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公开(公告)号：US20090028948A1
公开(公告)日：2009-01-29
申请号：US11813116
申请日：2005-12-30
申请人： Trevor Payne , Felix Meiser , Almar Postma , Raffaele Cammarano , James Williams , Paul McCormick , Aaron Dodd , Frank Caruso
发明人： Trevor Payne , Felix Meiser , Almar Postma , Raffaele Cammarano , James Williams , Paul McCormick , Aaron Dodd , Frank Caruso
IPC分类号： A61K9/14 , A61K31/519 , A61K31/551 , A61K31/192 , A61K31/196
CPC分类号： A61K9/5123 , A61K9/5192 , A61K31/192 , A61K31/196 , A61K31/4985 , A61K31/5513
摘要： The present invention relates to improved therapeutically active nanocomposite microstructure compositions, including nanoparticle compositions and nanoparticle preparations. Preferred embodiments include nanoparticle compositions comprising nanoparticles of a therapeutically active agent dispersed in a carrier matrix. The invention also relates to a method for preparing said compositions and preparations using solid-state mechanochemical synthesis. Further, it relates to therapeutic products produced using said compositions and to methods of treatment using the compositions.
摘要翻译： 本发明涉及改进的治疗活性纳米复合微结构组合物，包括纳米颗粒组合物和纳米颗粒制剂。 优选的实施方案包括纳米颗粒组合物，其包含分散在载体基质中的治疗活性剂的纳米颗粒。 本发明还涉及使用固态机械化学合成制备所述组合物和制剂的方法。 此外，它涉及使用所述组合物生产的治疗产品和使用该组合物的治疗方法。
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公开(公告)号：US20120135047A1
公开(公告)日：2012-05-31
申请号：US13266122
申请日：2010-04-23
申请人： Aaron Dodd , Felix Meiser , Marck Norret , Adrian Russell , H William Bosch
发明人： Aaron Dodd , Felix Meiser , Marck Norret , Adrian Russell , H William Bosch
IPC分类号： A61K31/196 , C07C229/42 , A61K9/14 , B82Y40/00 , B82Y5/00
CPC分类号： A61K31/196 , A61K9/0053 , A61K9/0087 , A61K9/14 , A61K9/141 , A61K9/143 , A61K9/145 , A61K9/146 , A61K9/16 , A61K9/1682 , A61K9/4808 , A61K9/4825 , A61K9/4858 , A61K9/5115 , A61K9/5123 , A61K9/513 , A61K9/5138 , A61K9/5192 , A61K47/12 , A61K47/20 , Y02A50/465 , Y10T428/2982
摘要： The present invention relates to methods for producing particles of diclofenac using dry milling processes as well as compositions comprising diclofenac, medicaments produced using diclofenac in particulate form and/or compositions, and to methods of treatment of an animal, including man, using a therapeutically effective amount of diclofenac administered by way of said medicaments.
摘要翻译： 本发明涉及使用干磨法生产双氯芬酸颗粒的方法以及包含双氯芬酸的组合物，使用颗粒形式的双氯芬酸和/或组合物制备的药物，以及使用治疗有效的方法治疗动物，包括人的方法 通过所述药物施用的双氯芬酸的量。
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公开(公告)号：US08735450B2
公开(公告)日：2014-05-27
申请号：US13266122
申请日：2010-04-23
申请人： Aaron Dodd , Felix Meiser , Marck Norret , Adrian Russell , H William Bosch
发明人： Aaron Dodd , Felix Meiser , Marck Norret , Adrian Russell , H William Bosch
IPC分类号： A61K31/196 , A61K9/14 , C07C229/42 , B82Y40/00
CPC分类号： A61K31/196 , A61K9/0053 , A61K9/0087 , A61K9/14 , A61K9/141 , A61K9/143 , A61K9/145 , A61K9/146 , A61K9/16 , A61K9/1682 , A61K9/4808 , A61K9/4825 , A61K9/4858 , A61K9/5115 , A61K9/5123 , A61K9/513 , A61K9/5138 , A61K9/5192 , A61K47/12 , A61K47/20 , Y02A50/465 , Y10T428/2982
摘要： The present invention relates to methods for producing particles of diclofenac using dry milling processes as well as compositions comprising diclofenac, medicaments produced using diclofenac in particulate form and/or compositions, and to methods of treatment of an animal, including man, using a therapeutically effective amount of diclofenac administered by way of said medicaments.
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公开(公告)号：US20120263760A1
公开(公告)日：2012-10-18
申请号：US13266115
申请日：2010-04-23
申请人： Aaron Dodd , Felix Meiser , Marck Norret , Adrian Russell , H. William Bosch
发明人： Aaron Dodd , Felix Meiser , Marck Norret , Adrian Russell , H. William Bosch
IPC分类号： A61K31/421 , A61P25/04 , B32B5/16 , A61K9/00
CPC分类号： C07D263/20 , A61K9/14 , A61K9/145 , A61K9/146 , A61K9/1617 , A61K9/1623 , A61K9/1641 , A61K9/1694 , A61K31/421 , Y10T428/2978
摘要： The present invention relates to methods for producing particles of metaxalone using dry milling processes as well as compositions comprising metaxalone, medicaments produced using metaxalone in particulate form and/or compositions, and to methods of treatment of an animal, including man, using a therapeutically effective amount of metaxalone administered by way of said medicaments.
摘要翻译： 本发明涉及使用干研磨方法生产美他沙酮颗粒的方法以及包含美他沙酮，以颗粒形式和/或组合物使用美他沙酮制备的药物的组合物，以及使用治疗有效的方法治疗动物，包括人的方法 通过所述药物施用的美他沙酮的量。
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公开(公告)号：US20120165410A1
公开(公告)日：2012-06-28
申请号：US13265914
申请日：2010-04-23
申请人： Aaron Dodd , Felix Meiser , Marck Norret , Adrian Russell , H William Bosch
发明人： Aaron Dodd , Felix Meiser , Marck Norret , Adrian Russell , H William Bosch
IPC分类号： A61K31/192 , A61P29/00
摘要： The present invention relates to methods for producing particles of a biologically active material using dry milling processes as well as compositions comprising such materials, medicaments produced using said biologically active materials in particulate form and/or compositions, and to methods of treatment of an animal, including man, using a therapeutically effective amount of said biologically active materials administered by way of said medicaments.
摘要翻译： 本发明涉及使用干磨法生产生物活性物质的颗粒的方法以及包含这些材料的组合物，使用所述生物活性材料以颗粒形式和/或组合物制备的药物，以及治疗动物的方法， 包括使用治疗有效量的通过所述药物施用的所述生物活性物质的人。
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6.发明申请METHOD FOR IMPROVING THE DISSOLUTION PROFILE OF A BIOLOGICALLY ACTIVE MATERIAL 审中-公开改善生物活性材料溶解度特征的方法公开(公告)号：US20120165323A1
公开(公告)日：2012-06-28
申请号：US13265927
申请日：2010-04-23
申请人： Aaron Dodd , Felix Meiser , Marck Norret , Adrian Russell , H William Bosch , Matt Callahan
发明人： Aaron Dodd , Felix Meiser , Marck Norret , Adrian Russell , H William Bosch , Matt Callahan
IPC分类号： A61K31/5415 , A61K31/196
CPC分类号： A61K9/1682 , A01N25/14 , A61K9/145 , A61K9/146 , A61K31/137 , A61K31/192 , A61K31/196 , A61K31/405 , A61K31/415 , A61K31/421 , A61K31/496 , A61K31/5415
摘要： The present invention relates to a method for improving the dissolution profile of a biologically active material comprising the steps of dry milling a solid biologically active material and a millable grinding matrix in a mill comprising a plurality of milling bodies, for a time period sufficient to produce particles of the biologically active material dispersed in an at least partially milled grinding material.
摘要翻译： 本发明涉及一种用于改善生物活性材料的溶出曲线的方法，包括以下步骤：在包含多个研磨体的研磨机中将固体生物活性材料和可研磨基质干磨，时间足以产生 分散在至少部分磨碎的研磨材料中的生物活性材料的颗粒。
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公开(公告)号：US20120148634A1
公开(公告)日：2012-06-14
申请号：US13266119
申请日：2010-04-23
申请人： Aaron Dodd , Felix Meiser , Marck Norret , Adrian Russell , H William Bosch
发明人： Aaron Dodd , Felix Meiser , Marck Norret , Adrian Russell , H William Bosch
IPC分类号： A61K9/14 , B32B5/16 , A61P25/04 , A61K31/192 , A61P25/00
CPC分类号： A61K31/192 , A61J3/02 , A61K9/14 , A61K9/141 , A61K9/145 , A61K9/146 , A61K9/1617 , A61K9/1623 , A61K9/1635 , A61K9/1682 , Y02A50/465 , Y10T428/2982
摘要： The present invention relates to methods for producing particles of naproxen using dry milling processes as well as compositions comprising naproxen, medicaments produced using naproxen in particulate form and/or compositions, and to methods of treatment of an animal, including man, using a therapeutically effective amount of naproxen administered by way of said medicaments.
摘要翻译： 本发明涉及使用干磨法生产萘普生颗粒的方法以及包含萘普生的组合物，使用纳豆酮颗粒形式和/或组合物制备的药物，以及使用治疗有效的方法治疗动物（包括人）的方法 通过所述药物施用萘普生的量。
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公开(公告)号：US20120141548A1
公开(公告)日：2012-06-07
申请号：US13266118
申请日：2010-04-23
申请人： Aaron Dodd , Felix Meiser , Marck Norret , Adrian Russell , H William Bosvch
发明人： Aaron Dodd , Felix Meiser , Marck Norret , Adrian Russell , H William Bosvch
IPC分类号： A61K31/5415 , A61P25/04 , B32B5/16 , A61K9/14
CPC分类号： C07D417/12 , A61K9/14 , A61K9/143 , A61K9/145 , A61K9/146 , A61K9/5115 , A61K9/5123 , A61K9/513 , A61K31/5415 , B02C23/06 , B63B22/026 , B63B27/34 , B63B2035/442 , B63B2035/448 , B65H75/38 , B65H75/4402 , B65H75/4415 , B65H75/4486 , B65H2701/33 , B67D9/00 , Y02A50/465 , Y10T428/2982
摘要： The present invention relates to methods for producing particles of meloxicam using dry milling processes as well as compositions comprising meloxicam, medicaments produced using meloxicam in particulate form and/or compositions, and to methods of treatment of an animal, including man, using a therapeutically effective amount of meloxicam administered by way of said medicaments.
摘要翻译： 本发明涉及使用干磨法生产美洛昔康颗粒的方法以及包含美洛昔康的组合物，使用颗粒形式和/或组合物的美洛昔康制备的药物以及使用治疗有效的方法治疗动物（包括人）的方法 通过所述药物施用的美洛昔康的量。
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9.发明申请METHOD FOR THE PRODUCTION OF COMMERCIAL NANOPARTICLE AND MICRO PARTICLE POWDERS 审中-公开生产商业纳米粒子和微粒子粉末的方法公开(公告)号：US20120160944A1
公开(公告)日：2012-06-28
申请号：US13265933
申请日：2010-04-23
申请人： Aaron Dodd , Felix Meiser , Marck Norret , Adrian Russell , H William Bosch
发明人： Aaron Dodd , Felix Meiser , Marck Norret , Adrian Russell , H William Bosch
IPC分类号： B02C19/00
CPC分类号： A61K9/1682 , A01N25/10 , A01N25/12 , A01N25/34 , A01N37/38 , A01N47/36 , A01N55/02 , A01N57/20 , A23L33/10 , A23P10/20 , A23P10/30 , A23V2002/00 , A61J3/02 , A61K9/0075 , A61K9/145 , A61K9/146 , A61K9/1617 , A61K9/1623 , A61K9/1635 , A61K9/1652 , A61K31/122 , A61K31/137 , A61K31/18 , A61K31/192 , A61K31/196 , A61K31/198 , A61K31/404 , A61K31/405 , A61K31/415 , A61K31/421 , A61K31/4709 , A61K31/496 , A61K31/497 , A61K31/53 , A61K31/5415 , A61K31/565 , A61K31/57 , A61K33/04 , A61K38/13 , B02C17/20 , B02C19/0056 , A01N39/04 , A01N47/14 , A01N57/12 , A01N59/02
摘要： The present invention relates to methods for producing nanoparticle and microparticle powders of a biologically active material which have improved powder handling properties making the powders suitable for commercial use using dry milling processes as well as compositions comprising such materials, medicaments produced using said biologically active materials in particulate form and/or compositions, and to methods of treatment of an animal, including man, using a therapeutically effective amount of said biologically active materials administered by way of said medicaments.
摘要翻译： 本发明涉及用于制备生物活性材料的纳米颗粒和微粒粉末的方法，其具有改善的粉末处理性质，使得使用干法研磨工艺适合商业用途的粉末以及包含这些材料的组合物，使用所述生物活性材料制备的药物 颗粒形式和/或组合物，以及使用治疗有效量的通过所述药物施用的所述生物活性物质治疗动物（包括人）的方法。
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公开(公告)号：US20120202694A1
公开(公告)日：2012-08-09
申请号：US13265936
申请日：2010-04-23
申请人： Aaron Dodd , Felix Meiser , Marck Norret , Adrian Russell , H William Bosch
发明人： Aaron Dodd , Felix Meiser , Marck Norret , Adrian Russell , H William Bosch
IPC分类号： A01N57/20 , A61K31/192 , A61K31/5415 , A61K31/405 , A23F5/08 , A61K31/635 , A61K31/196 , A61K31/421 , A01P13/00 , A23G1/02 , A61K31/137 , A61K31/496
CPC分类号： B02C17/10 , A01N25/34 , A01N39/04 , A01N47/10 , A01N57/20 , A23P10/30 , A61K9/14 , A61K9/145 , A61K9/146 , A61K9/1617 , A61K9/1623 , A61K9/1635 , A61K9/1652 , A61K31/137 , A61K31/192 , A61K31/196 , A61K31/405 , A61K31/415 , A61K31/421 , A61K31/496 , A61K31/5415
摘要： The present invention relates to methods for producing particles of a biologically active material using dry milling processes as well as compositions comprising such materials, medicaments produced using said biologically active materials in particulate form and/or compositions, and to methods of treatment of an animal, including man, using a therapeutically effective amount of said biologically active materials administered by way of said medicaments.
摘要翻译： 本发明涉及使用干磨法生产生物活性物质的颗粒的方法以及包含这些材料的组合物，使用所述生物活性材料以颗粒形式和/或组合物制备的药物，以及治疗动物的方法， 包括使用治疗有效量的通过所述药物施用的所述生物活性物质的人。
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