C-H ACIDIC COMPOUND 失效

    公开(公告)号：JP2002003460A

    公开(公告)日：2002-01-09

    申请号：JP2001154248

    申请日：2001-05-23

    申请人： DEGUSSA

    发明人： KOEHLER GUENTHER DR ,  KLEEMISS WOLFGANG DR ,  BAUER FRANK DR

    IPC分类号： C07C231/10 ,  C07C233/45 ,  C07C233/47

    摘要： PROBLEM TO BE SOLVED: To provide a method for producing a high-purity amino derivative of a C-H acidic compound of general formula I in a high yield by a simple method of nitrosation followed by hydrogenation. SOLUTION: A compound of general formula II is reacted with nitrous acid. In this case, the nitrosation is carried out in the presence of 1-10 equivalents of a carboxylic acid anhydride and operability after the separation of a reaction salt, the reaction product is catalytically hydrogenated.

    ALKYLHYDANTOIN COMPOUND
    6.
    发明专利
    ALKYLHYDANTOIN COMPOUND 失效

    公开(公告)号：JP2000327665A

    公开(公告)日：2000-11-28

    申请号：JP13860899

    申请日：1999-05-19

    申请人： MITSUBISHI CHEM CORP

    发明人： TAKUMA YUUKI ,  WATANABE NAOYUKI ,  YAMAGISHI MASAHIRO

    IPC分类号： C07D233/74 ,  C07C231/10 ,  C07C233/45 ,  C07C237/30 ,  C07D213/40

    摘要： PROBLEM TO BE SOLVED: To provide a new alkylhydantoin compound useful as a production intermediate for (L)-BOC-N-methyl-4-chlorophenylalanine, etc., useful as a raw material for pharmaceuticals and agrochemical compounds. SOLUTION: The objective compound is expressed by formula (R1 is a 1-4C alkyl; R2 is a substituted aryl or a 1-4C alkyl), e.g. 5-p-chlorobenzyl-1- methylhydantoin. The compound of formula can be produced by condensing a (substituted)benzaldehyde with an alkylhydantoin in a solvent (e.g. acetic acid) in the presence of a base (e.g. sodium acetate) and reducing the produced 5-(substituted benzal)-1-alkylhydantoin. The amounts of the components based on the alkylhydantoin are 2-100 times volume for the solvent, 0.5-3 times mol for the base and equal amount or excess for the benzaldehyde.

    DIRECT RESOLUTION OF BETA-HYDROXYCARBOXYLIC ACID DERIVATIVE
    9.
    发明专利
    DIRECT RESOLUTION OF BETA-HYDROXYCARBOXYLIC ACID DERIVATIVE 失效

    公开(公告)号：JPH03109351A

    公开(公告)日：1991-05-09

    申请号：JP24883489

    申请日：1989-09-25

    申请人： DAICEL CHEM

    发明人： MIYOSHI HARUO ,  TACHIBANA KOZO ,  ITO MICHIO

    IPC分类号： C07C67/00 ,  C07B57/00 ,  C07C67/48 ,  C07C69/675 ,  C07C231/20 ,  C07C233/45 ,  C07C235/04 ,  C07C327/22 ,  C07C327/26

    摘要： PURPOSE:To readily and rapidly determine the optical purity of the subject compound useful as a raw material of an intermediate of medicines and optically active functional materials by carrying out direct optical resolution of an enantiomer of the subject compound using a separating agent composed of a polysaccharide or a derivative thereof as the active component. CONSTITUTION:Using a separating agent composed of a polysaccharide (preferably homoglucane having high regularity and constant type of bond, especially cellulose, amylose, beta-1,4-chitosan, etc., capable of ready preparation of high- purity polysaccharide) or a derivative thereof in which H on the hydroxyl groups is partially or wholly, preferably in an amount of >=85%, substituted with another atomic group as the active component, an enantiomer of a compound of the formula (R is alkyl or nonsubstituted or substituted aromatic group; X is acyloxy, aryloxy, alkylthio, arylthio or non-substituted, mono- or disubstituted amino) is directly optically separated by the liquid chromatography, etc.