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公开(公告)号：US20100169990A1
公开(公告)日：2010-07-01
申请号：US12650873
申请日：2009-12-31
申请人： Michael F. Clarke , Tim Hoey , Xinhao Wang , Scott Dylla , Austin Gurney , Piero Dalerba , Grace Chen , Mark Prince
发明人： Michael F. Clarke , Tim Hoey , Xinhao Wang , Scott Dylla , Austin Gurney , Piero Dalerba , Grace Chen , Mark Prince
CPC分类号： C12N5/0695 , C12N5/0093 , Y10S435/968 , Y10S435/971
摘要： The present invention relates to compositions and methods for characterizing, treating and diagnosing cancer. In particular, the present invention provides a cancer stem cell profile, as well as novel stem cell cancer markers useful for the diagnosis, characterization, prognosis and treatment of cancer and in particular the targeting of solid tumor stem cells.
摘要翻译： 本发明涉及用于表征，治疗和诊断癌症的组合物和方法。 特别地，本发明提供癌症干细胞概况，以及用于癌症的诊断，表征，预后和治疗的新型干细胞癌标记物，特别是固体肿瘤干细胞的靶向。
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公开(公告)号：US07723112B2
公开(公告)日：2010-05-25
申请号：US11591019
申请日：2006-10-31
申请人： Michael F. Clarke , Tim Hoey , Xinhao Wang , Scott Dylla , Austin Gurney , Piero Dalerba , Mark Prince , Grace Chen
发明人： Michael F. Clarke , Tim Hoey , Xinhao Wang , Scott Dylla , Austin Gurney , Piero Dalerba , Mark Prince , Grace Chen
IPC分类号： G01N33/53
CPC分类号： C12N5/0695 , C12N5/0093 , Y10S435/968 , Y10S435/971
摘要： The present invention relates to compositions and methods for characterizing, treating and diagnosing cancer. In particular, the present invention provides a cancer stem cell profile, as well as novel stem cell cancer markers useful for the diagnosis, characterization, prognosis and treatment of cancer and in particular the targeting of solid tumor stem cells.
摘要翻译： 本发明涉及用于表征，治疗和诊断癌症的组合物和方法。 特别地，本发明提供癌症干细胞概况，以及用于癌症的诊断，表征，预后和治疗的新型干细胞癌标记物，特别是固体肿瘤干细胞的靶向。
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公开(公告)号：US20080318234A1
公开(公告)日：2008-12-25
申请号：US12081484
申请日：2008-04-16
申请人： Xinhao Wang
发明人： Xinhao Wang
CPC分类号： C12Q1/6886 , C12Q2600/118
摘要： The present invention relates to compositions and methods for treating, characterizing, and diagnosing cancer. In particular, the present invention provides gene expression profiles associated with solid tumor stem cells, as well as novel stem cell cancer gene signatures useful for the diagnosis, characterization, prognosis and treatment of solid tumor stem cells.
摘要翻译： 本发明涉及用于治疗，表征和诊断癌症的组合物和方法。 特别地，本发明提供了与实体肿瘤干细胞相关的基因表达谱，以及用于实体瘤干细胞的诊断，表征，预后和治疗的新型干细胞癌基因特征。
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4.发明申请Genetic characterization and prognostic significance of cancer stem cells in cancer 审中-公开癌症干细胞的遗传表征及预后意义公开(公告)号：US20070220621A1
公开(公告)日：2007-09-20
申请号：US11591122
申请日：2006-10-31
申请人： Michael Clarke , Xinhao Wang , Robert Cho
发明人： Michael Clarke , Xinhao Wang , Robert Cho
IPC分类号： A01K67/027 , C12Q1/68 , G01N33/574 , C12N5/08
CPC分类号： C12N5/0695 , A01K2267/0331 , C12N2517/02 , C12Q1/6886 , C12Q2600/106 , C12Q2600/118 , C12Q2600/136 , C12Q2600/158 , G01N33/5011 , G01N33/5023 , G01N33/5073 , G01N33/57415 , G01N33/57492 , G01N2333/7055 , G01N2333/70589 , G01N2333/70596
摘要： The present invention is related to the identification of cancer stem cells using the MMTV-Wnt-1 transgenic mouse model. These cancer stem cells have a gene expression signature that allows them to be distinguished from their non-tumorigenic counterparts. Moreover, the gene expression pattern can also predict survival in a diverse group of solid tumors.
摘要翻译： 本发明涉及使用MMTV-Wnt-1转基因小鼠模型鉴定癌症干细胞。 这些癌症干细胞具有允许其与非致瘤性对应物区分的基因表达特征。 此外，基因表达模式还可以预测不同组实体瘤的存活。
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公开(公告)号：US20070099209A1
公开(公告)日：2007-05-03
申请号：US11451773
申请日：2006-06-13
申请人： Michael Clarke , Xinhao Wang , John Lewicki , Austin Gurney
发明人： Michael Clarke , Xinhao Wang , John Lewicki , Austin Gurney
IPC分类号： C12Q1/68 , G01N33/574 , C12M3/00
CPC分类号： G01N33/57415 , C12Q1/6837 , C12Q1/6886 , C12Q2600/106 , C12Q2600/112 , C12Q2600/118 , C12Q2600/136 , G01N33/57484
摘要： The present invention relates to compositions and methods for treating, characterizing, and diagnosing cancer. In particular, the present invention provides gene expression profiles associated with solid tumor stem cells, as well as novel stem cell cancer gene signatures useful for the diagnosis, characterization, prognosis and treatment of solid tumor stem cells.
摘要翻译： 本发明涉及用于治疗，表征和诊断癌症的组合物和方法。 特别地，本发明提供了与实体肿瘤干细胞相关的基因表达谱，以及用于实体瘤干细胞的诊断，表征，预后和治疗的新型干细胞癌基因特征。
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公开(公告)号：US20110183866A1
公开(公告)日：2011-07-28
申请号：US13077380
申请日：2011-03-31
CPC分类号： G01N33/6887 , C12N5/0693 , C12N5/0695 , C12N2501/58 , C12Q1/6886 , G01N33/57484 , G01N2333/705
摘要： The present invention relates to compositions and methods for treating, characterizing, and diagnosing cancer. In particular, the present invention provides gene expression profiles and signatures associated with solid tumor stem cells, as well as novel stem cell cancer markers useful for the diagnosis, characterization, prognosis and treatment of solid tumor stem cells. More particularly, the present invention identifies two profiles of cancer stem cells useful for the diagnosis, characterization, and treatment of cancer and cancer metastases. The invention also provides a variety of reagents such as stem cell gene signatures for use in the diagnosis and management of cancer.
摘要翻译： 本发明涉及用于治疗，表征和诊断癌症的组合物和方法。 特别地，本发明提供了与实体肿瘤干细胞相关的基因表达谱和特征，以及用于实体瘤干细胞的诊断，表征，预后和治疗的新型干细胞癌标记。 更具体地，本发明鉴定了可用于癌症和癌症转移的诊断，表征和治疗的癌症干细胞的两个概况。 本发明还提供用于诊断和治疗癌症的多种试剂如干细胞基因特征。
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公开(公告)号：US20100093556A1
公开(公告)日：2010-04-15
申请号：US12512655
申请日：2009-07-30
CPC分类号： G01N33/6887 , C12N5/0693 , C12N5/0695 , C12N2501/58 , C12Q1/6886 , G01N33/57484 , G01N2333/705
摘要： The present invention relates to compositions and methods for treating, characterizing, and diagnosing cancer. In particular, the present invention provides gene expression profiles and signatures associated with solid tumor stem cells, as well as novel stem cell cancer markers useful for the diagnosis, characterization, prognosis and treatment of solid tumor stem cells. More particularly, the present invention identifies two profiles of cancer stem cells useful for the diagnosis, characterization, and treatment of cancer and cancer metastases. The invention also provides a variety of reagents such as stem cell gene signatures for use in the diagnosis and management of cancer.
摘要翻译： 本发明涉及用于治疗，表征和诊断癌症的组合物和方法。 特别地，本发明提供了与实体肿瘤干细胞相关的基因表达谱和特征，以及用于实体瘤干细胞的诊断，表征，预后和治疗的新型干细胞癌标记。 更具体地，本发明鉴定了可用于癌症和癌症转移的诊断，表征和治疗的癌症干细胞的两个概况。 本发明还提供用于诊断和治疗癌症的多种试剂如干细胞基因特征。
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公开(公告)号：US20070105133A1
公开(公告)日：2007-05-10
申请号：US11451774
申请日：2006-06-13
申请人： Michael Clarke , Xinhao Wang , John Lewicki , Austin Gurney
发明人： Michael Clarke , Xinhao Wang , John Lewicki , Austin Gurney
IPC分类号： C12Q1/68 , G01N33/574 , C12N5/08
CPC分类号： G01N33/6887 , C12N5/0693 , C12N5/0695 , C12N2501/58 , C12Q1/6886 , G01N33/57484 , G01N2333/705
摘要： The present invention relates to compositions and methods for treating, characterizing, and diagnosing cancer. In particular, the present invention provides gene expression profiles and signatures associated with solid tumor stem cells, as well as novel stem cell cancer markers useful for the diagnosis, characterization, prognosis and treatment of solid tumor stem cells. More particularly, the present invention identifies two profiles of cancer stem cells useful for the diagnosis, characterization, and treatment of cancer and cancer metastases. The invention also provides a variety of reagents such as stem cell gene signatures for use in the diagnosis and management of cancer.
摘要翻译： 本发明涉及用于治疗，表征和诊断癌症的组合物和方法。 特别地，本发明提供了与实体肿瘤干细胞相关的基因表达谱和特征，以及用于实体瘤干细胞的诊断，表征，预后和治疗的新型干细胞癌标记。 更具体地，本发明鉴定了可用于癌症和癌症转移的诊断，表征和治疗的癌症干细胞的两个概况。 本发明还提供用于诊断和治疗癌症的多种试剂如干细胞基因特征。
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公开(公告)号：US07939263B2
公开(公告)日：2011-05-10
申请号：US12512655
申请日：2009-07-30
IPC分类号： C12Q1/68
CPC分类号： G01N33/6887 , C12N5/0693 , C12N5/0695 , C12N2501/58 , C12Q1/6886 , G01N33/57484 , G01N2333/705
摘要： The present invention relates to compositions and methods for treating, characterizing, and diagnosing cancer. In particular, the present invention provides gene expression profiles and signatures associated with solid tumor stem cells, as well as novel stem cell cancer markers useful for the diagnosis, characterization, prognosis and treatment of solid tumor stem cells. More particularly, the present invention identifies two profiles of cancer stem cells useful for the diagnosis, characterization, and treatment of cancer and cancer metastases. The invention also provides a variety of reagents such as stem cell gene signatures for use in the diagnosis and management of cancer.
摘要翻译： 本发明涉及用于治疗，表征和诊断癌症的组合物和方法。 特别地，本发明提供了与实体肿瘤干细胞相关的基因表达谱和特征，以及用于实体瘤干细胞的诊断，表征，预后和治疗的新型干细胞癌标记。 更具体地，本发明鉴定了可用于癌症和癌症转移的诊断，表征和治疗的癌症干细胞的两个概况。 本发明还提供用于诊断和治疗癌症的多种试剂如干细胞基因特征。
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公开(公告)号：US20080064049A1
公开(公告)日：2008-03-13
申请号：US11591019
申请日：2006-10-31
申请人： Michael Clarke , Tim Hoey , Xinhao Wang , Scott Dylla , Austin Gumey , Pierro Dalerba , Grace Chen , Mark Prince
发明人： Michael Clarke , Tim Hoey , Xinhao Wang , Scott Dylla , Austin Gumey , Pierro Dalerba , Grace Chen , Mark Prince
IPC分类号： G01N33/574 , C12N5/06
CPC分类号： C12N5/0695 , C12N5/0093 , Y10S435/968 , Y10S435/971
摘要： The present invention relates to compositions and methods for characterizing, treating and diagnosing cancer. In particular, the present invention provides a cancer stem cell profile, as well as novel stem cell cancer markers useful for the diagnosis, characterization, prognosis and treatment of cancer and in particular the targeting of solid tumor stem cells.
摘要翻译： 本发明涉及用于表征，治疗和诊断癌症的组合物和方法。 特别地，本发明提供癌症干细胞概况，以及用于癌症的诊断，表征，预后和治疗的新型干细胞癌标记物，特别是固体肿瘤干细胞的靶向。
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