公开(公告)号：US08808751B2

公开(公告)日：2014-08-19

申请号：US12306948

申请日：2007-06-29

Applicant: Raffaele Cammarano ,  Felix Meiser ,  Almar Postma ,  Frank Caruso

Inventor： Raffaele Cammarano ,  Felix Meiser ,  Almar Postma ,  Frank Caruso

IPC: A61K9/16 ,  A61K31/40 ,  A61K31/192 ,  A61K31/196 ,  A61K31/496 ,  A61K31/4535 ,  A61K31/551 ,  A61K9/14

CPC classification number: A61K31/192 ,  A61K9/143 ,  A61K9/1617 ,  A61K31/196 ,  A61K31/4535 ,  A61K31/496 ,  A61K31/551

Abstract: A method for producing a composition comprising nanoparticles of a biologically active compound, comprising the step of: dry milling a solid biologically active compound and a millable grinding compound in a mill comprising a plurality of milling bodies, for a time period sufficient to produce a solid dispersion comprising nanoparticles of the biologically active compound dispersed in an at least partially milled grinding compound is described as are various compositions produced using such methods.

Abstract translation: 一种制备包含生物活性化合物的纳米颗粒的组合物的方法，包括以下步骤：将固体生物活性化合物和可磨碎的研磨化合物在包含多个研磨体的研磨机中干燥足够长的时间以产生固体 描述分散在至少部分磨碎的研磨化合物中的生物活性化合物的纳米颗粒的分散体描述为使用这种方法制备的各种组合物。

公开(公告)号：US20090028948A1

公开(公告)日：2009-01-29

申请号：US11813116

申请日：2005-12-30

Applicant: Trevor Payne ,  Felix Meiser ,  Almar Postma ,  Raffaele Cammarano ,  James Williams ,  Paul McCormick ,  Aaron Dodd ,  Frank Caruso

Inventor： Trevor Payne ,  Felix Meiser ,  Almar Postma ,  Raffaele Cammarano ,  James Williams ,  Paul McCormick ,  Aaron Dodd ,  Frank Caruso

IPC: A61K9/14 ,  A61K31/519 ,  A61K31/551 ,  A61K31/192 ,  A61K31/196

CPC classification number: A61K9/5123 ,  A61K9/5192 ,  A61K31/192 ,  A61K31/196 ,  A61K31/4985 ,  A61K31/5513

Abstract: The present invention relates to improved therapeutically active nanocomposite microstructure compositions, including nanoparticle compositions and nanoparticle preparations. Preferred embodiments include nanoparticle compositions comprising nanoparticles of a therapeutically active agent dispersed in a carrier matrix. The invention also relates to a method for preparing said compositions and preparations using solid-state mechanochemical synthesis. Further, it relates to therapeutic products produced using said compositions and to methods of treatment using the compositions.

Abstract translation: 本发明涉及改进的治疗活性纳米复合微结构组合物，包括纳米颗粒组合物和纳米颗粒制剂。 优选的实施方案包括纳米颗粒组合物，其包含分散在载体基质中的治疗活性剂的纳米颗粒。 本发明还涉及使用固态机械化学合成制备所述组合物和制剂的方法。 此外，它涉及使用所述组合物生产的治疗产品和使用该组合物的治疗方法。

公开(公告)号：US09410080B2

公开(公告)日：2016-08-09

申请号：US13695688

申请日：2011-05-05

Applicant: Raju Adhikari ,  Almar Postma ,  Kazunori Ueno ,  Kazuya Arima ,  Juo-Hao Li

Inventor： Raju Adhikari ,  Almar Postma ,  Kazunori Ueno ,  Kazuya Arima ,  Juo-Hao Li

IPC: B32B19/00 ,  C09K11/06 ,  H05B33/10 ,  C09B69/10

CPC classification number: C09K11/06 ,  C09B69/101 ,  C09B69/109 ,  C09K2211/1011 ,  C09K2211/1029 ,  C09K2211/1092 ,  C09K2211/1425 ,  C09K2211/1433 ,  C09K2211/185 ,  H05B33/10 ,  Y10S428/917

Abstract: An electroluminescence device having an emission layer comprising a single organic compound layer between a cathode and an anode. The single layer may comprise an emitter component on a single polymer chain of covalently linked (co)-polymer sections Y1, optionally in combination with Y2, and/or Y3, or different polymer chains Y1, optionally in combination with Y2, and/or Y3 blended together. Each of the (co)-polymer contains a spacer unit and a carrier transporting component and optionally an emitter moiety.

Abstract translation: 一种具有在阴极和阳极之间具有单一有机化合物层的发射层的电致发光器件。 单层可以在共价连接（共）聚合物部分Y1，任选地与Y2和/或Y 3，或不同的聚合物链Y1，任选地与Y2和/或其组合的组合的单个聚合物链上包含发射体组分。 Y3混合在一起 （共）聚合物中的每一个包含间隔单元和载流子传输组分以及任选的发射体部分。

公开(公告)号：US20130112957A1

公开(公告)日：2013-05-09

申请号：US13695688

申请日：2011-05-05

Applicant: Raju Adhikari ,  Almar Postma ,  Kazunori Ueno ,  Kazuya Arima ,  Juo-Hao Li

Inventor： Raju Adhikari ,  Almar Postma ,  Kazunori Ueno ,  Kazuya Arima ,  Juo-Hao Li

IPC: C09K11/06 ,  H01L51/00

CPC classification number: C09K11/06 ,  C09B69/101 ,  C09B69/109 ,  C09K2211/1011 ,  C09K2211/1029 ,  C09K2211/1092 ,  C09K2211/1425 ,  C09K2211/1433 ,  C09K2211/185 ,  H05B33/10 ,  Y10S428/917

Abstract: An electroluminescence device having an emission layer comprising a single organic compound layer between a cathode and an anode. The single layer may comprise an emitter component on a single polymer chain of covalently linked (co)-polymer sections Y1, optionally in combination with Y2, and/or Y3, or different polymer chains Y1, optionally in combination with Y2, and/or Y3 blended together. Each of the (co)-polymer contains a spacer unit and a carrier transporting component and optionally an emitter moiety.

Abstract translation: 一种具有在阴极和阳极之间具有单一有机化合物层的发射层的电致发光器件。 单层可以在共价连接（共）聚合物部分Y1，任选地与Y2和/或Y 3，或不同的聚合物链Y1，任选地与Y2和/或其组合的组合的单个聚合物链上包含发射体组分。 Y3混合在一起 （共）聚合物中的每一个包含间隔单元和载流子传输组分以及任选的发射体部分。

公开(公告)号：US20120091884A1

公开(公告)日：2012-04-19

申请号：US13257431

申请日：2010-05-21

Applicant: James Matthew Macdonald ,  Raju Adhikari ,  Almar Postma ,  Tadahiko Hirai ,  Kazunori Ueno

Inventor： James Matthew Macdonald ,  Raju Adhikari ,  Almar Postma ,  Tadahiko Hirai ,  Kazunori Ueno

IPC: H05B33/14 ,  C07D487/16

CPC classification number: C07D487/16 ,  C09K11/06 ,  C09K2211/1007 ,  C09K2211/1011 ,  C09K2211/1014 ,  C09K2211/1029 ,  C09K2211/1059 ,  C09K2211/1088 ,  C09K2211/1092 ,  C09K2211/1425 ,  H01L51/0072 ,  H05B33/10

Abstract: The present invention relates to an organic electroluminescent device comprising a pair of electrodes forming an anode and cathode, and one or more layers of organic compound arranged between the pair of electrodes, wherein the organic compound layer comprises heptaazaphenalene derivatives of formula (1). The present invention also relates to the said compounds.

Abstract translation: 本发明涉及包含形成阳极和阴极的一对电极和布置在该对电极之间的一层或多层有机化合物的有机电致发光器件，其中有机化合物层包含式（1）的七氮杂萘衍生物。 本发明还涉及所述化合物。

公开(公告)号：US20100298502A1

公开(公告)日：2010-11-25

申请号：US12670330

申请日：2008-07-23

Applicant: Graeme Moad ,  Michael Shane O'Shea ,  Gary Peeters ,  Almar Postma

Inventor： Graeme Moad ,  Michael Shane O'Shea ,  Gary Peeters ,  Almar Postma

IPC: C08F8/00

CPC classification number: C08J5/00 ,  B29C48/10 ,  B29C48/395 ,  B29C48/40 ,  B29C48/404 ,  B29C48/507 ,  B29C48/67 ,  B29C48/92 ,  B29C2948/92514 ,  B29C2948/92542 ,  B29C2948/92561 ,  B29C2948/92695 ,  B29C2948/92704 ,  B29C2948/92809 ,  B29C2948/92857 ,  B29C2948/92876 ,  B29C2948/92971 ,  B29K2023/06 ,  B29K2023/0641 ,  B29K2023/12 ,  C08F8/50 ,  C08F2810/10 ,  C08J2323/00 ,  C08F8/06 ,  C08F110/06 ,  C08F110/02

Abstract: The invention provides a process for increasing the melt flow index of a polyolefin, the process comprising using a melt mixing device to melt mix the polyolefin in contact with oxygen and a transition metal catalyst having a redox potential ranging from 0 to 2 volts, wherein oxygen is introduced to the melt mixing device, and wherein the transition metal catalyst in contact with the polyolefin forms at least part of a component of the melt mixing device.

Abstract translation: 本发明提供了一种提高聚烯烃的熔体流动指数的方法，该方法包括使用熔融混合装置将与氧接触的聚烯烃和氧化还原电位范围为0至2伏的过渡金属催化剂熔融混合，其中氧 被引入到熔融混合装置中，并且其中与聚烯烃接触的过渡金属催化剂形成熔融混合装置的组分的至少一部分。