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公开(公告)号：US08632753B2
公开(公告)日：2014-01-21
申请号：US12972965
申请日：2010-12-20
申请人： Hong Fan , Karen E. Linder , Edmund R. Marinelli , Palaniappa Nanjappan , Adrian D. Nunn , Radhakrishna K. Pillai , Kondareddiar Ramalingam , Ajay Shrivastava , Bo Song , Rolf E. Swenson , Mathew A. Von Wronski , Aaron K. Sato , Sharon Michele Walker , Daniel T. Dransfield
发明人： Hong Fan , Karen E. Linder , Edmund R. Marinelli , Palaniappa Nanjappan , Adrian D. Nunn , Radhakrishna K. Pillai , Kondareddiar Ramalingam , Ajay Shrivastava , Bo Song , Rolf E. Swenson , Mathew A. Von Wronski , Aaron K. Sato , Sharon Michele Walker , Daniel T. Dransfield
CPC分类号： A61K47/48246 , A61K38/16 , A61K47/42 , A61K47/60 , A61K47/64 , A61K49/221 , A61K49/223 , C07K7/08 , C07K7/64 , Y02A50/411
摘要： The invention provides compositions and methods for therapeutic and diagnostic applications.
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2.发明授权Compositions and methods for treating osteolytic disorders comprising MMP-14 binding proteins 有权用于治疗包含MMP-14结合蛋白的溶骨性病症的组合物和方法公开(公告)号：US08501181B2
公开(公告)日：2013-08-06
申请号：US13338622
申请日：2011-12-28
IPC分类号： A61K39/395
CPC分类号： C07K16/40 , C07K2317/56 , C07K2317/565 , C07K2317/76 , Y10T428/13
摘要： Provided are methods and compositions for using MMP-14 or MMP-9 binding proteins alone or in combination with other therapeutic agents to treat osteolytic disorders such as osteotropic cancer and osteoporosis.
摘要翻译： 提供了单独使用MMP-14或MMP-9结合蛋白或与其它治疗剂组合以治疗溶骨性疾病如骨性骨骼肌和骨质疏松症的方法和组合物。
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公开(公告)号：US20110286929A1
公开(公告)日：2011-11-24
申请号：US12972965
申请日：2010-12-20
申请人： Hong Fan , Karen E. Linder , Edmund R. Marinelli , Palaniappa Nanjappan , Adrian D. Nunn , Radhakrishna K. Pillai , Kondareddiar Ramalingam , Ajay Shrivastava , Bo Song , Rolf E. Swenson , Mathew A. Von Wronski , Aaron K. Sato , Sharon Michele Walker , Daniel T. Dransfield
发明人： Hong Fan , Karen E. Linder , Edmund R. Marinelli , Palaniappa Nanjappan , Adrian D. Nunn , Radhakrishna K. Pillai , Kondareddiar Ramalingam , Ajay Shrivastava , Bo Song , Rolf E. Swenson , Mathew A. Von Wronski , Aaron K. Sato , Sharon Michele Walker , Daniel T. Dransfield
CPC分类号： A61K47/48246 , A61K38/16 , A61K47/42 , A61K47/60 , A61K47/64 , A61K49/221 , A61K49/223 , C07K7/08 , C07K7/64 , Y02A50/411
摘要： The invention provides compositions and methods for therapeutic and diagnostic applications.
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公开(公告)号：US20110070165A1
公开(公告)日：2011-03-24
申请号：US12888736
申请日：2010-09-23
申请人： Christophe Arbogast , Philippe Bussat , Hong Fan , Karen E. Linder , Edmund R. Marinelli , Palaniappa Nanjappan , Adrian D. Nunn , Radhakrishna K. Pillai , Sibylle Pochon , Kondareddiar Ramalingam , Ajay Shrivastava , Bo Song , Rolf E. Swenson , Mathew A. Von Wronski , Feng Yan , Aaron K. Sato , Sharon Michele Walker , Daniel T. Dransfield
发明人： Christophe Arbogast , Philippe Bussat , Hong Fan , Karen E. Linder , Edmund R. Marinelli , Palaniappa Nanjappan , Adrian D. Nunn , Radhakrishna K. Pillai , Sibylle Pochon , Kondareddiar Ramalingam , Ajay Shrivastava , Bo Song , Rolf E. Swenson , Mathew A. Von Wronski , Feng Yan , Aaron K. Sato , Sharon Michele Walker , Daniel T. Dransfield
摘要： The invention provides compositions and methods for therapeutic and diagnostic applications.
摘要翻译： 本发明提供用于治疗和诊断应用的组合物和方法。
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公开(公告)号：US20110059105A1
公开(公告)日：2011-03-10
申请号：US12824823
申请日：2010-06-28
IPC分类号： A61K39/395 , C07K16/40 , G01N33/573 , A61P35/00 , A61P29/00
CPC分类号： C07K16/005 , C07K16/2863 , C07K2317/55 , C07K2317/565 , C07K2317/73 , C07K2317/75 , C07K2317/76 , C07K2319/00
摘要： Tie1 and Tie2 are receptor tyrosine kinase proteins that include a transmembrane domain. Tie1 and Tie2 are present on endothelial cells. This disclosure describes agents, such as antibodies, that bind to Tie1, Tie2, and Ang, including ones that inhibit endothelial cell activity.
摘要翻译： Tie1和Tie2是受体酪氨酸激酶蛋白，其包括跨膜结构域。 Tie1和Tie2存在于内皮细胞上。 本公开描述了结合Tie1，Tie2和Ang的试剂，例如抗体，包括抑制内皮细胞活性的抗体。
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公开(公告)号：US07745587B2
公开(公告)日：2010-06-29
申请号：US11648423
申请日：2006-12-29
申请人： Laetitia Devy , Henk Pieters , Robert C. Ladner , Rene Hoet , Daniel T. Dransfield , Clive R. Wood , Maria Henderikx
发明人： Laetitia Devy , Henk Pieters , Robert C. Ladner , Rene Hoet , Daniel T. Dransfield , Clive R. Wood , Maria Henderikx
IPC分类号： C07K16/40 , C07K16/00 , A61K39/395
CPC分类号： C07K16/40 , A61K51/1075 , A61K2039/505 , C07K16/30 , C07K2317/21 , C07K2317/24 , C07K2317/55 , C07K2317/56 , C07K2317/565 , C07K2317/73 , C07K2317/76 , C07K2317/92 , G01N33/573 , G01N2333/96486
摘要： Proteins that bind to matrix metalloproteinase 14 and methods of using such proteins are described.
摘要翻译： 描述了结合基质金属蛋白酶14的蛋白质和使用这些蛋白质的方法。
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7.发明申请KDR AND VEGF/KDR BINDING PEPTIDES AND THEIR USE IN DIAGNOSIS AND THERAPY 有权KDR和VEGF / KDR结合肽及其在诊断和治疗中的应用公开(公告)号：US20100003195A1
公开(公告)日：2010-01-07
申请号：US12480578
申请日：2009-06-08
申请人： Aaron K. Sato , Daniel J. Sexton , Daniel T. Dransfield , Robert C. Ladner , Christophe Arbogast , Philippe Bussat , Hong Fan , Sudha Khurana , Karen E. Linder , Edmund R. Marinelli , Palaniappa Nanjappan , Adrian D. Nunn , Radhakrishna Pillai , Sibylle Pochon , Kondareddiar Ramalingam , Ajay Shrivastava , Bo Song , Rolf E. Swenson , Mathew A. Von Wronski
发明人： Aaron K. Sato , Daniel J. Sexton , Daniel T. Dransfield , Robert C. Ladner , Christophe Arbogast , Philippe Bussat , Hong Fan , Sudha Khurana , Karen E. Linder , Edmund R. Marinelli , Palaniappa Nanjappan , Adrian D. Nunn , Radhakrishna Pillai , Sibylle Pochon , Kondareddiar Ramalingam , Ajay Shrivastava , Bo Song , Rolf E. Swenson , Mathew A. Von Wronski
IPC分类号： A61K49/22
CPC分类号： A61K49/221 , A61K38/00 , A61K47/62 , A61K49/223 , A61K51/088 , C07K7/08 , C07K14/001 , C07K14/52 , C07K14/71 , C07K2319/00 , Y02A50/411 , Y02A50/58
摘要： The present invention provides polypeptides, peptide dimer, and multimeric complexes comprising at least one binding moiety for KDR or VEGF/KDR complex, which have a variety of uses wherever treating, detecting, isolating or localizing angiogenesis is advantageous. Particularly disclosed are synthetic, isolated polypeptides capable of binding KDR or VEGF/KDR complex with high affinity (e.g., having a KD
摘要翻译： 本发明提供了包含用于KDR或VEGF / KDR复合物的至少一个结合部分的多肽，肽二聚体和多聚体复合物，其具有各种用途，无论何处治疗，检测，分离或定位血管发生都是有利的。 特别公开的是能够以高亲和力（例如具有KD <1μM）结合KDR或VEGF / KDR复合物的合成，分离的多肽，以及包含这些多肽的二聚体和多聚体构建体。
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公开(公告)号：US07211240B2
公开(公告)日：2007-05-01
申请号：US10379287
申请日：2003-03-03
申请人： Christophe Arbogast , Philippe Bussat , Hong Fan , Karen E. Linder , Edmund R. Marinelli , Palaniappa Nanjappan , Adrian Nunn , Radhakrishna Pillai , Sybille Pochon , Kondareddiar Ramalingam , Ajay Shrivastava , Bo Song , Rolf E. Swenson , Mathew A. Von Wronski , Aaron Sato , Sharon Michele Walker , Daniel T. Dransfield
发明人： Christophe Arbogast , Philippe Bussat , Hong Fan , Karen E. Linder , Edmund R. Marinelli , Palaniappa Nanjappan , Adrian Nunn , Radhakrishna Pillai , Sybille Pochon , Kondareddiar Ramalingam , Ajay Shrivastava , Bo Song , Rolf E. Swenson , Mathew A. Von Wronski , Aaron Sato , Sharon Michele Walker , Daniel T. Dransfield
IPC分类号： A61K49/00
摘要： The invention provides compositions and methods for therapeutic and diagnostic applications.
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公开(公告)号：US08663603B2
公开(公告)日：2014-03-04
申请号：US12888736
申请日：2010-09-23
申请人： Christophe Arbogast , Philippe Bussat , Hong Fan , Karen E. Linder , Edmund R. Marinelli , Palaniappa Nanjappan , Adrian D. Nunn , Radhakrishna K. Pillai , Sibylle Pochon , Kondareddiar Ramalingam , Ajay Shrivastava , Bo Song , Rolf E. Swenson , Mathew A. Von Wronski , Feng Yan , Aaron K. Sato , Sharon Michele Walker , Daniel T. Dransfield
发明人： Christophe Arbogast , Philippe Bussat , Hong Fan , Karen E. Linder , Edmund R. Marinelli , Palaniappa Nanjappan , Adrian D. Nunn , Radhakrishna K. Pillai , Sibylle Pochon , Kondareddiar Ramalingam , Ajay Shrivastava , Bo Song , Rolf E. Swenson , Mathew A. Von Wronski , Feng Yan , Aaron K. Sato , Sharon Michele Walker , Daniel T. Dransfield
IPC分类号： A61B8/00
摘要： The invention provides compositions and methods for therapeutic and diagnostic applications.
摘要翻译： 本发明提供用于治疗和诊断应用的组合物和方法。
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10.发明授权Evaluating MMP expression in patient stratification and other therapeutic, diagnostic and prognostic methods for cancer 失效评估患者分层中的MMP表达和癌症的其他治疗，诊断和预后方法公开(公告)号：US08183008B2
公开(公告)日：2012-05-22
申请号：US12337218
申请日：2008-12-17
IPC分类号： C12Q1/37
CPC分类号： G01N33/57492 , C12Q1/6886 , G01N33/57484
摘要： Provided are compositions, methods and kits for quantifying the expression and/or activity of MMP-14 and other biomarkers of cancer, which may be used diagnostically and prognostically, e.g., in patient stratification and evaluation of appropriate therapeutic regimens.
摘要翻译： 提供了用于定量MMP-14和其他癌症生物标志物的表达和/或活性的组合物，方法和试剂盒，其可以在诊断和预后中使用，例如在患者分层和评估适当的治疗方案中。
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