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公开(公告)号:US20230002435A1
公开(公告)日:2023-01-05
申请号:US17820921
申请日:2022-08-19
申请人: Conagen Inc.
发明人: Guohong Mao , Xiaodan Yu
IPC分类号: C07H15/24 , C07H1/00 , C12N9/10 , A23L2/60 , C07H15/256 , C12P19/56 , A23L27/30 , A23L33/10 , C12P19/18
摘要: Disclosed are steviol glycosides referred to as rebaudioside V and rebaudioside W. Also disclosed are methods for producing rebaudioside M (Reb M), rebausoside G (Reb G), rebaudioside KA (Reb KA), rebaudioside V (Reb V) and rebaudioside (Reb W).
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公开(公告)号:US20220275379A9
公开(公告)日:2022-09-01
申请号:US16036261
申请日:2018-07-16
申请人: Conagen, Inc.
摘要: The present invention relates to a Plasmid Addiction System for the stabilization of expression plasmids encoding proteins of interest. The invention uses a succinate cycle optimization to ensure the expression of plasmid(s) of interest. By ensuring that plasmids of interest contain genes necessary in the succinate cycle, the system ensures that the passage of the plasmid to daughters and therefore improves the efficiency of production and expression of genes and/or products of interest.
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公开(公告)号:US11421239B2
公开(公告)日:2022-08-23
申请号:US16036261
申请日:2018-07-16
申请人: Conagen, Inc.
摘要: The present invention relates to a Plasmid Addiction System for the stabilization of expression plasmids encoding proteins of interest. The invention uses a succinate cycle optimization to ensure the expression of plasmid(s) of interest. By ensuring that plasmids of interest contain genes necessary in the succinate cycle, the system ensures that the passage of the plasmid to daughters and therefore improves the efficiency of production and expression of genes and/or products of interest.
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公开(公告)号:US20220243230A1
公开(公告)日:2022-08-04
申请号:US17726387
申请日:2022-04-21
申请人: Conagen Inc.
发明人: Grace Park , Ernesto Simon
摘要: The present invention relates, at least in part, to the production of resveratrol from 4-coumaric acid. The production can be mediated in a transgenic Saccharomyces cell.
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公开(公告)号:US20210317485A1
公开(公告)日:2021-10-14
申请号:US16317844
申请日:2017-07-19
申请人: Conagen Inc.
发明人: Hui Chen , Xiaodan Yu , LanLan Zhou , Hongxue Wang , Min Wang
IPC分类号: C12P13/02 , C07C233/18 , C07C233/20 , A61K9/00 , C11B9/00 , A23L27/10
摘要: The present invention relates to the production of capsaicinoid compounds including Capsaicin and Nonivamide via microbial fermentation.
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公开(公告)号:US20210189448A1
公开(公告)日:2021-06-24
申请号:US17109473
申请日:2020-12-02
申请人: Conagen Inc.
发明人: Guohong Mao , Michael Batten , Phillip Hunt , Oliver (Xiaodan) Yu
摘要: The present disclosure relates to the production of steviol glycosides rebaudioside J and rebaudioside N through the use of rebaudioside A as a substrate and a biosynthetic pathway involving various 1,2 RhaT-rhamnosyltransferases.
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公开(公告)号:US10883130B2
公开(公告)日:2021-01-05
申请号:US16679032
申请日:2019-11-08
申请人: Conagen Inc.
发明人: Guohong Mao , Michael Batten , Phillip Hunt , Oliver (Xiaodan) Yu
摘要: The present disclosure relates to the production of steviol glycosides rebaudioside J and rebaudioside N through the use of rebaudioside A as a substrate and a biosynthetic pathway involving various 1,2 RhaT-rhamnosyltransferases.
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公开(公告)号:US10774103B2
公开(公告)日:2020-09-15
申请号:US15801411
申请日:2017-11-02
申请人: Conagen Inc.
发明人: Guohong Mao , Xiaodan Yu
IPC分类号: C07H15/24 , C12N9/10 , A23L33/10 , C12P19/18 , A23L27/30 , C07H1/00 , A23L2/60 , C07H15/256 , C12P19/56
摘要: Disclosed are steviol glycosides referred to as rebaudioside V and rebaudioside W. Also disclosed are methods for producing rebaudioside M (Reb M), rebausoside G (Reb G), rebaudioside KA (Reb KA), rebaudioside V (Reb V) and rebaudioside (Reb W).
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公开(公告)号:US10655150B2
公开(公告)日:2020-05-19
申请号:US16067161
申请日:2017-01-06
申请人: Conagen Inc.
发明人: Hui Chen , Xiaodan Yu
摘要: Provided herein are methods of making capsinoids including providing a capsiate synthase in a mixture or cellular system, feeding 8-methyl-6-nonenoyl-CoA, 6E-8-methylnonenoic acid or 8-methylnonanoic acid into the mixture or cellular system, feeding vanillyl alcohol into the mixture or cellular system, and collecting capsinoids from the mixture or cellular system.
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公开(公告)号:US10654881B2
公开(公告)日:2020-05-19
申请号:US15701613
申请日:2017-09-12
申请人: Conagen Inc.
IPC分类号: C07H15/24 , C07H15/256 , C12N9/10 , C12P19/56
摘要: Disclosed is a steviol glycoside referred to as rebaudioside D2. Rebaudioside D2 has five β-D-glucosyl units connected to the aglycone steviol. Also disclosed are methods for producing rebaudioside D2, a UDP-glycosyltransferase fusion enzyme, and methods for producing rebaudioside D and rebaudioside E.
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