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公开(公告)号：USD1048411S1
公开(公告)日：2024-10-22
申请号：US29848416
申请日：2022-08-02
申请人： Terumo BCT, Inc.
设计人： Bruce Ellingboe , David Gibbons , Charles L. Hake , Mark Hillam , Peter O'Brien , Anne Baker Oram , Drew Parker , John Pittinger , Taylor Polodna , Evan C. Provan , Dennis Bebie , Davis Benz , Pierre R. Emeric
摘要： FIG. 1 is a front perspective view of an apheresis device;
FIG. 2 is a rear perspective view thereof;
FIG. 3 is a front elevation view thereof;
FIG. 4 is a rear elevation view thereof;
FIG. 5 is a right side elevation view thereof;
FIG. 6 is a left side elevation view thereof;
FIG. 7 is a top plan view thereof; and,
FIG. 8 is a bottom plan view thereof.
The broken lines in the drawings illustrate portions of the apheresis device, which form no part of the claimed design.
The dot dash lines define the bounds of the claimed design and form no part thereof.-
公开(公告)号：US20240101946A1
公开(公告)日：2024-03-28
申请号：US18368879
申请日：2023-09-15
申请人： Terumo BCT, Inc.
IPC分类号： C12M1/00 , C12M1/26 , C12N5/0783
CPC分类号： C12M23/58 , C12M29/14 , C12M29/20 , C12M33/12 , C12N5/0636 , C12N2501/2302
摘要： Cells may be grown in a bioreactor, and the cells may be activated by an activator (e.g., a soluble activator complex). Nutrient and gas exchange capabilities of a closed, automated cell expansion system may allow cells to be seeded at reduced cell seeding densities, for example. Parameters of the cell growth environment may be manipulated to load the cells into a particular position in the bioreactor for the efficient exchange of nutrients and gases. System parameters may be adjusted to shear any cell colonies that may form during the expansion phase. Metabolic concentrations may be controlled to improve cell growth and viability. Cell residence in the bioreactor may be controlled. In embodiments, the cells may include T cells. The cells may include T cell subpopulations, including regulatory T cells (Tregs), for example.
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公开(公告)号：US20240091419A1
公开(公告)日：2024-03-21
申请号：US18367555
申请日：2023-09-13
申请人： Terumo BCT, Inc.
发明人： Aerie THUO , Adam HUDDLE , Gina Aga , Christina Gloor , Katherine Colagrosso , Bruce Gibbs
IPC分类号： A61M1/02
CPC分类号： A61M1/0218 , A61M2202/0415 , A61M2202/0427 , A61M2202/0429 , A61M2202/0439 , A61M2205/123
摘要： A disposable bag set for separating discrete volumes of a composite fluid includes a separation bag including the composite fluid to be separated; a first bag in fluid communication with the separation bag, the first bag configured to receive a first component of the composite fluid from the separation bag; and a second bag in fluid communication with the first bag and not the separation bag, the second bag configured to receive a product formed using the first component.
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公开(公告)号：US20240018475A1
公开(公告)日：2024-01-18
申请号：US18470861
申请日：2023-09-20
申请人： Terumo BCT, Inc.
摘要： Embodiments described herein generally provide for expanding cells in a cell expansion system. The cells may be grown in a bioreactor, and the cells may be activated by an activator (e.g., a soluble activator complex). Nutrient and gas exchange capabilities of a closed, automated cell expansion system may allow cells to be seeded at reduced cell seeding densities, for example. Parameters of the cell growth environment may be manipulated to load the cells into a particular position in the bioreactor for the efficient exchange of nutrients and gases. System parameters may be adjusted to shear any cell colonies that may form during the expansion phase. Metabolic concentrations may be controlled to improve cell growth and viability. Cell residence in the bioreactor may be controlled. In embodiments, the cells may include T cells. In further embodiments, the cells may include T cell subpopulations, including regulatory T cells (Tregs), for example.
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公开(公告)号：US11813553B2
公开(公告)日：2023-11-14
申请号：US17870916
申请日：2022-07-22
申请人： Terumo BCT, Inc.
CPC分类号： B01D21/262 , B04B5/0442 , B04B2005/0471 , C12M47/04
摘要： Embodiments relate to systems, chambers, and methods for processing particles by washing, concentrating, and/or treating the particles. Some embodiments provide for the processing of cells that may be in a liquid medium (e.g., a liquid in which the cells were grown) and are processed by being washed and concentrated for later use in research or other therapies.
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公开(公告)号：US20230310725A1
公开(公告)日：2023-10-05
申请号：US18116902
申请日：2023-03-03
申请人： Terumo BCT, Inc.
发明人： Mark E. Hillam , Evan C. Provan , Peter O’Brien
CPC分类号： A61M1/3496 , A61M1/3693
摘要： An apheresis system includes a chamber configured to receive a centrifuge assembly and a moving loop holder. The moving loop holder includes a loop holder that has a loop connection that is configured to interact with a flexible loop received by the centrifuge assembly. The moving loop holder is configured to move between a first position and a second position, where in the first position, the moving loop holder is a first distance from the centrifuge assembly, and in the second position, the moving loop holder is a second distance from the centrifuge assembly. The centrifuge assembly is prevented from moving from an operating state to a loading state when the moving loop holder is in the first position, and the centrifuge assembly is allowed to move from the operating state to the loading state when the moving loop holder is in the second position.
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公开(公告)号：US20230289173A1
公开(公告)日：2023-09-14
申请号：US18116988
申请日：2023-03-03
申请人： Terumo BCT, Inc.
IPC分类号： G06F8/65 , A61M1/34 , A61M1/36 , A61M60/205 , G16H40/67
CPC分类号： G06F8/65 , A61M1/3496 , A61M1/3693 , A61M60/205 , G16H40/67
摘要： A method includes detecting a startup of an apheresis machine; in response to detecting start up, transmitting data to a server; determining, based on the data, whether software of the apheresis machine is current; receiving, in response to the data, a response from the server; and preventing usage of apheresis machine if the response indicates the software is not current. The data transmitted to the server may include one or more of a data log, a firmware version identifier, and an error log. The response may include a lockout signal. The response may include a software update. The software update may include a firmware update. The method may include automatically initiating installation of the software update. The method may include ceasing prevention of usage of the apheresis machine following installation of the software update.
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公开(公告)号：US20230285652A1
公开(公告)日：2023-09-14
申请号：US18117006
申请日：2023-03-03
申请人： Terumo BCT, Inc.
CPC分类号： A61M1/36224 , G16H40/63 , A61M2205/502 , A61M2205/18 , A61M2205/3334 , A61M2205/3344
摘要： A method includes detecting a beginning of a donation process; in response to detecting the beginning of the donation process, providing an output; determining an amount of time remaining for the donation process; in response to detecting the amount of time remaining for the donation process, updating the output; detecting a loss in pressure; in response to detecting the loss in pressure, updating the output; detecting an ending of the donation process; and in response to detecting the ending of the donation process, updating the output. The donation process may include a plasma donation using an apheresis machine. The detecting the beginning of the donation process may include detecting a flow of fluid. The output may include one or more of a light and a sound. The output may be provided on a side of an apheresis machine.
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公开(公告)号：US20230285042A1
公开(公告)日：2023-09-14
申请号：US18116954
申请日：2023-03-03
申请人： Terumo BCT, Inc.
发明人： Anne Baker ORAM , Bruce ELLINGBOE
摘要： A flexure-based tubing state sensor includes a flexure block and a pressure sensor. The flexure block includes a body with a sensor aperture, a lever arm configured to pivot about a pivot axis between an unpivoted state and a pivoted state and including a tubing contact section and a sensor contact section arranged a first distance from the sensor aperture in the unpivoted state and a second distance from the sensor aperture in the pivoted state, a first flexure, a second flexure, and a fixed wall section disposed offset a tubing gap distance from the tubing contact section of the lever arm. The pressure sensor includes a pressure region adjacent the sensor aperture and in contact with the sensor contact section. The pressure sensor may detect pressure at the tubing contact section via rotation of the lever arm and the sensor contact section acting on the pressure region.
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公开(公告)号：US11685883B2
公开(公告)日：2023-06-27
申请号：US15616635
申请日：2017-06-07
申请人： Terumo BCT, Inc.
CPC分类号： C12M1/005 , C12M21/00 , C12M23/06 , C12M23/16 , C12M23/20 , C12M25/02 , C12M25/12 , C12M29/04 , C12M29/18
摘要： Embodiments described herein generally provide for the expansion of cells in a cell expansion system using an active promotion of a coating agent(s) to a cell growth surface. A coating agent may be applied to a surface, such as the cell growth surface of a hollow fiber, by controlling the movement of a fluid in which a coating agent is suspended. Using ultrafiltration, the fluid may be pushed through the pores of a hollow fiber from a first side, e.g., an intracapillary (IC) side, of the hollow fiber to a second side, e.g., an extracapillary (EC) side, while the coating agent is actively promoted to the surface of the hollow fiber. In so doing, the coating agent may be hydrostatically deposited onto a wall, e.g., inner wall, of the hollow fiber.
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