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公开(公告)号：US11992929B2
公开(公告)日：2024-05-28
申请号：US17277026
申请日：2019-09-18
发明人： Jacob Sheffield , Kendall Hal Seymour , Lance Hyatt , Scott Cunnington , Spencer Magleby , Larry L. Howell , Robert Lang
CPC分类号： B25G1/04 , A61B17/00234
摘要： A hollow rod developable actuator tool including a first link comprising an outer cylinder, a deployment ring including second link comprising a first portion pivotably connected to the first link at a first joint mounted in a first cavity in the wall of the outer cylinder and a third link comprising a second tool portion pivotably connected to the first portion at a second link, and a fourth link comprising an inner cylinder to which the second portion of the deployment ring is also pivotably connected at a third link mounted in a second cavity in the wall of the inner cylinder. When the inner cylinder of the fourth link is rotated in relation to the outer cylinder of the first link the actuator tool transitions from a first state where the deployment ring is stowed within the tool to a second state where the deployment ring is deployed externally.
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公开(公告)号：US20240127482A1
公开(公告)日：2024-04-18
申请号：US18486779
申请日：2023-10-13
发明人： Steven Paul Allen , Davi Ferrazza Cavinatto , Evan Samuel Conger , Paul-Emile Victor Passe-Carlus
IPC分类号： G06T7/80
CPC分类号： G06T7/80 , G06T2207/10088 , G06T2207/10132
摘要： A method includes determining, during a calibration phase without application of ultrasound waves, a per-pixel magnetic field gradient of a magnetic field that is generated using a calibration drive signal applied to a magnetic coil; generating, during a treatment phase, a magnetic field gradient that is applied to a treatment area by using a treatment drive signal applied to the magnetic coil, wherein treatment drive signal is different from the calibration drive signal; determining, based on the treatment drive signal applied to the magnetic coil, per-pixel phases of a treatment image of the treatment area, wherein the per-pixel phases of the treatment image are based on spin displacement at each pixel resulting from the applied ultrasound waves; and adjusting, for each pixel of the treatment image, the per-pixel phases of the treatment image based on the per-pixel magnetic field gradient for a corresponding pixel, to obtain a gradient-adjusted treatment image.
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公开(公告)号：US20240082209A1
公开(公告)日：2024-03-14
申请号：US18491644
申请日：2023-10-20
发明人： David Lee KOOYMAN
IPC分类号： A61K31/352 , A61K9/00 , A61K9/06 , A61K45/06 , A61K47/10 , A61K47/20 , A61K47/44 , A61P19/02
CPC分类号： A61K31/352 , A61K9/0014 , A61K9/06 , A61K45/06 , A61K47/10 , A61K47/20 , A61K47/44 , A61P19/02
摘要： The invention described herein relates to compositions and methods for treating pain with wogonin. In particular, described herein are compositions and methods for treating musculoskeletal pain and arthritis with wogonin.
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公开(公告)号：US11913941B2
公开(公告)日：2024-02-27
申请号：US16652381
申请日：2018-10-02
IPC分类号： G01N33/53 , B01L3/00 , C12Q1/70 , G01N33/487 , C12Q1/6825 , G01N35/00 , G01N33/543
CPC分类号： G01N33/5302 , B01L3/50273 , C12Q1/6825 , C12Q1/70 , G01N33/48721 , G01N33/54333 , G01N35/00 , B01L2200/0668 , G01N2035/00247 , C12Q1/6825 , C12Q2565/631 , C12Q2565/629 , C12Q2565/519 , C12Q1/70 , C12Q2565/631 , C12Q2565/629 , C12Q2565/519
摘要： A disclosed system uses modulations of ionic current across a nanopore in a membrane to detect target molecules passing through the nanopore. This principle has been applied mainly to nucleic acid sequencing, but can also be used to detect other molecular targets such as proteins and small molecules. In addition, the system delivers target molecules to a nanopore to provide label-free single molecule analysis using a chip-based system. Target molecules are concentrated on microscale carrier beads, and the beads are delivered and optically trapped in an area within the capture radius of the nanopore. The target molecules are released from the beads and detected using nanopore current modulation. In addition, the disclosed system combines sample preparation (e.g. purification, extraction, and pre-concentration) with nanopore-based readout on a microfluidic chip. Finally, target molecules can be specifically bound to carrier beads and particles are positioned within the capture volume of a nanopore using a chip-based microfluidic platform proven to handle specific detection of molecular targets from milliliters of raw sample.
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公开(公告)号：US11895781B1
公开(公告)日：2024-02-06
申请号：US16669408
申请日：2019-10-30
发明人： Robert Davis , Nick Morrill , David Miller
CPC分类号： H05K3/4644 , A61B5/0535 , A61B5/681 , G01R27/26 , G04G21/025 , H05K3/146 , H05K3/40 , A61B2562/0209
摘要： A method, system, apparatus, and/or device with a miniaturized impedance sensor. The method, system, apparatus, and/or device may include a substrate with locally non-flexible regions interconnected by a flexible material and a miniaturized impedance sensor disposed on the substrate. The miniaturized impedance sensor may include: an array of electrical contacts; an array of miniaturized electrodes disposed on the array of electrical contacts; and an interstitial filler disposed within the array of miniaturized electrodes. The locally non-flexible regions may correspond to subsets of the array of miniaturized electrodes. The locally non-flexible regions may retain shape as the flexible material changes shape.
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公开(公告)号：US11883146B1
公开(公告)日：2024-01-30
申请号：US16669412
申请日：2019-10-30
发明人： Robert Davis , Nick Morrill , David Miller
IPC分类号： A61B5/0531 , A61B5/021 , A61B5/00
CPC分类号： A61B5/0531 , A61B5/02116 , A61B5/681 , A61B5/0006
摘要： A method, system, apparatus, and/or device to select a depth within a body part to measure an impedance. The method, system, apparatus, and/or device may include: a band configured to extend at least partially around a body part of a user; a user interface coupled to the band; a miniaturized impedance sensor embedded in the band and positioned in the band to be pressed against the body part when the user wears the band, the miniaturized impedance sensor including an array of miniaturized electrodes, where the array of miniaturized electrodes is configured to measure an impedance at a depth within the body part and the depth corresponds to a subdermal feature within the body part; a processing device coupled to the band, where the processing device is configured to select the depth within the body part to measure an impedance; and an electrical circuit embedded in the band.
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公开(公告)号：US11701023B1
公开(公告)日：2023-07-18
申请号：US16669407
申请日：2019-10-30
发明人： Robert Davis , Nick Morrill , David Miller
IPC分类号： A61B5/0531 , A61B5/00
CPC分类号： A61B5/0531 , A61B5/681 , A61B5/7475 , A61B5/6831 , A61B2562/028 , A61B2562/0285
摘要： A method, system, apparatus, and/or device for measuring a physiological condition of a user. The method, system, apparatus, and/or device may include: a band configured to attach to a body part of a user; a housing coupled to the band; a processing device integrated into the band or disposed within the housing; an interface integrated into the band or disposed within the housing; and a miniaturized impedance sensor.
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8.发明公开公开(公告)号：US20230165937A1
公开(公告)日：2023-06-01
申请号：US17995794
申请日：2021-04-07
发明人： Pam VAN RY , Mary VALLECILLO
CPC分类号： A61K38/1732 , A61P21/00
摘要： Limb-girdle muscular dystrophy type 2B (LGMD2B) is caused by mutations in the dysferlin gene, resulting in non-functional dysferlin, a key protein found in muscle membrane. Treatment options available for patients are chiefly palliative in nature and focus on maintaining ambulation. A method of treating LGMD2B is disclosed herein. The method includes administering to a patient a suitable amount of a galectin protein or fragment thereof. Treatment with a recombinant galectin promoted myogenic maturation as indicated through improvements in size, myotube alignment, myoblast migration, and membrane repair capacity in dysferlin-deficient myo tubes, explant myofibers and mice.
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公开(公告)号：US11585756B2
公开(公告)日：2023-02-21
申请号：US16464929
申请日：2017-11-30
发明人： Troy Munro , Ryker Haddock
摘要： Embodiments disclosed herein relate to methods and systems for determining thermal properties of materials by using frequency modulated pump light intensity to cyclically heat a sample, and using probe light to induce fluorescent signals from fluorescent indicators on the surface of the material during the cyclic 5 heating. The methods and systems utilize the phase delay between the frequency modulated pump light and the corresponding fluorescent signals to determine the thermal properties of the material at one or more locations on the material sample.
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公开(公告)号：US11533018B2
公开(公告)日：2022-12-20
申请号：US17250134
申请日：2019-06-06
发明人： Spencer Magleby , Larry Howell , Nathan Pehrson
IPC分类号： H02S30/20
摘要： An apparatus can include a central member comprising a first side, a second side, and a third side, a first interior panel rotatably attached to the first side, a second interior panel rotatably attached to the second side, a third interior panel rotatably attached to the third side, a first exterior panel rotatably attached to the first interior panel, a second exterior panel rotatably attached to the second interior panel, a third exterior panel rotatably attached to the third interior panel, a first interior biasing member attached to the central member and the first interior panel and biasing the first interior panel to extend away from the central member toward a plane parallel to the central member, and a first interior restraint cable attached to the central member and the first interior panel and restraining the first interior panel from extending along the plane parallel to the central member.
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