NOVEL MRNA COMPOSITION AND PRODUCTION METHOD FOR USE IN ANTI-VIRAL AND ANTI-CANCER VACCINES

    公开(公告)号:US20220396798A1

    公开(公告)日:2022-12-15

    申请号:US17489357

    申请日:2021-09-29

    Abstract: This invention relates to a novel mRNA composition and its production method useful for developing and manufacturing RNA-based anti-viral and/or anti-cancer vaccines and medicines. This invention includes two types of mRNA constructs, namely “5′-hairpin messenger RNA (5hmRNA)” and “messenger-hairpin-messenger RNA (mhmRNA)”, respectively. Both of 5hmRNA and mhmRNA contain at least a hairpin-like stem-loop RNA structure. The 5hmRNA contains at least a stem-loop RNA structure in the 5′-UTR of a protein/peptide-coding mRNA, while the mhmRNA contains a middle stem-loop structure flanked with two protein/peptide-coding mRNA sequences on both sides. In mhmRNA, the first 5′-mRNA preferably encodes an RNA replicase, for amplifying the second 3′-mRNA in transfected cells. After transfection into target cells, 5hmRNA and mhmRNA can be further translated into at least a desired protein/peptide. To produce highly structured 5hmRNA and mhmRNA, a novel PCR-IVT methodology has been developed and used with a specially designed RNA polymerase-helicase mixture reaction

    Luggage with Utility Desk Panel
    4.
    发明申请

    公开(公告)号:US20210007453A1

    公开(公告)日:2021-01-14

    申请号:US16505404

    申请日:2019-07-08

    Inventor: Shiou Chang LIN

    Abstract: A luggage piece includes a luggage housing and a personal accessory arrangement. The personal accessory arrangement includes a utility desk panel pivotally connected to the luggage housing to move between an idle position and a working position, wherein in the idle position, the utility desk panel is pivotally moved toward the luggage housing to align with the surrounding surface of the luggage housing, wherein in the working position, the utility desk panel is pivotally moved to be securely held at a predetermined angle of inclination with the surrounding surface for allowing a user to work on the utility desk panel.

    Sensing faucet for integration of soap supply with water exit

    公开(公告)号:US10597854B1

    公开(公告)日:2020-03-24

    申请号:US16387563

    申请日:2019-04-18

    Abstract: A sensing faucet for the integration of soap supply with water exit includes a main body configured with a mounting portion having a first mounting zone and second mounting zone, where the first mounting zone is used to accept a water supply module, and the second mounting zone a soap supply module, where an obtuse angle is formed between the first and second mounting zones. With the above structure, the soap supply module can conform to a human factor design besides the water and soap supply modules are integrated with each other in the same sensing faucet, allowing users direct soap supply according hand washing habits without needing to touch any other components, and the hand cleaning convenience can then be achieved.

    PROPULSION DEVICE
    6.
    发明申请
    PROPULSION DEVICE 审中-公开

    公开(公告)号:US20180334243A1

    公开(公告)日:2018-11-22

    申请号:US15844566

    申请日:2017-12-17

    Applicant: Yao-Chang Lin

    Inventor: Yao-Chang Lin

    Abstract: A propulsion device includes a cylinder body, a first set of blades, a second set of blades, a first transmission shaft, a second transmission shaft, a power gear box and an accelerator. The first set of blades and the second set of blades are disposed in an airflow channel of the cylinder body. The first transmission shaft is connected to the first set of blades and the second transmission shaft is connected to the second set of blades. The first transmission shaft and the second transmission shaft are interconnected by the accelerator. The first set of blades has a first rotation speed, and the accelerator causes the second set of blades to have a second rotation speed. The second rotation speed is greater than the first rotation speed to increase the propulsion force.

    ACTIVATION DEVICE FOR AN ELECTONIC FAUCET
    8.
    发明申请

    公开(公告)号:US20170218606A1

    公开(公告)日:2017-08-03

    申请号:US15008448

    申请日:2016-01-28

    CPC classification number: E03C1/055 E03C1/057

    Abstract: An activation device for an electronic faucet comprises a body, a shell, and a battery. It is further characterized in that a wireless transmission module is arranged at the shell and electrically connected with the battery pack. The wireless transmission module has an activation switch which has a timer to be set to turn on/off the wireless transmission module. Therefore, the wireless transmission module may be not continuously operated so as to effectively reduce the power loss.

    Foamed soap dispensing structure
    9.
    发明授权

    公开(公告)号:US09603494B1

    公开(公告)日:2017-03-28

    申请号:US14932982

    申请日:2015-11-05

    CPC classification number: A47K5/14 A47K5/1211 A47K5/1217 B05B11/3087

    Abstract: A foamed soap dispensing structure comprises a container, a cover set, a faucet, and a foaming unit. The foaming unit has a foaming member and an outer ring. The foaming member has two inlets and a foam material. The outer ring has an assembling end corresponding to a connection end of a soap providing portion of the faucet. When the foaming unit is clogged, the foaming unit may be pulled out by an user so that the assembling end may be separated from the connection end of the soap providing portion to easily replace the foaming member and then to achieve the effect of easy construction.

    Voltage regulators, memory circuits, and operating methods thereof
    10.
    发明授权
    Voltage regulators, memory circuits, and operating methods thereof 有权
    电压调节器,存储器电路及其操作方法

    公开(公告)号:US09489989B2

    公开(公告)日:2016-11-08

    申请号:US12820712

    申请日:2010-06-22

    CPC classification number: G11C11/4074 G11C5/147

    Abstract: A voltage regulator includes an output stage electrically coupled with an output end of the voltage regulator. The output stage includes at least one transistor having a bulk and a drain. At least one back-bias circuit is electrically coupled with the bulk of the at least one transistor. The at least one back-bias circuit is configured to provide a bulk voltage, such that the bulk and the drain of the at least one transistor are reverse biased during a standby mode of a memory array that is electrically coupled with the voltage regulator.

    Abstract translation: 电压调节器包括与电压调节器的输出端电耦合的输出级。 输出级包括具有体积和漏极的至少一个晶体管。 至少一个背偏置电路与所述至少一个晶体管的主体电耦合。 至少一个背偏置电路被配置为提供体电压,使得在与电压调节器电耦合的存储器阵列的待机模式期间,至少一个晶体管的体积和漏极被反向偏置。

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