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公开(公告)号：US09101654B2
公开(公告)日：2015-08-11
申请号：US11995612
申请日：2006-07-12
申请人： Esmaiel Jabbari
发明人： Esmaiel Jabbari
IPC分类号： A61K31/765 , A61L27/36 , C08L67/04 , A61L27/18
CPC分类号： A61K31/765 , A61L27/18 , A61L27/365 , C08L67/04
摘要： Bioresorbable compositions for treating skeletal tissue are disclosed. The biomedical compositions are formed from a polylactide polymer, a polyglycolide polymer, or a poly(lactic-co-glycolic acid) polymer having a relatively low molecular weight. For instance, the average number molecular weight of the polymer is generally less than 10,000, such as from about 500 to about 5,000. Fumarate groups are incorporated into the low molecular weight polymer that provide crosslinking sites. If desired, ethyl-lene oxide groups and ceramic particles may also be incorporated into the polymer for producing compositions having a variety of properties. For example, the biomedical composition of the present disclosure can be used to treat soft skeletal tissue or to treat hard skeletal tissue. The biomedical compositions are biodegradable and can contain various therapeutic, beneficial and pharmaceutical agents that may be released during degradation of the polymer.
摘要翻译： 公开了用于治疗骨骼组织的生物可再吸收组合物。 生物医学组合物由聚丙交酯聚合物，聚乙交酯聚合物或具有相对较低分子量的聚（乳酸 - 共 - 乙醇酸）聚合物形成。 例如，聚合物的平均数分子量通常小于10,000，例如约500至约5,000。 富马酸盐基团被并入提供交联位点的低分子量聚合物中。 如果需要，乙烯基氧化物基团和陶瓷颗粒也可以引入到用于制备具有各种性能的组合物的聚合物中。 例如，本公开的生物医学组合物可用于治疗软骨骼组织或治疗硬骨骼组织。 生物医学组合物是可生物降解的，并且可以含有可在聚合物降解期间释放的各种治疗，有益和药物。
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2.发明申请Hydroxyapatite grafted fumarate based macromers for biodegradable composites 失效羟基磷灰石接枝富马酸盐的大分子单体用于可生物降解的复合材料公开(公告)号：US20060241246A1
公开(公告)日：2006-10-26
申请号：US10562591
申请日：2004-06-29
IPC分类号： C08F297/02
CPC分类号： C08F292/00 , A61F2/28 , A61F2002/30062 , A61F2210/0004 , A61F2310/00293 , A61L27/425
摘要： A composition is disclosed which comprises (i) a macromer prepared by reacting an unsaturated diacid having a carbon-carbon double bond and a saturated diacid, and (ii) a bioactive ceramic grafted to the macromer. In one embodiment, the unsaturated diacid having a carbon-carbon double bond is fumaric acid, the saturated diacid is compatible with fumaric acid and poly(propylene fumarate) such as succinic acid, glutaric acid, adipic acid, pimelic acid, suberic acid, azelaic acid, sebacic acid and mixtures thereof, and the bioactive ceramic is hydroxyapatite. In another embodiment, hydroxyapatite is grafted with a biodegradable and crosslinkable macromer comprising silane units alternating with furnarate and adipate units.
摘要翻译： 公开了一种组合物，其包含（i）通过使具有碳 - 碳双键的不饱和二酸和饱和二酸反应制备的大分子单体，和（ii）接枝到大分子单体上的生物活性陶瓷。 在一个实施方案中，具有碳 - 碳双键的不饱和二酸是富马酸，饱和二酸与富马酸和富马酸（丙烯酸富马酸）如琥珀酸，戊二酸，己二酸，庚二酸，辛二酸，壬二酸 酸，癸二酸及其混合物，生物活性陶瓷为羟基磷灰石。 在另一个实施方案中，羟基磷灰石用可生物降解和可交联的大分子单体接枝，其包含与富马酸和己二酸酯单元交替的硅烷单元。
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公开(公告)号：US20090110732A1
公开(公告)日：2009-04-30
申请号：US11995612
申请日：2006-07-12
申请人： Esmaiel Jabbari
发明人： Esmaiel Jabbari
CPC分类号： A61K31/765 , A61L27/18 , A61L27/365 , C08L67/04
摘要： Bioresorbable compositions for treating skeletal tissue are disclosed. The biomedical compositions are formed from a polylactide polymer, a polyglycolide polymer, or a poly(lactic-co-glycolic acid) polymer having a relatively low molecular weight. For instance, the average number molecular weight of the polymer is generally less than 10,000, such as from about 500 to about 5,000. Fumarate groups are incorporated into the low molecular weight polymer that provide crosslinking sites. If desired, ethylene oxide groups and ceramic particles may also be incorporated into the polymer for producing compositions having a variety of properties. For example, the biomedical composition of the present disclosure can be used to treat soft skeletal tissue or to treat hard skeletal tissue. The biomedical compositions are biodegradable and can contain various therapeutic, beneficial and pharmaceutical agents that may be released during degradation of the polymer.
摘要翻译： 公开了用于治疗骨骼组织的生物可再吸收组合物。 生物医学组合物由聚丙交酯聚合物，聚乙交酯聚合物或具有相对较低分子量的聚（乳酸 - 共 - 乙醇酸）聚合物形成。 例如，聚合物的平均数分子量通常小于10,000，例如约500至约5,000。 富马酸盐基团被并入提供交联位点的低分子量聚合物中。 如果需要，也可以将环氧乙烷基团和陶瓷颗粒引入到用于制备具有多种性质的组合物的聚合物中。 例如，本公开的生物医学组合物可用于治疗软骨骼组织或治疗硬骨骼组织。 生物医学组合物是可生物降解的，并且可以含有可在聚合物降解期间释放的各种治疗，有益和药物。
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公开(公告)号：US20080206308A1
公开(公告)日：2008-08-28
申请号：US10568058
申请日：2004-08-27
IPC分类号： A61K9/00 , C08J9/00 , C08J9/16 , C08G63/00 , A61K9/14 , A61K38/43 , A61K31/7052 , A61P43/00 , A61K38/02 , A61K38/16 , A61K38/14 , A61K39/395 , A61K31/70
摘要： Hydrogel microparticles with entrapped liquid are used as the porogen to reproducibly form interconnected pore networks in a porous scaffold. In one embodiment, a biodegradable unsaturated polymer, a crosslinking agent, and a porogen comprising biodegradable hydrogel microparticles are mixed together and allowed to form a porous scaffold in an mold or in a body cavity. Example biodegradable unsaturated polymers include poly(propylene fumarate) and poly(e-caprolactone-fumarate). The cosslinking agent may be a free radical initiator, or may include a free radical initiator and a monomer capable of addition polymerization. Example hydrogel microparticles include uncrosslinked or crosslinked collagen , an uncrosslinked or crosslinked collagen derivative, and an uncrosslinked or crosslinked synthetic biodegradable polymer such as oligo(poly(ethylene glycol) fumarate).
摘要翻译： 使用具有捕获液体的水凝胶微粒作为致孔剂，以在多孔支架中可再现形成互连的孔网络。 在一个实施方案中，将可生物降解的不饱和聚合物，交联剂和包含可生物降解的水凝胶微粒的致孔剂混合在一起并允许在模具或体腔中形成多孔支架。 可生物降解的不饱和聚合物的实例包括聚（丙烯酸富马酸酯）和聚（ε-己内酯 - 富马酸酯）。 该切断剂可以是自由基引发剂，或者可以包括自由基引发剂和能够进行加成聚合的单体。 示例性水凝胶微粒包括未交联或交联的胶原蛋白，未交联或交联的胶原衍生物，以及未交联或交联的合成生物可降解聚合物，例如寡（聚（乙二醇）富马酸酯）。
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5.发明申请Fabrication of Biomimetic Scaffolds with Well-Defined Pore Geometry by Fused Deposition Modeling 审中-公开通过熔融沉积建模制造具有良好定义的孔几何的仿生支架公开(公告)号：US20100084784A1
公开(公告)日：2010-04-08
申请号：US12575867
申请日：2009-10-08
申请人： Esmaiel Jabbari
发明人： Esmaiel Jabbari
IPC分类号： B29C33/38
摘要： A method for fabrication of a scaffold by fused deposition modeling is provided. The method includes forming a sacrificial mold with fused deposition modeling, the sacrificial mold comprising a dissolvable material. The method further includes infusing the sacrificial mold with a biodegradable composition and applying a solvent to the biodegradable composition infused sacrificial mold to dissolve the sacrificial mold and leave a scaffold formed from the biodegradable composition.
摘要翻译： 提供了通过熔融沉积建模制造支架的方法。 该方法包括形成具有熔融沉积建模的牺牲模具，所述牺牲模具包括可溶解材料。 该方法还包括用可生物降解的组合物注入牺牲模具，并将溶剂施加到可生物降解的组合物浸入的牺牲模具中以溶解牺牲模具并留下由可生物降解的组合物形成的支架。
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公开(公告)号：US20070043202A1
公开(公告)日：2007-02-22
申请号：US10562777
申请日：2004-06-29
IPC分类号： C08G69/08
CPC分类号： C08G63/08 , A61L24/0036 , A61L24/0042 , A61L24/0084 , A61L24/046 , A61L27/18 , A61L27/46 , A61L27/56 , A61L27/58 , A61L2430/02 , C08F290/00 , C08G63/60 , C08G63/912 , C08J9/26 , C08J2367/04 , C08K3/32 , C08L67/06 , C08L67/04
摘要： Fumaric acid or a salt thereof, such as a fumaryl halide (e.g., fumaryl chloride), which contains unsaturated carbon-carbon double bonds that can be used for in situ crosslinking, is copolymerized with a biodegradable poly(caprolactone) macromer that has a flexible backbone such that the resulting copolymer may self-crosslink in the absence of a crosslinking agent. The bio-compatible and bioresorbable poly(caprolactone fumarate) biomaterial is useful in the fabrication of injectable and in-situ hardening scaffolds for application in skeletal reconstruction.
摘要翻译： 富马酸或其盐，例如可用于原位交联的含有不饱和碳 - 碳双键的富马来酰卤（例如富马来酰氯）与具有柔性的可生物降解的聚（己内酯）大分子单体共聚 骨架，使得所得共聚物可在不存在交联剂的情况下自交联。 生物相容性和生物可吸收的聚（己内酯富马酸盐）生物材料可用于制造用于骨骼重建的可注射和原位硬化支架。
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7.发明申请Electrospun Fibrous Three-Dimensional Scaffolds with Well-Defined Pore Geometry 审中-公开具有良好定义孔径几何的电纺纤维三维支架公开(公告)号：US20100327494A1
公开(公告)日：2010-12-30
申请号：US12820691
申请日：2010-06-22
申请人： Esmaiel Jabbari
发明人： Esmaiel Jabbari
IPC分类号： B29C47/36
CPC分类号： D01D5/0076 , B29C48/02 , B29C48/475 , D01D7/00 , D04H3/005 , D04H3/011 , D04H3/04
摘要： In accordance with certain embodiments of the present disclosure, a method for fabricating multi-layer fibrous scaffolds with a well-defined pore geometry is provided. The method includes electrospinning generally parallel rows of biodegradable synthetic polymer fibers onto a collector plate, wherein the fibers of each generally parallel row on the collector plate are generally aligned as they are electrospun onto the collector plate. The collector plate is rotated and additional generally parallel rows of biodegradable synthetic polymer fibers are electrospun onto the collector plate, wherein the additional fibers on the collector plate are generally aligned as they are electrospun onto the collector plate and a multi-layer scaffold is formed. The process can be continued to form a multi-layer fibrous scaffold with macropores of well-defined geometry.
摘要翻译： 根据本公开的某些实施方案，提供了一种用于制备具有良好限定的孔几何形状的多层纤维支架的方法。 该方法包括将大致平行的可生物降解的合成聚合物纤维的行静电纺丝到集电板上，其中集电板上的每个大致平行的排的纤维通常对齐，因为它们电纺丝到收集板上。 收集器板旋转并且附加的大致平行的可生物降解的合成聚合物纤维的行电静电到集电板上，其中集电板上的附加纤维在它们电纺丝到收集板上时通常对准，并且形成多层支架。 该方法可以继续形成具有明确几何形状的大孔的多层纤维支架。
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8.发明申请Self-Assembled Biodegradable Nanoparticles for Medical and Biological Applications 审中-公开用于医疗和生物应用的自组装的可生物降解纳米颗粒公开(公告)号：US20100086607A1
公开(公告)日：2010-04-08
申请号：US12575876
申请日：2009-10-08
申请人： Esmaiel Jabbari
发明人： Esmaiel Jabbari
CPC分类号： B82Y5/00 , A61K47/6937 , C08H1/00
摘要： A method for forming a biodegradable composition that self-assembles into nanoparticles is provided. The method includes reacting N,N′-Disuccinimidyl carbonate with hydroxyl end-groups of poly(lactide-co-fumarate) to form a composition comprising succinimide-terminated poly(lactide-co-fumarate).
摘要翻译： 提供了一种形成自组装成纳米颗粒的可生物降解组合物的方法。 该方法包括使N，N'-二琥珀酰亚胺基碳酸酯与聚（丙交酯 - 共 - 富马酸盐）的羟基端基反应以形成包含琥珀酰亚胺封端的聚（丙交酯 - 共 - 富马酸盐）的组合物。
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9.发明授权Hydroxyapatite grafted fumarate based macromers for biodegradable composites 失效羟基磷灰石接枝富马酸盐的大分子单体用于可生物降解的复合材料公开(公告)号：US07642300B2
公开(公告)日：2010-01-05
申请号：US10562591
申请日：2004-06-29
IPC分类号： C08F297/02 , C08F297/00
CPC分类号： C08F292/00 , A61F2/28 , A61F2002/30062 , A61F2210/0004 , A61F2310/00293 , A61L27/425
摘要： A composition is disclosed which comprises (i) a macromer prepared by reacting an unsaturated diacid having a carbon-carbon double bond and a saturated diacid, and (ii) a bioactive ceramic grafted to the macromer. In one embodiment, the unsaturated diacid having a carbon-carbon double bond is fumaric acid, the saturated diacid is compatible with fumaric acid and poly(propylene fumarate) such as succinic acid, glutaric acid, adipic acid, pimelic acid, suberic acid, azelaic acid, sebacic acid and mixtures thereof, and the bioactive ceramic is hydroxyapatite. In another embodiment, hydroxyapatite is grafted with a biodegradable and crosslinkable macromer comprising silane units alternating with furnarate and adipate units.
摘要翻译： 公开了一种组合物，其包含（i）通过使具有碳 - 碳双键的不饱和二酸和饱和二酸反应制备的大分子单体，和（ii）接枝到大分子单体上的生物活性陶瓷。 在一个实施方案中，具有碳 - 碳双键的不饱和二酸是富马酸，饱和二酸与富马酸和富马酸（丙烯酸富马酸）如琥珀酸，戊二酸，己二酸，庚二酸，辛二酸，壬二酸 酸，癸二酸及其混合物，生物活性陶瓷为羟基磷灰石。 在另一个实施方案中，羟基磷灰石用可生物降解和可交联的大分子单体接枝，其包含与富马酸和己二酸酯单元交替的硅烷单元。
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10.发明授权Blend, cross-linkable poly(propylene fumarate) for immobilization and controlled drug delivery 有权用于固定和控制药物递送的共混物，可交联的聚（富马酸丙烯酯）公开(公告)号：US06884432B2
公开(公告)日：2005-04-26
申请号：US10423209
申请日：2003-04-25
申请人： Michael J. Yaszemski , Bradford L. Currier , Lichun Lu , Xun Zhu , Esmaiel Jabbari , Diederik H. R. Kempen
发明人： Michael J. Yaszemski , Bradford L. Currier , Lichun Lu , Xun Zhu , Esmaiel Jabbari , Diederik H. R. Kempen
CPC分类号： A61L27/54 , A61K9/1647 , A61L2300/414 , A61L2300/426 , A61L2300/602 , A61L2300/622 , Y10T428/2982 , Y10T428/2985 , Y10T428/2989
摘要： Microspheres for controlled release of a bioactive agent are disclosed, and in particular, blend, cross-linkable poly(propylene fumarate) for immobilization and controlled drug delivery. The microsphere includes poly(propylene fumarate), a polymeric material other than poly(propylene fumarate) (e.g., poly(lactic-co-glycolic acid)), and a bioactive agent. The bioactive agent is selected depending on the physiological effect desired. For example, in bone regeneration applications, the bioactive agent may be selected from osteoinductive agents, peptides, growth hormones, osteoconductive agents, cytokines and mixtures thereof. The bioactive agent is dispersed in the microsphere, the microsphere has a diameter in the range of 1 to 300 micrometers, the poly(propylene fumarate) and poly(lactic-co-glycolic acid) are distributed in the microsphere, and the microsphere releases the bioactive agent in a sustained manner after an initial burst release. The microspheres may be covalently attached to a poly(propylene fumarate) scaffold for tissue regeneration applications in which the bioactive agent is released from the scaffold.
摘要翻译： 公开了用于控制释放生物活性剂的微球，并且特别地，用于固定和控制药物递送的共混物，可交联聚（富马酸丙烯酯）。 微球包括聚（丙烯富马酸盐），聚（丙烯富马酸酯）以外的聚合物（例如聚（乳酸 - 共 - 乙醇酸））和生物活性剂。 取决于所需的生理效果来选择生物活性剂。 例如，在骨再生应用中，生物活性剂可以选自骨诱导剂，肽，生长激素，骨诱导剂，细胞因子及其混合物。 生物活性剂分散在微球中，微球的直径范围为1〜300微米，聚（丙烯富马酸）和聚（乳酸 - 共 - 乙醇酸）分布在微球中，微球释放出 初始爆发后持续的生物活性剂。 微球可以共价连接到用于组织再生应用的聚（丙烯富马酸酯）支架中，其中生物活性剂从支架中释放。
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