公开(公告)号：US5959161A

公开(公告)日：1999-09-28

申请号：US179688

申请日：1998-10-27

申请人： Hiroyuki Kenmochi ,  Teruyoshi Akiyama ,  Yoshifumi Yuasa ,  Toyohiko Kobayashi ,  Akio Tachikawa

发明人： Hiroyuki Kenmochi ,  Teruyoshi Akiyama ,  Yoshifumi Yuasa ,  Toyohiko Kobayashi ,  Akio Tachikawa

IPC分类号： C07B57/00 ,  A01N31/04 ,  C07C29/00 ,  C07C29/09 ,  C07C29/14 ,  C07C29/159 ,  C07C29/56 ,  C07C29/78 ,  C07C29/86 ,  C07C35/08 ,  C07C45/45

CPC分类号： C07C29/00 ,  C07C29/09 ,  C07C2101/14

摘要： To offer a method of producing useful para-menthane-3,8-diol having the excellent repellent action to harmful living things, including noxious insects, in high purity and high yield, simply, and economically by the use of citronellal as a raw material compound.The above-mentioned problems are resolved by the production method of this invention wherein citronellal is treated with aqueous sulfuric acid solution of 0.02 to 1.0 wt. % in concentration to produce para-menthane-3,8-diol. In case of recovering the produced para-menthane-3,8-diol, a method is preferably adopted, wherein after the reaction product is extracted with an aliphatic hydrocarbon solvent of 5 to 8 in carbon number, the extract is cooled down at temperature higher than the melting point of said aliphatic hydrocarbon solvent and of -10.degree. C. or less to crystallize para-menthane-3,8-diol.

摘要翻译： 提供一种生产有效的对 - 薄荷烷-3,8-二醇的方法，其以高纯度和高产率，有效地利用香茅醛作为原料，对有害生物（包括有毒昆虫）具有优异的驱避作用 复合。 通过本发明的制备方法解决了上述问题，其中香茅醛用0.02-1.0wt。的硫酸水溶液处理。 产生对偏苯甲烷-3,8-二醇的浓度为％。 在回收生成的对 - 薄荷烷-3,8-二醇的情况下，优选采用方法，其中反应产物用碳数为5至8的脂族烃溶剂萃取后，将提取物在更高温度下冷却 比所述脂族烃溶剂的熔点低-10℃或更低以使对 - 薄荷烷-3,8-二醇结晶。

公开(公告)号：US5463118A

公开(公告)日：1995-10-31

申请号：US254442

申请日：1994-06-02

申请人： Yoshifumi Yuasa ,  Yoshiki Okeda ,  Akio Tachikawa ,  Akira Nagakura ,  Haruki Tsuruta

发明人： Yoshifumi Yuasa ,  Yoshiki Okeda ,  Akio Tachikawa ,  Akira Nagakura ,  Haruki Tsuruta

IPC分类号： A23G3/34 ,  A23L27/30 ,  A61K8/44 ,  A61Q11/00 ,  C07C237/08 ,  C07C61/12 ,  A23L1/236

CPC分类号： A61Q11/00 ,  A23G3/346 ,  A23L27/30 ,  A61K8/44 ,  A23G2200/06

摘要： (2R,3R)-3-N-(L-aspartyl)amino-1-(1-methyl-2-norbornyl)-2-butanol and (2R,3R)-3-N-(L-aspartyl)amino-1-(3-methyl-2-norbornyl)-2-butanol as well as a sweetener comprising the same are disclosed. These compounds, which have excellent sweetness characteristics and are stable in acidic aqueous solutions, are highly useful as a sweetener in various fields.

摘要翻译： （2R，3R）-3-N-（L-天冬氨酰基）氨基-1-（1-甲基-2-降冰片基）-2-丁醇和（2R，3R）-3-N-（L-天冬氨酰基） 公开了1-（3-甲基-2-降冰片基）-2-丁醇以及含有该甜味剂的甜味剂。 这些具有优异的甜味特性并且在酸性水溶液中稳定的化合物作为各种领域的甜味剂是非常有用的。

公开(公告)号：US5128489A

公开(公告)日：1992-07-07

申请号：US592752

申请日：1990-10-04

申请人： Hidenori Kumobayashi ,  Akio Tachikawa ,  Yoshiki Okeda ,  Toshihiro Fujiwara

发明人： Hidenori Kumobayashi ,  Akio Tachikawa ,  Yoshiki Okeda ,  Toshihiro Fujiwara

IPC分类号： C07D309/12 ,  C07D498/06

CPC分类号： C07D309/12

摘要： A process for production of an optically active isomer of 2-(tetrahydropyran-2-yloxy)-1-propanol represented by formula (I): ##STR1## is disclosed, which comprises reacting an optically active isomer of a 1-acyloxy-2-propanol represented by formula (II): ##STR2## wherein R is a substituted or unsubstituted aryl group, with 3,4-dihydro-2H-pyran to obtain an optically active isomer of a 1-acyloxy-2-(tetrahydropyran-2-yloxy)propane represented by formula (III): ##STR3## wherein R is as defined above, and hydrolyzing the compound (III) to eliminate the acyl group. The optically active isomer of 2-(tetrahydropyran-2-yloxy)-1-propanol represented by formula (I) is an intermediate for synthesis of pyridobenzoxazine derivatives useful as a synthetic antibacterial agent, particularly an optically active isomer of ofloxacin.

公开(公告)号：US06570035B2

公开(公告)日：2003-05-27

申请号：US09759134

申请日：2001-01-16

申请人： Shinya Yamada ,  Yoshiki Okeda ,  Toshimitsu Hagiwara ,  Akio Tachikawa ,  Kouji Ishiguro ,  Shunichi Harada

发明人： Shinya Yamada ,  Yoshiki Okeda ,  Toshimitsu Hagiwara ,  Akio Tachikawa ,  Kouji Ishiguro ,  Shunichi Harada

IPC分类号： C07C6966

CPC分类号： C07C67/343 ,  C07C69/716

摘要： A process for producing a pivaloylacetic acid ester comprises reacting pivaloyl chloride with an acetoacetic acid ester of an alkyl group having 1 to 4 carbon atoms in the presence of at least one nitrogen-containing basic compound (a) selected from among pyridine compounds, N,N-dialkylanilines and imidazole compounds and from 0.01 to 0.5 mole equivalent, based on the pivaloyl chloride, of a magnesium compound (b) to thereby prepare a pivaloylacetoacetic acid ester and then alcholyzing or alkali-hydrolyzing the pivaloylacetoacetic acid ester to thereby give a pivaloylacetic acid ester having a high purity at a low cost.

摘要翻译： 一种生产新戊酰乙酸酯的方法，包括在至少一种选自吡啶化合物，N，N-二甲基甲酰胺的含氮碱性化合物（a）的存在下，使新戊酰氯与具有1至4个碳原子的烷基的乙酰乙酸酯反应， N-二烷基苯胺和咪唑化合物，和基于新戊酰氯的0.01至0.5摩尔当量的镁化合物（b），从而制备新戊酰乙酰乙酸酯，然后将新戊酰乙酰乙酸酯进行共沸或碱解水解，从而得到新戊酰乙酸 酸酯以低成本具有高纯度。

公开(公告)号：US5945559A

公开(公告)日：1999-08-31

申请号：US862263

申请日：1997-05-23

申请人： Tsukasa Sotoguchi ,  Yoshifumi Yuasa ,  Akio Tachikawa ,  Shunichi Harada

发明人： Tsukasa Sotoguchi ,  Yoshifumi Yuasa ,  Akio Tachikawa ,  Shunichi Harada

IPC分类号： B01J23/02 ,  C07B61/00 ,  C07C67/343 ,  C07C69/716 ,  C07C69/738 ,  C07C69/66 ,  C07C69/76

CPC分类号： C07C67/343

摘要： A novel process for producing 3-oxocarboxylic acid esters, which are useful as intermediates in the synthesis of ceramides to be used as a humectant, biodegradable polymers, drugs, etc., at a high purity and a high yield without requiring any troublesome procedure, is disclosed. The process comprises reacting an acetoacetic ester with a calcium compound, a barium compound or a strontium compound in the presence of an organic solvent at a temperature of 10 to 120.degree. C., further reacting the obtained product with a carboxylic acid chloride to thereby acylate it, and then adding thereto an alcohol in an amount 1 to 5 times by mol as much as the calcium compound, barium compound or strontium compound to thereby deacetylate the same.

摘要翻译： 一种生产3-氧代羧酸酯的新方法，其可用作合成用作保湿剂的神经酰胺的中间体，可生物降解的聚合物，药物等以高纯度和高产率而不需要任何麻烦的方法， 被披露。 该方法包括在有机溶剂存在下，在10〜120℃的温度下使乙酰乙酸酯与钙化合物，钡化合物或锶化合物反应，进一步使得到的产物与羧酰氯反应，从而酰化 然后向其中加入与钙化合物，钡化合物或锶化合物一样多的1至5倍摩尔量的醇，从而使其脱乙酰化。