公开(公告)号：US20090227016A1

公开(公告)日：2009-09-10

申请号：US12412796

申请日：2009-03-27

申请人： Jian Chen ,  Ellen Filvaroff ,  Sherman Fong ,  Audrey Goddard ,  Paul Godowski ,  J. Christopher Grimaldi ,  Austin Gumey ,  Hanzhong Li ,  Kenneth Hillan ,  Sarah G. Hymowitz ,  Daniel Tumas ,  Melissa A. Starovasnik ,  Menno VanLookeren ,  Richard Vandlen ,  Collin Watanabe ,  P. Mickey Williams ,  William I. Wood ,  Daniel Yansura

发明人： Jian Chen ,  Ellen Filvaroff ,  Sherman Fong ,  Audrey Goddard ,  Paul Godowski ,  J. Christopher Grimaldi ,  Austin Gumey ,  Hanzhong Li ,  Kenneth Hillan ,  Sarah G. Hymowitz ,  Daniel Tumas ,  Melissa A. Starovasnik ,  Menno VanLookeren ,  Richard Vandlen ,  Collin Watanabe ,  P. Mickey Williams ,  William I. Wood ,  Daniel Yansura

IPC分类号： C12N5/10 ,  C12N1/21 ,  C12N1/19 ,  C12N15/63 ,  C07H21/04

CPC分类号： C07K14/54 ,  A61K38/00 ,  C07K14/7155 ,  C07K2319/30 ,  C12N2510/00 ,  G01N33/6869 ,  G01N2500/04 ,  G01N2800/24

摘要： The present invention is directed to novel polypeptides having sequence identity with IL-17, IL-17 receptors and to nucleic acid molecules encoding those polypeptides. Also provided herein are vectors and host cells comprising those nucleic acid sequences, chimeric polypeptide molecules comprising the polypeptides of the present invention fused to heterologous polypeptide sequences, antibodies which bind to the polypeptides of the present invention and to methods for producing the polypeptides of the present invention. Further provided herein are methods for treating degenerative cartilaginous disorders and other inflammatory diseases.

摘要翻译： 本发明涉及与IL-17，IL-17受体和编码那些多肽的核酸分子具有序列同一性的新型多肽。 本文还提供了包含那些核酸序列的载体和宿主细胞，包含与异源多肽序列融合的本发明的多肽的嵌合多肽分子，与本发明的多肽结合的抗体以及本发明的多肽的制备方法 发明。 本文还提供了治疗退行性软骨疾病和其它炎性疾病的方法。

公开(公告)号：US20110064728A1

公开(公告)日：2011-03-17

申请号：US12825263

申请日：2010-06-28

申请人： Jian Chen ,  Ellen Filvaroff ,  Sherman Fong ,  Audrey Goddard ,  Paul Godowski ,  J. Christopher Grimaldi ,  Austin Gumey ,  Hanzhong Li ,  Kenneth Hillan ,  Sarah G. Hymowitz ,  Daniel Tumas ,  Melissa A. Starovasnik ,  Menno VanLookeren ,  Richard Vandlen ,  Colin Watanabe ,  P. Mickey Williams ,  William I. Wood ,  Daniel Yansura

发明人： Jian Chen ,  Ellen Filvaroff ,  Sherman Fong ,  Audrey Goddard ,  Paul Godowski ,  J. Christopher Grimaldi ,  Austin Gumey ,  Hanzhong Li ,  Kenneth Hillan ,  Sarah G. Hymowitz ,  Daniel Tumas ,  Melissa A. Starovasnik ,  Menno VanLookeren ,  Richard Vandlen ,  Colin Watanabe ,  P. Mickey Williams ,  William I. Wood ,  Daniel Yansura

IPC分类号： A61K39/395 ,  A61K38/16 ,  A61P1/00 ,  A61P11/06 ,  A61P17/00 ,  A61P19/00

CPC分类号： A61K38/20 ,  C07K14/54 ,  C07K14/7155 ,  C07K2319/30 ,  C12N15/1136 ,  C12N2310/11 ,  C12N2310/12 ,  C12N2310/15

摘要： The present invention is directed to novel polypeptides having sequence identity with IL-17, IL-17 receptors and to nucleic acid molecules encoding those polypeptides. Also provided herein are vectors and host cells comprising those nucleic acid sequences, chimeric polypeptide molecules comprising the polypeptides of the present invention fused to heterologous polypeptide sequences, antibodies which bind to the polypeptides of the present invention and to methods for producing the polypeptides of the present invention. Further provided herein are methods for treating degenerative cartilaginous disorders and other inflammatory diseases.

摘要翻译： 本发明涉及与IL-17，IL-17受体和编码那些多肽的核酸分子具有序列同一性的新型多肽。 本文还提供了包含那些核酸序列的载体和宿主细胞，包含与异源多肽序列融合的本发明的多肽的嵌合多肽分子，与本发明的多肽结合的抗体以及本发明的多肽的制备方法 发明。 本文还提供了治疗退行性软骨疾病和其它炎性疾病的方法。

公开(公告)号：US20080064049A1

公开(公告)日：2008-03-13

申请号：US11591019

申请日：2006-10-31

申请人： Michael Clarke ,  Tim Hoey ,  Xinhao Wang ,  Scott Dylla ,  Austin Gumey ,  Pierro Dalerba ,  Grace Chen ,  Mark Prince

发明人： Michael Clarke ,  Tim Hoey ,  Xinhao Wang ,  Scott Dylla ,  Austin Gumey ,  Pierro Dalerba ,  Grace Chen ,  Mark Prince

IPC分类号： G01N33/574 ,  C12N5/06

CPC分类号： C12N5/0695 ,  C12N5/0093 ,  Y10S435/968 ,  Y10S435/971

摘要： The present invention relates to compositions and methods for characterizing, treating and diagnosing cancer. In particular, the present invention provides a cancer stem cell profile, as well as novel stem cell cancer markers useful for the diagnosis, characterization, prognosis and treatment of cancer and in particular the targeting of solid tumor stem cells.

摘要翻译： 本发明涉及用于表征，治疗和诊断癌症的组合物和方法。 特别地，本发明提供癌症干细胞概况，以及用于癌症的诊断，表征，预后和治疗的新型干细胞癌标记物，特别是固体肿瘤干细胞的靶向。

公开(公告)号：US20090035261A1

公开(公告)日：2009-02-05

申请号：US12214762

申请日：2008-06-19

申请人： Jian Chen ,  Ellen Filvaroff ,  Sherman Fong ,  Audrey Goddard ,  Paul Godowski ,  J. Christopher Grimaldi ,  Austin Gumey ,  Hanzhong Li ,  Kenneth Hillan ,  Sarah G. Hymowitz ,  Daniel Tumas ,  Melissa A. Starovasnik ,  Menno VanLookeren ,  Richard Vandlen ,  Colin Watanabe ,  P. Mickey Williams ,  William I. Wood ,  Daniel Yansura

发明人： Jian Chen ,  Ellen Filvaroff ,  Sherman Fong ,  Audrey Goddard ,  Paul Godowski ,  J. Christopher Grimaldi ,  Austin Gumey ,  Hanzhong Li ,  Kenneth Hillan ,  Sarah G. Hymowitz ,  Daniel Tumas ,  Melissa A. Starovasnik ,  Menno VanLookeren ,  Richard Vandlen ,  Colin Watanabe ,  P. Mickey Williams ,  William I. Wood ,  Daniel Yansura

IPC分类号： A61K38/20 ,  C12N15/11 ,  C12N15/00 ,  C12N5/06 ,  C12N1/20 ,  C12N1/19 ,  C12P21/04 ,  G01N33/566 ,  A61P31/00 ,  C07K14/00 ,  C07K16/18 ,  A61K39/395 ,  G01N33/53 ,  C12Q1/68 ,  C12Q1/02

CPC分类号： C07K14/54 ,  A61K38/00 ,  C07K14/7155 ,  G01N33/6869 ,  G01N2500/04 ,  G01N2800/24

摘要： The present invention is directed to novel polypeptides having sequence identity with IL-17, IL-17 receptors and to nucleic acid molecules encoding those polypeptides. Also provided herein are vectors and hosT-cells comprising those nucleic acid sequences, chimeric polypeptide molecules comprising the polypeptides of the present invention fused to heterologous polypeptide sequences, antibodies which bind to the polypeptides of the present invention and to methods for producing the polypeptides of the present invention. Further provided herein are methods for treating degenerative cartilaginous disorders and other inflammatory diseases.

摘要翻译： 本发明涉及与IL-17，IL-17受体和编码那些多肽的核酸分子具有序列同一性的新型多肽。 本文还提供了包含这些核酸序列的载体和hosT细胞，包含与异源多肽序列融合的本发明多肽的嵌合多肽分子，与本发明的多肽结合的抗体以及与本发明的多肽结合的方法 本发明。 本文还提供了治疗退行性软骨疾病和其它炎性疾病的方法。

公开(公告)号：US20070020735A1

公开(公告)日：2007-01-25

申请号：US11529324

申请日：2006-09-29

申请人： Jian Chen ,  Ellen Filvaroff ,  Sherman Fong ,  Dorothy French ,  Audrey Goddard ,  Paul Godowski ,  J. Grimaldi ,  Austin Gumey ,  Kenneth Hillan ,  Sarah Hymowitz ,  Hanzhong Li ,  James Pan ,  Melissa Starovasnik ,  Daniel Tumas ,  Menno Lookeren ,  Richard Vandlen ,  Colin Watanabe ,  P. Williams ,  William Wood ,  Daniel Yansura

发明人： Jian Chen ,  Ellen Filvaroff ,  Sherman Fong ,  Dorothy French ,  Audrey Goddard ,  Paul Godowski ,  J. Grimaldi ,  Austin Gumey ,  Kenneth Hillan ,  Sarah Hymowitz ,  Hanzhong Li ,  James Pan ,  Melissa Starovasnik ,  Daniel Tumas ,  Menno Lookeren ,  Richard Vandlen ,  Colin Watanabe ,  P. Williams ,  William Wood ,  Daniel Yansura

IPC分类号： C07H21/04 ,  C12P21/04 ,  C07K14/54

CPC分类号： C07K16/244 ,  A61K38/00 ,  C07H21/04 ,  C07K14/54 ,  C07K14/7155 ,  C07K2317/21 ,  C07K2317/24 ,  C07K2317/35 ,  C07K2317/54 ,  C07K2317/55 ,  C07K2317/62 ,  G01N33/505 ,  G01N33/564 ,  G01N33/574 ,  G01N33/57407 ,  G01N33/57423 ,  G01N33/57438 ,  G01N33/57492 ,  G01N2333/54 ,  G01N2333/7155

摘要： The present invention is directed to novel polypeptides having sequence identity with IL-17, IL-17 receptors and to nucleic acid molecules encoding those polypeptides. Also provided herein are vectors and host cells comprising those nucleic acid sequences, chimeric polypeptide molecules comprising the polypeptides of the present invention fused to heterologous polypeptide sequences, antibodies which bind to the polypeptides of the present invention and to methods for producing the polypeptides of the present invention. Further provided herein are methods for treating degenerative cartilaginous disorders and other inflammatory diseases.

摘要翻译： 本发明涉及与IL-17，IL-17受体和编码那些多肽的核酸分子具有序列同一性的新型多肽。 本文还提供了包含那些核酸序列的载体和宿主细胞，包含与异源多肽序列融合的本发明的多肽的嵌合多肽分子，与本发明的多肽结合的抗体以及本发明的多肽的制备方法 发明。 本文还提供了治疗退行性软骨疾病和其它炎性疾病的方法。