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公开(公告)号：US09062118B2
公开(公告)日：2015-06-23
申请号：US12301827
申请日：2007-06-06
申请人： Julita S. Imperial , Baldomero M. Olivera , Paul F. Alewood , Heinz Terlau , David J. Craik , Estuardo Lopez-Vera , Pradip K. Bandyopadhyay
发明人： Julita S. Imperial , Baldomero M. Olivera , Paul F. Alewood , Heinz Terlau , David J. Craik , Estuardo Lopez-Vera , Pradip K. Bandyopadhyay
IPC分类号： A61K38/00 , C07K14/435
CPC分类号： C07K14/43504 , A61K38/00
摘要： The invention relates to relatively short peptides (termed J-Superfamily conotoxin peptides, J-conotoxins or J-conotoxin peptides herein), about 25 residues in length, which are naturally available in minute amounts in the venom of the cone snails or analogous to the naturally available peptides, and which preferably include two disulfide bonds. The J-conotoxins are useful for treating disorders involving voltage gated ion channels and/or receptors.
摘要翻译： 本发明涉及长度约25个残基的相对较短的肽（称为J-超家族荚果毒素肽，J-芋螺毒素或J-芋螺毒素肽），其在锥形蜗牛的毒液中天然可用量很少，或类似于 天然存在的肽，并且其优选包括两个二硫键。 J-芋螺毒素可用于治疗涉及电压门控离子通道和/或受体的疾病。
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公开(公告)号：US08487075B2
公开(公告)日：2013-07-16
申请号：US13367839
申请日：2012-02-07
申请人： Maren Watkins , Baldomero M. Olivera , David R. Hillyard , J. Michael McIntosh , Robert M. Jones
发明人： Maren Watkins , Baldomero M. Olivera , David R. Hillyard , J. Michael McIntosh , Robert M. Jones
CPC分类号： C07K14/43504 , A61K38/00 , C07K7/08 , C07K9/00 , Y10S530/855 , Y10S530/857
摘要： The invention relates to relatively short peptides (termed α-conotoxins herein), about 10-30 residues in length, which are naturally available in minute amounts in the venom of the cone snails or analogous to the naturally available peptides, and which preferably include two disulfide bonds.
摘要翻译： 本发明涉及相对短的肽（本文中称为α-芋螺毒素），长度约10-30个残基，其在锥形蜗牛的毒液中天然可以微量天然存在或类似于天然可得的肽，并且其优选包括两个 二硫键。
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公开(公告)号：US20120220539A1
公开(公告)日：2012-08-30
申请号：US13289494
申请日：2011-11-04
CPC分类号： C07K14/43504 , A61K38/00
摘要： The present invention relates conotoxin peptides that are analogs of the α-contoxin peptide RgIA. These conotoxin peptides block the α9α10 subtype of the nicotinic acetylcholine receptor (nAChR) and can be used for treating pain, such as neuropathic pain and inflammatory pain, inflammatory disorders, such as rheumatic diseases, and in the treatment of breast cancer.
摘要翻译： 本发明涉及作为α-轮廓蛋白肽RgIA的类似物的荚果毒素肽。 这些芋螺毒素肽阻断烟碱乙酰胆碱受体（nAChR）的α9α10亚型，可用于治疗疼痛，如神经性疼痛和炎性疼痛，炎性疾病如风湿性疾病，以及乳腺癌的治疗。
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公开(公告)号：US07115708B2
公开(公告)日：2006-10-03
申请号：US11198847
申请日：2005-08-08
CPC分类号： C07K14/43504
摘要： The present invention is directed to β-superfamily conotoxin peptides, derivatives or pharmaceutically acceptable salts thereof. The present invention is further directed to the use of this peptide, derivatives thereof and pharmaceutically acceptable salts thereof for the treatment of disorders associated with voltage-gated ion channels, ligand gated channels and other receptors. The invention is further directed to nucleic acid sequences encoding the β-superfamily conotoxin peptides and encoding β-superfamily conotoxin propeptides, as well as the β-superfamily conotoxin propeptides.
摘要翻译： 本发明涉及β-超家族荚果毒素肽，其衍生物或药学上可接受的盐。 本发明进一步涉及该肽，其衍生物和其药学上可接受的盐在治疗与电压门控离子通道，配体门控通道和其它受体相关的病症中的用途。 本发明还涉及编码β-超家族荚果毒素肽和编码β-超家族荚果毒素前肽以及β-超家族荚果毒素前肽的核酸序列。
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公开(公告)号：US06441132B1
公开(公告)日：2002-08-27
申请号：US09297771
申请日：1999-12-14
IPC分类号： C07K412
摘要： The present invention is directed to contryphan peptides having 6-12 amino acids, preferably including one or more D-tryptophan residues. More specifically, the present invention is directed to contryphan peptides having the general formula Xaa1-Cys-Xaa2-Xaa3-Glu-Pro-Trp-Cys (SEQ ID NO:1), wherein Xaa1 is Gly or des-Xaa1, Xaa2 is Pro or 4-trans-hydroxyproline and Xaa3 is D-Trp or L-Trp, preferably D-Trp. The present invention is further directed to the peptides contryphan R and des-Gly1 contryphan R. In contryphan R, Xaa1 is Gly and Xaa3 is D-Trp. These contryphans are useful as anticonvulsant or neuroprotective agents.
摘要翻译： 本发明涉及具有6-12个氨基酸的优选肽，优选包括一个或多个D-色氨酸残基。 更具体地，本发明涉及具有通式Xaa1-Cys-Xaa2-Xaa3-Glu-Pro-Trp-Cys（SEQ ID NO：1）的反式肽，其中Xaa1是Gly或des-Xaa1，Xaa2是Pro 或4-反式 - 羟基脯氨酸，Xaa3是D-Trp或L-Trp，优选D-Trp。 本发明进一步针对R和des-Gly1对应的肽。相反，Raa，Xaa1是Gly，Xaa3是D-Trp。 这些拮抗剂可用作抗惊厥药或神经保护剂。
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公开(公告)号：US06277825B1
公开(公告)日：2001-08-21
申请号：US09357141
申请日：1999-07-20
IPC分类号： A61K3800
CPC分类号： C07K14/43504 , A61K38/00
摘要： The present invention is directed to the use of conantokin peptides, conantokin peptide derivatives and conantokin peptide chimeras, referred to collectively as conantokins, having 10-30 amino acids, including preferably two or more &ggr;-carboxyglutamic acid residues, for the treatment of neurologic and psychiatric disorders, such as pain, e.g., as an analgesic agent.
摘要翻译： 本发明涉及使用具有10-30个氨基酸，包括优选两个或更多个γ-羧基谷氨酸残基的共同称为聚对二聚腺嘌呤肽，柯南多肽衍生物和柯南多肽嵌合体用于治疗神经病学和 精神疾病如疼痛，例如止痛剂。
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公开(公告)号：US06265541B1
公开(公告)日：2001-07-24
申请号：US09219446
申请日：1998-12-23
IPC分类号： C07K1400
CPC分类号： A61K38/17 , A61K38/08 , C07K14/43504
摘要： The present invention relates to the use of &agr;-conotoxin peptides having the general formula Xaa1-Xaa2-Cys-Cys-Xaa3-Xaa4-Pro-Xaa5-Cys-Xaa6-Cys (SEQ ID NO: 1) for treating disorders regulated at neuronal nicotinic acetylcholine receptors. Such disorders include, but are not limited to, cardiovascular disorders, gastric motility disorders, urinary incontinence, nicotine addiction, mood disorders (such as bipolar disorder, unipolar depression, dysthymia and seasonal effective disorder) and small cell lung carcinoma, as well as the localization of small cell lung carcinoma. In this formula, Xaa1 is des-Xaa1, Tyr, mono-iodo-Tyr or di-iodo-Tyr, Xaa2 is any amino acid, Xaa3 is any amino acid, Xaa4 is any amino acid, Xaa5 is any amino acid and Xaa6 represents a peptide of 3-7 amino acids. Disulfide linkages exist between the first and third cysteines and the second and fourth cysteines. Pro may be replaced with hydroxy-Pro. The C-terminus may contain a hydroxyl or an amide group, preferably an amide group.
摘要翻译： 本发明涉及具有用于治疗在神经元烟碱乙酰胆碱受体调节的病症的通式的α-芋螺毒素肽的用途。 这些病症包括但不限于心血管疾病，胃动力障碍，尿失禁，尼古丁成瘾，情绪障碍（例如双相情感障碍，单极抑郁，精神抑郁和季节性有效障碍）和小细胞肺癌，以及 小细胞肺癌的定位。 在该式中，Xaa1是des-Xaa1，Tyr，单碘-Tyr或二碘-Tyr，Xaa2是任何氨基酸，Xaa3是任何氨基酸，Xaa4是任何氨基酸，Xaa5是任何氨基酸，Xaa6表示 3-7个氨基酸的肽。 第一和第三半胱氨酸与第二和第四半胱氨酸之间存在二硫键。 Pro可以用羟基替代。 C末端可以含有羟基或酰胺基，优选酰胺基。
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公开(公告)号：US06197535B1
公开(公告)日：2001-03-06
申请号：US09247527
申请日：1999-02-10
IPC分类号： C12Q148
CPC分类号： G01N33/573 , C07K14/43504 , C12N9/88 , C12Q1/25 , G01N2333/43504 , G01N2333/9015
摘要： The present invention is relates to a method for purifying a &ggr;-carboxylase from Conus snails and to a method for assaying the activity of this &ggr;-glutamyl carboxylase.
摘要翻译： 本发明涉及一种从圆锥螺旋藻中纯化γ-羧化酶的方法以及测定该γ-谷氨酰羧化酶的活性的方法。
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公开(公告)号：US09717775B2
公开(公告)日：2017-08-01
申请号：US12307953
申请日：2007-07-17
CPC分类号： A61K38/1767 , G01N33/944 , G01N2500/00
摘要： The present invention relates to the use of compounds that block the α9α10 subtype of the nicotinic acetylcholine receptor (nAChR) for treating pain, such as neuropathic pain and inflammatory pain, and inflammatory disorders, such as arthritis. The present invention also relates to screening compounds to identify analgesic agents that block the α9α10 subtype of the nAChR.
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公开(公告)号：US07390785B2
公开(公告)日：2008-06-24
申请号：US11267257
申请日：2005-11-07
申请人： Craig Walker , Reshma Shetty , Baldomero M. Olivera , David Hooper , Richard Jacobsen , Doug Steel , Robert Jones
发明人： Craig Walker , Reshma Shetty , Baldomero M. Olivera , David Hooper , Richard Jacobsen , Doug Steel , Robert Jones
CPC分类号： C07K14/43504 , A61K38/00
摘要： The invention relates to relatively short peptides (termed τ-conotoxins herein), about 10-25 residues in length, which are naturally available in minute amounts in the venom of the cone snails or analogous to the naturally available peptides, and which preferably include two disulfide bonds.
摘要翻译： 本发明涉及相对较短的肽（本文中称为tau-芋螺毒素），长度约10-25个残基，其在锥形蜗牛的毒液中天然可以微量天然存在或类似于天然可得的肽，并且优选包括两个 二硫键。
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