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公开(公告)号：US08414624B2
公开(公告)日：2013-04-09
申请号：US12947664
申请日：2010-11-16
IPC分类号： A61B17/88
CPC分类号： A61B17/7035 , A61B17/7002 , A61B17/7032 , A61B17/704 , A61B2017/564
摘要： A method of providing spinal stabilization is provided herein. More specifically, the method includes positioning a plurality of fixation assemblies within a plurality of vertebrae in a trans-lamina orientation wherein each fixation assembly includes a proximal portion configured to securely receive a stabilization element (e.g., a stabilization rod). The proximal portions of the various fixation assemblies can be aligned so as to secure at least one stabilization element in a desired position (e.g., along and above a midline of the patient's spine, adjacent and parallel to the midline). A system for providing spinal stabilization is also provided which utilizes trans-lamina delivery and positioning of fixation assemblies within target vertebrae thereby providing stronger fixation and a significant reduction in associated tissue damage.
摘要翻译： 本文提供了一种提供脊柱稳定的方法。 更具体地，该方法包括将多个固定组件定位在跨椎板取向中的多个椎骨内，其中每个固定组件包括被配置为牢固地容纳稳定元件（例如稳定杆）的近端部分。 各个固定组件的近端部分可以对准，以便将至少一个稳定元件固定在期望的位置（例如，沿着和靠近患者脊柱的中线，邻近并平行于中线）。 还提供了一种用于提供脊柱稳定的系统，其利用跨椎板递送并将固定组件定位在目标椎骨内，从而提供更强的固定和相关组织损伤的显着减少。
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公开(公告)号：US20090216272A1
公开(公告)日：2009-08-27
申请号：US12035684
申请日：2008-02-22
CPC分类号： A61B17/7035 , A61B17/7002 , A61B17/7032 , A61B17/704 , A61B2017/564
摘要： A method of providing spinal stabilization is provided herein. More specifically, the method includes positioning a plurality of fixation assemblies within a plurality of vertebrae in a trans-lamina orientation wherein each fixation assembly includes a proximal portion configured to securely receive a stabilization element (e.g., a stabilization rod). The proximal portions of the various fixation assemblies can be aligned so as to secure at least one stabilization element in a desired position (e.g., along and above a midline of the patient's spine, adjacent and parallel to the midline). A system for providing spinal stabilization is also provided which utilizes trans-lamina delivery and positioning of fixation assemblies within target vertebrae thereby providing stronger fixation and a significant reduction in associated tissue damage.
摘要翻译： 本文提供了一种提供脊柱稳定的方法。 更具体地，该方法包括将多个固定组件定位在跨椎板取向中的多个椎骨内，其中每个固定组件包括被配置为牢固地容纳稳定元件（例如稳定杆）的近端部分。 各个固定组件的近端部分可以对准，以便将至少一个稳定元件固定在期望的位置（例如，沿着和靠近患者脊柱的中线，邻近并平行于中线）。 还提供了一种用于提供脊柱稳定的系统，其利用跨椎板递送并将固定组件定位在目标椎骨内，从而提供更强的固定和相关组织损伤的显着减少。
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公开(公告)号：US06668688B2
公开(公告)日：2003-12-30
申请号：US09893818
申请日：2001-06-28
IPC分类号： B25B2300
CPC分类号： A61B17/8685 , A61B17/686 , B25B31/00 , F16B13/02 , F16B13/066 , Y10S606/916
摘要： An apparatus for an expandable screw including an outer screw, a inner screw, and an end nut. An assembly and method for driving and expanding an expandable screw apparatus into a surface or structure. The assembly and method dynamically expand the expandable screw by driving and expanding the expandable screw simultaneously.
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公开(公告)号：US20110060368A1
公开(公告)日：2011-03-10
申请号：US12947664
申请日：2010-11-16
CPC分类号： A61B17/7035 , A61B17/7002 , A61B17/7032 , A61B17/704 , A61B2017/564
摘要： A method of providing spinal stabilization is provided herein. More specifically, the method includes positioning a plurality of fixation assemblies within a plurality of vertebrae in a trans-lamina orientation wherein each fixation assembly includes a proximal portion configured to securely receive a stabilization element (e.g., a stabilization rod). The proximal portions of the various fixation assemblies can be aligned so as to secure at least one stabilization element in a desired position (e.g., along and above a midline of the patient's spine, adjacent and parallel to the midline). A system for providing spinal stabilization is also provided which utilizes trans-lamina delivery and positioning of fixation assemblies within target vertebrae thereby providing stronger fixation and a significant reduction in associated tissue damage.
摘要翻译： 本文提供了一种提供脊柱稳定的方法。 更具体地，该方法包括将多个固定组件定位在跨椎板取向中的多个椎骨内，其中每个固定组件包括被配置为牢固地容纳稳定元件（例如稳定杆）的近端部分。 各个固定组件的近端部分可以对准，以便将至少一个稳定元件固定在期望的位置（例如，沿着和靠近患者脊柱的中线，邻近并平行于中线）。 还提供了一种用于提供脊柱稳定的系统，其利用跨椎板递送并将固定组件定位在目标椎骨内，从而提供更强的固定和相关组织损伤的显着减少。
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5.发明授权Hydroxyapatite grafted fumarate based macromers for biodegradable composites 失效羟基磷灰石接枝富马酸盐的大分子单体用于可生物降解的复合材料公开(公告)号：US07642300B2
公开(公告)日：2010-01-05
申请号：US10562591
申请日：2004-06-29
IPC分类号： C08F297/02 , C08F297/00
CPC分类号： C08F292/00 , A61F2/28 , A61F2002/30062 , A61F2210/0004 , A61F2310/00293 , A61L27/425
摘要： A composition is disclosed which comprises (i) a macromer prepared by reacting an unsaturated diacid having a carbon-carbon double bond and a saturated diacid, and (ii) a bioactive ceramic grafted to the macromer. In one embodiment, the unsaturated diacid having a carbon-carbon double bond is fumaric acid, the saturated diacid is compatible with fumaric acid and poly(propylene fumarate) such as succinic acid, glutaric acid, adipic acid, pimelic acid, suberic acid, azelaic acid, sebacic acid and mixtures thereof, and the bioactive ceramic is hydroxyapatite. In another embodiment, hydroxyapatite is grafted with a biodegradable and crosslinkable macromer comprising silane units alternating with furnarate and adipate units.
摘要翻译： 公开了一种组合物，其包含（i）通过使具有碳 - 碳双键的不饱和二酸和饱和二酸反应制备的大分子单体，和（ii）接枝到大分子单体上的生物活性陶瓷。 在一个实施方案中，具有碳 - 碳双键的不饱和二酸是富马酸，饱和二酸与富马酸和富马酸（丙烯酸富马酸）如琥珀酸，戊二酸，己二酸，庚二酸，辛二酸，壬二酸 酸，癸二酸及其混合物，生物活性陶瓷为羟基磷灰石。 在另一个实施方案中，羟基磷灰石用可生物降解和可交联的大分子单体接枝，其包含与富马酸和己二酸酯单元交替的硅烷单元。
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6.发明授权Blend, cross-linkable poly(propylene fumarate) for immobilization and controlled drug delivery 有权用于固定和控制药物递送的共混物，可交联的聚（富马酸丙烯酯）公开(公告)号：US06884432B2
公开(公告)日：2005-04-26
申请号：US10423209
申请日：2003-04-25
申请人： Michael J. Yaszemski , Bradford L. Currier , Lichun Lu , Xun Zhu , Esmaiel Jabbari , Diederik H. R. Kempen
发明人： Michael J. Yaszemski , Bradford L. Currier , Lichun Lu , Xun Zhu , Esmaiel Jabbari , Diederik H. R. Kempen
CPC分类号： A61L27/54 , A61K9/1647 , A61L2300/414 , A61L2300/426 , A61L2300/602 , A61L2300/622 , Y10T428/2982 , Y10T428/2985 , Y10T428/2989
摘要： Microspheres for controlled release of a bioactive agent are disclosed, and in particular, blend, cross-linkable poly(propylene fumarate) for immobilization and controlled drug delivery. The microsphere includes poly(propylene fumarate), a polymeric material other than poly(propylene fumarate) (e.g., poly(lactic-co-glycolic acid)), and a bioactive agent. The bioactive agent is selected depending on the physiological effect desired. For example, in bone regeneration applications, the bioactive agent may be selected from osteoinductive agents, peptides, growth hormones, osteoconductive agents, cytokines and mixtures thereof. The bioactive agent is dispersed in the microsphere, the microsphere has a diameter in the range of 1 to 300 micrometers, the poly(propylene fumarate) and poly(lactic-co-glycolic acid) are distributed in the microsphere, and the microsphere releases the bioactive agent in a sustained manner after an initial burst release. The microspheres may be covalently attached to a poly(propylene fumarate) scaffold for tissue regeneration applications in which the bioactive agent is released from the scaffold.
摘要翻译： 公开了用于控制释放生物活性剂的微球，并且特别地，用于固定和控制药物递送的共混物，可交联聚（富马酸丙烯酯）。 微球包括聚（丙烯富马酸盐），聚（丙烯富马酸酯）以外的聚合物（例如聚（乳酸 - 共 - 乙醇酸））和生物活性剂。 取决于所需的生理效果来选择生物活性剂。 例如，在骨再生应用中，生物活性剂可以选自骨诱导剂，肽，生长激素，骨诱导剂，细胞因子及其混合物。 生物活性剂分散在微球中，微球的直径范围为1〜300微米，聚（丙烯富马酸）和聚（乳酸 - 共 - 乙醇酸）分布在微球中，微球释放出 初始爆发后持续的生物活性剂。 微球可以共价连接到用于组织再生应用的聚（丙烯富马酸酯）支架中，其中生物活性剂从支架中释放。
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公开(公告)号：US07857835B2
公开(公告)日：2010-12-28
申请号：US12035684
申请日：2008-02-22
IPC分类号： A61B17/88
CPC分类号： A61B17/7035 , A61B17/7002 , A61B17/7032 , A61B17/704 , A61B2017/564
摘要： A method of providing spinal stabilization is provided herein. More specifically, the method includes positioning a plurality of fixation assemblies within a plurality of vertebrae in a trans-lamina orientation wherein each fixation assembly includes a proximal portion configured to securely receive a stabilization element (e.g., a stabilization rod). The proximal portions of the various fixation assemblies can be aligned so as to secure at least one stabilization element in a desired position (e.g., along and above a midline of the patient's spine, adjacent and parallel to the midline). A system for providing spinal stabilization is also provided which utilizes trans-lamina delivery and positioning of fixation assemblies within target vertebrae thereby providing stronger fixation and a significant reduction in associated tissue damage.
摘要翻译： 本文提供了一种提供脊柱稳定的方法。 更具体地，该方法包括将多个固定组件定位在跨椎板取向中的多个椎骨内，其中每个固定组件包括被配置为牢固地容纳稳定元件（例如稳定杆）的近端部分。 各个固定组件的近端部分可以对准，以便将至少一个稳定元件固定在期望的位置（例如，沿着和靠近患者脊柱的中线，邻近并平行于中线）。 还提供了一种用于提供脊柱稳定的系统，其利用跨椎板递送并将固定组件定位在目标椎骨内，从而提供更强的固定和相关组织损伤的显着减少。
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公开(公告)号：US07816461B2
公开(公告)日：2010-10-19
申请号：US11718962
申请日：2005-11-18
IPC分类号： C08G63/91
CPC分类号： A61L27/56 , A61L27/18 , A61L27/46 , B33Y70/00 , B33Y80/00 , C08G63/08 , C08G63/60 , C08G2261/126 , C08J9/26 , C08J2201/024 , C08J2201/0446 , C08J2367/06 , C08L67/06
摘要： Poly(propylene fumarate) is copolymerized with poly(caprolactone) diol to produce a block copolymer of poly(propylene fumarate) and poly(caprolactone). The biocompatible and bioresorbable block copolymer of poly(propylene fumarate) and poly(caprolactone) is useful in the fabrication of injectable and in-situ hardening scaffolds for tissue and/or skeletal reconstruction. The block copolymer can be crosslinked by redox or photo-initiation, with or without an additional crosslinker. Thus, the copolymer is both self-crosslinkable (without the use of any crosslinkers) and photocrosslinkable (in the presence of photons such as UV light).
摘要翻译： 聚（丙烯酸富马酸酯）与聚（己内酯）二醇共聚以制备聚（丙烯酸富马酸酯）和聚（己内酯）的嵌段共聚物。 聚（丙烯酸富马酸酯）和聚（己内酯）的生物相容性和生物可吸收的嵌段共聚物可用于制备用于组织和/或骨骼重建的可注射和原位硬化支架。 嵌段共聚物可以通过氧化还原或光引发交联，具有或不具有另外的交联剂。 因此，共聚物既可自交联（不使用任何交联剂）和光可交联（在诸如紫外光的光子存在下）。
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公开(公告)号：US20080206308A1
公开(公告)日：2008-08-28
申请号：US10568058
申请日：2004-08-27
IPC分类号： A61K9/00 , C08J9/00 , C08J9/16 , C08G63/00 , A61K9/14 , A61K38/43 , A61K31/7052 , A61P43/00 , A61K38/02 , A61K38/16 , A61K38/14 , A61K39/395 , A61K31/70
摘要： Hydrogel microparticles with entrapped liquid are used as the porogen to reproducibly form interconnected pore networks in a porous scaffold. In one embodiment, a biodegradable unsaturated polymer, a crosslinking agent, and a porogen comprising biodegradable hydrogel microparticles are mixed together and allowed to form a porous scaffold in an mold or in a body cavity. Example biodegradable unsaturated polymers include poly(propylene fumarate) and poly(e-caprolactone-fumarate). The cosslinking agent may be a free radical initiator, or may include a free radical initiator and a monomer capable of addition polymerization. Example hydrogel microparticles include uncrosslinked or crosslinked collagen , an uncrosslinked or crosslinked collagen derivative, and an uncrosslinked or crosslinked synthetic biodegradable polymer such as oligo(poly(ethylene glycol) fumarate).
摘要翻译： 使用具有捕获液体的水凝胶微粒作为致孔剂，以在多孔支架中可再现形成互连的孔网络。 在一个实施方案中，将可生物降解的不饱和聚合物，交联剂和包含可生物降解的水凝胶微粒的致孔剂混合在一起并允许在模具或体腔中形成多孔支架。 可生物降解的不饱和聚合物的实例包括聚（丙烯酸富马酸酯）和聚（ε-己内酯 - 富马酸酯）。 该切断剂可以是自由基引发剂，或者可以包括自由基引发剂和能够进行加成聚合的单体。 示例性水凝胶微粒包括未交联或交联的胶原蛋白，未交联或交联的胶原衍生物，以及未交联或交联的合成生物可降解聚合物，例如寡（聚（乙二醇）富马酸酯）。
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公开(公告)号：US08043341B2
公开(公告)日：2011-10-25
申请号：US11301473
申请日：2005-12-13
IPC分类号： A61B17/70
CPC分类号： A61B17/7058 , A61B17/70 , A61B17/7007 , A61B17/701
摘要： The invention provides for a spinal fixation support device to be used in conjunction with spinal fixation instrumentation. The invention further provides for methods of using the spinal fixation support device. In addition, the invention provides for a spinal fixation system that includes a spinal fixation support device of the invention and can further include spinal fixation instrumentation.
摘要翻译： 本发明提供了一种与脊柱固定装置结合使用的脊柱固定支撑装置。 本发明还提供了使用脊柱固定支撑装置的方法。 此外，本发明提供了一种包括本发明的脊柱固定支撑装置的脊柱固定系统，并且还可以包括脊柱固定装置。
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